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Anti-allergic Activity of Butanol Fraction of Asterias amurensis  

Yang, Ju-Hye (College of Pharmacy, Yeungnam University)
Na, Min-Kyun (College of Pharmacy, Yeungnam University)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
Publication Information
YAKHAK HOEJI / v.55, no.4, 2011 , pp. 295-300 More about this Journal
Abstract
We investigated the effects of butanol fraction of Asterias amurensis (BFA) on the anti-allergic activity. BFA inhibited both cyclooxygenase-2 dependent prostaglandin $D_2$ and 5-lipoxygenase dependent leukotriene $C_4$ generation in a concentration-dependent manner with $IC_{50}$ values of 174.6 and 22.2 ${\mu}g$/ml, respectively. In addition, BFA also inhibited the degranulation in a dose dependent manner. Furthermore, oral administration of BFA inhibited IgE-mediated passive cutaneous anaphylaxis in mice. These results suggested that BFA may be useful in regulating mast cell-mediated allergic diseases.
Keywords
Asterias amurensis; mouse bone marrow-derived mast cells; cyclooxygenase-2; 5-lipoxygenase; anti-allergic effect;
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