• Title/Summary/Keyword: M/M/1 model

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The Effect of Treadmill Exercise on Ischemic Neuronal Injury in the Stroke Animal Model: Potentiation of Cerebral Vascular Integrity (중풍 동물 모델에서의 트레드밀 운동이 허혈성 신경손상에 미치는 효과: 뇌혈관 통합성 강화)

  • Kang, Kyoung-Ah;Seong, Ho-Hyun;Jin, Han-Byeol;Park, Jong-Min;Lee, Jong-Min;Jeon, Jae-Yong;Kim, Youn-Jung
    • Journal of Korean Academy of Nursing
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    • v.41 no.2
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    • pp.197-203
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    • 2011
  • Purpose: This study was done to identify whether pre-conditioning exercise has neuroprotective effects against cerebral ischemia, through enhance brain microvascular integrity. Methods: Adult male Sprague-Dawley rats were randomly divided into four groups: 1) Normal (n=10); 2) Exercise (n=10); 3) Middle cerebral artery occlusion (MCAo), n=10); 4) Exercise+MCAo (n= 10). Both exercise groups ran on a treadmill at a speed of 15 m/min, 30 min/day for 4 weeks, then, MCAo was performed for 90 min. Brain infarction was measured by Nissl staining. Examination of the remaining neuronal cell after MCAo, and microvascular protein expression on the motor cortex, showed the expression of Neuronal Nuclei (NeuN), Vascular endothelial growth factor (VEGF) & laminin. Results: After 48 hr of MCAo, the infarct volume was significantly reduced in the Ex+MCAo group ($15.6{\pm}2.7%$) compared to the MCAo group ($44.9{\pm}3.8%$) (p<.05), and many neuronal cells were detected in the Ex+ MCAo group ($70.8{\pm}3.9%$) compared to the MCAo group ($43.4{\pm}5.1%$) (p<.05). The immunoreactivity of laminin, as a marker of microvessels and Vascular endothelial growth factor (VEGF) were intensively increased in the Ex+MCAo group compared to the MCAo group. Conclusion: These findings suggest that the neuroprotective effects of exercise pre-conditioning reduce ischemic brain injury through strengthening the microvascular integrity after cerebral ischemia.

A Study on Reliability and Training of Face-Bow Transfer Procedure (안궁의 신뢰성과 학습효과에 관한 연구)

  • So, Woong-Seup;Choi, Dae-Kyun;Kwon, Kung-Rock;Lee, Seok-Hyung
    • Journal of Dental Rehabilitation and Applied Science
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    • v.19 no.4
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    • pp.297-308
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    • 2003
  • Face-bow is used to transfer models to the articulator in diagnosing the patient or treating problems associated with occlusion. However, there have been few reports on the reliability of the face-bow procedure and the relationship between the experience of the operator and the reliability of the face-bow procedure. The purposes of this study are to examine the reliability of the face-bow procedure and to evaluate whether the face-bow transferring has any training effect. Nine dentists working at M hospital conducted a face-bow transfer in one patient having a normal dentition and interdental relationship. The procedure was done two times a week for four weeks. The maxillary model was mounted to the articulator every time, then the landmarks on the maxillary right first molar, the maxillary left central incisor, and the maxillary left first molar were measured with a special three-dimensional instrument. These data were input into a computer, and evaluated statistically. The results were as follows ; 1. When examined with ANOVA test, the results were p=0.2040 in maxillary right first molar, p=0.0578 in maxillary left incisor, and p=0.1433 in maxillary left first molar. There was no significant(0< $p{\leq}0.05$). 2. Training 1) The correlation coefficient between trial and rejection was -0.578 when analyzed with T-distribution. The more we tried, the less errors we found. 2) When the S.D. of the first three trials was compared to the S.D. of the last three trials in face-bow transfer, the results showed that the former was larger than the latter in thirty-nine times, and the latter was larger than the former in fifteen times. The more we tried face-bow transfer, the less errors we found. 3. When the S.D. of x, y, z coordinates were examined, the S.D. of x coordinates had the largest measurement in five times, the S.D. of y coordinates had the largest measurement in four times, and the S.D. of z coordinates had the largest measurement in nine times. The possibility which the error can occur in z coordinate was the highest.

The Impact of Feeding Diets of High or Low Energy Concentration on Carcass Measurements and the Weight of Primal and Subprimal Lean Cuts

  • Schinckel, A.P.;Einstein, M.E.;Jungst, S.;Matthews, J.O.;Fields, B.;Booher, C.;Dreadin, T.;Fralick, C.;Tabor, S.;Sosnicki, A.;Wilson, E.;Boyd, R.D.
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.4
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    • pp.531-540
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    • 2012
  • Pigs from four sire lines were allocated to a series of low energy (LE, 3.15 to 3.21 Mcal ME/kg) corn-soybean meal-based diets with 16% wheat midds or high energy diets (HE, 3.41 to 3.45 Mcal ME/kg) with 4.5 to 4.95% choice white grease. All diets contained 6% DDGS. The HE and LE diets of each of the four phases were formulated to have equal lysine:Mcal ME ratios. Barrows (N = 2,178) and gilts (N = 2,274) were fed either high energy (HE) or low energy (LE) diets from 27 kg BW to target BWs of 118, 127, 131.5 and 140.6 kg. Carcass primal and subprimal cut weights were collected. The cut weights and carcass measurements were fitted to allometric functions (Y = A $CW^B$) of carcass weight. The significance of diet, sex or sire line with A and B was evaluated by linearizing the equations by log to log transformation. The effect of diet on A and B did not interact with sex or sire line. Thus, the final model was cut weight = (1+$b_D$(Diet)) A($CW^B$) where Diet = -0.5 for the LE and 0.5 for HE diets and A and B are sire line-sex specific parameters. Diet had no affect on loin, Boston butt, picnic, baby back rib, or sparerib weights (p>0.10, $b_D$ = -0.003, -0.0029, 0.0002, 0.0047, -0.0025, respectively). Diet affected ham weight (bD = -0.0046, p = 0.01), belly weight (bD = 0.0188, p = 0.001) three-muscle ham weight ($b_D$ = -0.014, p = 0.001), boneless loin weight (bD = -0.010, p = 0.001), tenderloin weight ($b_D$ = -0.023, p = 0.001), sirloin weight ($b_D$ = -0.009, p = 0.034), and fat-free lean mass ($b_D$ = -0.0145, p = 0.001). Overall, feeding the LE diets had little impact on primal cut weight except to decrease belly weight. Feeding LE diets increased the weight of lean trimmed cuts by 1 to 2 percent at the same carcass weight.

Preventive Effect of Actinidia Valvata Dunn Extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced Gastrointestinal Cancer in Rats

  • Wang, Xia;Liu, Hao;Wang, Xin;Zeng, Zhi;Xie, Li-Qun;Sun, Zhi-Guang;Wei, Mu-Xin
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6363-6367
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    • 2014
  • Purpose: This study was conducted to assess the preventive effect of Actinidia valvata Dunn (AVD) extract on an animal model of gastrointestinal carcinogenesis on the basis of changes in tumor incidence, cell proliferation, and apoptosis. Materials and Methods: Seventy-five male Wistar rats were divided into five different treatment groups with 15 rats in each group. Group I was given normal feed, whereas Groups II to IV were treated with 10% sodium chloride in the first six weeks and 100ug/mL of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 24 weeks. Group II was then given normal feed, whereas Group III was given AVD extract (0.24g/kg/day) for 12 weeks. Group IV was given AVD extract from the first week to the 36th week, whereas Group V was treated with AVD extract alone for 36 weeks. All rats were sacrificed at the end of the 36-week experiment and assessed for the presence of gastrointestinal tumors. The occurrence of cancer was evaluated by histology. Bax, Bcl-2, Caspase-3, and cyclinD1 were determined by immunohistochemical staining and Western blotting. Results: The incidences of gastric cancer were 0% in Group I, 73.3% in Group II, 33.3% in Group III, 26.7% in Group IV, and 0% in Group V. Bcl-2 and cyclinD1 expression was decreased in AVD extract treated groups, whereas Bax and Caspase-3 expression was increased. Comparison with group II revealed significant differences (p<0.01). Conclusions: AVD extract exhibits an obvious preventive effect on gastrointestinal carcinogenesis induced by MNNG in rats through the regulation of cell proliferation and apoptosis.

Research on the Visual Characteristics of a Representative View of the Skyline; - Referring to Landscape Assessment of Mt. Mudeung from Various Viewpoints - (도시 배후 산 지형 스카이라인 경관의 조망 특성과 경관 대표성 평가 - 시점 위치에 따른 무등산 조망경관 분석을 중심으로 -)

  • Cho, Tong-Buhm
    • Journal of the Korean Institute of Landscape Architecture
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    • v.35 no.6
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    • pp.84-96
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    • 2008
  • This research investigated the landscape characteristics of the skyline and the cognitive characteristics of Mt. Mudeung (1,186m) from various viewpoints. Mt. Mudeung, the representative landscape of Gwangju City, has been recognized as a natural landmark and theme of paintings. By analyzing the perspective from 32 points with a digital terrain model, some landscape indices of the skyline were derived and the relationships are discussed. Assessment of the semantic differential scale with 21 adjective variables and representativeness to 15 landscape photographs of the mountain were accomplished. 1. Through regression analysis of the skyline indices, significant relationships were found between them the angle from the visual axis and number of skyline jumps, the vertical angle fluctuation and number of jumps per degree, the visual depth fluctuation and vertical angle fluctuation of skyline, and between the vertical angle mean and number of jumps per degree. Meaningful relations were found between the number of jumps of skyline to number of jumps per degree and the angle from visual axis to visual distance. However, in the representative assessment no difference was found on the angle from visual axis of viewpoints. On the other hand, it seemed to relate representativeness with visual clarity based on visual distance. 2. We found 4 factors "familiarity", "fluctuation of skylines", "openness", and "feeling of texture" in the results of factor analysis of semantic differential assessment. When considering the results of assessment for representativeness, adjective words for familiarity and openness seemed to have a close assessment. Specifically, the research showed that the landscape representation was highly assessed in a view which could be seen from the higher parts to the lower part of hills. This result indicates that the management of viewpoints which could get a scene from intermediate to distant, and locating a high elevation is important. 3. In the picturesque expression of Mt. Mudeung, various impressions from the different points, a skyline based on the top of Mt. Mudeung and a mono structure by overlapping hills were common characteristics. These common characteristics were also partially found through the analysis of topographical landscape indices and landscape images. Therefore, the viewpoints for the representative landscape management should be selected in natural or open spaces.

The Uncertainty Analysis of SWAT Simulated Streamflow Applied to Chungju Dam Watershed (충주댐 유역의 유출량에 대한 SWAT모형의 예측불확실성 분석)

  • Joh, Hyung-Kyung;Park, Jong-Yoon;Shin, Hyung-Jin;Lee, Ji-Wan;Kim, Seong-Joon
    • Proceedings of the Korea Water Resources Association Conference
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    • 2011.05a
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    • pp.29-29
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    • 2011
  • SWAT (Soil and Water Assessment Tool) 모형은 물리적 기반의 준분포형 강우-유출 모형으로서, 대규모의 복잡한 유역에서 장기간에 걸친 다양한 종류의 토양과 토지이용 및 토지관리 상태에 따른 유출과 유사 및 오염물질의 거동에 대한 토지관리 방법의 영향을 예측이 가능하여, 수자원 관리 계획 및 유역관리를 위한 의사결정 지원 등 그 적용 범위가 매우 광범위하다. 이러한 모형의 적용성 검증을 위해서는 매개변수 민감도 분석 및 검 보정, 예측 불확실성 분석을 필요로 한다. 최근 수문 모델의 불확실성을 분석하기 위한 다양한 기법들이 개발 되었는데, 본 연구는 충주댐 유역(6,581.1 m)을 대상으로 유역출구점의 실측 일 유출량 자료(1998~2003)를 바탕으로 SWAT 모형의 유출관련 매개변수(총 18개)에 대한 불확실성 분석을 실시하였다. 이때 사용된 분석 기법으로는 SUFI2 (Sequential Uncertainty FItting algorithm 2), GLUE (Generalized Likelihood Uncertainty Estimation), ParaSol (Parameter Solution)등을 적용 하였다. 이러한 기법은 모두 SWAT-CUP (SWAT-Calibration Uncertainty Program, Abbaspour, 2007) 모형에 탑재되어있으며, 모형의 결과로써 검 보정, 매개변수의 민감도 분석, 각종 목적 함수 및 불확실성의 범위 등이 자동으로 산출 되므로 모형의 사용자가 불확실성 평가 기법의 분석 및 비교를 손쉽게 할 수 있다. 그 결과 대표적인 목적 함수인 결정 계수( $^2$)와 NSE (Nash-Sutcliffe Model Efficiency)는 모두 0.65에서 0.92사이의 값을 나타내어 대체적으로 모의가 잘 이루어졌음을 알 수 있었다. 그러나 불확실성의 범위를 나타내는 지표인 p-factor 및 r-factor에서는 평가 기법 별로 그 차이가 확연하게 드러났다. 여기서 p-factor는 불확실성 범위에 실측치가 포함되는 비율이며, r-factor는 불확실성의 상대적인 범위로 각각 1과 0에 가까울수록 모의 기법의 성능이 우수함을 의미한다. 세 가지 알고리듬 중에서 SUFI2의 p-factor가 약 0.51로 가장 높게 나타났으며, ParaSol의 r-factor가 0.00으로 가장 작게 나타났다. 여기서 p-factor는 불확실성 범위에 실측치가 포함되는 비율이며, r-factor는 불확실성의 상대적인 범위를 의미한다. 본 연구의 결과는 SWAT 모형을 이용한 수문모델링에서 수문분석에 따른 예측결과의 불확실성을 정량적으로 평가함으로서, 모형의 적용성 평가 및 모의결과의 신뢰성 확보에 근거자료로 활용이 가능할 것으로 판단된다.

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Effects of Carbenoxolone and P2X recepter antagonist combined therapy on oral neuropathic pain in rat (신경병증 통증 모델에서 Carbenoxolone과 P2x receptor 길항제의 효과)

  • Ku, In-Young;Moon, Seon-Jeong;Ka, Kyung-Hwan;Park, Min-Kyoung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.2
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    • pp.123-128
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    • 2016
  • The study was conducted to confirm the analgesic effects of the Carbenoxolone(CBX)and P2X receptor antagonist(iso-PPADS), which separates the gap junction in the facial neuropathic pain model. The experiment used white male Sprague-Dawley rats (240~280g). The second left molars on the lower jaw was extracted to induce facial neuropathic pain, and small dental implants were implanted to induce damage to the inferior alveolar nerve. When CBX was injected twice daily to the abdominal cavity, a significant analgesic effect at 5ug/kg was observed(p<0.05). In addition, when iso-PPADS was injected twice daily into the abdominal cavity, a significant analgesic reaction was observed at $25{\mu}g/kg$(p<0.05). When the two drugs were injected together at a low concentration, in which they did not display an effect, they displayed a significant analgesic reaction at CBX 1ug/kg and iso-PPADS 2.5ug/kg(p<0.05). When a gap injunction block using a low concentration of CBX and a low concentration P2X receptor antagonist was injected together, the pain suppressing effect was observed against the orofacial neuropathic pain mechanism. These results make it possible to determine that the gap junction block using CBX and the injection of the P2X receptor antagonist plays an important role in the pain management of the facial region.

Determination of Appropriate Sampling Time for Job Stress Assessment: the Salivary Chromogranin A and Cortisol in Adult Females

  • Hong, Ran-Hi;Yang, Yun-Jung;Kim, Sang-Yon;Lee, Won-Young;Hong, Yeon-Pyo
    • Journal of Preventive Medicine and Public Health
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    • v.42 no.4
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    • pp.231-236
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    • 2009
  • Objectives : This study was conducted to determine the appropriate sampling time of the salivary stress markers, chromogranin A (CgA) and cortisol as objective indices of job stress assessment in adult females. Methods : The subjects were 20${\sim}$39-year-old women (13 office workers, 11 sales-service workers, and 11 college students) who were eligible for the study and free of acute and chronic medical conditions. Salivary CgA and cortisol levels were determined by enzyme-linked immunosorbent assay (ELISA). Saliva samples were collected (2 $m{\ell}$ each) at 7:00, 8:00, 10:30, 12:00, 17:30, and 22:30 on a typical day. Salivary CgA and cortisol levels, according to sampling time, were compared among the three groups using general linear model. The full version of the Korean Occupational Stress Scale (KOSS), which includes socioeconomic characteristics, health behavior, workrelated characteristics, and BMI, was used to access the subjects' job stress. Multiple regression analysis of the job stressors identified by the KOSS was performed on salivary CgA and cortisol levels. Results : The salivary CgA level peaked at 7:00 (time of awakening), then decreased and were maintained at a low level throughout the day, and increased slightly at 17:30. The salivary cortisol level increased steeply within the 1st hour after awakening, followed by a gradual decrease by 12:00, and was then maintained at a low level throughout the day. The salivary cortisol levels of subjects who worked ${\leq}$5 days per week and graduated from the university were significantly lower at 8:00 (p=0.006). The salivary cortisol levels of non-smokers were significantly lower at 7:00 p=0.040) and 8:00 (p=0.003) compared to smokers. There were no significant differences in salivary CgA and cortisol levels at 10:30 and 12:00 in general characteristics. The regression coefficients on salivary CgA level were significant with interpersonal conflict at 17:30 and job insecurity at 22:30. Regression coefficients on salivary cortisol level were significant with organizational system and total job stressors at 17:30. Conclusions : We suggest that the appropriate sampling times for the salivary stress markers, CgA and cortisol, are at 7:00 (time of awakening), 8:00 (1 hour after awakening), 17:30 (early evening), and 22:30 (before sleep).

EXperimental Studies on the Hair Growth Activity of Mylabris Phalerata Pall. Extracts and Fractions in C57BL/6N Mice (C57BL/6N 생쥐에서 반모추출물과 분획물을 이용한 발모(發毛)효과에 대한 실험적 연구)

  • Jo, Han-Young;Kim, Tae-Heon;Kim, Ho;Jeong, Han-Sol;Lee, Chang-Hyun;Lee, Gwang-Gyu
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.2
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    • pp.357-364
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    • 2008
  • Mylabris is the dried body of the chinese blister beetle. The species used in medicine are Mylabris phalerata and M. cichorii. In recent studies, it has been found that Mylabris possesses antitumor properties, increases the number of leukocytes, and has irritant effects on the urinary organs. The crude extracts of Mylabris have been noted for their highly irritant action and other traditional uses of Mylabris include treatment of poor local blood circulation. The active constituent of Mylabris is cantharidin. The chemical is notable for its vesicant properties, but with severe side effects such as nephrotoxicity. This experiment examined the effect of extracts and fractions, obtained from Mylabris phalerata Pall. on hair growth activity of the C57BL/6N mice after topical application to skin. First, we examined the effect of an extracts, obtained from the alcohol extracts of dried Mylabris phalerata Pall. on hair growth activity of the C57BL/6N mice after topical application to skin. Second, we examined on hair growth activity of the cantharidin fraction of Mylabris phalerata Pall. compared to the control and 1% minoxidil groups. Third, we investigated the number of hair follicle and mast cells after topical application of extracts of Mylabris phalerata Pall. to skin for 16 days. The results were as follows: Hair growth effect from the extracts of Mylabris phalerata Pall.(0.312%) was observed in 80% of mice whose hair had been removed in 13 days. Hair growth effect from the extract of Mylabris phalerata Pall.(0.312 and 0.625%) and 1% minoxidil group was observed in 100% of mice whose hair had been clipped in 20 days. Hair growth effect from the cantharidin fraction(0.5%) and water fraction(0.5%) of Mylabris phalerata Pall. was observed in 100% of mice whose hair had been clipped in 24 days. The hair growth effect on the cantharidin fraction(0.125%) was observed to be strong compared with the minoxidil(3%) group, commercial hair growth agents, in mice whose hair had been clipped in 19 days. In the spontaneous alopecia mice model, the hair growth effect from the cantharidin fraction (0.125%) was observed to be strong as compared with the states before the 13 days experiment. These experiments suggest that extracts and fractions of Mylabris phalerata Pall. may stimulate the topical hair growth activity in low doses.

A study on the Derivation of GIUH-Clark Model (GIUH-Clark 모형의 유도에 관한 연구)

  • Lee, Byung Woon;Jang, Dae Won;Kim, Hung Soo;Seoh, Byung Ha
    • Proceedings of the Korea Water Resources Association Conference
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    • 2004.05b
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    • pp.731-736
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    • 2004
  • 강우-유출과정의 수문학적 현상을 보다 정확히 분석하고 예측하는 기법으로 강우에 의한 유출의 반응을 나타내는 지체시간, 도달시간 등 수문학적 반응시간을 유역의 지형형태학적 인자들과 연계하는 방법이 많이 이용되고 있다. 이에 본 연구에서는 Clark방법과 지형형태학적 순간단위도(GIUH)를 이용하여 계측유역의 강우-유출반응을 모의하였고, 이를 관측된 값과 비교하여 미계측유역의 적용성 여부를 검토해보았다. 대상 유역의 하상지형인자 및 지형형태학적 특성은 Arc-View를 이용하여 구하였으며, 이를 기존의 문헌자료와 비교해보았다. Clark방법의 매개변수의 결정에 있어서 시간-면적곡선은 HEC-1의 무차원 식을 이용하였고, 도달시간은 Kirpich 공식을 이용하여 구하였으며, 저류상수는 Clark방법에 의해 추정된 순간단위도의 첨두유량이 Horton의 차수비의 함수로 구한 철두유량과 같아지는 값으로 결정하였다. 본 연구는 전적비교를 출구점으로하는 유역면적 $8.5km^2$인 설마천을 대상유역으로 하였으며, 모의된 강우-유출반응과 비교하기 위해 사용된 강우사상은 2002년의 8월 4일과 2002년 10월 6일의 10분 단위 우량이다. Clark방법과 GIUH를 이용하여 모의한 유출곡선과 관측된 유출곡선을 비교해본 결과 첨두유량은 8월의 강우사상 때는 $21\%$크게, 10월의 강우사상 때는 $35\%$작게 나타났다. 첨두시간은 모의된 경우가 각각 10분, 20분 빨리 도달하였다. 또한 이러한 결과는 유역의 도달시긴에 가장 민감하게 반응함을 알 수 있었다. 따라서, 유역의 도달시간 산정에 주의를 요한다면 프랙탈 차원이 유사한 미계측유역의 수문곡선 산정에 있어서 Clark방법과 GIUH를 이용하는 방법도 유용하다고 사료된다. 주는 각 수문인자 중 강우시간분포와 유효우량 산정방법 그리고 유출모형에 대해 자자 검토하였으며, 최종적으로 면적에 따른 임계지속기간과 유출량의 변화를 검토해 보았다.이를 각각의 경우의 해석해 결과와 비교${\cdot}$분석하였다. 후방추적 퍼프모형은 전방추적 퍼프모형에 비하여 사용된 퍼프수와 관계없이 작은 오차를 발생하였으며, 전체적으로 퍼프 모형이 입자모형보다는 훨씬 적은 수의 계산을 통해서도 작은 오차를 나타낼 수 있다는 것을 알 수 있었다. 그러나 Gaussian 분포를 갖는 퍼프모형은 전단흐름에서의 긴 유선형 농도분포를 모의할 수 없었고, 이에 관한 오차는 전단계수가 증가함에 따라 비선형적으로 증가하였다. 향후, 보다 다양한 흐름영역에서 장${\cdot}$단점 분석 및 오차해석을 수행한 후에 각각의 Lagrangian 모형의 장점만을 갖는 모형결합 방법을 제시할 수 있을 것으로 판단된다.mm/$m^{2}$로 감소한 소견을 보였다. 승모판 성형술은 전 승모판엽 탈출증이 있는 두 환아에서 동시에 시행하였다. 수술 후 1년 내 시행한 심초음파에서 모든 환아에서 단지 경등도 이하의 승모판 폐쇄 부전 소견을 보였다. 수술 후 조기 사망은 없었으며, 합병증으로는 유미흉이 한 명에서 있었다. 술 후 10개월째 허혈성 확장성 심근증이 호전되지 않아 Dor 술식을 시행한 후 사망한 예를 제외한 나머지 6명은 특이 증상 없이 정상 생활 중이다 결론: 좌관상동맥 페동맥이상 기시증은 드물기는 하나, 영유아기에 심근경색 및 허혈성 심근증 또는 선천성 승모판 폐쇄 부전등을 초래하는 심각한 선천성 심질환이다. 그러나 진단 즉시 직접 좌관상동맥-대동맥 이식술로 수술적 교정을 해줌으로써 좋은 성적을 기대할 수 있음을 보여주었다.특히 교사들이 중요하

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