The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis

합병증을 동반하지 않은 2형 당뇨병 환자에 대한 백호가인삼탕과 혈당강하제 병행치료의 혈당 강하 효과 및 안전성 연구 : 체계적 문헌 고찰과 메타분석

  • Shin, Jae-ik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Baek, Ji-soo (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Shin, Seon-mi (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Cho, Chung-sik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
  • 신재익 (대전대학교 한의과대학 신계내과학교실) ;
  • 백지수 (대전대학교 한의과대학 신계내과학교실) ;
  • 신선미 (세명대학교 한의과대학 신계내과학교실) ;
  • 조충식 (대전대학교 한의과대학 신계내과학교실)
  • Received : 2021.09.15
  • Accepted : 2021.10.06
  • Published : 2021.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0180).

References

  1. Park CI, Gu HS, Choi KY, Kang DY, Kang CS, Kwon GY, et al. Textbook of phathology. Seoul: Gomunsa; 2005, p. 649.
  2. Korean Diabetes Association. Diabetes Fact Sheet in Korea 2020. Seoul: Diabetes Fact Sheet in Korea; 2020.
  3. Jeong EG. Weekly health and disease. Cheongju. Korea Centers for Disease Control and Prevention 2019;12(45):1984.
  4. Cha BS. Step to Internal Medicine. Seoul: Jeongdam; 2008, p. 164.
  5. Heo J. Donguibogam. Gyeongsangnamdo: Donguibogam Publishing House; 2005, p. 1444.
  6. Kim JB. Geumgweyoryakbyeonseok. Korea: Hangukmoonhwasa; 2003, p. 358.
  7. Xiang Q, Chiang WG, Yu R, Wu YG, Yin YS, Liu X, et al. Effect of White Tiger plus Ginseng Soup on Intestinal UCP2, AMPK Expression and GLP-1 Secretion in Type 2 Diabetes Mice. Journal of Hunan University of Traditional Chinese Medicine 2020;40(12):1444-8.
  8. Peng SL, Wang DC, Zhang WY, Zhao HX. Effect of White Tiger Plus Ginseng Soup on the Treatment of Type 2 Diabetes Mellitus with Dry Heat and Deficiency of Qiyin. New Traditional Chinese Medicine 2015;47(01):84-6.
  9. Kim SY, Park JE, Seo HJ, Seo HS, Son HJ, Sin CM, et al. NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. Seoul: National Evidence-based Healthcare Collaborating Agency; 2011.
  10. Feng ZR, Xu TY, Zhao Q. White Tiger Decoction Plus Ginseng Treatment Clinical Observation on 30 Cases of Type 2 Diabetes with Deficiency of Qi and Yin. Hunan Journal of Traditional Chinese Medicine 2020;36(8):51-3.
  11. Liao S, Liu XM, Zhao HX, Liu DL, Chu SF, Zhang XW, et al. Effect of White Tiger Decoction Plus Ginseng on Oxidative Stress Level and Serum Adiponectin in Type 2 Diabetes Patients. Journal of Guangzhou University of Traditional Chinese Medicine 2020;37(7):1229-34.
  12. Mo RJ. Efficacy of White Tiger Decoction Plus Ginseng in the Treatment of Diabetes (Symptoms of Driedness and Fever). Inner Mongolia Journal of Traditional Chinese Medicine 2020;39(5):36-7.
  13. Rong YH. White Tiger Decoction Plus Ginseng for Diabetes Treatment (Pulmonary and Gastric Heat) random parallel control study. Journal of Practical Traditional Chinese Internal Medicine 2019;33(5):32-4.
  14. Cheng SL. A Clinical Observation on the Glycemic Variability of Type 2 Diabetes Mellitus with Exuberance of Fire and Heat Syndrome with Treatment of White Tiger Decoction Plus Ginseng Combined Short-term Insulin Intensive Therapy. Chengdu University of Traditional Chinese Medicine 2019:1-70.