• Journal of Convergence for Information Technology
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• v.10 no.3
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• pp.195-199
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• 2020

This study examined the effect of the nervous-system-stimulating caffeine on the nerve conduction velocity. The purpose of this study is to investigate the effect of caffeine that stimulates the nervous system on nerve conduction test. Although both measurement intervals did not show statistically significant differences when comparing the pre- and post-NCV values within the control and individual experimental groups, it was found that the nerve conductivity in the Axilla-Above Elbow section increased significantly after caffeine intake for the experimental group. Caffeine intake, which has increased the nerve conduction velocity (NCV), was determined to play roles in improving motor skills, muscle strength and nerve performance by temporarily increasing the nerve conduction velocity. Through this study, we learned that caffeine has an influence on the peripheral nervous system as it helps to improve the nerve conduction velocity. upon an appropriate amount of caffeine intake. We hope that these results will help develop treatment and diagnostic methods for patients with nerve dysfunction and myofunctional disorders.

• Korean Journal of Acupuncture
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• v.17 no.1
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• pp.101-121
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• 2000

The purpose of this morphological studies was to investigate the relation to the meridian, acupoint and nerve. The common locations of the spinal cord and brain projecting to the the gallbladder, GB34 and common peroneal nerve were observed following injection of transsynaptic neurotropic virus, pseudorabies virus(PRV), into the gallbladder, GB34 and common peroneal nerve of the rabbit. After survival times of 96 hours following injection of PRV, the thirty rabbits were perfused, and their spinal cord and brain were frozen sectioned($30{\mu}m$). These sections were stained by PRV immunohistochemical staining method, and observed with light microscope. The results were as follows: 1. In spinal cord, PRV labeled neurons projecting to the gallbladder, GB34 and common peroneal nerve were founded in thoracic, lumbar and sacral spinal segments. Densely labeled areas of each spinal cord segment were founded in lamina V, VII, X, intermediolateral nucleus and dorsal nucleus. 2. In medulla oblongata, The PRV labeled neurons projecting to the gallbladder, GB34 and common peroneal nerve were founded in the A1 noradrenalin cells/C1 adrenalin cells/caudoventrolateral reticular nucleus, rostroventrolateral reticular nucleus, medullary reticular nucleus, dorsal motor nucleus of vagus nerve, nucleus tractus solitarius, raphe obscurus nucleus, raphe pallidus nucleus, raphe magnus nucleus, gigantocellular nucleus, lateral paragigantocellular nucleus, principal sensory trigeminal nucleus and spinal trigeminal nucleus. 3. In Pons, PRV labeled neurons were parabrachial nucleus, Kolliker-Fuse nucleus and cochlear nucleus. 4. In midbrain, PRV labeled neurons were founded in central gray matter and substantia nigra. 5. In diencephalon, PRV labeled neurons were founded in lateral hypothalamic nucleus, suprachiasmatic nucleus and paraventricular hypothalamic nucleus. 6. In cerebral cortex, PRV labeled neuron were founded in hind limb area.This results suggest that PRV labeled common areas of the spinal cord projecting to the gallbladder, GB34 and common peroneal nerve may be first-order neurons related to the somatic sensory, viscero-somatic sensory and symapathetic preganglionic neurons, and PRV labeled common area of the brain may be first, second and third-order neurons response to the movement of smooth muscle in gallbladder and blood vessels.These PRV labeled neurons may be central autonomic center related to the integration and modulation of reflex control linked to the sensory system monitoring the internal environment, including both visceral sensation and various chemical and physical qualities of the bloodstream. The present morphological results provide that gallbladder meridian and acupoint may be related to the central autonomic pathways.

• Molecules and Cells
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• v.41 no.8
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• pp.742-752
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• 2018

Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (DAergic) neurons, particularly in the substantia nigra (SN). Although circadian dysfunction has been suggested as one of the pathophysiological risk factors for PD, the exact molecular link between the circadian clock and PD remains largely unclear. We have recently demonstrated that $REV-ERB{\alpha}$, a circadian nuclear receptor, serves as a key molecular link between the circadian and DAergic systems. It competitively cooperates with NURR1, another nuclear receptor required for the optimal development and function of DA neurons, to control DAergic gene transcription. Considering our previous findings, we hypothesize that $REV-ERB{\alpha}$ may have a role in the onset and/or progression of PD. In the present study, we therefore aimed to elucidate whether genetic abrogation of $REV-ERB{\alpha}$ affects PD-related phenotypes in a mouse model of PD produced by a unilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. $REV-ERB{\alpha}$ deficiency significantly exacerbated 6-OHDA-induced motor deficits as well as DAergic neuronal loss in the vertebral midbrain including the SN and the ventral tegmental area. The exacerbated DAergic degeneration likely involves neuroinflammation-mediated neurotoxicity. The $REV-erb{\alpha}$ knockout mice showed prolonged microglial activation in the SN along with the over-production of interleukin $1{\beta}$, a pro-inflammatory cytokine, in response to 6-OHDA. In conclusion, the present study demonstrates for the first time that genetic abrogation of $REV-ERB{\alpha}$ can increase vulnerability of DAergic neurons to neurotoxic insults, such as 6-OHDA, thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.479-487
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• 2004

Biopotential signals have been used as command in systems using electrical stimulation of motor nerves to restore movement after an injury to the central nervous system (CNS). In order to use the voluntary EMG (electromyography) among the biopotentials as a control signal for the electrical stimulation of the same muscle for CNS injury patients, it is necessary to remove M-wave of having high magnitude from raw data. We designed an optimal filter for removing the M-wave and preserving the voluntary EMG and showed that the optimal filter is eigen filter. We also proved that the previous method using the prediction error filter(PEF) is a suboptimal filtering in the sense of preserving the voluntary EMG. On basis of the data obtained from a model for M-wave and voluntary EMG and from actual CNS injury patients, with false-positive rate analysis, the proposed adaptive filter showed a very promising performance in comparison with previous method.

• The Journal of Korean Academy of Sensory Integration
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• v.18 no.2
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• pp.55-68
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• 2020

Objective : The purpose of this study is to summarize the best-available intervention evidence for children's sensory integration therapy, drawn from studies published domestically in Korea over the last 10 years. Methods : The articles evaluated in this study were collected from the RISS and DBpia databases using the search terms "sensory integration," "sensory processing," and "Ayres Sensory Integration (ASI)". A total of 19 papers were analyzed. The selected studies were then assessed using the Population, Intervention, Outcomes, and Comparison method, the International Classification of Functioning, Disability and Health (ICF) method, and the modified Evidence Alert Traffic Light Grading System. Results : Development delay was the most commonly applied diagnosis for children's sensory integration therapy and individual sensory integration therapy was the most frequently used intervention method. The intervention effect was 91 percent in the body structure and function of ICF. The areas concentrated on were sensory modulation, sensory processing, fine and gross motor, body scheme, body-self concept, balance, basic movement, postural control and hand function, attention, and self-esteem. Conclusion : This simple overview of the efficacy of children's sensory integration therapy provides a basis for easy understanding and use by therapists, researchers and families with children.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.12
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• pp.2641-2646
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• 2009

The more growing on home automation system at automatic control, the more efficiency required for energy consumption and for recycling energy in near future. Heating is essential in general apartment. Heating method is two types in apartment. One uses electricity, and other one uses warm water. If use electricity, is not efficient by rise of electric charges. But, It can reduce much in expense aspect, if use warm water. When use warm water, temperature of warm water is not equal from all pipe parts. Therefore, indoor tempera can be unequal with set point. Solution of these problems is as following. Temperature sensor in warm water attach pipe. The measured temperature transmits by real time. Temperature of warm water controls in receiver side. In this paper, we propose an automatic temperature transmission system for the heating pipe at home, that is a low-power based, and supply the energy source from a small AC motor resided in bottom cement mortal. The proposed system is used in power mechanism from a collision process of water-jet using propeller water-difference and also designed a CPU module by Atmega8 at ATMEL co., Inc. and a communication module by CC1020 at Chipcon co., Inc.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.11
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• pp.2689-2696
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• 2015

Radioactive isotopes which are manufactured using a cyclotron in a radioisotope used for radiation diagnosis is affected by the production yield according to size and shape of the beam and beam uniform degree from irradiated location when the proton beam investigated the target by cyclotron. Therefore, in this paper developed the BPM(Beam Profile Monitor) device capable of measuring the beam cross-section at the cyclotron beam line. It was configured so as to be able to remote control the BPM device in LabView and used the BPM program it was to be able to easily monitor and display to analyze the graph of two-dimensional graph and a three-dimensional beam distribution numerical information of the beam obtained while scanning the tungsten wire to the X and Y axis. The time it takes to measure the beam can be confirmed 37seconds when step motor driving speed was 2000pps. Through a beam readjusted based on the measured beam distribution information by optimizing the beam distribution it can be made to maximize the RI production yield and contribute supply stabilization.

• Journal of Life Science
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• v.29 no.11
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• pp.1258-1266
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• 2019

Yangkyuksanhwa-Tang (YKSH), consisting of nine different herbs, is commonly used in Soyangin-type individuals with stroke, based on the Sasang Constitution Theory in Korea. However, no evidence has yet confirmed a beneficial effect of YKSH in ischemic stroke treatment. In this study, we investigated the effects of YKSH on ischemic brain injury in a mouse model of cerebral ischemia. Focal cerebral ischemia in mice was induced by photothrombosis, and behavioral recovery was evaluated. Infarct volume, inflammation, and newly generated cells were evaluated by histology and immunochemistry. YKSH treatment resulted in a significant recovery from the motor impairments induced by focal cerebral ischemia, as determined with wire grip and rotarod tests. YKSH treatment also decreased the infarct volume and the number of cells positive for tumor necrosis factor-${\alpha}$ and myeloperoxidase when compared with a vehicle-treated control group. By contrast, YKSH treatment considerably increased the number of cells positive for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1, as well as the number of cells doubly positive for Ki67/doublecortin when compared with the vehicle-treated group. These results suggest that YKSH treatment attenuated the infarct size by anti-inflammatory action, astrocyte and microglia activation, and neuronal proliferation, thereby facilitating neurofunctional recovery from a cerebral ischemic assault. YKSH could therefore be a potential treatment for neurofunctional restoration of the injured brains of patients with stroke.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.12 no.4
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• pp.456-465
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• 2019

PHEV(Plug in Hybrid Electric Vehicle) and BEV(Battery Electric Vehicle) equip high voltage batteries to drive motor and vehicle electric system. Those vehicle require OBC(On-Board Charger) for charging batteries and LDC(Low DC/DC Converter) for converting from high voltage to low voltage. Since the charger and the converter actually separate each other in electrical vehicles, there is a margin to reduce the vehicle weight and area of installation by integration two systems. This paper studies a 1.5kW LDC converter that can be integrated into an OBC using an isolated current-fed converter by simplifying the design of LDC transformers. The proposed LDC can control the final output voltage of the LDC by using a fixed arbitrary output voltage of the bidirectional buck-boost converter, so that Compared to the existing OBC-LDC integrated system, it has the advantage of simplifying the transformer design considering the battery voltage range, converter duty ratio and OBC output turn ratio. Prototype of the proposed LDC was made to confirm normal operation at 200V ~ 400V input voltage and maximum efficiency of 91.885% was achieved at rated load condition. In addition, the OBC-LDC integrated system achieved a volume of about 6.51L and reduced the space by 15.6% compared to the existing independent system.

• Phonetics and Speech Sciences
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• v.13 no.1
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• pp.53-64
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• 2021

According to Demand and Capacity Model (DCM), external and internal environments influence the disfluency of children who stutter (CWS). This study investigated the effects of simultaneous changes in motoric and linguistic demands on CWS and children who do not stutter (CWNS). Participants were 4-6 years old CWS and CWNS. A sentence imitation task with changes in speech rate, utterance length, and sentence complexity was used to examine their effects on children's disfluency. When the utterance length changed, CWS showed more disfluency regardless of utterance length and as the speech rate changed, CWS showed more disfluency at fast speech rate than CWNS. When the utterance length and speech rate changed, at fast speech rate, CWS showed more disfluency in both utterances than CWNS. When sentence complexity changed, CWS showed more disfluency than CWNS in complex sentences. Changes in linguistic elements such as speech rate, utterance length, and sentence complexity affect disfluency in CWS, especially when they were exposed to faster, longer, and more complex sentences. This indicates that CWS are vulnerable to fast and complex speech motor control and language processing ability than CWNS. Thus, this study suggests that parents and therapists consider both the speech rate and the utterance length when talking with CWS.