• 대한통합의학회지
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• 제2권3호
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• pp.9-14
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• 2014

Purpose : The purpose of this research was to determine the effects of nap between therapeutic interventions on motor learning in patients with stroke. Method : Thirty stroke patients with hemiplegia were participated in this study. After the screening by questionnaire about nap time, the patients were assigned to nap or non-nap group. Therapeutic interventions for 30 min were provided two times per day for 5 days per week and the serial reaction time tasks were conducted 2 times before and after a nap per day for 3 days per week. Between the therapeutic interventions, a nap for 60~120 minutes was allowed to the nap group while non-nap group was not. Intervention programs were carried out during the total 15-day. Result : Compared with the non-nap group, the reaction-precision level of nap group was increased (p<.05) for the non-affected upper extremity in the serial reaction time tasks. Conclusion : This study demonstrated that nap between therapeutic interventions has positive effects on motor learning in patients with stroke.

• Journal of Pharmaceutical Investigation
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• 제27권2호
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• pp.109-117
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• 1997

In order to elucidate the effect of phenobarbital (PB) on the nonlinear pharmacokinetic behavior of naproxen (NAP), we compared the dose dependent hepatic intrinsic clearance, biliary excretion and protein binding of NAP in control rats to those in the PB-pretreated rats which were intraperitoneally pretreated with PB sodium (75 mg/kg) once a day for four days. NAP was injected via femoral (1.5 mg/kg) and portal(0.25, 0.5, 1.5, 15 and 30 mg/kg) vein to the control and PB-pretreated rats, respectively. And also, we measured the plasma free fraction of NAP with the equilibrium dialysis method and the biliary excreted total amounts of NAP in both rats. Plasma free fraction of NAP was decreased in lower concentration than $150\;{\mu}g/ml$ of NAP due to PB pretreatment. In higher concentration, however, plasma free fraction was increased. These in vitro results suggest that the total protein concentration was increased but the total binding capacity of NAP to protein was decreased by PB-pretreatment. The total plasma clearance and the hepatic intrinsic clearance of NAP had similar values in both groups, respectively. And, both clearances of NAP were significantly increased by PB-pretreatment. Even though the plasma free fractions of NAP in both groups were constantly remained within the concentration range according to the increase of administration dose, the hepatic intrinsic clearances of NAP were significantly increased in both groups with the increased dose. And, the biliary excreted total amounts of NAP were significantly increased by PB-pretreatment at the lower dose, but decreased at the higher dose. These in vivo results suggest that NAP represents the uncommon nonlinear pharmacokinetic behavior that the hepatic intrinsic clearance was enhanced with the increased dose, and that PB enhances further the hepatic intrinsic clearance of NAP with the increased dose due to its enzyme induction effect.

• Molecules and Cells
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• 제20권1호
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• pp.112-118
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• 2005

It was previously shown that AtNAP1 is a plastidic SufB protein involved in Fe-S cluster assembly in Arabidopsis. In this study, we investigated the effects of depleting SufB protein from plant cells using virus-induced gene silencing (VIGS). VIGS of NbNAP1 encoding a Nicotiana benthamiana homolog of AtNAP1 resulted in a leaf yellowing phenotype. NbNAP1 was expressed ubiquitously in plant tissues with the highest level in roots. A GFP fusion protein of the N-terminal region (M1-V103) of NbNAP1 was targeted to chloroplasts. Depletion of NbNAP1 resulted in reduced numbers of chloroplasts of reduced size. Mitochondria also seemed to be affected. Despite the reduced number and size of the chloroplasts in the NbNAP1 VIGS lines, the expression of many nuclear genes encoding chloroplast-targeted proteins and chlorophyll biosynthesis genes remained unchanged.

• 재활치료과학
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• 제7권1호
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• pp.27-35
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• 2018

목적 : 본 연구는 편측 공간무시 환자의 평가도구 중 KF-NAP (Kessler Foundation - Neglect Assessment Process)과 지필검사 (직선이분검사, 글자소거검사, 알버트 검사) 사이의 상관관계와 편측 공간무시에 대한 민감도가 높은 평가도구를 알아보고자 한다. 연구방법 : 2014년 9월부터 2015년 9월까지 서울 소재의 병원 재활의학과에 입원한 32명의 뇌졸중 환자를 대상으로 하였다 (남성 19명, 여성 13명, 평균연령 61.8세). KF-NAP과 지필평가는 입원 7일 이내에 시행하였으며, 각 평가도구의 결과 값으로 편측 공간무시 정도를 비교하였다. 결과 : 편측 공간무시 정도는 KF-NAP 93.8%, 직선이분검사 53.1%, 글자지우기 53.1%, 알버트 검사 37.5%로 편측 공간무시에 대한 민감도가 가장 높은 평가도구는 KF-NAP이었다. KF-NAP은 직선이분검사(r=.430), 글자 지우기(r=.641), 알버트 검사(r=.398) 모두에서 유의한 상관관계가 있었다 (p<0.05). 결론 : KF-NAP은 환자의 일상생활 동안 편측 공간무시를 평가하는 도구로써 지필검사에 비해 편측 공간무시의 진단에 더 민감할 뿐 아니라 편측 공간무시의 중증도에 대한 평가가 가능하다. 따라서 편측 공간무시의 평가에 KF-NAP이 유용하게 사용되어져야 한다.

• 생명과학회지
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• 제20권10호
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• pp.1563-1568
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• 2010

암(dark) 상태에서 재배한 대두의 하배축 길이 생장의 분자 기작을 연구하기 위한 일환으로 암 상태에서 재배한 대두 하배축으로부터 cDNA library를 제작한 후 ESTs를 구축하였다. 이들 ESTs 중 색소체 ABC 단백질과 아미노산 서열이 매우 유사한 clone을 선발한 후 이 유전자의 전체염기서열을 결정하였다. GmNAP1 단백질은 엽록체로 향하는 transit peptide 서열이 존재한다. 빛에 의해 GmNAP1 유전자 전사가 어떻게 변화되는지 알아보기 위해 지속적인 적색광, 근적색광 그리고 암 상태에서 성장시키면서 유전자의 전사량을 확인하였다. 이 색소체 NAP1는 엽록소의 전구 물질인 protoporphytin IX를 세포질에서 엽록체로 이동시키는 기능을 한다. 대두에서 분리된 GmNAP1 유전자의 기능을 확인하기 위하여 35S 프로모터 뒤에 GmNAP1 유전자를 접합한 후 애기장대에 형질전환하였다. 형질전환 된 애기장대의 엽록소 함량은 야생형의 엽록소 함량보다 훨씬 높게 측정되었다.

• 대한치과의사협회지
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• 제49권9호
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• pp.535-548
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• 2011

The anterolateral thigh flap(ALT flap) was originally described in 1984 as a septocutaneous nap based on the descending branch of the lateral circumflex artery. This nap has some significant advantages for reconstruction of the head and neck. It can be raised as a subcutaneous flap, a fasciocutaneous nap, or a myocutaneous nap and can resurface large defects in the head and neck. In addition, it has a large and long vascular pedicle, and because of the distance of the donor site from the head and neck, it can easily be harvested with a two-team approach. However, the number and locations of cutaneous perforators vary individually, and thus, it is not widely used because nap elevation is often complicated and time-consuming owing to unexpected anatomical variations. The purposes of this study are to clarify the vascular anatomy and to assess the suitability of anterolateral thigh nap for oral cavity reconstruction in Koreans. In addition, we used anterolateral thigh free nap for oral cavity reconstruction in 20 oral cancer patients from 2006 to 2011. Through our clinical experience, we discuss a series of practical "pearls and pitfalls". Our experience has not only given us new flap choice using anterolateral thigh nap in oral cavity reconstruction, but also given us a new possibility on the applicability of chimeric naps.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 춘계학술대회논문집
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• pp.542-548
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• 2003

This paper describes an overall Noise Assurance Plan(NAP) in the project for developing a new rolling stock. In this paper, the procedure for implementing noise control activities for each development stage on the basis of the NAP is also described. The NAP was developed by KITECH(Korea Institute of Industrial Technology) and ODS(${\Phi}$degaard ＆ Danneskiold-Samsoe in DENMARK). Generally, the main objective of NAP is that noise assurance plan applies to the establishment of organization and personnel's roles and responsibilities, set-up of overall procedure and internal audit program. Here, a few comments are made to the deviations of the actual procedure(G7 Project) relative to the suggested NAP presented. The major difference between the suggested NAP and the actual procedure was the late involvement of the noise consultant resulting in suggestions for design improvements could not be implemented due to the advanced stage of the design. Similarly, the important task of preparing sub-supplier specifications was performed. The proposed NAP will be an efficient tool for noise management in the R＆D project for new rolling stock. Specially, in case that several companies and institutes are involoved in the R＆D team

• 한국패류학회지
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• 제28권4호
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• pp.305-312
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• 2012

나프탈렌이 바지락 (각장 $32.74{\pm}2.18mm$, 전중 $8.29{\pm}1.41g$) 의 생존, 성비 및 생식소발달에 미치는 영향에 대해 연구하였다. 노출농도는 대조구, solvent 대조구 (에탄올), 30, 60, 90, $120{\mu}g$ Nap $L^{-1}$ 였으며, 노출기간은 20주였다. 노출 종료 후 바지락의 생존율은 $60{\mu}g$ Nap $L^{-1}$ 이상의 농도에서 감소하였다. 성비는 대조구와 비교해 solvent 대조구 (에탄올)와 $30{\mu}g$ Nap $L^{-1}$ 실험구는 별다른 차이를 보이지 않았지만, $60{\mu}g$ Nap $L^{-1}$ 실험구의 경우 수컷의 비율이 높았다. 그 후 농도가 높아질수록 수컷의 비율이 감소하였다. 생식소 발달단계는 암컷의 경우 $60{\mu}g$ Nap $L^{-1}$ 이상의 농도에서, 수컷의 경우 $30{\mu}g$ Nap $L^{-1}$ 이상의 농도에서 발달이 지연되는 결과를 보였다. 생식소에서 관찰된 intersex는 암컷에서 16.28%, 수컷에서 1.68%를 나타냈다. 이러한 결과들을 볼 때 나프탈렌은 바지락의 생존 뿐 만 아니라 성비와 생식에 영향을 주는 것으로 보인다.

• 기록학연구
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• 제65호
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• pp.199-226
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• 2020

이 논문에서는 사회적 기억의 기록화를 위해서 파편적으로 흩어져 있는 기록의 사회적 맥락을 고려한 수집 전략이 필요하다는 전제하에, 광역 지역의 기록화를 위한 새로운 수집 방법론으로서 서사 기반 수집 실행지침을 개발하여 실행한 서울기록원 사례를 통해 그 적용 가능성을 검토하였다. 서사 기반 수집 실행지침 개발을 위해 먼저 광역 지역 전체를 아우르는 수집 주제 영역을 개발하였으며, 다음으로 지역학 연구 성과 및 사회, 경제, 문화예술 분야를 아우르는 자료 분석을 통하여 수집 실행단위를 설계하였다. 이를 기반으로 본 논문에서는 9개 주제 영역과 61개 상위 수집실행지침, 184개 하위 수집실행지침의 구조와 내용을 도출하는 과정에 대해 설명하였다. 마지막으로, 논문에서 기록의 의미와 가치에 중점을 둔 기록 콘텐츠로의 활용가능성과 기록 활동 네트워크의 지원 도구로서의 활용가능성을 제안하였다.

• Journal of Microbiology and Biotechnology
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• 제15권4호
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• pp.866-872
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• 2005

H. pylori is known to cause severe gastric diseases, including peptic ulcers and gastric cancers, and a link has also been suggested with iron-deficiency anemia (IDA). However, little is known about the pathogenesis of H. pylori-associated IDA. In the present study, to determine whether H. pylori strains are correlated with the prevalence of IDA, we analyzed and compared the sequences of the napA genes encoding a bacterioferritin-like protein in H. pylori strains. A total of 20 H. pylori strains were isolated from antral biopsies of patients with and without IDA, and the napA genes amplified from the genomic DNA were sequenced. A comparison of the deduced amino acid sequences for NapA revealed two sites with major variations. At residue 70, five out of the 12 non-IDA strains ($41.7\%$) contained serine, while only one of the 8 IDA strains ($12.5\%$) contained serine, indicating a significantly higher frequency of serine in the non-IDA strains. In addition, the NapA proteins from all 17 Western strains available on Web sites were found to contain serine residues at this position. Meanwhile, the other major variation was located at residue 73, where all eight IDA strains ($100\%$) contained leucine, while this was only true for eight of the 12 non-IDA strains ($66.7\%$). Therefore, these results indicated that the strains within each group were more genetically related to each other than to strains in the other group. When the expression level of the napA genes in the H. pylori strains was measured using RT-PCR, no significant difference was observed between the two groups, suggesting a similar intensity for the inflammatory responses induced by the NapA protein among the strains. Consequently, when taken together, the present data suggest that the occurrence of H. pylori-associated IDA may be partly determined by the infecting H. pylori strain, and the non-IDA strains are more closely related to Western strains than the IDA strains.