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http://dx.doi.org/10.4162/nrp.2011.5.5.375

Inorganic sulfur reduces the motility and invasion of MDA-MB-231 human breast cancer cells  

Kim, Jin-Joo (Department of Food Science and Nutrition, Dankook University)
Ha, Hwa-Ae (Department of Food Science and Nutrition, Dankook University)
Kim, Hee-Sun (Department of Food and Nutrition, Beawha Women's University)
Kim, Woo-Kyoung (Department of Food Science and Nutrition, Dankook University)
Publication Information
Nutrition Research and Practice / v.5, no.5, 2011 , pp. 375-380 More about this Journal
Abstract
This study investigated the effects of inorganic sulfur on metastasis in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured in the absence or presence of various concentrations (12.5, 25, or 50 ${\mu}mol$/L) of inorganic sulfur. Cell motility, invasion, and the activity and mRNA expression of matrix metalloproteases (MMPs) were examined. Numbers of viable MDA-MB-231 cells did not differ by inorganic sulfur treatment from 0 to 50 ${\mu}mol$/L within 48 h. Inorganic sulfur significantly decreased cell motility and invasion in the MDA-MB-231 cells in a dose-dependent manner (P<0.05), as determined using a Boyden chamber assay and a Matrigel chamber. The activities of MMP-2 and MMP-9 were significantly reduced by inorganic sulfur in a dose-dependent manner (P<0.05). The inorganic sulfur also significantly inhibited MMP-2 and MMP-9 expression in the cells (P<0.05). These data suggest that inorganic sulfur can suppress cancer cell motility and invasion by inhibiting MMP-2 and MMP-9 activity and gene expression in MDA-MB-231 cells.
Keywords
Inorganic sulfur; invasion; motility; matrix metalloprotease; MDA-MB-231 cells;
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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