• Translational and Clinical Pharmacology
• /
• v.26 no.4
• /
• pp.166-171
• /
• 2018

Although there are many commercially available training software programs for pharmacokinetics, they lack flexibility and convenience. In this study, we develop simulation software to facilitate pharmacokinetics education. General formulas for time courses of drug concentrations after single and multiple dosing were used to build source code that allows users to simulate situations tailored to their learning objectives. A mathematical relationship for a 1-compartment model was implemented in the form of differential equations. The concept of population pharmacokinetics was also taken into consideration for further applications. The source code was written using R. For the convenience of users, two types of software were developed: a web-based simulator and a standalone-type application. The application was built in the JAVA language. We used the JAVA/R Interface library and the 'eval()' method from JAVA for the R/JAVA interface. The final product has an input window that includes fields for parameter values, dosing regimen, and population pharmacokinetics options. When a simulation is performed, the resulting drug concentration time course is shown in the output window. The simulation results are obtained within 1 minute even if the population pharmacokinetics option is selected and many parameters are considered, and the user can therefore quickly learn a variety of situations. Such software is an excellent candidate for development as an open tool intended for wide use in Korea. Pharmacokinetics experts will be able to use this tool to teach various audiences, including undergraduates.

• Structural Engineering and Mechanics
• /
• v.69 no.4
• /
• pp.439-455
• /
• 2019

This research deals with thermo-electro-mechanical buckling analysis of the sandwich nano-beams with face-sheets made of functionally graded carbon nano-tubes reinforcement composite (FG-CNTRC) based on the nonlocal strain gradient elasticity theory (NSGET) considering various higher-order shear deformation beam theories (HSDBT). The sandwich nano-beam with FG-CNTRC face-sheets is subjected to thermal and electrical loads while is resting on Pasternak's foundation. It is assumed that the material properties of the face-sheets change continuously along the thickness direction according to different patterns for CNTs distribution. In order to include coupling of strain and electrical field in equation of motion, the nonlocal non-classical nano-beam model contains piezoelectric effect. The governing equations of motion are derived using Hamilton principle based on HSDBTs and NSGET. The differential quadrature method (DQM) is used to calculate the mechanical buckling loads of sandwich nano-beam as well as critical voltage and temperature rising. After verification with validated reference, comprehensive numerical results are presented to investigate the influence of important parameters such as various HSDBTs, length scale parameter (strain gradient parameter), the nonlocal parameter, the CNTs volume fraction, Pasternak's foundation coefficients, various boundary conditions, the CNTs efficiency parameter and geometric dimensions on the buckling behaviors of FG sandwich nano-beam. The numerical results indicate that, the amounts of the mechanical critical load calculated by PSDBT and TSDBT approximately have same values as well as ESDBT and ASDBT. Also, it is worthy noted that buckling load calculated by aforementioned theories is nearly smaller than buckling load estimated by FSDBT. Also, similar aforementioned structure is used to building the nano/micro oscillators.

• Journal of Convergence for Information Technology
• /
• v.9 no.8
• /
• pp.155-163
• /
• 2019

Laminar mixed convection of a nanofluid consists of water and $Al_2O_3$ in a horizontal circular tube has been studied numerically. Two-phase mixture model has been used to investigate hydrodynamic and thermal behaviors of the nanofluid with variables physical properties. Three dimensional Navier-Stokes, energy and volume fraction equations have been discretized using the finite volume method. The Brownian motions of nanoparticles have been considered to determine the thermal conductivity and dynamic viscosity of $Al_2O_3$-Water nanofluid, which depend on temperature. The calculated results show good agreement with the previous numerical data. Results show that in a given Reynolds number (Re), increasing solid nanoparticles volume fraction and Richardson number (Ri) increases the convective heat transfer coefficient and wall shear stress.

• Advances in nano research
• /
• v.7 no.5
• /
• pp.293-310
• /
• 2019

In this paper, thermal-buckling behavior of the functionally graded (FG) nanocomposite plates reinforced with graphene oxide powder (GOP) is studied under three types of thermal loading once the plate is supposed to be rested on a two-parameter elastic foundation. The effective material properties of the nanocomposite plate are considered to be graded continuously through the thickness according to the Halpin-Tsai micromechanical scheme. Four types of GOPs' distribution namely uniform (U), X, V and O, are considered in a comparative way in order to find out the most efficient model of GOPs' distribution for the purpose of improving the stability limit of the structure. The governing equations of the plate have been derived based on a refined higher-order shear deformation plate theory incorporated with Hamilton's principle and solved analytically via Navier's solution for a simply supported GOP reinforced (GOPR) nanocomposite plate. Some new results are obtained by applying different thermal loadings to the plate according to the GOPs' negative coefficient of thermal expansion and considering both Winkler-type and Pasternak-type foundation models. Besides, detailed parametric studies have been carried out to reveal the influences of the different types of thermal loading, weight fraction of GOP, aspect and length-to-thickness ratios, distribution type, elastic foundation constants and so on, on the critical buckling load of nanocomposite plates. Moreover, the effects of thermal loadings with various types of temperature rise are investigated comparatively according to the graphical results. It is explicitly shown that the buckling behavior of an FG nanocomposite plate is significantly influenced by these effects.

• Computers and Concrete
• /
• v.24 no.2
• /
• pp.125-135
• /
• 2019

Concrete pipelines are the most efficient and safe means for gas and oil transportation over a long distance. The use of nano materials and nono-engineering can be considered for enhancing concrete pipelines properties. the tests show that SiO2 nanoparticles can improve the mechanical behavior of concrete. Moreover, severe hazard for pipelines is seismic ground motion. Over the years, scientists have attempted to understand pipe behavior against earthquake most frequently via numerical modeling and simulation. Therefore, in this paper, the dynamic response of underwater nanocomposite submerged pipeline conveying fluid is studied. The structure is subjected to the dynamic loads caused by earthquake and the governing equations of the system are derived using mathematical model via Classic shell theory and Hamilton's principle. Navier-Stokes equation is employed to calculate the force due to the fluid in the pipe. As well, the effect of external fluid is modeled with an external force. Mori-Tanaka approach is used to estimate the equivalent material properties of the nanocomposite. 1978 Tabas earthquake in Iran is considered for modelling seismic load. The dynamic displacement of the structure is extracted using differential quadrature method (DQM) and Newmark method. The effects of different parameters such as SiO2 nanoparticles volume percent, boundary conditions, thickness to radius ratios, length to radius ratios, internal and external fluid pressure and earthquake intensity are discussed on the seismic response of the structure. From results obtained in this paper, it can be found that the dynamic response of the pipe is increased in the presence of internal and external fluid. Furthermore, the use of SiO2 nanoparticles in concrete pipeline reduces the displacement of the structure during an earthquake.

• Steel and Composite Structures
• /
• v.30 no.2
• /
• pp.81-96
• /
• 2019

The behavior of a new Three-Tube Buckling-Restrained Brace (TTBRB) with circumference pre-stress (${\sigma}_{{\theta},pre}$) in core tube are investigated through a verified finite element model. The TTBRB is composed of one core tube and two restraining tubes. The core tube is in the middle to provide the axial stiffness, to carry the axial load and to dissipate the earthquake energy. The two restraining tubes are at inside and outside of the core tube, respectively, to restrain the global and local buckling of the core tube. Based on the yield criteria of fringe fiber, a design method for restraining tubes is proposed. The applicability of the proposed design equations are verified by TTBRBs with different radius-thickness ratios, with different gap widths between core tube and restraining tubs, and with different levels of ${\sigma}_{{\theta},pre}$. The outer and inner tubes will restrain the deformation of the core tube in radius direction, which causes circumference stress (${\sigma}_{\theta}$) in the core tube. Together with the ${\sigma}_{{\theta},pre}$ in the core tube that is applied through interference fit of the three tubes, the yield strength of the core tube in the axial direction is improved from 160 MPa to 235 MPa. Effects of gap width between the core tube and restraining tubes, and ${\sigma}_{{\theta},pre}$ on hysteretic behavior of TTBRBs are presented. Analysis results showed that the gap width and the ${\sigma}_{{\theta},pre}$ can significantly affect the hysteretic behavior of a TTBRB.

• Journal of the Korean earth science society
• /
• v.40 no.4
• /
• pp.353-381
• /
• 2019

The general world model for homogeneous and isotropic universe has been proposed. For this purpose, we introduce a global and fiducial system of reference (world reference frame) constructed on a (4+1)-dimensional space-time, and assume that the universe is spatially a 3-dimensional hypersurface embedded in the 4-dimensional space. The simultaneity for the entire universe has been specified by the global time coordinate. We define the line element as the separation between two neighboring events on the expanding universe that are distinct in space and time, as viewed in the world reference frame. The information that determines the kinematics of the geometry of the universe such as size and expansion rate has been included in the new metric. The Einstein's field equations with the new metric imply that closed, flat, and open universes are filled with positive, zero, and negative energy, respectively. The curvature of the universe is determined by the sign of mean energy density. We have demonstrated that the flat universe is empty and stationary, equivalent to the Minkowski space-time, and that the universe with positive energy density is always spatially closed and finite. In the closed universe, the proper time of a comoving observer does not elapse uniformly as judged in the world reference frame, in which both cosmic expansion and time-varying light speeds cannot exceed the limiting speed of the special relativity. We have also reconstructed cosmic evolution histories of the closed world models that are consistent with recent astronomical observations, and derived useful formulas such as energy-momentum relation of particles, redshift, total energy in the universe, cosmic distance and time scales, and so forth. The notable feature of the spatially closed universe is that the universe started from a non-singular point in the sense that physical quantities have finite values at the initial time as judged in the world reference frame. It has also been shown that the inflation with positive acceleration at the earliest epoch is improbable.

• Advances in nano research
• /
• v.10 no.4
• /
• pp.359-371
• /
• 2021

A tumor immune interaction is a main topic of interest in the last couple of decades because majority of human population suffered by tumor, formed by the abnormal growth of cells and is continuously interacted with the immune system. Because of its wide range of applications, many researchers have modeled this tumor immune interaction in the form of ordinary, delay and fractional order differential equations as the majority of biological models have a long range temporal memory. So in the present work, tumor immune interaction in fractional form provides an excellent tool for the description of memory and hereditary properties of inter and intra cells. So the interaction between effector-cells, tumor cells and interleukin-2 (IL-2) are modeled by using the definition of Caputo fractional order derivative that provides the system with long-time memory and gives extra degree of freedom. Moreover, in order to achieve more efficient computational results of fractional-order system, a discretization process is performed to obtain its discrete counterpart. Furthermore, existence and local stability of fixed points are investigated for discrete model. Moreover, it is proved that two types of bifurcations such as Neimark-Sacker and flip bifurcations are studied. Finally, numerical examples are presented to support our analytical results.

• Journal of Korea Society of Industrial Information Systems
• /
• v.25 no.6
• /
• pp.143-158
• /
• 2020

This study examines the effect of VMD (Visual merchandising) of unmanned stores and the affordance of unmanned systems on a customer's value and intention of revisit. The proposed research model and developed hypotheses were tested using structural equations modeling based on data collected from 297 customers with experience in unmanned stores. The results of the study confirm the positive effects of the unmanned system's affordance and unmanned stores' VMD on customer value. In addition, there is a positive relationship between a customer's value and intention of revisit. The study provides valuable insights into the sustainability of unmanned stores after post-COVID 19 and the importance of developing unmanned stores' VMD and affordance.

• Steel and Composite Structures
• /
• v.39 no.5
• /
• pp.631-643
• /
• 2021

The aim of this work is to study the hygro-thermo-mechanical bending responses of simply supported FG plate resting on a Winkler-Pasternak elastic foundation. The effect transverse shear strains is taken into account in which the zero transverse shear stress condition on the top and bottom surfaces of the plate is ensured without using any shear correction factors. The developed model contains only four unknowns variable which is reduced compared to other HSDTs models. The material properties of FG-plate are supposed to vary across the thickness of the plate according to power-law mixture. The differential governing equations are derived based on the virtual working principle. Numerical outcomes of bending analysis of FG plates under hygro-thermo-mechanical loads are performed and compared with those available in the literature. The effects of the temperature, moisture concentration, elastic foundation parameters, shear deformation, geometrical parameters, and power-law-index on the dimensionless deflections, axial and transverse shear stresses of the FG-plate are presented and discussed.