[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.22246/jikm.2021.42.4.672

A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis

Shin, Jae-ik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
Baek, Ji-soo (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
Shin, Seon-mi (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University)
Cho, Chung-sik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)

Publication Information

The Journal of Internal Korean Medicine / v.42, no.4, 2021 , pp. 672-686 More about this Journal

Abstract

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

Keywords

Baekhogainsam-tang; Baihujiarenshen-tang; type 2 diabetes mellitus; hypoglycemic effect; systematic review; meta-analysis;

Citations & Related Records

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