• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.403-406
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• 1996

Since most human activities in a nuclear power plant are perfirmed in the main control room (MCR), it is important to have its design well human-engineered, both physically and cognitively. Much research efforts have been given for better, operator-centered designs of human-machine interface in MCR capitalizing today's advanced information technology. Korea is among those who are actively expending such research for the next-generation nuclear plants. This paper analyzes two forerunners among the emerging MCR designs, namely Nuplex 80+ and N4, from the perspective of cognitive systems engineering. Since the two show some fundamental differences in their design concepts, the principles with their pros and cons must be enumerated to benefit our own design of new control rooms. This paper also lists many other decision-making points that emerged due to the new availability of cognitively based on cognitive engineering principles. The future scope and directions of related research are suggested.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2012.04a
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• pp.420-423
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• 2012

원자력 발전소는 화재 발생 시 대규모 피해를 야기하는 특수한 시설물로서 일반 건축물에 비하여 매우 엄격한 화재 안전 기준을 적용하고 있으며 일반 건축물과 차별화된 화재안전 설계 조건을 요구한다. 본 연구에서는 원자력 발전소의 화재안전성을 평가하기 위한 기초연구로써 원자력 발전소 내 주 제어실(이하 MCR)에 대해 화재시나리오 및 환기조건에 따른 화재해석모델의 계산결과를 비교분석하여 각 해석모델의 특성을 파악하고자 한다. MCR 내 화재안전성을 평가하기 위해 Field Model인 FDS 와 Zone Model인 CFAST를 이용하였으며 NUREG/RC-6850, NUREG/RC-1894에 기초하여 화재시뮬레이션을 수행하였다. 해석결과로써 연기농도, 가시거리, 연층높이 등의 데이터를 분석하여 MCR내의 거주가능 시간을 평가하였으며 이를 통해 원자력 시설물의 안전성 확보를 위한 정량적인 자료를 제공하고자 한다.

• Investigative Magnetic Resonance Imaging
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• v.25 no.2
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• pp.76-80
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• 2021

Post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) is a major factor that contributes to the increased socioeconomic burden caused by TBI. Myelin loss has been implicated in the development of PCS following mTBI. Diffusion tensor imaging (DTI), a traditional imaging modality for the evaluation of axonal and myelin integrity in mTBI, has intrinsic limitations, including its lack of specificity and its time-consuming and labor-intensive post-processing analysis. More recently, various fast MR techniques based on multicomponent relaxometry (MCR), including QRAPMASTER, mcDESPOT, and MDME sequences, have been developed. These MCR-based sequences can provide myelin water fraction/myelin volume fraction, a quantitative parameter more specific to myelin, which might serve as a surrogate marker of myelin volume, in a clinically feasible time. In this review, we summarize the clinical application of the MCR-based fast MR techniques in mTBI patients.

• Communications for Statistical Applications and Methods
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• v.26 no.1
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• pp.35-46
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• 2019

Multivariate Confidence Region (MCR) cannot be used to obtain the confidence region of the mean vector of multivariate data when the normality assumption is not satisfied; however, the Quantile Confidence Region (QCR) could be used with a Multivariate Quantile Vector in these cases. The coverage rate of the QCR is better than MCR; however, it has a disadvantage because the QCR has a wide shape when the probability density function follows a bimodal form. In this study, we propose a Quantile Confidence Region using the Highest density (QCRHD) method with the Highest Density Region (HDR). The coverage rate of QCRHD was superior to MCR, but is found to be similar to QCR. The QCRHD is constructed as one region similar to QCR when the distance of the mean vector is close. When the distance of the mean vector is far, the QCR has one wide region, but the QCRHD has two smaller regions. Based on these features, it is found that the QCRHD can overcome the disadvantages of the QCR, which may have a wide shape.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.529-541
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• 2003

Yukmijihwang-tang has been widely used as an and-aging herbal medicine for hundred years in Asian countries. Numerous studies show that Yukmijihwangtang has anti-oxidative effect both in vivo and in vitro. It has been reported that Moutan Cortex Radicis extract (MCR) was the most effective herb in Yukmijihwang-tang on undifferentiated PC12 cells upon oxidative-stressed with hydrogen peroxide. The purpose of this study is to; 1) evaluate the recovery of neuronal damage by assessing the anti-oxidant effect of MCR on PC12 cells differentiated with nerve growth factor (NGF), 2) identify candidate genes responsible for anti-oxidative effect on differentiated PC12 cells by oligonucleotide chip microarray. PC12 cells, which were differentiated by treating with NGF, were treated without or with hydrogen peroxide in the presence or absence of various concentration of MCR. Cell survival was determined by using MTS assay. Measurement of intracellular reactive oxygen species (ROS) generation was determined using the H2DCFDA assay The viability of cells treated with MCR was significantly recovered from stressed PC12 cell. In addition, wide rage of concentrations of MCR shows dose-dependent inhibitory effect on ROS production in oxidative-stressed cells. Total RNAs of cells without treatment(Control group), only treated with H₂O₂ (stressed group) and treated with both H₂O₂ and of MCR (MCR group) were isolated, and cDNAs was synthesized using oligoT7(dT) primer. The fragmented cRNAs, synthesized from cDNAs, were applied to Affymetrix GeneChip Rat Neurobiology U34 Array. mRNA of Calcium/calmodulin-dependent protein kinase II delta subunit(CaMKII), neuron glucose transporter (GLUT3) and myelin/oligodendrocyte glycoprotein(MOG) were downregulated in Stressed group comparing to Control group. P2X2-5 receptor (P2X2R-5), P2X2-4 receptor (P2X2R-4), c-fos, 25 kDa synaptosomal attachment protein(SNAP-25a) and GLUT3 were downregulated, whereas A2 adenosine receptor (A2AR), cathechol-O-methyltransferase(COMT), glucose transporter 1 (GLUT1), EST223333, heme oxygenase (HO), VGF, UI-R-CO-ja-a-07-0-Ul.s1 and macrophage migration inhibitory factor (MIF) were upregulated in MCA group comparing to Control group. Expression of Putative potassium channel subunit protein (ACK4), P2X2A-5, P2X2A-4, Interferon-gamma inducing factor isoform alpha precursor (IL-18α), EST199031, P2XR, P2X2 purinoceptor isoform e (P2X2R-e), Precursor interleukin 18 (IL-18) were downregulated, whereas MOO, EST223333, GLUT-1, MIF, Neuronatin alpha, UI-R-C0-ja-a-07-0-Ul.s1, A2. adenosine receptor, COMT, neuron-specific enolase (NSE), HO, VGF, A rat novel protein which is expressed with nerve injury (E12625) were upregulated in MCR group comparing to Stressed group. The results suggest that decreased viability and AOS production of PC12 cell by H₂O₂ may be, at lease, mediated by impaired glucose transporter expression. It is implicated that the MCR treatment protect PC12 cell from oxidative stress via following mechanisms; improving glucose transport into the cell, enhancing expression of anti-oxidative genes and protecting from dopamine cytotoxicity by increment of COMT and MIF expression. The list of differentially expressed genes may implicate further insight on the action and mechanism behind the anti-oxidative effects of herbal extract Moutan Cortex Radicis.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.4
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• pp.145-152
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• 2009

Domestic Kori-1 MCR was partially modified in 2007 and will be renovated entirely in 2013. Digital devices partially replacing original analog devices have been introduced and standard alone computer systems such as SPDS have been integrated into the plant computer. Upgrading KSNP's MCR based on the ditalization is planned for 2015. However, the site engineers and operators are reluctant to the advanced systems. Therefore, a prototype for the KSNP's advanced MCR has been developed to increase the acceptance level of the operators and field engineers and also, to evaluate user interfaces and I&C architecture. For enhancing support of the operators' work, a P&ID based display system composed of multi-layers, which are linked through a context sensitive menu each other, has been adopted. The $1^{st}$ layer displays a simplified P&ID, the $2^{nd}$ layer control related diagrams such as controllers and logic diagrams, the $3^{rd}$ layer trends, etc. The end point view of MCR for KSNP is also suggested considering reliability and operability of the digital systems. Additionally, modernization strategies over the overhaul periods, that do not have much impact on operation and configuration efforts are suggested.

• Korean Journal of Microbiology
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• v.52 no.2
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• pp.157-165
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• 2016

Under flooded rice fields, methanogens produce methane which comes out through rice stalks, thus rice fields are known as one of the anthropogenic sources of atmospheric methane. Studies have shown that use of manure increases amount of methane emission from rice. To investigate mechanisms by which manure boosts methane emission, comparative soil metagenomics between inorganically (NPK) and pig manure fertilized paddy soils (PIG) were conducted. Results from taxonomy analysis showed that more abundant methanogens, methanotrophs, methylotrophs, and acetogens were found in PIG than in NPK. In addition, BLAST results indicated more abundant carbohydrate mabolisetm functional genes in PIG. Among the methane metabolism related genes, PIG sample showed higher abundance of methyl-coenzyme M reductase (mcrB/mcrD/mcrG) and trimethylamine-corrinoid protein Co-methyltransferase (mttB) genes. In contrast, genes that down regulate methane emission, such as trimethylamine monooxygenase (tmm) and phosphoserine/homoserine phosphotransferase (thrH), were observed more in NPK sample. In addition, more methanotrophic genes (pmoB/amoB/mxaJ), were found more abundant in PIG sample. Identifying key genes related to methane emission and methane oxidation may provide fundamental information regarding to mechanisms by which use of manure boosts methane emission from rice. The study presented here characterized molecular variation in rice paddy, introduced by the use of pig manure.

• The KIPS Transactions:PartC
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• v.13C no.7 s.110
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• pp.889-896
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• 2006

ATM Forum has defined a guaranteed frame rate (GFR) service to serve Internet traffic efficiently. The GFR service provides virtual connections (VCs) for minimum cell rate (MCR) guarantees and allows them to fairly share the residual bandwidth. And ATM Forum has recommended a frame-based generic cell rate algorithm (F-GCRA) as a frame classifier, which determines whether an Am cell is eligible to use the guaranteed bandwidth in a frame level. An ATM switch accommodates cells in its buffer or drops them in a frame level according to current buffer occupancy. A FIFO shared buffer has so simple structure as to be feasibly implemented in switches, but has not been able to provide an MCR guarantee for each VC without buffer management based on per-VC accounting. In this paper, we enhance the F-GCRA frame classifier to guarantee an MCR of each VC without buffer management based on per-VC accounting. The enhanced frame classifier considers burstness of TCP traffic caused by congestion control algorithm so as to enable each VC to use its reserved bandwidth sufficiently. In addition, it is able to alleviate the unfairness problem in usage of the residual bandwidth. Simulation results show that the enhanced frame classifier satisfies quality of services (QoSs) of the GFR service for the TCP traffic.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.1925-1932
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• 2000

Damage detection methods using vibration modes are investigated on ring structures and. modal behavior of the slightly asymmetric rings is examined. Mode shapes changes, MSER(modal strain energy ratio) and MCR(modal curvature ratio) are applied to identify the locations of faults or damages. Parameters are calculated and compared by finite element analysis on rings with designed local damages. Damages are modeled as reduced stiffness in the analysis. The results show MSER and MCR can be proper factors to detect local damages in ring structures.

• The Transactions of the Korea Information Processing Society
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• v.7 no.9
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• pp.3011-3018
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• 2000

On ATM networks, ABR services are provided using the remained bandwidth after allocating CBR and VBR traffic. Realtime services such as transmitting audio or video data may be provided using CBR and VBR which have a constrained transmission delay, but in these cases, the communications bandwidth may be wasted. This paper proposes an efficient bandwidth allocation algorithm to transfer real-time data using ABR service. The proposed algorithm guarantees MCR and allocates bandwidth to each connection proportional to its MCR. The proposed algorithm divides the connections in two groups - a satisfied state group and a bottlenecked state group - and enhances bandwidth utilization by allowing the remained bandwidth after allocating the connections in the satisfied state to be allocated to the connections in the bottlenecked state. Our algorithm uses a Queue control function proposed by Ghani[5] to keep the Queue length within some boundary, which makes the transmission delay constant. We simulate and compare the performance of the proposed algorithm with that of the algorithms proposed by ATM Forum[1] and Kalampoukas[2].