• Communications for Statistical Applications and Methods
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• v.27 no.5
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• pp.535-546
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• 2020

In genetic association studies, pleiotropy is a phenomenon where a variant or a genetic region affects multiple traits or diseases. There have been many studies identifying cross-phenotype genetic associations. But, most of statistical approaches for detection of pleiotropy are based on individual tests where a single variant association with multiple traits is tested one at a time. These approaches fail to account for relations among correlated variants. Recently, multivariate regularization methods have been proposed to detect pleiotropy in analysis of high-dimensional genomic data. However, they suffer a problem of tuning parameter selection, which often results in either too many false positives or too small true positives. In this article, we applied selection probability to multivariate regularization methods in order to identify pleiotropic variants associated with multiple phenotypes. Selection probability was applied to individual elastic-net, unified elastic-net and multi-response elastic-net regularization methods. In simulation studies, selection performance of three multivariate regularization methods was evaluated when the total number of phenotypes, the number of phenotypes associated with a variant, and correlations among phenotypes are different. We also applied the regularization methods to a wild bean dataset consisting of 169,028 variants and 17 phenotypes.

• Communications for Statistical Applications and Methods
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• v.2 no.2
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• pp.243-248
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• 1995

The problem of optimal design for a nonparametric regression with binary data is considered. The aim of the statistical analysis is the estimation of a quantal response surface in two dimensions. Bias, variance and IMSE of kernel estimates are derived. The optimal design density with respect to asymptotic IMSE is constructed.

• Communications for Statistical Applications and Methods
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• v.25 no.1
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• pp.1-13
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• 2018

In many studies, a researcher attempts to describe a population where units are measured for multiple outcomes, or responses. In this paper, we present an efficient procedure based on ranked set sampling to estimate and perform hypothesis testing on a multivariate mean. The method is based on ranking on an auxiliary covariate, which is assumed to be correlated with the multivariate response, in order to improve the efficiency of the estimation. We showed that the proposed estimators developed under this sampling scheme are unbiased, have smaller variance in the multivariate sense, and are asymptotically Gaussian. We also demonstrated that the efficiency of multivariate regression estimator can be improved by using Ranked set sampling. A bootstrap routine is developed in the statistical software R to perform inference when the sample size is small. We use a simulation study to investigate the performance of the method under known conditions and apply the method to the biomarker data collected in China Health and Nutrition Survey (CHNS 2009) data.

• Communications for Statistical Applications and Methods
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• v.3 no.2
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• pp.53-67
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• 1996

Numerous classical as well as robust methods have been proposed in the literature for the detection of multiple outlier in multivariate data. The effectiveness and power of each of these methods have not been thoroughly investigated. In this paper we first reduce the vast number of outlier detection methods to a small number of viable ones. This reduction is based on previous work of other researches and on some theoretical arguments. Then we design and implement a Monte Carlo experiment for comparing these methods. The main goal of our study is to determine which methods are most powerful in the detection of multiple outlier and in dealing with the masking and swamping problems. The results of the Monte Carlo study indicate that two of the methods seem to hace better performances than the others for the detection of multiple outlier in multivariate data.

• Communications for Statistical Applications and Methods
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• v.6 no.3
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• pp.939-946
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• 1999

We propose methods for detecting influential observations that have a large influence on the likelihood ratio test statistic for the multivariate Behrens-Fisher problem. For this purpose we derive the influence curve and the derivative influence of the likelihood ratio test statistic. An illustrative example is given to show the effectiveness of the proposed methods on the identification of influential observations.

• Journal of Preventive Medicine and Public Health
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• v.31 no.4 s.63
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• pp.875-884
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• 1998

Missing observations are common in medical research and health survey research. Several statistical methods to handle the missing data problem have been proposed. The EM algorithm (Expectation-Maximization algorithm) is one of the ways of efficiently handling the missing data problem based on sufficient statistics. In this paper, we developed statistical models and methods for survey data with multivariate missing observations. Especially, we adopted the EM algorithm to handle the multivariate missing observations. We assume that the multivariate observations follow a multivariate normal distribution, where the mean vector and the covariance matrix are primarily of interest. We applied the proposed statistical method to analyze data from a health survey. The data set we used came from a physician survey on Resource-Based Relative Value Scale(RBRVS). In addition to the EM algorithm, we applied the complete case analysis, which uses only completely observed cases, and the available case analysis, which utilizes all available information. The residual and normal probability plots were evaluated to access the assumption of normality. We found that the residual sum of squares from the EM algorithm was smaller than those of the complete-case and the available-case analyses.

• Communications for Statistical Applications and Methods
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• v.8 no.3
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• pp.875-883
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• 2001

We derive the asymptotic relative efficiencies in two special cases of Chaudhuri's estimators for the multivariate one sample problem. And we compare those two when observations are independent and identically distributed from a family of spherically symmetric distributions including normal distributions.

• Communications for Statistical Applications and Methods
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• v.5 no.3
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• pp.591-597
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• 1998

We prove (at least empirically) that some forms of the scaled residuals calculated from i.i.d. multivariate normal random vectors are ancillary. We further show that, if the scaled residuals are ancillary, then they have the same distribution whatever form of rotation is rosed to remove sample correlations.

• Communications for Statistical Applications and Methods
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• v.11 no.1
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• pp.189-196
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• 2004

The sensitivity of the multivariate Box-Cox transformation model to simultaneous perturbations of all the data based on the likelihood displacement is studied in order to detect outliers. An example is given for illustration.

• Communications for Statistical Applications and Methods
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• v.1 no.1
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• pp.33-40
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• 1994

The conditional expectation of a random variable in a multivariate normal random vector is a multiple linear regression on its predecessors. Using this fact, the least median of squares estimation method developed in a multiple linear regression is adapted to a multivariate data to identify influential observations. The resulting method clearly detect outliers and it avoids the masking effect.