• Bulletin of the Korean Chemical Society
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• v.29 no.9
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• pp.1732-1736
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• 2008

The endogenous dipeptides, carnosine and related compounds, are the naturally occurring dipeptides with multiple neuroprotective properties. We have examined the protective effects of carnosine, homocarnosine and anserine on the aggregation of neurofilament-L (NF-L) induced by neurotoxin, acrolein. When NF-L was incubated with acrolein in the presence of carnosine, homocarnosine or anserine, protein aggregation was inhibited in a concentration-dependent manner. These compounds inhibited the formation of protein carbonyl compounds and dityrosine in acrolein-mediated NF-L aggregates. The aggregates of NF-L displayed thioflavin T reactivity, reminiscent of amyloid. This thioflavin T reactivity was inhibited by carnosine and related compounds. This effect was associated with decreased formation of oxidatively modified proteins. Our results suggested that carnosine and related compounds might have protective effects to brain proteins under pathophysiological conditions leading to degenerative damage such as neurodegenerative disorders.

• Journal of Ginseng Research
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• v.36 no.4
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• pp.342-353
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• 2012

Ginseng, the root of the Panax ginseng, has been a popular and widely-used traditional herbal medicine in Korea, China, and Japan for thousands of years. Now it has become popular as a functional health food and is used globally as a natural medicine. Evidence is accumulating in the literature on the physiological and pharmacological effects of P. ginseng on neurodegenerative diseases. Possible ginseng- or ginsenosides-mediated neuroprotective mechanisms mainly involve maintaining homeostasis, and anti-inflammatory, anti-oxidant, anti-apoptotic, and immune-stimulatory activities. This review considers publications dealing with the various actions of P. ginseng that are indicative of possible neurotherapeutic efficacies in neurodegenerative diseases and neurological disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis and multiple sclerosis.

• Korean Journal of Childcare and Education
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• v.14 no.5
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• pp.101-115
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• 2018

Objective: The goals of this research were (1)to examine the relationship among parental conflict, mothers' depression and preschoolers' sleep problems, and (2) to examine the mediating effects of mothers' depression between marital conflict and preschoolers' sleep problems. Methods: The participants were 1,639 mothers with preschoolers taken from the 5th year Korean Children Panel. Date were analyzed using descriptive statistics, partial correlation analysis, and multiple regression analysis. Results: The results were as follows: First, preschoolers' sleep problems were positively related to marital conflicts. Second, preschoolers' sleep problems were positively related to mothers' depression. Third, marital conflict was positively related to mothers' depression. Lastly, mothers' depression fully mediated the relationship between marital conflict and preschoolers' sleep problems. That is, marital conflict had an effect on preschoolers' sleep problem, only through mothers' depression. Conclusion/Implications: Based on the results, intervention programs should be developed to prevent preschoolers' sleep problems such as marital relationship improvement programs and mothers' depression improvement programs.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.2
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• pp.158-167
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• 2012

Purpose: To determine the mediating as well as moderating effect on both the emotional labor and burnout of professional self-concept perspective organ transplantation coordinators (OTC)'. Method: A self-report questionnaire was collected from 86 OTCs nationwide. The data were analyzed using t-test, ANOVA, Scheffe' test, Pearson' Correlation Coefficients, AMOS 20.0, and multiple regression. Results: For effects of professional self-concept on emotional labor and burnout, higher emotional labor was related to higher burnout. When professional self-concept was mediated, emotional labor had a greater effect on burnout however, a partial mediating effect was detected. From the regression analysis with the independent variables of emotional labor (A) and professional self-concept (B), adding relation of both variables ($A{\times}B$) increased the explained variance to 56.3% ($p$<.05). It was confirmed that professional self-concept had a moderating effect on emotional labor and burnout. Conclusion: The results of this study indicate that, when professional self-concept was mediated emotional labor of an OTC decreased, and burnout decreased when professional self-concept was high. Also, by controlling professional self-concept, emotional labor and burnout decreased. Therefore, it's necessary to map out the environment and develop strategies to reduce emotional labor and burnout in organ transplantation coordinators.

• The Korean Journal of Zoology
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• v.39 no.3
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• pp.292-298
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• 1996

Receptor-mediated endocytosis of coelomic fluid proteins (CP), yolk precursor proteins, appears to be regulated by multiple GTP-binding proteins during oogenesis of a polychaete, Pseudopotamilla occelata. Transport of 125 I-CP into the oocytes of intermediate size class, at which CP is the most actively transported, is enhanced by GTP but inhibited by GTP analogues, either GTPrS or GTP$\beta$S. The effects of GTP and GTPrS on the transport were also confirmed by tracing internalization of gold-labeled CP with transmission electron microscope. Internalization of gold-labeled CP into the yolk granules was enhanced by GTP but inhibited by GTPrS.

• Journal of Korean Public Health Nursing
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• v.27 no.1
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• pp.16-26
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• 2013

Purpose: The aim of this study was to identify a conceptual link between role conflict, job satisfaction, and organizational commitment, with a specific examination on how job satisfaction mediated the relationship between role conflict and organizational commitment, among community healthcare workers. Methods: Participants were 119 community healthcare workers of the Seoul Preventive Project for Metabolic Syndrome at 15 community health centers. Descriptive analysis, correlations analysis, and multiple regression analysis were used for statistical analysis of our data. Additionally, Sobel's test was used to verify the significance of the mediating effect. Results: An inverse association between role conflict and organizational commitment was found (beta=-0.53, p<.001). This relationship was fully mediated by job satisfaction (z=-6.43, p<.001). Conclusion: Job satisfaction mediates the effects of role conflict on the organizational commitment of healthcare workers in community health centers. Strategies for improving the components of job satisfaction are needed to achieve better outcomes in organizational commitment in the Seoul Preventive Project for Metabolic Syndrome and possibly other work settings.

• Korean Journal of Health Education and Promotion
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• v.33 no.5
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• pp.93-105
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• 2016

Objectives: This study was to examine the independent and mediating effect of socioeconomic position and social relationship on depression. Methods: The study analyzed the data from the 2014 Korea Welfare Panel Study(n=9,172) using descriptive statistics, Kendall's rank correlation analysis, multiple regression analysis and the Sobel test. Results: Much of the connection between parental socioeconomic position and respondent depression was explained by respondent educational attainment in men but was not in women. A large portion of the association between educational attainment and depression was explained by type of household and satisfaction with social relationship among men. The effect of educational attainment on depression was fully mediated by type of household among women. The effect of type of household on depression was partly mediated by satisfaction with social relationship in men and women. Lastly, educational attainment, type of household and satisfaction with social relationship had an independent association with depression among men, but educational attainment was not statistically significant among women. Conclusions: Our study illuminated the importance of the independent and mediating effect of parental and respondent socioeconomic position and social relationship in the production of depression for South Korean adults.

• Journal of the Korean Home Economics Association
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• v.48 no.2
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• pp.39-49
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• 2010

This study focused on the links between emotionality, interpersonal and intrapersonal intelligence, and behavior problems in a sample of 185 four- to five-year-old children in kindergarten and daycare centers in Seoul. All variables were measured by the teachers of surveyed children. Collected data were analyzed by Simple Regression and Hierarchical Multiple Regression. The main results of this study were as follows: Firstly, children's positive and negative emotionality each exerted negative and positive effects on their interpersonal and intrapersonal intelligence. Secondly, children's positive emotionality had a negative influence on internalizing behavior problems. On the other hand, children's negative emotionality had a positive influence on internalizing and externalizing behavior problems. Finally, effect of children's positive emotionality on their internalizing behavior problems was totally mediated by interpersonal and intrapersonal intelligence. On the other hand, effect of children's negative emotionality on their internalizing and externalizing behavior problems was partially mediated by their interpersonal and intrapersonal intelligence.

• Journal of Families and Better Life
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• v.32 no.3
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• pp.137-146
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• 2014

The aims of this study were to investigate the relationships among mothers' emotion expression, preschool children's temperament, and preschool children's emotion regulation. The participants in this study were 75 5-year-old children from five child-care centers located in Seoul. The collected data were analyzed using simple regression and hierarchical multiple regression. The major findings were as follows. First, mothers' positive emotion expression had a positive influence on children's effortful control, and mothers' negative emotion expression had a positive influence on children's negative affect. Second, mothers' positive emotion expression had a positive influence on children's emotion regulation, while mothers' negative emotion expression had a negative influence on children's emotion regulation. Last, the effect of mothers' positive emotion expression on children's emotion regulation was fully mediated by children's effortful control. Also, the effect of mothers' negative emotion expression on children's emotion regulation was partially mediated by children's negative affect. These results suggest that mothers' emotion expression and children's temperament may predict children's emotion regulation.

• Human Ecology Research
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• v.53 no.6
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• pp.629-640
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• 2015

This study examined the effect of interparental conflict and parent-child conflict on overt aggression in upper elementary school students and investigates if children's father-child conflict or mother-child conflict mediated the effect of interparental conflict on overt aggression. The participants of this study were 532 of fifth to sixth graders from three elementary schools located in Seoul and Gyeong-gi province. Participants were asked to respond to a written questionnaire to measure research variables of the Peer Conflict Scale, the Conflict Tactics Scales, and the Conflict Behavior Questionnaire. Data were analyzed by descriptive statistics and hierarchical multiple regression. Mediating effects were examined using analysis procedures of Baron and Kenny. The major findings were as follows: first, the level of interparental conflict and parent-child conflict of both mothers and fathers in upper elementary school students increased the level of overt aggression. Second, parent-child conflict of both mothers and fathers in upper elementary school students partially mediated the relation between interparental conflict and overt aggression. Higher levels of interparental conflict resulted in higher levels of parent-child conflict, and the subsequently higher frequency of overt aggression in upper elementary school students.