• Kyungpook Mathematical Journal
• /
• v.57 no.4
• /
• pp.711-719
• /
• 2017

Let Inn(Q) denote the inner automorphism group on a quandle Q. For a subset M of Q, let c(M) denote the orbit of M under the Inn(Q)-action on Q. Then c satisfies the axioms of the closure operator. In this paper, we study the topological space Q corresponding to the topology obtained from the closure operator c.

• Journal of IKEEE
• /
• v.21 no.3
• /
• pp.260-263
• /
• 2017

Based on several CPU cores, an SoC including ADCs, DC-DC converter and 2M-byte SRAM is proposed in this paper. The CPU core consists of a 12-bit MENSA, a 32-bit Symmetric multi-core processor, as well as 16-bit CDSP. To eliminate the external SDRAM memory, internal 2M-byte SRAM is implemented. Because the SRAM normally occupies huge area, the parasitic components reduce the speed of SoC. In this work, the SRAM blocks are divided into small pieces to reduce the parasitic components. The proposed SoC is developed in a standard 55nm CMOS process and the speed of SoC is 200MHz.

• KSBB Journal
• /
• v.21 no.6 s.101
• /
• pp.466-473
• /
• 2006

Impaired insulin secretion from pancreatic beta-cells in response to glucose is an important feature in the pathology of non-insulin-dependent diabetes mellitus (NIDDM). In the course of screening for useful insulin secretagogues, we have isolated and identified YHB-2017 (Genistein) as a insulin secretion potentiator from fermentation broths of our in-house microbial library. The insulinotropic activity of YHB-2017 in isolated rat pancreatic islets was exerted only at high concentration of glucose (8.3-16 mM) but not at low concentration of glucose (3.3-5.5 mM). Also, in perifusion study with isolated rat pancreatic islets, YHB-2017 stimulated insulin secretion in a time-dependent manner when YHB-2017 was added to KRB buffer containing 16 mM glucose. In the presence of $200\;{\mu}M$ diazoxide and 35 mM KCI, which stimulates maximum $Ca^{2+}$ influx independently of KATP channel, YHB-2017 enhanced KATP channel-independent insulin secretion at high concentration glucose (16 mM). To elucidate the mechanisms of the glucose-dependent potentiation effect of YHB-2017, pharmacologic inhibitors for protein kinase A, protein kinase C and calcium/calmodulin kinase II were pre-treated and then the potentiation effect of YHB-2017 on insulin secretion was investigated. Pre-treatment of H89 as a PKA inhibitor had a significant inhibitory effect on YHB-2017-induced potentiation effect. Furthermore, western immunoblotting analyses revealed that YHB-2017 increased phosphorylation of PKA substrates and cAMP response element-binding protein (CREB) under high concentration of glucose. These results demonstrated that the insulinotropic effect of YHB-2017 is mediated through PKA signal pathway and activated amplifying $K_{ATP}$ channel-independent insulin secretion pathway.

• Journal of the Chungcheong Mathematical Society
• /
• v.30 no.2
• /
• pp.177-181
• /
• 2017

Let $f:M{\rightarrow}M$ be a diffeomorphism of a compact smooth manifold M. In this paper, we show that $C^1$ generically, if a chain transitive set ${\Lambda}$ is locally maximal then it admits a dominated splitting. Moreover, $C^1$ generically if a chain transitive set ${\Lambda}$ of f is locally maximal then it has zero entropy.

• Journal of the Chungcheong Mathematical Society
• /
• v.30 no.1
• /
• pp.77-102
• /
• 2017

As an analogy of $Poincar{\acute{e}}$ series in the space of modular forms, T. Ono associated a module $M_c/P_c$ for ${\gamma}=[c]{\in}H^1(G,R^{\times})$ where finite group G is acting on a ring R. $M_c/P_c$ is regarded as the 0-dimensional twisted Tate cohomology ${\hat{H}}^0(G,R^+)_{\gamma}$. In the case that G is the Galois group of a Galois extension K of a number field k and R is the ring of integers of K, the vanishing properties of $M_c/P_c$ are related to the ramification of K/k. We generalize this to arbitrary n-dimensional twisted cohomology of the ring of integers and obtain the extended version of theorems. Moreover, some explicit examples on quadratic and biquadratic number fields are given.

• Publications of The Korean Astronomical Society
• /
• v.32 no.1
• /
• pp.147-149
• /
• 2017

Since the launch of the Herschel Space Observatory, our understanding about the photo-dissociation regions (PDR) has taken a step forward. In the bandwidth of the Fourier Transform Spectrometer (FTS) of the Spectral and Photometric Imaging REceiver (SPIRE) on board Herschel, ten CO rotational transitions, including J = 4 - 3 to J = 13 - 12, and three fine structure lines, including [$C{\small{I}}$] 609, [$C{\small{I}}$] 370, and [$N{\small{II}}$] $205{\mu}m$, are covered. I present our findings from the FTS observations at the nuclear region of M83, based on the spatially resolved physical parameters derived from the CO spectral line energy distribution (SLED) map and the comparisons with the dust properties and star-formation tracers. This article discusses (1) the potential of using [$N{\small{II}$] 205 and [$C{\small{I}}$] $370{\mu}m$ as star-formation tracers; (2) the excitation mechanisms of warm CO in the nuclear region of M83.

• The Plant Pathology Journal
• /
• v.33 no.6
• /
• pp.597-601
• /
• 2017

The clpks18 gene was first cloned and identified in Curvularia lunata. It contains 6571 base pairs (bp) and an 6276 bp open reading frame encoding 2091 amino acids. The ClPKS18 deletion mutant displayed an albino phenotype, and almost lost the ability to product 5-(hydroxymethyl) furan-2-carboxylate (M5HF2C) toxin, implying that clpks18 gene in C. lunata is not only involved in 1,8-dihydroxynaphthalene melanin synthesis, but also relatively associated with M5HF2C toxin biosynthesis of the pathogen. The pathogenicity assays revealed that ${\Delta}ClPKS18$ was impaired in colonizing the maize leaves, which corresponds to the finding that ClPKS18 controls the production of melanin and M5HF2C in C. lunata. Results indicate that ClPKS18 plays a vital role in regulating pathogenicity of in C. lunata.

• The Journal of Internal Korean Medicine
• /
• v.38 no.1
• /
• pp.1-9
• /
• 2017

Objective: This study investigated the effect of purified Carthamus tinctorius (C. tinctorius) extracted with a hot water and ethanol method on adipogenic differentiation of mouse bone marrow-derived mesenchymal stromal stem cells (mBMSCs). Methods: The C. tinctorius was extracted using hot water and ethanol. The samples were concentrated by a rotary evaporator and were then dried using a freeze-dryer. The mBMSCs were cultured and maintained in a minimum essential medium eagle alpha (${\alpha}-MEM$) supplemented with 10% FBS and 1% antibiotic antimycotic solution. To induce adipogenic differentiation, the cells were treated with Dulbecco's modified eagle's medium-low glucose (DMEM-LG) containing 1 mg/mL insulin, 1 mM dexamethasone, and 0.5 mM 3-isobutyl-1-methylxanthine. To evaluate the adipogenic differentiation ability, oil-red O staining was performed after adipogenic differentiation for 21 days. The mRNA expression and protein level of adipogenic-related genes were quantified by quantitative real-time PCR and western blotting, respectively. Results: In the results of the MTT assay, no concentrations of C. tinctorius extracts showed toxicity on mBMSCs, so we fixed the treatment concentration of the extract at 100 ng/mL. In oil-red O staining, the water-C. tinctorius extract treatment significantly decreased adipogenic differentiation compared with the control and ethanol extract groups. The water-C. tinctorius extract group in particular showed reduced mRNA and protein expression of Peroxisome proliferator-activated receptor gamma ($Ppar{\gamma}$) and CCAAT/enhancer-binding protein alpha ($C/ebp{\alpha}$), which are adipogenic-related transcription factors. Conclusion: These data suggest that extract of C. tinctorius decreased the adipogenic differentiation of mBMSCs, while only water-C. tinctorius extract had an effect on different adipogenesis in mBMSCs. The C. tinctorius will be a useful therapeutic reagent for the prevention of obesity-related diseases such as diabetes, hyperlipidemia, coronary artery disease, and osteoporosis.

• Journal of the Korean Society for Heat Treatment
• /
• v.30 no.5
• /
• pp.197-206
• /
• 2017

The microstructure of a high-carbon and high-chromium cast steel (HK700) for cold-work die inserts was analyzed by advanced scanning electron microscopy. A continuous network of primary $M_7C_3$ carbide was developed among austenitic matrix after casting. A small amount of $M_2C$ was added to the carbide network owing to the enrichment of Mo and W during the solidification. After quenching in which the austenitization was performed at $1030^{\circ}C$ and double tempering at $520^{\circ}C$, the network structure of $M_7C_3$ was preserved while most of the matrix was transformed to martensite because of additional carbide precipitation. The $M_2C$ in the as-cast microstructure was also transformed to $M_6C$ due to its instability. The continuous network of coarse carbides owing to the absence of hot-working had little influence on the hardness after quenching and tempering, whereas it resulted in severe brittleness upon flexural loading.

• Journal of the Korean Society for Heat Treatment
• /
• v.30 no.2
• /
• pp.43-52
• /
• 2017

Heat treatment condition for dissolution of the M23C6 carbides in 2.25Cr-1Mo-V-Ti material for thermal power plant tube was investigated using a dilatometer method. 2.25Cr-1Mo-V-Ti material was heat-treated at $900{\sim}1,100^{\circ}C$ for 0, 10, 30 min to find the proper dissolution condition of M23C6 carbides. The phase identification and volume fraction of the carbide were measured by using OM, SEM, EBSD and TEM analysis. Optimal heat treatment condition of M23C6 carbide dissolution was selected by predicting dissolution temperature of carbide using Bs points appeared at dilatometer curve. Experimental results showed that the conditions of carbide dissolution was 900, 1,000, $1,100^{\circ}C$ for 30 min. Eventually, the optimal heat treatment condition for dissolution was 30 min at $1,000^{\circ}C$ considering the minimum coarsening of Austenite grain size.