• Biomolecules & Therapeutics
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• v.8 no.4
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• pp.318-324
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• 2000

We have examined inhibitory erects on gasritis using omeprazole-cholestyramine resinate, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. To test the pharmacological action of this, we investigated the effect of omeprazole-cholestyramine resinate on indomethacin-induced gastritis in rats. Omeprazole was used as a reference drug. Orally administered omeprazole-cholestyramine resinate inhibited the indomethacin-induced gastritis in a dose-dependent manner. The inhibitory effect of omeprazole-cholestyramine resinate on the gastritis was similar to that of reference drug. In addition, rectal adminstration of the omeprazole-cholestyramine resinate inhibited the indomethacin-induced gastritis in a dose-dependent manner. The inhibitory effect of omeprazole-cholestyramine resinate was equipotent to reference drug. The basal gastric acid secretion was decreased when it was administered either orally or rectally. This inhibition of omfprazole-cholestyramine resinate was similar to that of omeprazole. These data suggest that omeprazole-cholestyramine resinate inhibit the gastritis in rats, and are comparable to omeprazole available in market.

• Proceedings of the KSEG Conference
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• 2000.04a
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• pp.3-18
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• 2000

Engineering projects often run into "difficult" ground donditions which cause delays, failures, hugely increased costs or even abandonment with consequent disputes and claims. Pertinent questions are "what constitute difficult conditions\ulcorner" and "how might they be foreseen\ulcorner" and these questions provide the focus for this paper. Geological, geotechnical and hydrogeological models for engineering projects(simplified representations of the ground) need to be developed in a systematic manner. Within these models, the potential hazards associated with material (small) and mass (large) scale attributes of the geology, the environmental setting and the influence of the engineering works themselves need to be considered individually and in a progressive, systematic manner. This paper introduces the concept of a Geotechnical Hazard Review with reference to examples from various engineering works.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.7
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• pp.2800-2814
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• 2020

5G network optimization problem is a challenging optimization problem in the practical engineering applications. In this paper, to tackle this issue, Pareto fronts-driven Multi-Objective Cuckoo Search (PMOCS) is proposed based on Cuckoo Search. Firstly, the original global search manner is upgraded to a new form, which is aimed to strengthening the convergence. Then, the original local search manner is modified to highlight the diversity. To test the overall performance of PMOCS, PMOCS is test on three test suits against several classical comparison methods. Experimental results demonstrate that PMOCS exhibits outstanding performance. Further experiments on the 5G network optimization problem indicates that PMOCS is promising compared with other methods.

• Food Science and Biotechnology
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• v.18 no.2
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• pp.552-555
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• 2009

This study investigated the proapoptotic effect of ethanol extracts obtained from dandelion (Taraxacum officinale) flower on human ovarian cancer SK-OV-3 cells. Cells were treated with dandelion flowers ethanol extract (DFE) ranging from 1.5625 to $100{\mu}g/mL$ for 24 hr. Significant antiproliferative effects of DFE were first observed from at $6.25{\mu}g/mL$ (p<0.05), and this inhibition showed in a dose-dependent manner. When cells were treated with more than $6.25{\mu}g/mL$ DFE, cell-cycle analysis showed that DFE caused an increase in the percentage of sub-G0/G1 cells and arrested at the S and G2/M phase in a dose-dependent manner. Moreover, apoptosis induction by DFE involved p53 activation and bax upregulation as well as downregulation of bcl-2. Our findings indicate that DFE resulted in apoptotic cell death, suggesting that DFE possesses potential anticancer properties.

• Journal of the Korean Home Economics Association
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• v.45 no.9
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• pp.1-13
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• 2007

By targeting 113 gifted underachievers and 128 gifted achievers from 17 elementary schools, this study examines the home variables that affect gifted children's underachievement. In an effort to determine home variables of gifted achievers and underachievers, their homes' socio-economic status was analyzed and their parental child-rearing behavior was examined. First, the home environments of the gifted achievers and underachievers were compared, with the finding that their homes' socio-economic status, parental child-rearing behavior and other home factors differed. Parents of gifted achievers raised their children in a rational and democratic manner, while those of gifted underachievers tended to raise their children in an irrational and authoritarian manner. Second, discrimination analysis was conducted using home variables that showed a statistically significant difference, indicating that their homes' socio-economic status showed a low discrimination compared with their parental child-rearing behavior. Likewise, among the family factors, active involvement had the greatest effect on the underachievement of gifted children.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.4
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• pp.35-41
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• 2014

Real-life time series characteristic data has significant amount of non-stationary components, especially periodic components in nature. Extracting such components has required many ad-hoc techniques with external parameters set by users in a case-by-case manner. In this study, we used Empirical Mode Decomposition Method from Hilbert-Huang Transform to extract them in a systematic manner with least number of ad-hoc parameters set by users. After the periodic components are removed, the remaining time-series data can be analyzed with traditional methods such as ARIMA model. Then we suggest a different way of setting control chart limits for characteristic data with periodic components in addition to ARIMA components.

• YAKHAK HOEJI
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• v.39 no.3
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• pp.337-345
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• 1995

The effects of ginkgolides(natural mixture of ginkgolides, ginkgolide B, ginkgolide C) and flavonoids(quercetin, kaempferol, myricetin), extracted from Ginkgo biloba, on ADP and PAF-induced platelet aggregation in vitro and ex vivo were investigated. In these experiments, both of ginkgolides and ginkgoflavonoids did not affect the ADP(5 $\mu{M}$) induced platelet aggregation in vitro. The IC$_{50}$ value on PAF (0.3 $\mu{M}$) induced platelet aggregation were 2.52 $\mu{M}$ (ginkgolide B) and 6.35 $\mu{M}$ (natural mixture of ginkgolides) and 2.80 $\mu{M}$ (mixture of ginkgolide B and quercetin). Oral administration of ginkgolide B (1 and 3 mg/kg) and quercetin (3 and 9 mg/kg) to rabbits inhibited ex vivo PAF induced platelet aggregation in a dose-dependent manner. Ginkomin-F tablets administered to the diabetic patients showed inhibitory activities on the ADP and PAF induced platelet aggregation in a dose and time dependent manner.

• Proceedings of the KSR Conference
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• 2002.10b
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• pp.1059-1064
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• 2002

The behavior of an opening and the performance of support system depend upon the load-deformation characteristics of ground and support as well as of the manner and of timing of support installation. The load-deformation characteristics of ground and support are derived by the interaction between ground and support. The interaction between ground and support is qualitatively illustrated by a ground response curve. The behavior of an opening and the performance of support system depend upon the load-deformation characteristics of ground and support as well as of the manner and of timing of support installation. The interaction between ground and support is qualitatively illustrated by a ground response curve. The convergence-confinement method don't need the basic assumptions for a mathematical model. Also This is applicable to general tunnel. Consequently the stability of tunnel must be qualitatively investigated by a ground response curve and quantitatively adjudged by a numerical analysis for the reasonable design of tunnel.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.10
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• pp.80-89
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• 1996

This paper proposes a new COA (center of area) defuzzifier that is working in the accurate and fast manner. The proposed COA defuzzifier involves both membership values and the spans of membership functions in clauclating a crisp value. In additon, it avoid division by replacing the COA calculation with the searching of the momentum equilibrium point. The moment equilibrium point is searched in the coarse-to-fine manner such that the moment computing points during the coarse searching are moved in the interval of fuzzy terms until they are reached at two adjacent fuzzy terms searching method accerlates the finding of the moment equilibrium point by O(M) mazimally when compared iwth the equal interval searching method of ruitz. In order to verify the accuracy of the proposed COA defuzzifier, the crisp values obtained form the proposed coarse-to-fine searching are compared with the precise crisp values from the arithmetic calculation. Application to the truck backer-upper control problem of the proposed COA defuzzifier is presented. The control performance is compared with that of the conventional COA defuzzifier in tems of the average tracing distance.

• YAKHAK HOEJI
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• v.55 no.4
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• pp.295-300
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• 2011

We investigated the effects of butanol fraction of Asterias amurensis (BFA) on the anti-allergic activity. BFA inhibited both cyclooxygenase-2 dependent prostaglandin $D_2$ and 5-lipoxygenase dependent leukotriene $C_4$ generation in a concentration-dependent manner with $IC_{50}$ values of 174.6 and 22.2 ${\mu}g$/ml, respectively. In addition, BFA also inhibited the degranulation in a dose dependent manner. Furthermore, oral administration of BFA inhibited IgE-mediated passive cutaneous anaphylaxis in mice. These results suggested that BFA may be useful in regulating mast cell-mediated allergic diseases.