• Journal of the Chungcheong Mathematical Society
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• v.16 no.2
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• pp.59-73
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• 2003

Throughout this paper, we denote that R is a near-ring and G an R-group. We initiate the study of R-substructures of G, representations of R on G, monogenic R-groups, faithful R-groups and faithful D.G. representations of near-rings. Next, we investigate some properties of monogenic near-ring groups, faithful monogenic near-ring groups, monogenic and faithful D.G. representations in near-rings.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.1
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• pp.34-42
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• 2018

Purpose: Monogenic inflammatory bowel disease (IBD) patients do not respond to conventional therapy and are associated with a higher morbidity. We summarized the clinical characteristics of monogenic IBD patients and compared their clinical outcomes to that of non-monogenic IBD patients. Methods: We performed a retrospective cohort study of all children <18 years old who were diagnosed with IBD between 2005 and 2016. A total of 230 children were enrolled. Monogenic IBD was defined as a presentation age less than 6 years old with confirmation of a genetic disorder. We subdivided the groups into monogenic IBD (n=18), non-monogenic very early-onset IBD (defined as patients with a presentation age <6 years old without a confirmed genetic disorder, n=12), non-monogenic IBD (defined as all patients under 18 years old excluding monogenic IBD, n=212), and severe IBD (defined as patients treated with an anti-tumor necrosis factor excluding monogenic IBD, n=92). We compared demographic data, initial pediatric Crohn disease activity index/pediatric ulcerative colitis activity index (PCDAI/PUCAI) score, frequency of hospitalizations, surgical experiences, and height and weight under 3rd percentile among the patients enrolled. Results: The initial PCDAI/PUCAI score (p<0.05), incidence of surgery per year (p<0.05), and hospitalization per year (p<0.05) were higher in the monogenic IBD group than in the other IBD groups. Additionally, the proportion of children whose weight and height were less than the 3rd percentile (p<0.05 and p<0.05, respectively) was also higher in the monogenic IBD group. Conclusion: Monogenic IBD showed more severe clinical manifestations than the other groups.

• East Asian mathematical journal
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• v.19 no.1
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• pp.151-164
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• 2003

Throughout this paper, we will consider that R is a near-ring and G is an R-group. We initiate the study of monogenic and strongly monogenic R-groups and their basic properties. Also, we investigate some properties of D.G. R-groups, faithful R-groups and monogenic R-groups and we determine that when near-rings are rings.

• Journal of applied mathematics & informatics
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• v.26 no.1_2
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• pp.401-406
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• 2008

In this paper, we will introduce the noetherian quotients in R-groups, and then investigate the related substructures of the near-ring R and G and the R-group G. Also, applying the annihilator concept in R-groups and d.g. near-rings, we will survey some properties of the substructures of R and G in monogenic Rgroups, and show that R becomes a ring for faithful monogenic R-groups with some condition.

• East Asian mathematical journal
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• v.25 no.2
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• pp.171-177
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• 2009

Throughout this paper, we denote that R is a near-ring and G an R-group. We initiate a study of R-substructures of G, monogenic R-groups, faithful R-groups and faithful D.G. representations of near-rings. Next, we investigate some properties of monogenic R-groups, faithful monogenic R-groups and a generalization of annihilator concepts in R-groups.

• Communications of the Korean Mathematical Society
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• v.19 no.4
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• pp.601-618
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• 2004

Throughout this paper, we will consider that R is a near-ring and G an R-group. We initiate the study of monogenic, strongly monogenic R-groups, 3 types of nonzero R-groups and their basic properties. At first, we investigate some properties of D.G. (R, S)-groups, faithful R-groups, monogenic R-groups, simple and R-simple R-groups. Next, we introduce modular right ideals, t-modular right ideals and 3 types of primitive near-rings. The purpose of this paper is to investigate some properties of primitive types near-rings and their characterizations.

• Journal of Genetic Medicine
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• v.20 no.1
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• pp.15-24
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• 2023

Monogenic disorders are traditionally attributed to the presence of mutations in a single gene. However, recent advancements in genomics have revealed instances where the phenotypic expression of apparently monogenic disorders cannot be fully explained by mutations in a single gene alone. This review article aims to explore the emerging concept of digenic or oligogenic inheritance in seemingly monogenic disorders. We discuss the underlying mechanisms, clinical implications, and the challenges associated with deciphering the contribution of multiple genes in the development and manifestation of such disorders. We present relevant studies and highlight the importance of adopting a broader genetic approach in understanding the complex genetic architecture of these conditions.

• Journal of Interdisciplinary Genomics
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• v.4 no.1
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• pp.7-10
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• 2022

Purpose:Maturity onset diabetes of the young (MODY) is the most common hereditary form of diabetes mellitus (DM), with similar clinical manifestations to type 1 or type 2 DM, leading to diagnostic ambiguity. Despite increased genetic research on monogenic DM, studies with Asian populations are limited. Therefore, we investigated mutation in possible monogenic DM and MODY in Korean children and aldolescents. Methods: Targeted panel exome sequencing including 32 targets genes was performed for 41 patients with suspected monogenic DM at Kyungpook National University Children's Hospital. Results: Variants were detected in 19 patients, including those in known MODY-associated genes (HNF4A, GCK, HNF1A, CEL, PAX4, INS, and BLK) and monogenic DM-associated genes (WFS1, FRX6, and GLIS3). Conclusion: MODY variants were detected more than expected. Targeted exon sequencing is helpful in diagnosing MODY or possible monogenic DM patients.

• The Pure and Applied Mathematics
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• v.18 no.4
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• pp.305-312
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• 2011

In this paper, we denote that R is a near-ring and G an R-group. We initiate the study of the substructures of R and G. Next, we investigate some properties of R-groups, d.g. near-rings and monogenic (R, S)-groups.

• Korean Journal of Mathematics
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• v.16 no.3
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• pp.271-280
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• 2008

In this paper, we initiate a study of faithful R-group G and some substructures of R and G. Next, we investigate a faithful representation of near-ring R and some properties of monogenic Rgroups.