• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.10a
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• pp.245-248
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• 2009

Recently, Many studies have been progressing to path-finding with dynamic information on the Terminal Based Navigation System(TBNS). However, the most of existing algorithms are based on $A{\ast}$ algorithm. Path-finding algorithms which use heuristic function may occur a problem of the increase of exploring cost in case of that there is no way determined by heuristic function or there are 2 way more which have almost same cost. In this paper, two abstract graph(AG) that are different method of construction, Homogeneous Node merging($AG^H$) and Connected Node Merging($AG^C$), are implemented. The abstract graph is a simple graph of real road network. The method of using the abstract graph is proposed for reducing dependency of heuristic and exploring cost. In result of evaluation of performance, $AG^C$ has better performance than $AG^H$ at construction cost but $AG^C$ has worse performance than $AG^H$ exploring cost.

• Korean Journal of Plant Resources
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• v.34 no.1
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• pp.23-30
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• 2021

Hemistepta lyrata Bunge (HL) has been used as a folk remedy to treat cancer, inflammation, bleeding, hemorrhoids and fever, and leaves and young shoots have been used as famine food. Nevertheless, the biological activities and underlying mechanisms of the anti-inflammatory effects remain unclear. In this study, it was undertaken to explore the functions of the aerial part of HL as a suppressor of inflammation by using RAW 264.7 cells. As immune response parameters, the productions of as nitric oxide (NO) and prostaglandin E2 (PGE2), cytokines such tumor necrotic factor (TNF)-α and interleukin (IL)-6 were evaluated. Although the release of TNF-α remained unchanged in HL-treated RAW 264.7 cells, the productions of NO, PGE2 and IL-6 were significantly increased at concentrations with no cytotoxicity. Furthermore, HL significantly attenuated the mitogen-activated protein kinases (MAPK) pathway including decreasing the phosphorylation of the extracellular signal-regulated kinase (ERK1/2) and p38 mitogen-activated protein kinases. Collectively, this study provides evidence that HL inhibits the production of major pro-inflammatory molecules in LPS-stimulated RAW 264.7 cells via suppression of ERK and P38 MAPK signaling pathways. These findings suggest that the beneficial therapeutic effects of HL may be attributed partly to its ability to modulate immune functions in macrophages.

• Journal of Advanced Marine Engineering and Technology
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• v.22 no.1
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• pp.108-116
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• 1998

In this paper it is investigated the roles of key elementary reactions for NO formation in methane-air one-dimensional premixed flame and counterflow diffusion flame, which were studied numerically by using NO kinetics and $C_{2}$ -chemistry complied by Miller and Bowman. The spatial distributions of the reaction rates of 9 main elementary reactions directly related to NO formation and destruction were calculated. Integration of the rates of all reactions in the NO formation across the flame yields the quantitative reaction path diagram, which shows clearly relative importance of each reaction path in NO formation and how it changes with the type and parameters of the flame. The results show that the thermal and Fenimore mechanisms are dominant respectively for learn and rich premixed flames, and the latter is dominant for diffusion flames. In addition, it was found that the HCN recycle route is important for diffusion flame, and that the routes of mutual transformation between NO and NO$^{2}$, and between NO and HNO do not contribute to the net NO formation.

• Proceedings of the Optical Society of Korea Conference
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• 2009.10a
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• pp.26-27
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• 2009

• Journal of the Korean GEO-environmental Society
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• v.13 no.2
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• pp.75-81
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• 2012

Because N-Nitrosodimethylamine(NDMA) is well-known as a potential carcinogen, extensive research has addressed its treatment by ultraviolet(UV) and its degradation pathway. However, the detailed mechanism by which NDMA is photolyzed to form oxidized products, i.e., ${NO_2}^-$ and ${NO_3}^-$, is still not understood. This study reveals a key reactive species during the photolysis of NDMA. The study on a key reactive species was indirectly performed with the formation of nitrogen oxidized products and reactions between methanol and an unknown reactive species formed during the photolysis of NDMA. The peroxynitrite($ONOO^-$) generated by the direct UV photolysis of NDMA would be identified as a key reactive species in oxidizing nitrogen intermediates to ${NO_2}^-$and ${NO_3}^-$.

• Journal of Korea Spatial Information System Society
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• v.11 no.4
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• pp.39-46
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• 2009

Generally, Path-finding algorithms which use heuristic function may occur a problem of the increase of exploring cost in case of that there is no way determined by heuristic function or there are 2 way more which have almost same cost. In this paper, we propose an abstract graph for path-finding with dynamic information. The abstract graph is a simple graph as real road network is abstracted. The abstract graph is created by fixed-size cells and real road network. Path-finding with the abstract graph is composed of two step searching, path-finding on the abstract graph and on the real road network. We performed path-finding algorithm with the abstract graph against A* algorithm based on fixed-size cells on road network that consists of 106,254 edges. In result of evaluation of performance, cost of exploring in path-finding with the abstract graph is about 3~30% less than A* algorithm based on fixed-size cells. Quality of path in path-finding with the abstract graph is, However, about 1.5~6.6% more than A* algorithm based on fixed-size cells because edges eliminated are not candidates for path-finding.

• Journal of Life Science
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• v.32 no.2
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• pp.125-134
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• 2022

This study investigated whether or not the major bioactive compounds of Noni (Morinda citrifolia) are involved in anti-inflammatory activity through the JAK/STAT upper signaling pathway in RAW 264.7 cells. The experimental results show that the M. citrifolia ethyl acetate fraction (Mc-EtOAc) obtained by sequential fractionation with organic solvents from the plant's dried fruits exhibits the highest antioxidant activity. In addition, the cytoprotective effects of Mc-EtOAc against H₂O₂-induced oxidative stress in the RAW 264.7 cells suppressed cytotoxicity in a dose-dependent manner. The group pretreated with Mc-EtOAc at a concentration of 240 ㎍/ml showed higher cell viability of 84.5%, compared to 71.6% in the LPS-treated group, and LPS-induced NO production decreased to half the amount in the positive control group. Mc-EtOAc treatment also led to a significant dose-dependent reduction in iNOS expression. Although COX-2 expression was increased by 300% following LPS induction, it was significantly decreased in a dose-dependent manner by pretreatment with Mc-EtOAc at concentrations of 120 and 240 ㎍/ml. An inhibition of the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α was observed. The investigation also revealed that the phosphorylation levels of pJAK1 and pSTAT3 in LPS-induced RAW 264.7 cells were significantly reduced by Mc-EtOAc treatment.

• Journal of the Korean Institute of Gas
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• v.24 no.4
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• pp.39-47
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• 2020

Flue gas recirculation(FGR) is an effective combustion technique for reducing nitrogen oxides(NOx) and is applied in various fields of low-pollution combustion. Continuing the previous study, a numerical analysis was conducted to identify changes of flame characteristics and NOx formation mechanism with applying FGR technique in CH₄/air premixed counterflow flames. NOx emitted was divided into four main reaction paths(thermal NO, prompt NO, N₂H and N₂O), showing relatively the production rate of NO with the recirculation ratio. As a result, thermal NO contributed greatly to the overall NO whereas the effect of N₂H was minimal. In addition, emission index of NO was compared as the recirculation ratio increased by modifying the UC San Diego mechanism to examine the contribution of thermal NO.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.2
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• pp.225-232
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• 2012

A chemical reactor network (CRN) was developed for a lean premixed gas turbine combustor to predict the emission of pollutants such as NOx and CO. In this study, the predictions of NOx and CO emissions from lean premixed methane-air combustion in the gas turbine were carried out using CHEMKIN and a GRI 3.0 methane-air combustion mechanism, which includes the four NO formation mechanisms for various load conditions. The calculated results were compared with experimental data obtained from a modified test combustor to validate the model. The contributions of the four NO pathways were investigated for various load conditions. The effects of nonuniformity of the mass flux and of the equivalence ratio of the injector on the NOx formation were investigated, and a method of reducing the pollutant formation was suggested for the development of a sub-10 ppm gas turbine combustor.

• Spatial Information Research
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• v.18 no.4
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• pp.89-98
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• 2010

Recently, the target of navigation system is moving from the cars to pedestrians. Many researches are in progress regarding pedestrian navigation, However, in most cases, the path-finding is based on the existing node/link network model. which is widely used for the car navigation, and thus showing its limitation. The reasons arc that a) unlike with a car, the paths that pedestrians take arc not limited to the roads, b) pedestrians an~ not restricted in rotation or direction, and c) they can freely move within the walkable space. No alternatives have been offered yet, especially for openspaces such as a park or square. Therefore, in this research, we suggested appropriate methods to create paths that can be used in pedestrian navigation service, by using motion-planning technology, which is used in the field of robotics for planning the motion of an object, and conducted tests for their applicability.