• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.4
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• pp.597-606
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• 2008

Resorption of alveolar bone in periodontitis is due to excessive differentiation and activation of osteoclasts. Bacterial antigens causing periodontitis activates CD4 T cells, which leads to expressing RANK ligand (RANKL) on CD4 T cells. RANKL binds RANK on preosteoclasts or osteoclasts, and enhances the differentiation preosteoclasts into osteoclasts and the activation of mature osteoclasts. CD137, one of TNF receptor (TNFR) family, expressed on activated T cells binds with CD137 ligand (CD137L) on antigen presenting cells. Cross-linking of CD137 by CD137L acts as T cell co-stimulatory signals and, therefore, enhances the activation of T cell. In this study, I elucidated the biological responses of CD137L on (pre)osteoclasts and RANKL on T cells in the context of in vivo interaction between T cells and osteoclasts. RAW264.7, murine monocytic cells, constitutively express CD137L. Ligation of CD137L with anti-CD137L mAb inhibited RANKL-induced osteoclast formation in a dosedependent manner. Bone marrow cells are expressed CD137L by the treatment with M-CSF. Cross-linking of CD137L abolished M-CSF/ RANKL-evoked the formation of multi-nucleated osteoclasts. Both mouse CD4 and CD8 T cells are expressed RANKL following their activation. Ligation of RANKL with OPG, the decoy receptor for RANKL, inhibited both CD4 and CD8 T cell proliferation. These effects were attributed to RANKL-induced apoptosis. These data indicate that CD137L and RANKL on osteoclasts and T cells, respectively provide them with inhibitory signal.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.2
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• pp.432-443
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• 2017

The primary goal of the MPEG-H 3D Audio standard is to provide immersive audio environments for high-resolution broadcasting services such as UHDTV. This standard incorporates a wide range of technologies such as encoding/decoding technology for multi-channel/object/scene-based signal, rendering technology for providing 3D audio in various playback environments, and post-processing technology. The reference software decoder of this standard is a structure combining several modules and can operate in various modes. Each module is composed of independent executable files and executed sequentially, real time decoding is impossible. In this paper, we make DLL library of the core decoder, format converter, object renderer, and binaural renderer of the standard and integrate them to enable frame-based decoding. In addition, by measuring the computation complexity of each mode of the MPEG-H 3D-Audio decoder, this paper also provides a reference for selecting the appropriate decoding mode for various hardware platforms. As a result of the computational complexity measurement, the low complexity profiles included in Korean broadcasting standard has a computation complexity of 2.8 times to 12.4 times that of the QMF synthesis operation in case of rendering as a channel signals, and it has a computation complexity of 4.1 times to 15.3 times of the QMF synthesis operation in case of rendering as a binaural signals.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.5
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• pp.95-103
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• 2009

An efficient symbol time synchronization scheme for IEEE 802.11n MIMO-OFDM based WLAN systems using cyclic shift diversity (CSD) preamble is proposed. CSD is used to prevent unintentional beamforming when the same preamble signal is transmitted through transmit antennas. However, it is difficult to find a proper starting-point of the OFDM symbol with the conventional algorithms because of time offset by multi-peaks which are result from cross-correlation of received CSD preamble with a known short training symbol. In addition, the performance of symbol time sync. is affected by AGC and packet detection position. In this paper, an optimal symbol time synch. algorithm which is composed of the boundary detection scheme between LTS and OFDM symbols, the verification scheme for enhancement of boundary detection accuracy, and the SNR-varying threshold estimation scheme is proposed. Simulation result show that the proposed algorithm has performance gains of 4.3dB in SNR compared to the conventional algorithms at the rate of 1% sync. failure probability for $2{\times}2$ MIMO-OFDM system and 18dB at 0.1% when maximum frequency offset exists. It also can be applied to $4{\times}4$ MIMO-OFDM system without any modification. Hence, it is very suitable for MIMO-OFDM WLAN systems using CSD preamble.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.5
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• pp.146-153
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• 2009

Recently, the research relative to NGN(Next Generation Network) is progressing in 3GPP(The 3rd Generation Partnership Progect), IETF(Internet Engineering Task Force), and so on. Although user needs frequently mobility which is various service pattern, In accordance with the development of these various applications, IMS(IP Multimedia Subsystem) and hierarchical networks ie, Femtocell/WiBro/3G etc is constructed for more user demands which provide service in anytime, anywhere. It is necessary to optimum network selection criterion which consider to wireless signal quality add to user service profile and service network traffic balance. NGN also needs a method to perform heterogeneous handover and to constraint Ping-pong phenomenon when using existing terminal-based handover decision. This paper proposes scheme for network selection and heterogeneous handover procedure in hierarchical wireless multi-access network based on SIP-MIH(Session Initiation Protocol-Media Independent Handover) with IMS by using user service profile that the considerations are dealing with not only selection and registration of various access network but also easy of developing the terminal.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.49 no.3
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• pp.38-46
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• 2012

Atrial fibrillation is needed to be detected at paroxysmal stage and to be treated. But, paroxysmal atrial fibrillation ECG is hardly obtained with 12-lead electrocardiographs but Holter systems. Presently, the averaged beat subtraction(ABS) method is solely used to estimate atrial fibrillatory waves even with somewhat large residual error. As an alternative, in this study, we suggested an ESAF(event-synchronous adaptive filter) based algorithm, in which the AF ECG was treated as a primary input and event-synchronous impulse train(ESIT) as a reference. And, ESIT was generated so to be synchronized with the ventricular activity by detecting QRS complex. We tested proposed algorithm with simulated AF ECGs and real AF ECGs. As results, even with low computational cost, this ESAF based algorithm showed better performance than the ABS method and comparable performance to algorithm based on PCA(principal component analysis) or SVD(singular value decomposition). We also proposed an expanded version of ESAF for some AF ECGs with multi-morphologic ventricular activities and this also showed reasonable performance. Ultimately, with Holter systems including our proposed algorithm, atrial activity signal can be precisely estimated in real-time so that it will be possible to calculate atrial fibrillatory rate and to evaluate the effect of anti-arrhythmic drugs.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.8 s.111
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• pp.773-787
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• 2006

An airborne radar is an essential aviation electronic system for the aircraft to perform various civil and/or military missions in all weather environments. This paper presents the design, development, and test results of the multi-mode X-band pulsed Doppler radar system test model for helicopter-borne flight test. This radar system consists of 4 LRUs(Line-Replacement Unit), which include antenna unit, transmitter and receiver unit, radar signal & data processing unit and display Unit. The developed core technologies include the planar array antenna, TWTA transmitter, coherent I/Q detector, digital pulse compression, MTI, DSP based Doppler FFT filter, adaptive CFAR, moving clutter compensation, platform motion stabilizer, and tracking capability. The design performance of the developed radar system is verified through various ground fixed and moving vehicle test as well as helicopter-borne field tests including MTD(Moving Target Detector) capability for the Doppler compensation due to the moving platform motion.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.10 s.101
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• pp.1050-1058
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• 2005

This paper presents how to design and implement a very compact, cost effective and broad band receiver module for IEEE 802.16 FWA(Fixed Wireless Access) in the 40 GHz band. The presented receiver module is fabricated in a multi-layer LTCC(Low Temperature Cofired Ceramic) technology with cavity process to achieve excellent electrical performances. The receiver consists of two MMICs, low noise amplifier and sub-harmonic mixer, an embedded image rejection filter and an IF amplifier. CB-CPW, stripline, several bond wires and various transitions to connect each element are optimally designed to keep transmission loss low and module compact in size. The LTCC is composed of 6 layers of Dupont DP-943 with relative permittivity of 7.1. The thickness of each layer is 100 um. The implemented module is $20{\times}7.5{\times}1.5\;mm^3$ in size and shows an overall noise figure of 4.8 dB, an overall down conversion gain of 19.83 dB, input P1 dB of -22.8 dBm and image rejection value of 36.6 dBc. Furthermore, experimental results demonstrate that the receiver module is suitable for detection of Digital TV signal transmitted after up-conversion of $560\~590\;MHz$ band to 40 GHz.

• International Journal of Aeronautical and Space Sciences
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• v.8 no.1
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• pp.10-20
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• 2007

For spacecraft attitude control, reaction wheel (RW) steering laws with more than three wheels for three-axis attitude control can be derived by using a control allocation (CA) approach.1-2 The CA technique deals with a problem of distributing a given control demand to available sets of actuators.3-4 There are many references for CA with applications to aerospace systems. For spacecraft, the control torque command for three body-fixed reference frames can be constructed by a combination of multiple wheels, usually four-wheel pyramid sets. Multi-wheel configurations can be exploited to satisfy a body-axis control torque requirement while satisfying objectives such as minimum control energy.1-2 In general, the reaction wheel steering laws determine required torque command for each wheel in the form of matrix pseudo-inverse. In general, the attitude control command is generated in the form of a feedback control. The spacecraft body angular rate measured by gyros is used to estimate angular displacement also.⁵ Combination of the body angular rate and attitude parameters such as quaternion and MRPs(Modified Rodrigues Parameters) is typically used in synthesizing the control command which should be produced by RWs.¹ The attitude sensor signals are usually corrupted by noise; gyros tend to contain errors such as drift and random noise. The attitude determination system can estimate such errors, and provide best true signals for feedback control.⁶ Even if the attitude determination system, for instance, sophisticated algorithm such as the EKF(Extended Kalman Filter) algorithm⁶, can eliminate the errors efficiently, it is quite probable that the control command still contains noise sources. The noise and/or other high frequency components in the control command would cause the wheel speed to change in an undesirable manner. The closed-loop system, governed by the feedback control law, is also directly affected by the noise due to imperfect sensor characteristics. The noise components in the sensor signal should be mitigated so that the control command is isolated from the noise effect. This can be done by adding a filter to the sensor output or preventing rapid change in the control command. Dynamic control allocation(DCA), recently studied by Härkegård, is to distribute the control command in the sense of dynamics⁴: the allocation is made over a certain time interval, not a fixed time instant. The dynamic behavior of the control command is taken into account in the course of distributing the control command. Not only the control command requirement, but also variation of the control command over a sampling interval is included in the performance criterion to be optimized. The result is a control command in the form of a finite difference equation over the given time interval.⁴ It results in a filter dynamics by taking the previous control command into account for the synthesis of current control command. Stability of the proposed dynamic control allocation (CA) approach was proved to ensure the control command is bounded at the steady-state. In this study, we extended the results presented in Ref. 4 by adding a two-step dynamic CA term in deriving the control allocation law. Also, the strict equality constraint, between the virtual and actual control inputs, is relaxed in order to construct control command with a smooth profile. The proposed DCA technique is applied to a spacecraft attitude control problem. The sensor noise and/or irregular signals, which are existent in most of spacecraft attitude sensors, can be handled effectively by the proposed approach.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6155-6157
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• 2012

Background: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell proliferation. MKP - a dual specific phosphatase - interacts with activated ERK2 via the common docking (CD) domain of the later to inactivate (dephosphorylate) and effectively terminate further cell proliferation. A constitutively active form of ERK2 carrying a single point mutation - E322K in its CD domain, was earlier reported by our laboratory. In the present study, we investigated the prevalence of this CD domain E322K mutation in 88 well differentiated OSCC tissue samples. Materials and Method: Genomic DNA specimens isolated from 88 oral squamous cell carcinoma tissue samples were amplified with primers flanking the CD domain of the ERK2 gene. Subsequently, PCR amplicons were gel purified and subjected to direct sequencing to screen for mutations. Results: Direct sequencing of eighty eight OSCC samples identified an E322K CD domain mutation in only one (1.1%) OSCC sample. Conclusions: Our result indicates that mutation in the CD domain of ERK2 is rare in OSCC patients, which suggests the role of genetic alterations in other mitogenic genes in the development of carcinoma in the rest of the patients. Nevertheless, the finding is clinically significant, as the relatively rare prevalence of the E322K mutation in OSCC suggests that ERK2, being a common end point signal in the multi-hierarchical mitogen activated signaling pathway may be explored as a viable drug target in the treatment of OSCC.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.263-268
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• 2000

In this paper, a new indirect feedback active noise control (ANC) scheme based on the fundamental frequency estimation is proposed for systems with a harmonic noise. When reference signals necessary for feedforward ANC configuration is difficult to obtain, the conventional ANC algorithms for multi-tonal noise do not measure the reference signals but generate them with the estimated frequencies. However, the beating phenomena, in which certain frequency components of the noise vanish intermittently, may make the adaptive frequency estimation difficult. The confusion in the estimated frequencies due to the beating phenomena makes the generated reference signals worthless. The proposed algorithm consists of two parts. The first part is a reference generator using the fundamental frequency estimation and the second one is the conventional feedforward control. We propose the fundamental frequency estimation algorithm using decision rules, which is insensitive to the beating phenomena. In addition, the proposed fundamental frequency estimation algorithm has good tracking capability and lower variance of frequency estimation error than that of the conventional cascade ANF method. We are also able to control all interested modes of the noise, even which cannot be estimated by the conventional frequency estimation method because of the poor SIN ratio. We verify the performance of the proposed ANC method through simulations for the measured cabin noise of a passenger ship and the measured time-varying engine booming noise of a passenger vehicle.