• Title/Summary/Keyword: New formulation

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Stability Review of Formulations Produced with Ozone Free Plasma (제형별 오존 free 플라즈마 안정도 검토)

  • You-Yeon Chun;Ha Hyeon Jo;Moonki Baek;Sun Ju Park;Sofia Brito;Bum-Ho Bin
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.50 no.2
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    • pp.143-151
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    • 2024
  • Ozone is a colorless, toxic gas that is produced when nitrogen oxides and hydrocarbons undergo a photochemical oxidation reaction in the sun's rays. Even at low concentrations, it affects the respiratory system, causing coughing and other harmful effects. It was confirmed that ozone was generated from nitrogen plasma among cosmetic raw materials, and it was found that the concentration of ozone decreased after 1 day. On the other hand, ozone was not detected in ozone-free plasma generated with argon gas. Therefore, we aimed to produce ozone-free cosmetics by utilizing ozone-free plasma. For efficient plasma processing, the non-sinking method was utilized to inject the plasma into layer separation mists, toners, and ampoules, and the stability was observed. It was found that the successful injection of plasma in the layer separation mist was higher than the other two formulations, but decreased sharply compared to the toner and ampoule. It was found that the ozone-free plasma used did not affect the stability of the layer separation mist, toner, and ampoule under low temperature (4 ℃), room temperature (25 ℃), and high temperature (37 ℃, 50 ℃) conditions. Therefore, this study suggests the importance of ozone-free plasma for cosmetic potential and stability of each formulation.

Effect of MeOH/IPA Ratio on Coating and Fluxing of Organic Solderability Preservatives (유기 솔더 보존제의 코팅 및 플럭싱에 대한 메탄올/이소프로필알콜 비율의 영향)

  • Lee, Jae-Won;Kim, Chang Hyeon;Lee, Hyo Soo;Huh, Kang Moo;Lee, Chang Soo;Choi, Ho Suk
    • Korean Chemical Engineering Research
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    • v.46 no.2
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    • pp.402-407
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    • 2008
  • Recent popularity in mobile electronics requires higher standard on the mechanical strength of electronic packaging. Thus, the method of soldering between chip and substrate in electronic packaging process is changing from conventional method using intermetallic compound to a new method using organic solderability preservative (OSP) in order to improve the stability and the reliability of final product. Since current organic solder preservatives have several serious problems like thermo-stability during packaging process, however, it is necessary to develop new OSPs having thermo-stability. The main purpose of this study is to investigate the effect of MeOH/IPA (Isopropyl alcohol) ratio on the fluxing of a new OSP, developed in previous research, andto find out an optimum formulation of flux components for the application of the OSP in current packaging process. As a result of this study, it was revealed that higher MeOH/IPA ratio in flux showed better performance of fluxing a new OSP.

DEVELOPMENT OF THREE-DIMENSIONAL DYNAMIC ANALYSIS MODEL HIGH SPEED TRAIN-BRIDGE INTERACTION (철도 차량 - 교량 상호작용에 의한 3차원 동적 해석 모델 개발)

  • Dinh, Van Nguyen;Kim, Ki Du;Shim, Jae Soo;Choi, Eun Soo;Songsak, Suthasupradit
    • Journal of Korean Society of Steel Construction
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    • v.20 no.1
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    • pp.151-163
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    • 2008
  • A formulation of three-dimensional model of articulated train-b ridge dynamic interaction has been made for the Korean eXpress Train (KTX). Semi-periodic profiles of rail irregularities consisting of elevation, alignment, cross and gauge irregularities have also been proposed using FRA maximum tolerable rail deviations. The effects of rail joints and sleeper step were also included. The resulting system matrices of train and bridge are very spare, and thus, are stored in one-dimensional arrays, yielding a time-efficient solution. A numerical algorithm for computing bridge-train response including an iterative scheme is also formulated. A program simulating train-bridge interaction and solving this problem using the new algorithm is implemented as new modules for the f inite element analysis software named XFINAS. Computed results using the new program are then checked by that of the validated 2-D bridge-train interaction model. This new 3D analysis provides more detailed train responses such as swaying, bouncing, rolling, pitching and yawing accelerations, which are useful inevaluating passenger riding comfort. Train operation safety and derailment could also be directly investigated by relative wheel displacements computed from this program.

Basic Properties and Solution Behavior of New Naturally Derived Cosmetic Preservative, and Stability of Cosmetic Formulation (신규 화장품용 천연유래 보존제의 물성 측정, 용액 거동 및 보존제 포함 화장품의 제형 안정성)

  • Subin Shin;Jeongeun Park;Nayeon Ko;Mijung Kim;Hyewon Shin;Dasom Lee;Narae Kim;Taeshik Earmme;Gugin Jeong;Joonwon Bae
    • Applied Chemistry for Engineering
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    • v.35 no.2
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    • pp.122-127
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    • 2024
  • Cosmetic preservatives are an important class of ingredients in terms of ensuring sustainable use and providing customer satisfaction. Recently, a great deal of interest has been drawn to the production and use of toxic-free, naturally derived preservatives. In this work, a new naturally derived preservative (laurimino bispropanediol, LB) was developed to replace the most widely used diol preservatives, such as 1,2-hexanediol or 1,2-octanediol. The basic properties of the obtained preservative were measured, and the solution behavior of the preservative in an aqueous medium was examined. The feasibility of micelle formation in the preservative solution was investigated using the fluorescence (FL) based pyrene method. Micelle formation was feasible owing to the relatively long hydrophobic chains and increased hydroxyl groups in the preservative molecules. The emulsification capability of the preservative was assessed using the Rosano and Kimura method, showing that the preservative possessed emulsifying capability in an organic solvent (benzene) and soy bean oil. In addition, the dispersion stability of cosmetic formulations, including the new LB preservatives such as essence and lotion, was demonstrated by comparing the light transmittance of the formulations. This article provides important information for future research regarding the synthesis and practical applications of new toxic-free naturally derived preservatives.

New Synthesis of Sestamibi and Comparison of Stability of Its Formulation (Sestamibi의 신규합성과 제제화에 따른 안정성 비교)

  • Son, Mi-Won;Lim, Joong-In;Chang, Young-Soo;Jung, Mi-Young;Jeong, Lak-Shin;Kim, Soon-Hoe;Kim, Won-Bae;Jeong, Jae-Min
    • The Korean Journal of Nuclear Medicine
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    • v.35 no.5
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    • pp.334-341
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    • 2001
  • Purpose: Ascorbic acid us known to act as an antioxidant. Therefore, it can be used in increasing the efficiency of radiochemical labeling of Technetium-99m setamibi by inhibition of oxidation of $Sn^{2+}$ at low concentration. We intended to estimate the efficiency of radiochemical labeling and the stability of the newly formed formulation when ascorbic acid was added to a commercial kit. Materials and Methods: Synthesis of sestamibi was performed according to Dong-A's patent procedure (No.10-2001-0012877). First, we undertook a study to evaluate the efficiency of radiochemical labeling of sestamibi containing ascorbic acid. The stability of the vials was assessed using either $7.5{\mu}g\;or\;75{\mu}g$ of ascorbic acid, added to commercial vials under the accelerated condition(Temp : $40^{\circ}C{\pm}2^{\circ}C$, Relative humidity : $75{\pm}5%$). Results: Sestamibi was synthesized in overall 35-40% yield over 5 steps from a commercially available methallyl chloride as a starling material. When ascorbic acid was added, the efficiency of radiochemical labeling was maintained compared to the vial with no ascorbic acid. The accelerated test showed that the addition of ascorbic acid inhibited the oxidation of $Sn^{2+}$ ion by antioxidation mechanism. Also, the efficiency of radiochemical labeling of this vial after 9 months was nearly the same as the starting point. Therefore, the storage period of the kit is likely to be extended. Taken together, it suggests that the addition of ascorbic acid as a stabilizer is desirable. Conclusion: To increase the stability of a sestamibi cold kit, it is desirable to add ascorbic acid as a stabilizer to the commercial formulation.

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A Study on Formulation Optimization for Improving Skin Absorption of Glabridin-Containing Nanoemulsion Using Response Surface Methodology (반응표면분석법을 활용한 Glabridin 함유 나노에멀젼의 피부흡수 향상을 위한 제형 최적화 연구)

  • Se-Yeon Kim;Won Hyung Kim;Kyung-Sup Yoon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.3
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    • pp.231-245
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    • 2023
  • In the cosmetics industry, it is important to develop new materials for functional cosmetics such as whitening, wrinkles, anti-oxidation, and anti-aging, as well as technology to increase absorption when applied to the skin. Therefore, in this study, we tried to optimize the nanoemulsion formulation by utilizing response surface methodology (RSM), an experimental design method. A nanoemulsion was prepared by a high-pressure emulsification method using Glabridin as an active ingredient, and finally, the optimized skin absorption rate of the nanoemulsion was evaluated. Nanoemulsions were prepared by varying the surfactant content, cholesterol content, oil content, polyol content, high-pressure homogenization pressure, and cycling number of high-pressure homogenization as RSM factors. Among them, surfactant content, oil content, high-pressure homogenization pressure, and cycling number of high-pressure homogenization, which are factors that have the greatest influence on particle size, were used as independent variables, and particle size and skin absorption rate of nanoemulsion were used as response variables. A total of 29 experiments were conducted at random, including 5 repetitions of the center point, and the particle size and skin absorption of the prepared nanoemulsion were measured. Based on the results, the formulation with the minimum particle size and maximum skin absorption was optimized, and the surfactant content of 5.0 wt%, oil content of 2.0 wt%, high-pressure homogenization pressure of 1,000 bar, and the cycling number of high-pressure homogenization of 4 pass were derived as the optimal conditions. As the physical properties of the nanoemulsion prepared under optimal conditions, the particle size was 111.6 ± 0.2 nm, the PDI was 0.247 ± 0.014, and the zeta potential was -56.7 ± 1.2 mV. The skin absorption rate of the nanoemulsion was compared with emulsion as a control. As a result of the nanoemulsion and general emulsion skin absorption test, the cumulative absorption of the nanoemulsion was 79.53 ± 0.23%, and the cumulative absorption of the emulsion as a control was 66.54 ± 1.45% after 24 h, which was 13% higher than the emulsion.

A New Sample Preparation Technique for SEM Observation of Polyolefin Microstructure (주사전자현미경상에서의 고분자 미세구조 관찰)

  • Park, Je-Myung
    • Applied Microscopy
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    • v.29 no.4
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    • pp.405-415
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    • 1999
  • In general, transmission electron microscopy (TEM) is usually used in the investigation of polymer microstructure. Microtoming, solution casting, staining and carbon replica method are frequently introduced to the study of the polymer morphology with TEM, however the sample preparation procedure of those techniques is very difficult, and it takes a long time. The purpose of this study is to develop a new sample preparation technique which is suitable for the investigation of the various shapes and species of polyolefin microstructure by scanning electron microscopy (SEM). By modifying the conventional chemical etching method, we developed a new chemical etching technique and sample preparation procedure that are suitable for SEM study of polymer microstructure. In this study the permanganate etching method is introduced and the optimum etching condition are determined by simply adjusting the etchant formulation, concentration and etching time. This technique has shown good reproducibility and it's morphological results agree well with other works on various types of microstructures such as spherulite characterization of isotatic polypropylene $(\alpha/\beta)$, polyethylene and poly-propylene copolymer characterization, and the study of lamellar growth pattern of unsheared or oriented materials. This technique has also been applied to the industrial fields for characterization of the polyolefin film, automobile products and the others.

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A Study on the Applicability of East Asian Welfare State Discourse to the Development of Korean Welfare State(Regime) (서구적 동아시아 복지국가 담론의 한국에 대한 적용 가능성 연구)

  • Na, Byong Kyun
    • Korean Journal of Social Welfare Studies
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    • v.41 no.3
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    • pp.5-27
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    • 2010
  • The objective of this study is to examine the dicourse of East Asian Welfare Models and its applicability to explain the development of the Korean Welfare State(regime). The Confucianist Welfare State, representing East Asian Welfare Models has limitations in explaining the current features and dynamics of east asian welfare states. Compared to the western and northern european welfare states, the Welfare State(Regime) of Korea, one of the east asian countries show the clear differences in terms of its origin, the background of formulation, the orientation of the policy and the actors. Thus, a new approach to examine the East Asian Welfare Model is needed. As a theoretical framework, the origin and the growth of the Korean Welfare State(Regime) can be understood and explained in the boundary of concept and the theoretical framework of the Authoritative Developmental State; Historically, the democratization of the 1980s and the financial crisis of the end of 1990s in Korea contributed to the growth of the welfare policies and institutions in Korea. Japan, Taiwan and other east asian counties, such as Hong Kong and Singapore have many similarities with Korea in terms of welfare policies and institutions. Comparative studies of these countries can create significant and useful results to develop a new concept and model of East Asian Welfare States. Case studies and active academic exchanges among welfare state researchers in these east asian countries are very important to develop a new concept of East Asian Welfare State Models.

Analysis of Changes in Restaurant Attributes According to the Spread of Infectious Diseases: Application of Text Mining Techniques (감염병 확산에 따른 레스토랑 선택속성 변화 분석: 텍스트마이닝 기법 적용)

  • Joonil Yoo;Eunji Lee;Chulmo Koo
    • Information Systems Review
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    • v.25 no.4
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    • pp.89-112
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    • 2023
  • In March 2020, as it was declared a COVID-19 pandemic, various quarantine measures were taken. Accordingly, many changes have occurred in the tourism and hospitality industries. In particular, quarantine guidelines, such as the introduction of non-face-to-face services and social distancing, were implemented in the restaurant industry. For decades, research on restaurant attributes has emphasized the importance of three attributes: atmosphere, service quality, and food quality. Nevertheless, to the best of our knowledge, research on restaurant attributes considering the COVID-19 situation is insufficient. To respond to this call, this study attempted an exploratory approach to classify new restaurant attributes based on understanding environmental changes. This study considered 31,115 online reviews registered in Naverplace as an analysis unit, with 475 general restaurants located in Euljiro, Seoul. Further, we attempted to classify restaurant attributes by clustering words within online reviews through TF-IDF and LDA topic modeling techniques. As a result of the analysis, the factors of "prevention of infectious diseases" were derived as new attributes of restaurants in the context of COVID-19 situations, along with the atmosphere, service quality, and food quality. This study is of academic significance by expanding the literature of existing restaurant attributes in that it categorized the three attributes presented by existing restaurant attributes and further presented new attributes. Moreover, the analysis results have led to the formulation of practical recommendations, considering both the operational aspects of restaurants and policy implications.

Application Strategies of Superintelligent AI in the Defense Sector: Emphasizing the Exploration of New Domains and Centralizing Combat Scenario Modeling (초거대 인공지능의 국방 분야 적용방안: 새로운 영역 발굴 및 전투시나리오 모델링을 중심으로)

  • PARK GUNWOO
    • The Journal of the Convergence on Culture Technology
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    • v.10 no.3
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    • pp.19-24
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    • 2024
  • The future military combat environment is rapidly expanding the role and importance of artificial intelligence (AI) in defense, aligning with the current trends of declining military populations and evolving dynamics. Particularly, in the civilian sector, AI development has surged into new domains based on foundation models, such as OpenAI's Chat-GPT, categorized as Super-Giant AI or Hyperscale AI. The U.S. Department of Defense has organized Task Force Lima under the Chief Digital and AI Office (CDAO) to conduct research on the application of Large Language Models (LLM) and generative AI. Advanced military nations like China and Israel are also actively researching the integration of Super-Giant AI into their military capabilities. Consequently, there is a growing need for research within our military regarding the potential applications and fields of application for Super-Giant AI in weapon systems. In this paper, we compare the characteristics and pros and cons of specialized AI and Super-Giant AI (Foundation Models) and explore new application areas for Super-Giant AI in weapon systems. Anticipating future application areas and potential challenges, this research aims to provide insights into effectively integrating Super-Giant Artificial Intelligence into defense operations. It is expected to contribute to the development of military capabilities, policy formulation, and international security strategies in the era of advanced artificial intelligence.