• 한국발생생물학회지:발생과생식
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• 제23권3호
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• pp.255-262
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• 2019

Previously, we reported negative effects of low-dose nonylphenol (NP) exposure on the reproductive organs of F1 male mice. In the present study was further investigated the endocrine disrupting effect of NP exposure to F2 generation male mice. Mice were divided into 2 groups; (1) CON, control animals and (2) NP-50 ($50{\mu}g/L$), animals were treated with NP via drinking water. NP exposures were continuously conducted from parental pre-mating period until the postnatal day (PND) 55 of F2 offsprings. Mice were sacrificed on PND 55 and the reproductive tissue weights were measured. The initial (at PND 21) and terminal (PND 55) body weights of the NP-50 group animals were not significantly different from those of control group animals. NP exposure fail to induce a significant weight change of the testes, seminal vesicle and prostate except absolute epididymal weight (p<0.05). However, pathohistological studies revealed that NP-treated F2 animals showed evident decrease in seminiferous tubule diameters, reduced luminal area and number of germ cells. Also, sloughing morphologies in the tubules were notable. In the caudal epididymis, fewer mature sperms and swollen epithelial cells were found in the NP-treated group. The present study demonstrated that the subchronic low-dose NP exposure induced pathohistological abnormalities in testis and epididymis of F2 mice, and we assumed that these 'qualitative' changes in reproductive tissues could be derived from the epigenetic modifications such as DNA methylation, histone modification, altered DNA accessibility and chromatin structure. Further studies are needed to achieve a better understanding on the multi- or trans-generational effects of NP on the reproductive health and a human application.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.338-344
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• 2021

본 연구는 방탄시험의 효과적인 운영을 위해 시험절차를 분석하여 문제점을 도출하고, 개선방안으로 시료거치 시스템을 개발하였다. 기존 시스템에서 도출된 문제점은 다양한 시료 형태 및 다양한 시험규격의 적용이 불가능한 점과 장비조작의 불편함 및 과다한 시험 준비시간이었다. 이를 개선하기 위한 시료거치 시스템은 기본베이스, 거치대, 각종 조절부로 구분된다. 다목적 거치대와 헬멧 거치대는 다양한 크기와 형상의 시료를 거치 및 다양한 규격을 시험할 수 있도록 설계하였다. 다목적 거치대는 방탄복 시험을 위한 후면재 지지대와 호환된다. 시료 고정틀은 내부에 위치하여 별도의 탈/부착 과정이 없이 수직 이동 및 고정을 통해 다양한 크기와 형상의 시료를 거치할 수 있도록 설계하였다. 기본베이스는 표준화하여 거치대와 호환이 용이하도록 설계하였고, 탄착점 위치 조절부는 자동으로 높이와 수평 이동조정이 가능하여 신속하고 정확하게 탄착점 설정이 가능하도록 설계하였다. 시스템의 경제성을 분석하기 위해 시스템 도입 전과 후를 기준으로 실제 운영데이터를 비교/분석한 결과, 시험 건수, 장비활용률은 대폭 증가하고 시간당 비용은 감소하였다.

• 한국임상약학회지
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• 제31권2호
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• pp.125-135
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• 2021

Background: Generally, pharmacokinetics (PK) models could be stratified into two models. The compartment PK model uses the concept of simple compartmentalization to describe complex bodies, and the physiologically based pharmacokinetic (PBPK) model describes the body using multi-compartment networking. Notwithstanding sharing a theoretical background in both models, there was still a lack of knowledge to enhance compatibility in both models. Objective: This study aimed to evaluate the compatibility among PBPK, lumping model and compartment PK model with voriconazole PK case study. Methods: The number of compartments and blood flow on each tissue in the PBPK model were modified using the lumping method, considering physiological similarities. The concentration-time profiles and area under the concentration-time curve (AUC) parameters were simulated at each model, assuming taken voriconazole oral 400 mg single dose. After that, those mentioned PK parameters were compared. Results: The PK profiles and parameters of voriconazole in the three models were similar that proves their compatibility. The AUC of central compartment in the PBPK and lumping model was within a 2-fold range compared to those in the 2- compartment model. The AUC of non-eliminating tissues compartment in the PBPK model was similar to those in the lumping model. Conclusion: Regarding the compatibility of the three PK models, the utilization of the lumping method was confirmed by suggesting its reliable PK parameters with PBPK and compartment PK models. Further case studies are recommended to confirm our findings.

• 영미문화
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• 제18권1호
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• pp.1-21
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• 2018

In Woman Watches over the World, Linda Hogan explores the broken identity of herself and her family, the issue of the poverty and the identity crisis, the alcoholism, prevalent in the Native American community and their silenced history. Previous studies have claimed that her memoir contributes to the restoration of Native American identity and history by accusing the violence of white culture, and seeks to recognize a dialogue between native culture and white mainstream culture as well. However they seem to overlook the complicated relations among story, identity, body and nature, to which Hogan as a multi-binded storyteller resorts as a way to break the silence of herself and her tribe for healing. Her own story, as a way to break the silence, becomes the formative drive to reveal the silenced history of her own tribe to lead the young generation to the future. She also understands the formative function of the story, which becomes the vehicle for embodying and connecting themselves to nature. To her, healing lies in the restoration of sympathetic relationship with nature. History, as a type of story, can be made up or mistold just like a story. There may be a blind spot where one can not assess what is true. In spite of the vision of the parallel worlds of the two cultures she presents, there seems to be no immediate solution to the discrimination against the Native American, poverty, identity crisis, and environmental problems which the Native American community faces. However, it can be said that her memoir serves as a rudder by presenting a direction to not only the Native American but also to readers in other cultures in its quest for practical possibilities for the future.

• 한국환경보건학회지
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• 제47권3호
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• pp.227-244
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• 2021

Objectives: The Korean National Environmental Health Survey provides representative biomonitoring data for environmental pollutants in South Korea. Over the last decade, there have been various studies published using this data. In this study, we aimed to provide information and implications by reviewing each study. Methods: We searched comprehensive electronic databases from PubMed, Google Scholar, and Naver Academic database using the key words 'Korean National Environmental Health Survey' and 'KoNEHS' through March 2021. A total of 57 studies were selected after reviewing the relevance of the data. Results: The most frequently studied pollutants were heavy metals (10), Cotinine (8), Bisphenol A (7), and Phthalates (6), in that order. In particular, Phthalates, Bisphenol A, and Parabens were often studied together (6). A decline in urinary cotinine and heavy metals in the body was shown over time among studies on exposure association. It was demonstrated that Phthalates and Bisphenol A were significantly related to obesity and diabetes from the studies of health impacts. Cross-section study design, spot urine, and insufficient health status information were mostly reported as limitations of the data. Conclusion: Since research has been focused on adults, further investigations of children and adolescents are required. In this regard, it is necessary to maintain the consistency of the data structure and provide integrated weights for all ages. In addition, it would allow the measurement of several environmental pollutants by considering subsample design. Lastly, integrated studies with multi-cycles and the health effects from co-exposure to multiple chemicals would be expected to provide important knowledge.

• 한국정보통신학회논문지
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• 제24권8호
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• pp.963-969
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• 2020

지역 내의 도시들은 인구수, 계절, 교통량, 산업단지 등의 변수에 따라 대기오염의 수치가 다르게 관측되기 때문에 소규모 지역에 대해 정확하게 모니터링을 할 수 없는 문제점이 발생하고 있다. 이러한 문제점을 해결하기 위해 본 논문에서는 인체에 악영향을 미치는 대표적인 대기오염 물질 SO2, PM10, NO2, CO, O3이 관측되는 소규모 지역에 대해 결정계수(Coefficient of determination)를 통해 비교분석 하였다. 그리고 본페로니(Bonferroni) 다중 비교분석을 기반하여 기간별 대기 오염도를 나타내었다. 그리고 모니터링 시스템을 위해 지도를 각 소규모 도시의 좌표와 연동하여 분석 데이터를 기반으로 소규모 도시들에 대한 대기오염 물질을 시각화 하였다. 이를 통해 지역에 대한 대기오염 물질을 보다 정밀하게 사용자에게 모니터링 시스템을 제공할 수 있으며 일상생활에서 대기오염으로 발생할 수 있는 사고로부터 예방할 수 있을 것으로 보인다.

• The Korean Journal of Physiology and Pharmacology
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• 제27권1호
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• pp.49-59
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• 2023

Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status in pre-MetS subjects. In this study, we sought to examine cardiac autonomic functions in pre-MetS and to determine which MetS component is more responsible for impaired cardiac autonomic functions. A total of 182 subjects were recruited and divided into healthy controls (n=89) and pre-MetS subjects (n=93) based on inclusion and exclusion criteria. We performed biochemical profiles on fasting blood samples to detect pre-MetS. Using standardized protocols, we evaluated anthropometric data, body composition, baroreflex sensitivity (BRS), heart rate variability (HRV), and autonomic function tests (AFTs). We further examined these parameters in pre-MetS subjects for each MetS component. Compared to healthy controls, we observed a significant cardiac autonomic dysfunction (CAD) through reduced BRS, lower overall HRV, and altered AFT parameters in pre-MetS subjects, accompanied by markedly varied anthropometric, clinical and biochemical parameters. Furthermore, all examined BRS, HRV, and AFT parameters exhibited an abnormal trend and significant correlation toward hyperglycemia. This study demonstrates CAD in pre-MetS subjects with reduced BRS, lower overall HRV, and altered AFT parameters. Hyperglycemia was considered an independent determinant of alterations in all the examined BRS, HRV, and AFT parameters. Thus, hyperglycemia may contribute to CAD in pre-MetS subjects before progressing to MetS.

• 한국시뮬레이션학회논문지
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• 제19권1호
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• pp.13-22
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• 2010

본 논문에서는 해상 크레인이 인양하는 중량물의 운동 감쇠를 위하여 Tagline을 이용한 PD제어를 수행하였다. 해상 크레인 및 중량물을 각각 6자유도 운동을 하는 강체로 가정하고 뉴턴의 제 2법칙에 따라 운동 방정식을 유도하였다. 중량물의 운동을 감쇠하기 위한 제어 메커니즘으로 Tagline을 사용 하였고, 해상 크레인의 Deck에 설치한 Winch로 Tagline의 장력을 조절하였다. 장력을 조절하는 제어 알고리즘으로는 PD제어를 사용 하였다. 이를 바탕으로 수치적 제어 시뮬레이션을 수행하였다. 또한, 1/100 Scale의 모형 해상 크레인을 제작하고 실험을 통해 제어 시뮬레이션의 결과를 검증 하였다. 제어 시뮬레이션과 모형 시험 수행 결과 Tagline을 이용한 제어가 중량물의 운동을 감쇠시키는데 효과가 있음을 알 수 있었다.

• BMB Reports
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• 제56권5호
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• pp.314-319
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• 2023

Sepsis is a life-threatening multi-organ dysfunction with high mortality caused by the body's improper response to microbial infection. No new effective therapy has emerged that can adequately treat patients with sepsis. We previously demonstrated that interferon-β (IFN-β) protects against sepsis via sirtuin 1-(SIRT1)-mediated immunosuppression. Another study also reported its significant protective effect against acute respiratory distress syndrome, a complication of severe sepsis, in human patients. However, the IFN-β effect cannot solely be explained by SIRT1-mediated immunosuppression, since sepsis induces immunosuppression in patients. Here, we show that IFN-β, in combination with nicotinamide riboside (NR), alleviates sepsis by blocking endothelial damage via SIRT1 activation. IFN-β plus NR protected against cecal ligation puncture-(CLP)-induced sepsis in wild-type mice, but not in endothelial cell-specific Sirt1 knockout (EC-Sirt1 KO) mice. IFN-β upregulated SIRT1 protein expression in endothelial cells in a protein synthesis-independent manner. IFN-β plus NR reduced the CLP-induced increase in in vivo endothelial permeability in wild-type, but not EC-Sirt1 KO mice. IFN-β plus NR suppressed lipopolysaccharide-induced up-regulation of heparinase 1, but the effect was abolished by Sirt1 knockdown in endothelial cells. Our results suggest that IFN-β plus NR protects against endothelial damage during sepsis via activation of the SIRT1/heparinase 1 pathway.

• Smart Structures and Systems
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• 제29권5호
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• pp.653-660
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• 2022

Gravel scattering that is generated during operation of high-speed railway vehicle is cause to damage of vehicle such as windows, axle protector and so on. Especially, those are frequently occurred in winter season when snow ice is generated easily. Above all, damage of vehicle windows has not only caused maintenance cost but also increased psychological anxiety of passengers. Various methods such as heating system using copper wire, heating jacket and heating air are applied to remove snow ice generated on the under-body of vehicle. However, the methods require much run-time and man power which can be low effectiveness of work. Therefore, this paper shows that large-area heating system was developed based on heating coat in order to fundamentally prevent snow ice damage on high-speed railway vehicle in the winter season. This system gives users high convenience because that can remotely control the heating system using IoT-based wireless communication. For evaluating the applicability to railroad sites, a field test on an actual high-speed railroad operation was conducted by applying these techniques to the brake cylinder of a high-speed railroad vehicle. From the results, it evaluated how input voltage and electric power per unit area of the heating specimen influences exothermic performance to draw the permit power condition for icing. In the future, if the system developed in the study is applied at the railroad site, it may be used as a technique for preventing all types of damages occurring due to snow ice in winter.