• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.208-215
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• 2017

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a cardiomyopathy characterized by predominant right ventricular fibro-fatty replacement, right ventricular dysfunction and ventricular arrhythmias. It is a rare but important cause of sudden cardiac death in children and young adults. A meta-analysis on risk stratification of major ventricular tachyarrhythmic events indicating the need for implantable cardioverter defibrillator therapy in ARVC was performed. Methods: The pubmed database was searched from its inception to May 2015. Of the 433 citations identified, 12 were included in this meta-analysis. Data regarding major ventricular tachyarrhythmic events were retrieved in 817 subjects from the studies. For the variables, a combined odds ratio (OR) was calculated using a fixed-effects meta-analysis. Results: Extensive right ventricular dysfunction (OR, 2.44), ventricular late potential (OR, 1.66), inducible ventricular tachyarrhythmia during electrophysiology study (OR, 3.67), non-sustained ventricular tachycardia (OR, 3.78), and history of fatal event/sustained VT (OR, 5.66) identified as significant risk factors (p<0.0001). Conclusion: This meta-analysis shows that extensive right ventricular dysfunction, ventricular late potential, inducible ventricular tachyarrhythmia during electrophysiological study, non-sustained ventricular tachycardia, and history of sustained ventricular tachycardia/fibrillation are consistently reported risk factors of major ventricular tachyarrhythmic events indicating implantable cardioverter defibrillator therapy in patients with ARVC.

• 디지털융복합연구
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• 제15권4호
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• pp.317-326
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• 2017

본 연구는 간호대학생의 메타인지와 자기효능감 및 임상수행능력의 정도를 파악하고 임상수행능력에 영향을 주는 요인을 파악하고자 시도된 서술적 조사연구이다. 간호대학생 153명을 대상으로 자기보고형 설문지를 통해 2015년 9월1일부터 9월30일까지 자료를 수집하였다. SPSS/Win 18.0 프로그램을 이용하여, 빈도와 백분율, 평균과 표준편차, Pearson's Correlation coefficient, t-test, One-way ANOVA, 다중회귀분석을 사용하였다. 본 연구결과 메타인지와 자기효능감이 임상수행능력과 양의 상관관계가 있었다. 대상자의 특성 중 전공만족과 임상실습만족을 포함시켰을 때는 임상수행능력의 7%를 설명하였다(F=2.76, p=.030). 메타인지를 추가적으로 투입하였을 때는 임상수행능력이 25%의 설명력을 나타내었으며 자기효능감을 추가적으로 투입하였을 때는 임상수행능력이 27%의 설명력이 나타났다. 결론적으로 스스로의 문제해결능력이 강조되고 있는 간호현장의 상황을 고려할 때 임상수행능력 향상을 위해서는 체계적인 교육과정의 개발 및 다양한 교수학습방법의 활성화가 필요할 것으로 사료된다.

• 정보관리학회지
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• 제26권1호
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• pp.185-214
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• 2009

본 연구는 온라인목록의 Open API 기반 일반 검색시스템과 온라인목록의 Open API 기반 메타 검색시스템을 구축하고 두 실험시스템의 사용성을 비교 평가하여 온라인목록의 Open API 기반 메타 검색시스템의 유용성을 밝히고자 하였다. 사용성은 전체적으로 온라인목록의 Open API 기반 일반 검색시스템 보다온라인목록의 Open API 기반 메타 검색시스템이 더 높게 나타났고, 통계적으로유의한 차이가 있는 것으로 나타났다. 국내 도서관들이 인터넷서점, 검색엔진, 웹포털 등에서 공개한 도서검색용 Open API를 통해 제공되는 풍부한 콘텐트를 온라인목록에서 공유하고 활용하면 서지데이터의 확충, 주제접근과 주제검색 능력의 확대, 메타 검색서비스의 확장, 소장도서의 이용가능성 증대, 목록비용의 절감 등에 도움이 될 것으로 기대된다.

• 임상간호연구
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• 제25권3호
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• pp.221-236
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• 2019

Purpose: The purpose of this study was to systematically review and identify factors relevant to the positive psychological capital of clinical nurses. Methods: These was no limit on year of publication. Articles related to Korean clinical nurses were retrieved from computerized database using a manual search. A systematic review was conducted based on the PRISMA flow. The total correlational effect size (ESr) for each related factor was calculated from Fisher's Zr. Funnel plots, fail-safe numbers, and Egger regression tests were used to evaluate publication bias in meta-analysis studies. The correlational effect size of 25 studies was analyzed through meta-analysis using Comprehensive Meta-Analysis software 3.0 (CMA). Results: The review included 25 studies. In the systematic review, 14 demographic factors and 46 organizational factors were found to be influential. Eleven factors (6 demographic factors and 5 organizational factors) were appropriate for meta-analysis. The overall effect size was .26. The demographic total correlation effect size of related factors was .20 and the total effect size of organization was .46. Organizational commitment (ESr=.38) and job satisfaction (ESr=.54) were statistically positively related variables. Negative variables were burnout (ESr=-.61), turnover intention (ESr=-.41) and workplace bullying (ESr=-.33). The total effect size of the organizational factors was larger than the demographic total effect size. There was no publication bias except for demographic variables. Conclusion: Organizational factors and adjustable variables have a significant impact on positive psychological capital. The results of this study support the need for development of interventions focusing on organizational factors.

• 임상간호연구
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• 제25권3호
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• pp.251-264
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• 2019

Purpose: This study was a systematic review and meta-analysis to explore the factors related to quality of life in heart transplant recipients. Methods: To identify studies that suggested the factors related to the quality of life in heart transplant recipients, we searched the articles published from 1974 to November 2018 using Six databases, PubMed, CINAHL, EMBASE, Cochrane, KMBASE and RISS. A total of 22 studies were selected out of 5,234 for the systematic review and meta-analysis on the basis of the PRISMA flow. The quality of study was assessed by assessment tool form the NIH and meta-analysis was performed using the 'R 3.5.2' version to analyze the correlated effect sizes. Results: Factors related to quality of life in heart transplant recipients were categorized into six domains based on the health-related quality of life model introduced by Ferrans: individual, environmental, biological function, symptoms, functional status, and general health perception. In the meta-analysis, 34 factors were used and 17 factors having significant effect sizes were as follows: self-efficacy, demoralization, perceived control, current occupational status, age, marital status, health promotion life style in the individual characteristics; stress in environmental characteristics; physical function status, creatinine level, left ventricular ejection fraction (LVEF) in biological function; anxiety, depression, symptom frequency and distress in symptoms domain; coping, self-care compliance in functional status. Conclusion: The findings indicate that the multi-dimensional factors influencing the quality of life in heart transplant recipients and provide the evidence for developing effective interventions for improving the quality of life of recipients.

• 대한한방내과학회지
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• 제42권4호
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• pp.672-686
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• 2021

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

• Nutrition Research and Practice
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• 제15권3호
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• pp.329-345
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• 2021

BACKGROUD/OBJECTIVES: Evidence has suggested an association between serum vitamin D and metabolic syndrome (MetS), but prospective studies are very limited. The objective was to assess the dose-response association between serum vitamin D concentration and MetS risk using a systematic review and meta-analysis of updated observational studies. MATERIALS/METHODS: Using MEDLINE, PubMed, and Embase, a systematic literature search was conducted through February 2020 and the references of relevant articles were reviewed. A random-effects model was used to estimate the summary odds ratio/relative risk and 95% confidence interval (CI). Heterogeneity among studies was evaluated with I² statistic. In total, 23 observational studies (19 cross-sectional studies, and four cohort studies) were included in the meta-analysis. RESULTS: The pooled estimates (95% CI) for MetS per 25-nmol/L increment in serum vitamin D concentration were 0.80 (95% CI, 0.76-0.84; I² = 53.5) in cross-sectional studies, and 0.85 (95% CI, 0.72-0.98; I² = 85.8) in cohort studies. Similar results were observed, irrespectively of age of study population, study location, MetS criteria, and adjustment factors. There was no publication bias for the dose-response meta-analysis of serum vitamin D concentrations and MetS. CONCLUSIONS: Dose-response meta-analysis demonstrated that a 25-nmol/L increment in the serum vitamin D concentration was associated with 20% and 15% lower risks of MetS in cross-sectional studies and cohort studies, respectively.

• 디지털융복합연구
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• 제19권7호
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• pp.427-440
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• 2021

본 연구는 여대생을 대상으로 한 식이 행동 중재프로그램의 효과를 조사하기 위한 체계적인 검토 및 메타분석이다. 분석 대상 논문은 2015년부터 2020년 2월 29일까지의 연구로, PRISMA에 따라 체계적으로 수집되었다. 메타분석을 위해 총 9편의 논문이 최종 선정되었고, 효과 크기를 추정하기 위해 Comprehensive Meta-Analysis 3.0을 사용하여 분석하였다. 여대생을 대상으로 적용된 식이 행동 중재프로그램 연구의 전체적인 효과 크기는 큰 것으로 나타났고, 문제 식이 행동 여대생을 대상으로 한 6편의 연구에서 효과 크기가 더 큰 것으로 확인되었다. 전체 여대생과 문제 식이행동 여대생 모두 식이 행동 관련 변수 및 심리사회적 관련 변수에서 유의한 효과 크기를 나타냈다. 그러므로 본 연구결과는 향후 여대생을 대상으로 차별화 된 식이 행동 중재프로그램을 개발하는 기초자료로써 연구의 의의가 있다.

• Journal of Periodontal and Implant Science
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• 제51권1호
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• pp.18-29
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• 2021

Purpose: The aim of this study was to compare the characteristic expression patterns of advanced periodontitis in 2 cohort data sets analyzed using different microarray platforms, and to identify differentially expressed genes (DEGs) through a meta-analysis of both data sets. Methods: Twenty-two patients for cohort 1 and 40 patients for cohort 2 were recruited with the same inclusion criteria. The 2 cohort groups were analyzed using different platforms: Illumina and Agilent. A meta-analysis was performed to increase reliability by removing statistical differences between platforms. An integrative meta-analysis based on an empirical Bayesian methodology (ComBat) was conducted. DEGs for the integrated data sets were identified using the limma package to adjust for age, sex, and platform and compared with the results for cohorts 1 and 2. Clustering and pathway analyses were also performed. Results: This study detected 557 and 246 DEGs in cohorts 1 and 2, respectively, with 146 and 42 significantly enriched gene ontology (GO) terms. Overlapping between cohorts 1 and 2 was present in 59 DEGs and 18 GO terms. However, only 6 genes from the top 30 enriched DEGs overlapped, and there were no overlapping GO terms in the top 30 enriched pathways. The integrative meta-analysis detected 34 DEGs, of which 10 overlapped in all the integrated data sets of cohorts 1 and 2. Conclusions: The characteristic expression pattern differed between periodontitis and the healthy periodontium, but the consistency between the data sets from different cohorts and metadata was too low to suggest specific biomarkers for identifying periodontitis.

• 대한수학교육학회지:학교수학
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• 제16권3호
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• pp.409-444
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• 2014

수학교육 연구 공동체에서는 모델링 활동을 통한 수학 학습에 대한 논의들이 지속되어 왔다. 모델링 활동은 대안적인 수학 교수 학습 방법으로 논의되어 왔으나, 모델링 활동을 통하여 이루어지는 수학 학습은 어떠한 성격을 갖는지, 그리고 이는 어떠한 과제 설계와 수업 실행을 통하여 달성할 수 있는지에 대한 합의점은 도출되지 못한 실정이다. 모델링 활동을 통한 수학 학습을 시도해 온 선행 연구들의 논의로부터, 본 연구에서는 모델링 활동이 메타수준의 수학적 담론 생성과 메타규칙의 변화를 포함하는 메타수준 학습을 촉진할 수 있을 것으로 판단하였다. 이에 본 연구에서는 메타수준 학습을 촉진할 수 있는 모델링 과제 설계와 수업 실행 방안을 도출하고, 이를 실행하여 수학 교수 학습에서 모델링 활동의 잠재력을 확인하는 데 목적을 둔다.