The Korean Journal of Zoology (한국동물학회지)

The Korean Society for Integrative Biology (한국통합생물학회)
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Progesterone Inhibits Luteinizins Hormone $\beta$ Subunit (LHP) Gene Expression in the Rat Pituitary in a Svnergic Manner

프로제스테론은 흰쥐 뇌하수체에서 LH$\beta$유전 발현을 에스트로젠과 상승작용으로 억제한다.

  • 조병남 (서울대 자연대 분자생물학과 및 세포분화연구센터) ;
  • 성재영 (서울대 자연대 분자생물학과 및 세포분화연구센터)
  • Published : 1994.07.01
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Abstract

The present study examines the inhibitow effect of progesterone (P) on luteinizing hormone $(LH)\beta$ subunit gene expression in anterior pituitary of ovariectomized, estradiol-treated adult rats. A single injection of P (1mg) further decreased the estradiol-Induced decrease in $LH\beta$ mRNA levels in ovariectomTzed rats in a time-dependent manner. p suppressed UIP mRNA levels at lower doses (0.1 and 1mg), but increased $LH\beta$ mRNA levels 81 a high dose (toms). The inhibitor action of P on $Uf\beta$ mRNA was restored when Ru486, a P receptor antagonist, was administered 1h before P treatment. These data clearly indicate that P inhibits gene expression of $LH\beta$ in the rift pituitary in a swersic manner with estrogen.

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