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Anti-inflammatory and Anti-allergic Effects of Lycii Fructus Extract

Lee Young-Sun (Department of Traditional Health Resource Development, College of Sung Duk, The RMIT Chinese Medicine Research Group, RMIT University. Bundoora West)
Lee Geum-Hong (Department Pathology, College of Oriental Medicine, Daegu Haany University)
Kwon Young-Kyu (Department Physiology, College of Oriental Medicine, Daegu Haany University)
Lee In-Kyung (Department of Traditional Health Resource Development, College of Sung Duk)
Xue Charlie-C.L. (The RMIT Chinese Medicine Research Group, RMIT University. Bundoora West)
Li Chun-G (The RMIT Chinese Medicine Research Group, RMIT University. Bundoora West)
Lee Se-Young (Department of Public Health, Keimyung University)
Shin Sang-Woo (Department Pathology, College of Oriental Medicine, Daegu Haany University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.19, no.5, 2005 , pp. 1386-1390 More about this Journal

Abstract

Lycii Fructus (LF) has been reported to possess various biological activities. In this study, we investigated the anti-inflammatory and anti-allergic effects of LF extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells and rat peritoneal mast cells(RPMC). LF extract inhibited NO production and the expressions of inducible NO synthase (iNOS) mRNA and enzyme protein, determined by Griess reactions, RT-PCR and Western blotting, respectively, in LPS-stimulated RAW 264.7 macrophages cells. LF extract significantly inhibited histamine release in compound48/80 stimulated rat peritoneal mast cells compared with the compound48/80 only treated cells. It is suggested that the LF extract can improve the inflammation status that involves the histamine release.

Keywords

Lycii Fructus; anti-allergic; anti-inflammatory; NO; Compound 48/80;

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