• Journal of Mechanical Science and Technology
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• v.15 no.8
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• pp.1090-1096
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• 2001

In this paper, new methods for efficiently solving linear acceleration equations of multibody dynamic simulation exploiting sparsity for real-time simulation are presented. The coefficient matrix of the equations tends to have a large number of zero entries according to the relative joint coordinate numbering. By adequate joint coordinate numbering, the matrix has minimum off-diagonal terms and a block pattern of non-zero entries and can be solved efficiently. The proposed methods, using sparse Cholesky method and recursive block mass matrix method, take advantages of both the special structure and the sparsity of the coefficient matrix to reduce computation time. The first method solves the η$\times$η sparse coefficient matrix for the accelerations, where η denotes the number of relative coordinates. In the second method, for vehicle dynamic simulation, simple manipulations bring the original problem of dimension η$\times$η to an equivalent problem of dimension 6$\times$6 to be solved for the accelerations of a vehicle chassis. For vehicle dynamic simulation, the proposed solution methods are proved to be more efficient than the classical approaches using reduced Lagrangian multiplier method. With the methods computation time for real-time vehicle dynamic simulation can be reduced up to 14 per cent compared to the classical approach.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.11
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• pp.1144-1151
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• 2012

A damage in structure alters its dynamic characteristics. The change is characterized by changes in the modal parameter, i.e., modal frequencies, modal damping value and mode shape associated with each modal frequency. Changes also occur in some of the structural parameters; namely, the mass, damping, stiffness matrices of the structure. In this paper, evaluation of changes in stiffness matrix of a structure is presented as a method not only for identifying the presence of the damage but also locating the damage. It is shown that changed stiffness matrix can be accurately estimated a sensitivity coefficient matrix derived from modifying mode shapes, First, with 4 story shear structure models, the effect of presence of damage in a structure on its stiffness matrix is studied. By using these analytical model, the effectiveness of using change of stiffness matrix in detecting and locating damages is demonstrated. To validate the predicted changing stiffness and its location, the obtained results are compared to the reanalysis result which shows good agreement.

• Journal of the Korean Data and Information Science Society
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• v.24 no.2
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• pp.303-310
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• 2013

Forty two female students whose fat mass ratio was over 30% were participated in the experiment of fat mass loss of two treatments for 8 weeks. They kept diary for foods they ate every day, took a picture of the foods, transmitted the picture to the experimenter by the camera phone. Among those, 28 students took the picture by regular camera phone (Treatment A), and the other students used smart phone (Treatment B). Fat mass weight and its related variables had been measured repeatedly four times at an interval of two weeks during 8 weeks. It was shown from mixed model analysis of repeated measurements data that AR(1) covariance matrix was selected as the optimal covariance matrix pattern. The correlation between two successive times is highly correlated as 0.838. Based upon the AR(1) covariance matrix structure, the students using smart phones were somewhat more effective in losing fat mass weight than the students using regular camera phones. The time effect was highly significant, but the treatment-time interaction effect was insignificant. The baseline effect and total cholesterol were found to be significant, but the calories with taking foods were somewhat significant, but the waist to hip ratio was found to be insignificant.

• Journal of the Earthquake Engineering Society of Korea
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• v.5 no.5
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• pp.25-33
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• 2001

For the seismic design and analysis of LMR(liquid metal reactor) being developed in Korea, it is necessary to develop the simple seismic analysis model including the fluid-structure interaction effects. In this paper, the theoretical backgrounds for the fluid added mass of the immersed concentric cylinders are investigated and the seismic analysis code using the Runge-Kutta algorithm, which can consider the fluid added mass matrix in system matrix, are developed to perform the time history seismic analysis. Form the coupled modal analysis and the seismic analysis for the simple immersed concentric cylinders, it is verified that the fluid added mass significantly affect the vibration characteristics and the seismic responses. Therefore the fluid coupled effects should be carefully considered in seismic response analysis of the immersed concentric cylinders.

• Mass Spectrometry Letters
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• v.10 no.1
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• pp.18-26
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• 2019

We developed a bioanalytical method for simultaneous determination of nine NBOMe derivatives (25H-NBOMe, 25B-NBOMe, 25E-NBOMe, 25N-NBOMe, 25C-NBOH, 25I-NBOH, 25B-NBF, 25C-NBF, and 25I-NBF) in human plasma using liquid chromatography tandem mass spectrometry (LC-MS/MS). Human plasma samples were pre-treated using solid-phase extraction. Separation was achieved on a C18 column under gradient elution using a mobile phase containing 0.1% formic acid in acetonitrile and 0.1% formic acid in water at a flow rate of 0.3 mL/min. Mass detection was performed in the positive ion mode using multiple reaction monitoring. The calibration range was 1-100 ng/mL for all quantitative analytes, with a correlation coefficient greater than 0.99. The intra- and inter-day precision and accuracy varied from 0.85 to 6.92% and from 90.19 to 108.69%, respectively. The recovery ranged from 86.36 to 118.52%, and the matrix effects ranged from 27.09 to 99.72%. The stability was acceptable in various conditions. The LC-MS/MS method was validated for linearity, accuracy, precision, matrix effects, recovery and stability in accordance with the FDA guidance. The proposed method is suitable for reliable and robust routine screening and analysis of nine NBOMe derivatives in forensic field.

• Geomechanics and Engineering
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• v.21 no.1
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• pp.11-21
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• 2020

The traditional formulations for estimation of bearing capacity in rock mechanics assume a homogeneous and isotropic rock mass. However, it is common that the rock mass consists of different layers of different rock properties or of the same rock matrix with distinct geotechnical quality levels. The bearing capacity of a heterogeneous rock is estimated traditionally through the weighted average. In this paper, the solution of the weighted average is compared to the finite difference method applied to a bilayer rock mass. The influence of different parameters such as the thickness of the layers, the rock type, the uniaxial compressive strength and the overall geotechnical quality of the rock mass on the bearing capacity of a bilayer rock mass is analyzed. A parametric study by finite difference method is carried out to develop a bearing capacity factor in function of the layer thickness and the rock mass quality expressed in terms of the geological strength index, which is presented in a form of a chart. Therefore, this correlation factor allows estimating the bearing capacity of a rock mass that is formed by two layers with distinct GSI, depending on the bearing capacity of the rock mass formed only by the upper layer and considered by that way as homogenous and isotropic rock mass.

• Journal of Microbiology and Biotechnology
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• v.29 no.6
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• pp.887-896
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• 2019

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based pathogen identification relies on the ribosomal protein spectra provided in the proprietary database. Although these mass spectra can discern various pathogens at species level, the spectra-based method still has limitations in identifying closely-related microbial species. In this study, to overcome the limits of the current MALDI-TOF MS identification method using ribosomal protein spectra, we applied MALDI-TOF MS of low-mass profiling to the identification of two genetically related Bacillus species, the food-borne pathogen Bacillus cereus, and the insect pathogen Bacillus thuringiensis. The mass spectra of small molecules from 17 type strains of two bacilli were compared to the morphological, biochemical, and genetic identification methods of pathogens. The specific mass peaks in the low-mass range (m/z 500-3,000) successfully identified various closely-related strains belonging to these two reference species. The intensity profiles of the MALDI-TOF mass spectra clearly revealed the differences between the two genetically-related species at strain level. We suggest that small molecules with low molecular weight, 714.2 and 906.5 m/z can be potential mass biomarkers used for reliable identification of B. cereus and B. thuringiensis.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.3
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• pp.10-17
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• 2016

This paper presents a laboratory validation of a new approach for Finite Element Model Updating(FEMU) on short-span bridges by combining ambient vibration measurements with static load input-deflection output measurements. The conventional FEMU approach based on modal parameters requires the assumption on the system mass matrix for the eigen-value analysis. The proposed approach doesn't require the assumption and even provides a way to update the mass matrix. The proposed approach consists of two steps: 1) updating the stiffness matrix using the static input-deflection output measurements, and 2) updating the mass matrix using a few lower natural frequencies. For a validation of the proposed approach, Young's modulus of the laboratory model was updated by the proposed approach and compared with the value obtained from strain-stress tests in a Universal Testing Machine. Result of the conventional FEMU was also compared with the result of the proposed approach. It was found that proposed approach successfully estimated the Young's modulus and the mass density reasonably while the conventional FEMU showed a large error when used with higher-modes. In addition, the FE modeling error was discussed.

• Bulletin of the Korean Chemical Society
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• v.23 no.11
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• pp.1590-1594
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• 2002

Liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS) has been used for the determination of sulfonamides in meat. Five typical sulfonamides were selected as target compounds, and beef meat was selected as a matrix sample. As internal standards, sulfapyridine and isotope labeled sulfamethazine (${13}^C_6$-SMZ) were used. Compared to the results of recent reports, our result have shown improved precision to a RSD of 1.8% for the determination of sulfamethazine spiked with 75 ng/g level in meat.

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.1025-1038
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• 2014

Linear mixed model has often been utilized for genetic association analysis with family-based samples. The correlation matrix for family-based samples is constructed with kinship coefficient and assumes that parental phenotypes are independent and the amount of correlations between parent and offspring is same as that of correlations between siblings. However, for instance, there are positive correlations between parental heights, which indicates that the assumption for correlation matrix is often violated. The statistical validity and power are affected by the appropriateness of assumed variance covariance matrix, and in this thesis, we provide the linear mixed model with flexible variance covariance matrix. Our results show that the proposed method is usually more efficient than existing approaches, and its application to genome-wide association study of body mass index illustrates the practical value in real data analysis.