• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1386-1390
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• 2005

Lycii Fructus (LF) has been reported to possess various biological activities. In this study, we investigated the anti-inflammatory and anti-allergic effects of LF extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells and rat peritoneal mast cells(RPMC). LF extract inhibited NO production and the expressions of inducible NO synthase (iNOS) mRNA and enzyme protein, determined by Griess reactions, RT-PCR and Western blotting, respectively, in LPS-stimulated RAW 264.7 macrophages cells. LF extract significantly inhibited histamine release in compound48/80 stimulated rat peritoneal mast cells compared with the compound48/80 only treated cells. It is suggested that the LF extract can improve the inflammation status that involves the histamine release.

• Korean Journal of Food Science and Technology
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• v.24 no.6
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• pp.597-602
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• 1992

To improve utilization of boxthorn (Lycii Fructus), the boxthron and mixed boxthron (Lycii Fructus, Schizandrae Fructus, Corni Fructus, Zizyphi Fructus, Zingiberis Rhizoma, Cinnamami Cortex) hot-water extractable concentrates were prepared by vaccum evaporation and its rheological properties were investigated. The rheological properties of concentrates $(20{\sim}50^{\circ}Bx)$ followed power low model and showed a pseudoplastic behavior at the temperature range of $20{\sim}60^{\circ}C$. The apparent viscosity of $20^{\circ}Bx$, $30^{\circ}Bx$, $40^{\circ}Bx$ and $50^{\circ}Bx$ boxthron hot-water extractable concentrate was 0.0074 Pa s, 0.0175 Pa s, 0.0431 Pa s and 0.0988 Pa s, that of mixed boxthorn hot-water extractable concentrate was 0.0099 Pa s, 0.0328 Pa s, 0.0720 Pa s and 0.1940 Pa s at $20^{\circ}C$ and 1500 l/s, respectively. The yield stress of boxthron and mixed boxthron hot-water extractable concentrates ranged from 0.045 to 6.253 Pa and from 0.022 to 8.891 Pa, respectively. The activation energy for the flow of boxthron and mixed boxthorn hot-water extractable concentrates increased from 1.6182 to $2.0543{\times}10^7\;J/kg{\cdot}mol$ and from 1.7057 to $2.1462{\times}10^7\;J/kg{\cdot}mol$ with the concentrations of concentrates, respectively.

• The Korea Journal of Herbology
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• v.27 no.5
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• pp.1-7
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• 2012

Objectives : This study was conducted to 9% compared with the previous experimental obesity-induced metabolic function in rats that it was a mixture of pear extract and herbal drugs(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on high fat diet-induce obesity rats. Methods : The animals were used in male rats. Control group fed high-fat diet only. Experimental groups were divided four, ExpI group was fed high-fat diet with a mixture pear extract and Lycii Fructus 9%, Exp II group was fed high-fat diet with a mixture pear extract and Coicis Semen 9%, Exp III group was fed high-fat diet with a mixture pear extract and Alimatis Rhizoma 9%, and Exp IV group was fed high-fat diet with a mixture pear extract and Astragali Radix 9% for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in all Exp groups than the control group. The concentrations of serum total cholesterol (TC), LDL-cholesterol, and free fatty acid were significantly lower in Exp II than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp IV group than in the control group. In inflammatory activities, the Exp II, IV group was significantly lower than the control group. Conclusion : The results indicated that Exp I group (administered a mixture of pear extract and Lycii Fructus) reduced fat accumulation, body weight and the highest elevated lipid metabolism, while the Exp II group (administered the mixture of pear extract and Coicis Semen) and Exp IV group (administered the mixture of pear extract and Astragali Radix) had the highest elevated immune activity.

• Korean Journal of Medicinal Crop Science
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• v.4 no.4
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• pp.283-287
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• 1996

As a part of studies on the quality control for drying methods in Lycii Fructus. Dried Lycii Fructus were obtained from several treatments to examine the control of the extracts and its physical properties, and also to analyze the inorganic elements and proximate compositions. The results were summerized as follows; the changes of solid matter contents dried at $50^{\circ}C\;for\;4\;hrs\;and\;60^{\circ}C$ for 28 hrs were highest. The changes of Hunter values were 66 in lightness, 5.0 in redness and 51.3 in yellowness, respectively in treatment No. 1. And also the viscosity of treatment No. 1. was some high compared to the other treatment. The desirable drying temperature were at $50^{\circ}C$ for 2hrs in initial and at $60^{\circ}C$ for 24hrs in final temperature and it was the best conditions as a quality, economics and chemical compositions of Lycii Fructus.

• Korean Journal of Medicinal Crop Science
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• v.15 no.6
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• pp.391-397
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• 2007

To develop new high valuable Gugija (Lycium chinensis), biofunctionalities of Gugija standard species and its hybrids were investigated and compared with each water extracts and methanol extracts from Lycii Fructus, Lycii Folium and buds and Lycii Cortex Radicis. Among various biofunctionalities of Gugija standard species, antioxidant activity was showed the highest in methanol extracts from buds of Cheongwoon species (93%) and antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity was 84.1% in the water extracts from Lycii Cortex Radicis of Cheongyang NO.7. Futhermore, methanol extracts from Lycii Cortex Radicis of Myungan A-2 hybrid showed 93.1% of antioxidant activity and 96.9% of ACE inhibitory activity was also showed in the methanol extracts from Lycii Fructus of DO148-72(A11) hybrid. However, fibrinolytic activity and anticholesteromia HMG-CoA reductase inhibitory activity were weak or not detected in almost of Gugija standard species and its hybrids. Therefore, we finally selected Cheongwoon Gugija standard species (buds) and Myungan A-2 hybrid (Lycii Cortex Radicis) as good antioxidant sources and also DO148-72 (A11) hybrid (Lycii Fructus) as excellent antihypertensive ACE inhibitior sources for manufacturing functional food product.

• Korean Journal of Pharmacognosy
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• v.15 no.2
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• pp.98-103
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• 1984

A ginseng preparation consisting of ginseng ext., lycii fructus ext., four vitamins and caffeine was chosen and its efficacy was evaluated with respect to nutritional supplement, antifatigue activity and liver protective action. Animals administered orally in both one-third and three fold doses of the preparation showed no significant increments of their body weights when compared with those of the normal animals, suggesting no supplemental activity. However, the preparation in the above two doses significantly prolonged swimming time to 53 and 63%, respectively. Ginseng and lycii fructus ext. were found to be responsible for the antifatigue activity. And also the preparation significantly inhibited lipid peroxidation of mouse liver after ethanol-induced acute intoxication.

• Biomedical Science Letters
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• v.10 no.1
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• pp.49-54
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• 2004

The hair growth effect of the oriental medicine extract which is composed of Polygoni multiflori Radix, Angelica gigantis Radix and Lycii Fructus was studied biochemically and histologically. The study was conducted dividelly into three groups, control, propecia and oriental medicine extract and three groups were compared each other in skin androgen, testosterone (T) and dihydrotestosterone (DHT), content biochemically and the number of hair follicular unit and hair follicle histologically. The oriental medicine extract and propecia decreased skin DHT conetent and increased skin total (T+DHT) content compared with control. In transverse sections of skin specimens the oriental medicine extract and propecia increased total counts of follicular units and follicles compared with control. On the basis of the result, the oriental medicine extract has same hair growth effect as propecia and it is suggested that the oriental medicne extract is capable of a therapeutic agent of alopecia.

• Korean Journal of Food Science and Technology
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• v.35 no.1
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• pp.77-83
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• 2003

Quality and shelf life of the wet noodle made with 1, 3, 5, and 7% (w/w%) Lycii fructus powder were investigated. Increase in L. fructus power concentration increased the initial pasting temperature and cooking loss, while maximum viscosity, temperature at maximum viscosity, weights and volumes of cooking noodles, and textural properties (hardness, cohesiveness, chewiness, springiness) of cooked noodle prepared with composite flour decreased. The sensory evaluation of cooked noodles showed that wet noodles with high quality could be produced by 3% inclusion of L. fructus powder. Bacterial counts of wet noodles made with L. fructus powder were lower than those of the control after storage at $5{\pm}1^{\circ}C$. Shelf life of wet noodles during storage at $5{\pm}1^{\circ}C$ extended as the L. fructus powder concentration increased.

• Biomedical Science Letters
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• v.10 no.3
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• pp.317-324
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• 2004

In order to examine the clinical effects on male pattern hair loss, the oriental medicine extract composed of Polygoni multiflori Radix, Angelica gigantis Radix and Lycii Fructus was tested to balding people. 40 males and 10 females were participated in this experiment, and they had spread the extract on their scalp themselves one time a day for 18 months. After 18 months, all participants submitted the reports that had questionnaires to determine the effect of topical oriental medicine extract on hair growth and/or hair loss preventing in balding people. In the results, ir was found that hair density on the entire scalp was gradually increased during the spreading period of the extract in most of balding people. The hair loss was observed about 1 week or 2 months after extract treatment and hair growth was observed about 6 months after extract treatment. In the reports, 74％ of participants answered that the extract was effective on hair growth and hair loss preventing, and improvement of scalp condition. From these results, it is suggested that the extract composed of Polygoni multiflori Radix, Angelica gigantis Radix and Lycii Fructus may be an effective medical care to hair growth and hair loss preventing in human.

• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.291-295
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• 1996

For the screening of antidiabetic effect, this study was carried out to some natural products by measurements of glucose level. MeOH and $CH_2Cl_2$ extracts of natural products were investigated for the effect on glucose level of $N_2$-STZ diabeted Rat. Among the natural products, Dioscorea Rhizoma, Trichosanthes Radix, Nelumbis Semem and Lycii Fructus were shown a remarkable antidiabetic effect.