• English Language & Literature Teaching
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• v.16 no.1
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• pp.41-59
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• 2009

The present study investigated Korean learners' knowledge on the range of possible interpretations of English locative PPs with manner of motion verbs, and considers whether learners can arrive at a superset L2 grammar on the basis of positive L2 input. Unlike Korean, some English locative PPs occurring with manner of motion verbs (such as in John jumped on the bed) are ambiguous as they can be interpreted as either directional or locational. Thirty Korean learners of English in three distinct groups (Advanced EFL-only group; Intermediate-EFL-only group; and ESL-experienced group) participated in an experimental study, along with a control group of nine native speakers of English. The results of the study showed that I) Korean learners, overall, tended to interpret English locative PPs as only locational, failing to recognize the ambiguity between the directional and locational readings in the target structure; 2) For the learners who experienced only the EFL context, even highly proficient learners, as well as intermediate level learners, failed to acknowledge the ambiguity; 3) The learners who experienced the ESL context for an extended period of time could identify the target reading to some extent, although they still could not reach the native-like competence. From these results, it is argued that robustness of positive evidence, not simply its availability, is critical in the acquisition of the superset L2 targets like the present one.

• KIEAE Journal
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• v.13 no.1
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• pp.29-37
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• 2013

This study intended to introduce the method of designing an eco-friendly building based on BIM(Building Information Modeling) and BIM-based application. The proposed application aimed to generate the environmental performance of the designed alternative automatically in real-time manner in the process of architectural design. We focused on the feasibility of BIM-based eco-friendly design process and the applicability of the developed application for the architectural design practice. In this manner, in the end of paper, we proposed the so-call EcoBIM which is the performance evaluation module for the designed alternative using BIM in the real-time manner and the new design process with it. EcoBIM generate the coefficient of overall heat transmission of wall, roof and slab of the designed alternative with their physical characteristics such as thickness, thermal resistance and so on.

• Toxicological Research
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• v.32 no.2
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• pp.115-121
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• 2016

This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II collagen was performed in control, SNP-treated and SNP plus SSZ ($50{\sim}200{\mu}g/mL$) rabbit articular chondrocytes. Cellular proliferation was decreased significantly in the SNP-treated group compared with that in the control (p < 0.01). SSZ treatment clearly increased the SNP-reduced proliferation levels in a concentration-dependent manner (p < 0.01). SNP treatment induced significant dedifferentiation and inflammation compared with control chondrocytes (p < 0.01). Type II collagen expression levels increased in a concentration-dependent manner in response to SSZ treatment but were unaltered in SNP-treated chondrocytes (p < 0.05 and < 0.01, respectively). Cylooxygenase-2 (COX-2) expression increased in a concentration-dependent manner in response to SSZ treatment but was unaltered in SNP-treated chondrocytes (p < 0.05). Immunofluorescence staining showed that SSZ treatment increased type II collagen expression compared with that in SNP-treated chondrocytes. Furthermore, phosphorylated extracellular regulated kinase (pERK) expression levels were decreased significantly in the SNP-treated group compared with those in control chondrocytes (p < 0.01). Expression levels of pERK increased in a concentration-dependent manner by SSZ but were unaltered in SNP-treated chondrocytes. pp38 kinase expression levels increased in a concentration-dependent manner by SSZ but were unaltered in control chondrocytes (p < 0.01). In summary, SSZ significantly inhibited nitric oxide-induced cell death and dedifferentiation, and regulated extracellular regulated kinases 1 and 2 and p38 kinase in rabbit articular chondrocytes.

• The Journal of Internal Korean Medicine
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• v.36 no.1
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• pp.1-12
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• 2015

Objectives : This study was performed to investigate the anti-cancer effects of Rhus verniciflua Stokes (RVS) extracted with sterile distilled water on cholangiocarcinoma cell lines. Materials and Methods : Two cholangiocarcinoma cell lines, SNU-1079 and SNU-1196, were used in this study. Cells were treated with different concentrations of RVS for 24, 48, and 72 hours. Cell count, viability, apoptosis, and mRNA expression of Bax, Bcl-2, Mcl-1, survivin, caspase-3, and cyclin D1 and P21 were determined with an automatic cell counter (ADAM-MC), MTT assay, apoptosis assay (Annexin-V/PI staining), and RT-PCR. Results : All cells treated with RVS showed decreased cell counts in a dose-dependent manner. RVS inhibited proliferation of SNU-1196 in a dose-dependent manner, but SNU-1079 proliferation was inhibited in the long-time culture group in a dose-dependent manner. The proportion of early and late-stage apoptotic cells was increased by RVS in a dose-dependent manner in SNU-1196. In contrast, it was increased significantly in SNU-1079 treated with high-dose RVS. After treatment with RVS, the mRNA expression of Bcl-2 was decreased while Bax was increased in SNU-1079. Cyclin D1 mRNA levels were decreased in SNU-1196 in a dose-dependent manner. P21 expression was increased in all cells after the treatment with RVS. Conclusions : RVS appears to have potential as a therapeutic agent for cholangiocarcinoma.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.3
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• pp.575-580
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• 2006

This Study was designed to investigate the effects of Mixture of Bambusae Caulis in Liquamen and Bamboo Extract on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal and cerebral ischemic rats. Experimental materials were as follows ; BE- 1 was Bamboo Extract (BE) extracted with 70% ethyl alcohol, BE-11 was BE extracted with distilled water at $121^{\circ}C$ for 30 min, BE-111 was BE extracted with distilled water at $121^{\circ}C$ for 3 hrs, MLC was mixture of Bambusae Caulis in Liquamen (BCL) and BE-111 mixed at the ratio of 1 to 100 (MLC100), 1 to 50 (MLC50), 1 to 20 (MLC20), 1 to 10 (MLC10), 1 to 5 (MLC5). The results were as follows , The Changes of BE- 1 on the rCBF and MABP in normal rats were not showed, BE- 11 significantly decreased rCBF in a dose-dependent manner Dut increased MABP in a dose-dependent manner. BE-111 increased rCBF in a dose-dependent manner, MLC significantly increased rCBF in a dose-dependent manner and increased MABP in a dose-dependent manner. rCBF was significantly and stably increased by MLC5 (1 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. As results above ; The present author thought that BE- 111 and MLC increased rCBF by dilating pial arterial diameter.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.115-121
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• 2020

The primary aim of this paper is to discuss the historical development or grammaticalization of English adverbial -ly suffix and provide a diachronic analysis of manner adverbs and sentence adverbs from the perspective of secondary grammaticalization. The grammaticalization includes both the primary grammaticalization from a lexical to a grammatical and the secondary grammaticalization from a less grammatical to a more grammatical status. The emergence of the manner adverbs is due to the primary grammaticalization from OE adjectival suffix -lic to ME adverbial suffix -ly. In contrast, the emergence of sentence adverbs is due to the secondary grammaticalization from manner adverbs in VP domain to sentence adverbs in TP domain with grammatical features of tense and modality. This paper concludes that the secondary grammaticalization of the English adverbial -ly suffix includes the change from manner adverbs to sentence adverbs which obtain a new grammatical function of tense and modality.

• Journal of Digital Convergence
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• v.17 no.8
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• pp.293-301
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• 2019

The purpose of this study was to explore the relationship andinfluence of Focusing manner to deal with somatization symptoms of adolescents with experience of cyberbullying. For this study, we conducted on teenagers aged 14 to 19. A total of 366 of these results -84 men (23%) and 282 women(77%)- were used for the analysis. Data was analyzed through frequency analysis, reliability analysis, correlation analysis, and multiple regression analysis. As a result, cyber-bullying experiences have a positive effect on somatizaion symptoms. Among the sub-factors of focusing manner, "knowledge" and "reviewing" have a negative effect on somatizaion symptoms, and "expression" has an negative effect on somatizaion symptoms. Based on the results of the study, the need for a therapeutic approach to focusing manner was presented when appealing for somatizaion symptoms of adolescents who experienced cyberbullying.

• The Journal of the Korea Contents Association
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• v.21 no.3
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• pp.653-663
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• 2021

The purpose of this study was to examine the effects of ambivalent sexism and focusing manner on self-concept for middle-aged women, and to verify the factors that can help middle-aged women's positive self-concept. The self-concept scale, the focusing manner scale, and the ambivalent sexism scale were used for this study through the online community targeting middle-aged women aged 35 to 55. As a result of the analysis using SPSS 21.0, it was investigated that there was a significant positive correlation between hostile sexism and benevolent sexism. In addition, It was found out that ambivalent sexism had a significant negative effect on self-concept. It was found out that the high hostile sexism of ambialent sexism led to lowering the self esteem, emotional stability, problem solving stability, interpersonal relationship and interpersonal trust of middle-aged women. Focusing manner had a significant positive effect on self concept, but there were differences for each sub-factor. Express, accept, and keeping one's composure had a significant positive effect, while awareness had a negative effect, and reflecting attitude did not have a significant effect. Finally, limitations of this study were discussed.

• Journal of the Korean Institute of Landscape Architecture
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• v.44 no.5
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• pp.26-37
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• 2016

As activities and convenience of residents in outdoor spaces in apartment houses have been considered important, strategies for making outdoor spaces in apartment houses healing spaces have emerged as a major interest. The purpose of this study is to draw elements for planning healing to create healing spaces in collective housing areas and to present design guidelines. The findings of this study are as follows. Functional elements of a healing environment were classified into safe environment, therapeutic environment, ancillary environment, orientation-reinforcing environment, amenities, and social environment. Outdoor spaces in collective housing areas were divided into collective housing entrance areas, internal and external spread areas, outdoor activity areas, and areas by theme. First, collective housing entrance areas should be planned in such a manner that residents can feel the area is private and easy to recognize. Second, internal and external spread areas should be planned in such a manner that they are easy to access and communicate with neighbors. Third, outdoor activity areas should be divided into an open space, resting space, playing space, and sports space. Open spaces should be planned in such a manner that they can command a fine view and respect the privacy of nearby residents. Resting spaces should be equipped with a shelter that protects users from direct sunlight, rain, and snow as well as include a movable bench. Playing spaces should be built considering development of children's curiosity, adventurous spirit, character, stimulation, and physical health. Playing spaces should be designed in such a manner that roadways and sidewalks can be separated for safe traffic. Sport spaces should be planned in such a manner that they can be associated with a pavilion and trail that provide residents with an opportunity to communicate with each other and rest. Fourth, spaces by theme are classified into sense garden, therapeutic garden, experiential garden, and learning garden. Sense gardens are a small garden based on the five senses. Sense gardens should be designed in such a manner that they can improve users' mental and physical health through programs that stimulate the sense of sight, auditory sense, and olfactory sense. Therapeutic gardens should be designed in such a manner that they can provide a comfortable and relaxing space by minimizing noise. It is advisable for therapeutic gardens to be equipped with a medicinal herb garden, meditation garden, and sense garden. Experiential and learning gardens should be designed in such a manner that they can provide users with a space in which they can enjoy nature and leisure activities. It is advisable for experiential and learning gardens to be equipped with a tea garden, vegetable garden, and camping garden. Healing programs should be designed in such a manner that users can feel relaxed by providing a healing environment, making the most of the natural environment. Further research on evaluating whether the findings of this study are effective in healing in a qualitative and quantitative manner is needed.

• The Korean Journal of Zoology
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• v.37 no.3
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• pp.377-384
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• 1994

The present study examines the inhibitow effect of progesterone (P) on luteinizing hormone $(LH)\beta$ subunit gene expression in anterior pituitary of ovariectomized, estradiol-treated adult rats. A single injection of P (1mg) further decreased the estradiol-Induced decrease in $LH\beta$ mRNA levels in ovariectomTzed rats in a time-dependent manner. p suppressed UIP mRNA levels at lower doses (0.1 and 1mg), but increased $LH\beta$ mRNA levels 81 a high dose (toms). The inhibitor action of P on $Uf\beta$ mRNA was restored when Ru486, a P receptor antagonist, was administered 1h before P treatment. These data clearly indicate that P inhibits gene expression of $LH\beta$ in the rift pituitary in a swersic manner with estrogen.