• Journal of IKEEE
• /
• v.13 no.4
• /
• pp.70-74
• /
• 2009

In this paper, We propose the visible light communication(VLC) link based on white light emitting diode (LED) and Photo detector(PD). The proposed architecture is demonstrated experimentally and its performance is verified through the experimental results of quality-factor(Q-factor) and eye pattern of 10Mb/s PRBS signal. The ambient light effect from a typical type fluorescent lamp source was also analyzed. when the distance between the LED and the PD is about 1m, error free wireless transmission of the LED was achieved up to 10Mb/s data rate. Under the condition with ambient light, low BER, data transmission of the VLC link is achieved up to 5Mb/s data rate at 1m. Also, when the PD is placed away from the center, low BER data transmission of the VLC link is achieved up to 1Mb/s at 10cm and 10Mb/s at 5cm.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.16
• /
• pp.6997-7002
• /
• 2015

Background: In cervical cancer patients it has been reported that there in a significant Ki-67/MIB-1 expression is correlated with survival in cervical cancer patients. However, the prognostic value is still not well understood. Materials and Methods: In the present meta-analysis the prognostic value of Ki-67/MIB-1 with regard to overall survival (OS) and disease-free survival (DFS) in cervical cancer was investigated. The databases of PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, EMBASE, Science Direct and Wiley Online Library were used to identify appropriate literature. Results: In order to explore the relationship between Ki-67/MIB-1 and cervical cancer, we have included 13 studies covering 894 patients in the current meta-analysis. The effect of Ki-67/MIB-1 on OS for pooled random effects HR estimate was 1.63 (95%confidence interval (CI) 1.09-2.45; P<0.05). The pooled HR for DFS was 1.26 (95%CI 0.58-2.73; P>0.05) and the subgroup analysis indicated Ki-67/MIB1 was associated with DFS (HR=3.67, 95%CI 2.65-5.09) in Asians. Conclusions: According to this meta-analysis, Ki-67/MIB-1 has prognostic value for OS in patients suffering from cervical cancer. For better evaluation of the prognostic role of Ki-67/MIB-1 on DFS, studies with larger numbers of patients are needed to validate present findings in the future.

• Journal of Advanced Navigation Technology
• /
• v.8 no.1
• /
• pp.73-80
• /
• 2004

In the case of Non-Line-of-Sight (NLOS), common telecommunication systems typically have Rayleigh distributed amplitude characteristics. However measurement result of Ultra Wideband (UWB) Multi-Band Orthogonal Frequency Division Multiplexing (MB-OFDM) system which is proposed as one of candidate standard in IEEE 802. 15. 3a for Wireless Personal Area Network (WPAN) shows that it has independent log normal fading in each cluster as well as in each ray within the cluster. Based on this clustering phenomenon observed, MB-OFDM channel model derived from Saleh-Valenzuela model with a couple of slight modifications. In this paper, channel remodeling for RF frequency hopping in MB-OFDM system is achieved, and performances of MB-OFDM system for each channel mode and data rate are verified using modified channel model.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.19 no.9
• /
• pp.1000-1009
• /
• 2008

The purpose of this paper is to analyze the performance of MB-OFDM UWB system when the interference signal that can be WIMAX signal or 4 G system signal is received by detection limit of -80 dBm/MHz proposed in Korea for DAA(Detect And Avoid) to permit UWB in $3.1{\sim}4.8$ GHz. MB-OFDM UWB system supports two transmission modes; one is TFI(Time frequency Interleaving) mode that transmits OFDM symbols using different carrier frequency from symbol to symbol according to Time Frequency(TF) codes, the other is FFI(Fixed Frequency Interleaving) mode that transmits OFDM symbols using a specific carrier frequency. In this paper, we considered the TX average power and the synchronization structure to reflect the effect of frequency hopping according to TFC. Interference analysis results show that the WiMAX system is fenced thoroughly from UWB interference in domestic DAA regulation, but the performance of MB-OFDM UWB system is degraded seriously by an interference signal with the DAA detection limit even in frequency Hopping mode that can get frequency diversity effect.

• Journal of Acupuncture Research
• /
• v.26 no.3
• /
• pp.27-38
• /
• 2009

목적 : 이 연구는 Vipera lebetinat turanica의 사독약침액(蛇毒藥鍼液)(Snake venom toxin, SVT)이 인간 유방암 세포주인 MCF-7과 MDA-MB-231 세포에서 암세포성장의 억제 및 그 기전에 대하여 살펴보고자 하였다. 방법 : SVT를 처리한 후 MCF-7과 MDA-MB-231의 성장억제를 관찰하기 위해 CCK-8 assay를 시행하였고, apoptosis 평가에는 TUNEL assay를 시행하였다. 세포자멸사 관련 세포기전을 보기 위하여 세포내 활성산소량 및 미토콘드리아의 세포막전위 변화를 측정하였고, 세포자멸사 조절 단백인 Bax, Bcl-2 발현 변화 관찰에는 westem blot analysis를 시행하였다. 결과 : MCF-7과 MDA-MB-231 세포에 SVT를 처리한 후, 유방암 세포의 성장, Apoptosis의 유발 및 기전에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. MCF-7 세포와 MDA-MB-231 세포에서 SVT를 처리한 후 유방암 세포 성장이 억제되었다. 2. TUNEL assay를 통한 세포자멸사 평가에서 SVT를 처리한 MCF-7세포와 MDA-MB-231 세포 모두 세포자멸사 활성세포의 유의한 증가를 나타내었다. 3. 세포자멸사 관련 세포기전연구에서 SVT를 처리한 MCF-7 세포와 MDA-MB-231 세포에서 세포내 활성산소의 유의한 증가와 미토콘드리아 세포막 전위의 유의한 변동이 관찰되었다. 4. SVT를 처리한 MCF-7세포와 MDA-MB-231세포는 세포자멸사 관련 단백 발현에서 Bax의 유의한 증가와 Bcl-2의 유의한 감소를 나타내었다. 결론 : 이상의 결과는 SVT가 세포내 활성산소를 증가시킴으로써 미토콘드리아의 세포막전위에 변화를 일으켜 유방암 세포주인 MCF-7과 MDA-MB-231 세포에 세포자멸사를 유발하여 증식억제 효과가 있음을 입증한 것이다.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.35 no.6
• /
• pp.671-676
• /
• 2006

We investigated the effect of gingerol (Zingiber officinale Roscoe, Zingiberaceae) on Bcl-2 and Bax expression in MDA-MB-231 human breast cell lines. The oleoresin from rhizomes of ginger contains [6]-gingerol (1-[4'-hydroxy-3'-methoxyphenyl]-5-hydroxy-3-decanone). We previously reported that [6]-gingerol inhibits cell proliferation in MDA-MB-231 human breast cancer cell lines. In this study, we examined protein and mRNA expression associated with cell apoptosis in MDA-MB-231 human breast cancer cell lines. We cultured MDA-MB-231 cells in presence of various concentrations 0, 2.5, 5 and $10\;{\mu}M$ of [6]-gingerol. Bcl-2 protein and its mRNA levels were decreased dose-dependently in cells treated with [6]-gingerol, but Bax protein and its mRNA levels were unchanged by [6]-gingerol treatment. Bcl-2/Bax ratio was decreased in a dose dependent manner treated with [6]-gingerol. Caspase-3 activity was significantly increased dose-dependently in cell treated with [6]-gingerol (p<0.05). In conclusion, we have shown that [6]-gingerol induces apoptosis in MDA-MB-231 human breast cancer cell lines.

• Biomolecules & Therapeutics
• /
• v.23 no.5
• /
• pp.449-457
• /
• 2015

The present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and mice, respectively. Male ICR mice were orally administered MB12662 (5, 10, 25 or 50 mg/kg) for 10 days, during which intraperitoneally challenged with cisplatin (3.5 mg/kg) from day 4 to 7, and sacrificed on day 10 for the pathological examination. Male ferrets were orally administered MB12662 (25, 50 or 100 mg/kg) for 7 days, subcutaneously challenged with cisplatin (5 mg/kg), and monitored for vomiting reflexes and survival of the animals. Four-day injection of cisplatin (3.5 mg/kg) to mice caused body weight loss and degeneration and atrophy of intestinal villi, reducing villi/crypt ratio to a half level of control animals. Cisplatin also induced renal and hepatic toxicities, and depletion of splenocytes and bone marrow progenitor cells. The systemic toxicities including decreased villi/crypt ratio, immune system atrophy, splenocyte depletion, and decreased cellularity in bone marrow were improved by MB12662. Cisplatin (5 mg/kg) induced retching and emetic responses of ferrets, which were remarkably attenuated by MB12662 in a dose-dependent manner. All the ferrets pretreated with MB12662 survived the challenge of cisplatin, in comparison with 40% mortality in vehicle-treated animals, and blood parameters of nephrotoxicity and hepatotoxicity were markedly recovered. It is expected that MB12662 could be a candidate for the body protection against burden, including emesis, of chemotherapeutic agents.

• Journal of Software Assessment and Valuation
• /
• v.15 no.1
• /
• pp.37-42
• /
• 2019

Many similarity analysis methods, one of the dispute resolution methods for computer programs, have been studied. This paper is about quantitative similarity analysis of MIB (Management Information Base) file. Quantitative similarity means that the source codes of two computers are analyzed and the results are compared with a certain standard. The source code to analyze is a program that provides network device management functions such as configuration management, fault management, and performance management using SNMP protocol for WiMAX CPE devices. Here, WiMAX refers to the IEEE 802.16 wireless network standard protocol and can be classified into fixed WiMAX and mobile WiMAX. WiMAX CPE is a wireless Internet terminal that is fixedly used in a customer's home or office. In this paper, we analyze the similarity between MIB file of company A and company B. We will analyze whether the MIB file leaked from the damaged company is not just a list to describe the product specifications, but whether the property value can be recognized.

• Journal of Microbiology and Biotechnology
• /
• v.17 no.1
• /
• pp.130-137
• /
• 2007

A disease resistance related gene, MbR7, was identified in the wild apple species, Malus baccata. The MbR7 gene has a single open reading frame (ORF) of 3,288 nucleotides potentially encoding a 1,095-amino acid protein. Its deduced amino acid sequence resembles the N protein of tobacco and the NL27 gene of potato and has several motifs characteristic of a TIR-NBS-LRR R gene subclass. Ectopic expression of MbR7 in Arabidopsis enhanced the resistance against a virulent pathogen, Pseudomonas syringae pv. tomato DC3000. Microarray analysis confirmed the induction of defense-related gene expression in 35S::MbR7 heterologous Arabidopsis plants, indicating that the MbR7 gene likely activates a downstream resistance pathway without interaction with pathogens. Our results suggest that MbR7 can be a potential target gene in developing a new disease-resistant apple variety.

• Nutrition Research and Practice
• /
• v.5 no.5
• /
• pp.375-380
• /
• 2011

This study investigated the effects of inorganic sulfur on metastasis in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured in the absence or presence of various concentrations (12.5, 25, or 50 ${\mu}mol$/L) of inorganic sulfur. Cell motility, invasion, and the activity and mRNA expression of matrix metalloproteases (MMPs) were examined. Numbers of viable MDA-MB-231 cells did not differ by inorganic sulfur treatment from 0 to 50 ${\mu}mol$/L within 48 h. Inorganic sulfur significantly decreased cell motility and invasion in the MDA-MB-231 cells in a dose-dependent manner (P<0.05), as determined using a Boyden chamber assay and a Matrigel chamber. The activities of MMP-2 and MMP-9 were significantly reduced by inorganic sulfur in a dose-dependent manner (P<0.05). The inorganic sulfur also significantly inhibited MMP-2 and MMP-9 expression in the cells (P<0.05). These data suggest that inorganic sulfur can suppress cancer cell motility and invasion by inhibiting MMP-2 and MMP-9 activity and gene expression in MDA-MB-231 cells.