• Molecules and Cells
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• v.42 no.3
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• pp.270-283
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• 2019

This study was aimed to explore if lncRNA MALAT1 would modify chemo-resistance of non-small cell lung cancer (NSCLC) cells by regulating miR-197-3p and p120 catenin (p120-ctn). Within this investigation, we totally recruited 326 lung cancer patients, and purchased 4 NSCLC cell lines of A549, H1299, SPC-A-1 and H460. Moreover, cisplatin, adriamycin, gefitinib and paclitaxel were arranged as chemotherapies, and half maximal inhibitory concentration (IC50) values were calculated to evaluate the chemo-resistance of the cells. Furthermore, mice models of NSCLC were also established to assess the impacts of MALAT1, miR-197-3p and p120-ctn on tumor growth. Our results indicated that MALAT1 and miR-197-3p were both over-expressed within NSCLC tissues and cells, when compared with normal tissues and cells (P < 0.05). The A549, H460, SPC-A-1 and SPC-A-1 displayed maximum resistances to cisplatin ($IC50=15.70{\mu}g/ml$), adriamycin ($IC50=5.58{\mu}g/ml$), gefitinib ($96.82{\mu}mol/L$) and paclitaxel (141.97 nmol/L). Over-expression of MALAT1 and miR-197-3p, or under-expression of p120-ctn were associated with promoted viability and growth of the cancer cells (P < 0.05), and they could significantly strengthen the chemo-resistance of cancer cells (P < 0.05). MALAT1 Wt or p120-ctn Wt co-transfected with miR-197-3p mimic was observed with significantly reduced luciferase activity within NSCLC cells (P < 0.05). Finally, the NSCLC mice models were observed with larger tumor size and weight under circumstances of over-expressed MALAT1 and miR-197-3p, or under-expressed p120-ctn (P < 0.05). In conclusion, MALAT1 could alter chemo-resistance of NSCLC cells by targeting miR-197-3p and regulating p120-ctn expression, which might assist in improvement of chemo-therapies for NSCLC.

• Korean Journal of Clinical Pharmacy
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• v.29 no.1
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• pp.45-55
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• 2019

Background: Although the importance of pharmaceutical care service has been growing to meet the needs of customers with the improvement of clinical and humanistic outcomes, there was not a systematic strategy to promote research in Korea. The aim of this study was to suggest the core agendas for pharmaceutical care services research and development (R&D) considering priorities. Methods: Based on desk researches, we developed R&D agendas for the needs of improving pharmaceutical care services in the area of institution, community, and public health. To determine the priority of agendas in developing pharmaceutical care service, analytic hierarchy process (AHP) analysis was performed by the 14 experts. Criteria and subcriteria were assessed for significance by pairwise comparisons. Then, agendas were evaluated for importance according to each subcriteria, and rank ordered considering the weight calculated by multiplying the importance scores of the criteria and the subcriteria. Results: We derived 25 agendas including 13 for institutional pharmaceutical care service, 8 for community pharmaceutical care service, and 4 for public-health related pharmaceutical care service. AHP model was constructed based on 4 criteria and 8 subcriteria by a hierarchical structure. From the AHP survey, the 'Development of pharmaceutical care service for metabolic and chronic disease' agenda accounted for the highest priority. Conclusion: We have developed the R&D agendas of the pharmaceutical care service which should be promoted. The results should be utilized by the government to nationally support the development of the standards and relevant regulations related to pharmaceutical care services in Korea.

• Journal of IKEEE
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• v.22 no.4
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• pp.1140-1146
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• 2018

Recently, a methodology for analyzing complex bio-signals using a deep learning model has emerged among studies that recognize human emotions. At this time, the accuracy of emotion classification may be changed depending on the evaluation method and reliability depending on the kind of data to be learned. In the case of biological signals, the reliability of data is determined according to the noise ratio, so that the noise detection method is as important as that. Also, according to the methodology for defining emotions, appropriate emotional evaluation methods will be needed. In this paper, we propose a wavelet -based noise threshold setting algorithm for verifying the reliability of data for multimodal bio-signal data labeled Valence and Arousal and a method for improving the emotion recognition rate by weighting the evaluation data. After extracting the wavelet component of the signal using the wavelet transform, the distortion and kurtosis of the component are obtained, the noise is detected at the threshold calculated by the hampel identifier, and the training data is selected considering the noise ratio of the original signal. In addition, weighting is applied to the overall evaluation of the emotion recognition rate using the euclidean distance from the median value of the Valence-Arousal plane when classifying emotional data. To verify the proposed algorithm, we use ASCERTAIN data set to observe the degree of emotion recognition rate improvement.

• Journal of Digital Convergence
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• v.16 no.11
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• pp.231-236
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• 2018

In order to survive the competition, companies are developing new knowledge, applying and communicating, and accumulating numerous knowledge management activities. Therefore, it is important to establish and operate an effective knowledge management system to introduce and utilize effective knowledge management. So, the purpose of this study is to confirm the relation between the learning orientation of the organization and the knowledge management which are the main results in the knowledge management. In other words, this study investigated how the knowledge management system of a company affects the learning orientation of the corporate members, so as to be a basis for establishing the direction of knowledge management in the future. This study synthesized theory and previous studies, developed hypotheses and research models, and conducted empirical analysis through questionnaire surveys. This study is analyzed that knowledge management system has a positive effect on learning growth will. In addition, it was confirmed that the knowledge management system has a statistically significant relationship with the intention of internal improvement. Therefore, for the successful operation and management of the support management system, maintenance of the system that can focus on the strategic and appropriate learning model of the organization and the role of the organization member is an important variable. The results of this study are expected to provide meaningful guidance not only in the practical field but also in the study of the organization's knowledge management system.

• The Journal of Korean Academy of Sensory Integration
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• v.17 no.1
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• pp.19-29
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• 2019

Objective : The aim of this study was to verify validity of the Activity Participation Assessment for school-age children. Methods : A questionnaire consisting of 30 items from the APA, 75 items from the PACS, and 55 items from the CAPE was administered to elementary school students. A total of 207 questionnaires were analyzed. Confirmatory factor analysis was performed to confirm the construct validity of the APA. Convergence validity and discriminant validity were verified with the average variance extracted (AVE) and the square of the correlation coefficient. The discriminant validity was the Pearson correlation coefficient of the APA, PACS, and CAPE. Results : The results of the analysis were as follows: 1) For construct validity, the goodness of fit of the modified hierarchical second-order factor model was found to be appropriate (p < .001), 2) For convergent validity, the AVE was higher than .50 for all latent variables, 3) For discriminant validity, the AVE of the latent variable was greater than the square of the correlation coefficient (0.239), 4) For concurrent validity, the correlation between the total sum of the APA and PACS scores showed a positive correlation in all domains, and the correlation coefficient ranged from .303 to .647 at a statistically significant level (p < .01), 5) The correlation coefficient between the total sum of the APA and CAPE scores was .490 for recreational activities, .329 for physical activities, .571 for social activities, .401 for skill-based activities, and .390 for self-improvement activities. All domains showed a positive correlation, and were statistically significant (p < .01). Conclusion : APA can be used as a valid assessment tool to measure the participation of school aged children.

• Journal of Korea Technology Innovation Society
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• v.21 no.3
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• pp.992-1020
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• 2018

The purpose of this study is to investigate the ways to enhance the creativity of R & D teams of government-funded research institutes through systematic empirical studies. For this purpose, a research model was established based on existing research on group creativity and verified through empirical studies. Specifically, This study first attempts to investigate the influence that team diversity, team cohesion, team autonomy and team efficacy have on team creativity. Second, it intends to verify the mediating effects of team efficacy between team characteristics and team creativity. An empirical study was conducted on 102 R & D teams of government-funded research institutes. In the team creativity measurement, the evaluation by the leaders and the self evaluation of the members were performed in parallel. This is to increase the accuracy of the evaluation and to compare the differences of the viewpoints of the two subjects. The result of the analysis demonstrated that team cohesion among the others had a positive influence on team creativity, and that team efficacy possessed certain positive qualities in mediating the relationship between team diversity, team autonomy, and team creativity. Based on these findings, this study discussed its academic implications as well as its practical limitations, and made suggestions on future research tasks that remain.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.7
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• pp.847-857
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• 2017

The present situations of the education and training systems for the response to marine HNS spill incidents in domestic and foreign countries were reviewed and the plans to improve domestic system were suggested on the basis of the comparison between domestic and foreign education systems. There were almost no private education and training institutions in Korea, and they have not been activated, compared with those of foreign countries such as USA, Canada, Australia and UK. The domestic marine HNS-related education has been implemented uniformly under Korean government initiative. In addition, there were differences in the targets and duration of the education offered by Korea Coast Guard Academy (KCGA) and Marine Environment Research & Training Institute (MERTI) in Korea. Domestic HNS-related curriculum was relatively simple, compared with the curricula of foreign countries, and has not accepted two levels (operational level and manager level) required in HNS model courses of International Maritime Organization (IMO). The domestic education and training period was short relatively to those of foreign countries. The following suggestions were made to improve the education and training system for the response to domestic marine chemical incidents. In the short term, an HNS education and training management consultation body (tentative name) should be established, with both KCGA and MERTI participating jointly while maintaining the current system of the two institutions (KCGA and MERTI) simultaneously. In the more distant and long term, the HNS-related departments of KCGA and MERTI should be incorporated into a National Marine HNS Response Academy (tentative name) as unified system to enable international competitiveness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.517-524
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• 2019

The overdrive hub clutch is attached to a 6-speed automatic transmission to reduce fuel consumption by using the additional power of the engine. This paper proposes a means to minimize the load and roll-over ratio on the punch during the piercing process for the overdrive hub clutch product. Die clearance, shear angle, and friction coefficient, which can affect the load and roll-over ratio of the punch during processing, were set as the design variables. Sensitivity analysis was also conducted to determine the influence of each design variable on the punch load and roll-over ratio. As a result, shear angle, friction coefficient and die clearance were found to be sensitive to load and roll-over ratio. The punch load and roll-over ratio were set as the objective function and the equation of each design variable and objective function was derives using the Response Surface Method. Finally, the optimal value of the design variables was derived using the Response Surface Method. Application of this model to finite element analysis resulted in 22.14% improvement in the roll-over ratio of the punch load and material.

• Journal of Korea Port Economic Association
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• v.35 no.1
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• pp.57-76
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• 2019

This study deals with the determinants of employment productivity of transportation labor, who are the main agents of the transportation industry that has made significant contributions to our country's industrial development. The study selected the determinants of employment productivity using the Korea Labor and Income Panel Study data, and analyzed the effects of various factors using panel logistic regression, panel OLS model, and panel robust regression. The results were as follows. First, a more positive effect was shown when employees held a regular job, had a "high level of education", "joining the labor union" and "experiencing vocational training". Second, in the case of job security, having a "high level of education" and "joining the labor union" showed a more positive effect; further, job security was higher for employees who worked in a "big company" or were "married". Third, in the case of higher income productivity, higher values of "age", "academic ability" and "company size" had a more positive effect, whereas larger values of "education" and "health condition except job training" had a negative one. Fourth, in the case of job satisfaction, "female", "joining the labor union" and having a higher "income" or "job security" led to higher satisfaction and a better "health condition compared to an average person". Further, a higher "overall life satisfaction" and "economic level" led to lower job satisfaction. The analysis of the determinants of employment productivity of transportation business and seeking for improvement plan is expected to improve the employment productivity in the transportation business.

• The Korean Journal of Archival Studies
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• no.34
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• pp.57-105
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• 2012

The CAMS(Central Archives Management System) of NAK(National Archives of Korea) is an important system which receives and manages large amount of electronic records annually from 2015. From the point of view in database design, this paper analyzes the database schema of CAMS and discusses the direction of overall improvement of the CAMS. Firstly this research analyzes the tables for records and folders in the CAMS database which are core tables for the electronic records management. As a result, researchers notice that it is difficult to trust the quality of the records in the CAMS, because two core tables are entirely not normalized and have many columns whose roles are unknown. Secondly, this study suggests directions of normalization for the tables for records and folders in the CAMS database like followings: First, redistributing the columns into proper tables to reduce the duplication. Second, separating the columns about the classification scheme into separate tables. Third, separating the columns about the records types and sorts into separate tables. Lastly, separating metadata information related to the acquisition, takeover and preservation into separate tables. Thirdly, this paper suggests considerations to design and manage the database schema in each phase of archival management. In the ingest phase, the system should be able to process large amount of records as batch jobs in time annually. In the preservation phase, the system should be able to keep the management histories in the CAMS as audit trails including the reclassification, revaluation, and preservation activities related to the records. In the access phase, the descriptive metadata sets for the access should be selected and confirmed in various ways. Lastly, this research also shows the prototype of conceptual database schema for the CAMS which fulfills the metadata standards for records.