• Clinical and Experimental Pediatrics
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• 제65권1호
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• pp.1-9
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• 2022

With advancements in neonatal care and nutrition, the postnatal growth of preterm infants has improved; however, it remains an issue. Accurate assessments of growth using a standardized reference are needed to interpret the intrauterine and postnatal growth patterns of preterm infants. Growth in the earlier periods of life can contribute to later outcomes, and the refinement of postnatal growth failure is needed to optimize outcomes. Catch-up growth occurs mainly before discharge and until 24 months of age, and very low birth weight infants in Korea achieve retarded growth later in life. Knowing an infant's perinatal history, reducing morbidity rates during admission, and performing regular monitoring after discharge are required. Preterm infants with a lower birth weight or who were small for gestational age are at increased risk of poor neurodevelopmental outcomes. Furthermore, poor postnatal growth is predictive of adverse neurodevelopmental outcomes. Careful monitoring and early intervention will contribute to better development outcomes and national public health improvements.

• Journal of Preventive Medicine and Public Health
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• 제49권3호
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• pp.165-175
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• 2016

Objectives: The present study was undertaken to study the maternal risk factors for preterm birth (PTB) and low birth weight (LBW) with a special emphasis on assessing the proportions of maternal genitourinary and periodontal infections among Indian women and their association with adverse pregnancy outcomes. Methods: A hospital-based prospective study comprising 790 pregnant women visiting the obstetrics clinic for a routine antenatal check-up was undertaken. Once recruited, all study participants underwent clinical and microbiological investigations for genitourinary infections followed by a dental check-up for the presence of periodontitis. The study participants were followed up until their delivery to record the pregnancy outcomes. Infectious and non-infectious risk factors for PTB and LBW were assessed using univariate and multivariate Cox regression analysis. Independent risk factors for PTB and LBW were reported in terms of adjusted relative risk (ARR) with the 95% confidence interval (CI). Results: Rates of PTB and LBW in the study population were 7.6% and 11.4%, respectively. Previous preterm delivery (ARR, 5.37; 95% CI, 1.5 to 19.1), periodontitis (ARR, 2.39; 95% CI, 1.1 to 4.9), Oligohydramnios (ARR, 5.23; 95% CI, 2.4 to 11.5), presence of Nugent's intermediate vaginal flora (ARR, 2.75; 95% CI, 1.4 to 5.1), gestational diabetes mellitus (ARR, 2.91; 95% CI, 1.0 to 8.3), and maternal height <1.50 m (ARR, 2.21; 95% CI, 1.1 to 4.1) were risk factors for PTB, while periodontitis (ARR, 3.38; 95% CI, 1.6 to 6.9), gestational hypertension (ARR, 3.70; 95% CI, 1.3 to 10.8), maternal height <1.50 m (ARR, 2.66; 95% CI, 1.3 to 5.1) and genital infection during later stages of pregnancy (ARR, 2.79; 95% CI, 1.2 to 6.1) were independent risk factors for LBW. Conclusions: Our study findings underscore the need to consider screening for potential genitourinary and periodontal infections during routine antenatal care in developing countries.

• 대한지리학회지
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• 제51권3호
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• pp.367-380
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• 2016

본 연구에서는 우리나라에서 발생한 저체중아 출생 집계 자료를 공간적으로 지도화하기 위한 기법들을 검토 비교하고, 이를 기반으로 우리나라의 LBW 지도를 작성하였다. 표준화사망률이나 조사망률 등은 역학 분야에서 지속적으로 광범위하게 사용되고 있는 지표이다. 그러나 이러한 표준화사망률은 집계 단위의 샘플 수에 영향을 많이 받는다는 단점을 가지고 있다. 이에, 본 연구에서는 베이지언 기법을 활용하여 샘플 수에 따른 통계적 변동성을 감소시키고자 하였다. 이를 위해 경험적 베이지언 기법과 풀 베이지언 기법을 모두 활용하였고, 결과적으로 유사한 통계량을 산출한 것을 확인할 수 있었다. 반면, SMR 기반의 통계량은 높은 분산을 가지고 있음을 확인하였다. 연구의 결과에 따른 통계 지도는 우리나라 저체중아 출생의 높은 위험도를 가지는 지역들을 파악할 수 있도록 한다.

• Clinical and Experimental Reproductive Medicine
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• 제47권4호
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• pp.300-305
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• 2020

Objective: The feasibility of a gonadotropin-releasing hormone agonist (GnRHa) trigger in normal responders is still a matter of debate. The aim of this study was to compare the number of mature oocytes, the number of good-quality embryos, and the live birth rate in normal responders triggered by GnRHa alone, GnRHa and human chorionic gonadotropin (hCG; a dual trigger), and hCG alone. Methods: A retrospective cohort study was conducted at the infertility clinic of a university hospital. Data from 200 normal responders who underwent controlled ovarian hyperstimulation and intracytoplasmic sperm injection with a GnRH antagonist protocol between January 2016 and January 2017 were reviewed. The first study group consisted of patients with cycles triggered by GnRHa alone. The second study group consisted of patients with cycles triggered by both GnRHa and low-dose hCG (a dual trigger). The control group consisted of patients with cycles triggered by hCG alone. Results: The groups were comparable in terms of demographics and cycle characteristics. The numbers of total oocytes retrieved and metaphase II oocytes were similar between the groups. The total numbers of top-quality embryos were 3.2±2.9 in the GnRHa group, 4.4±3.2 in the dual-trigger group, and 2.9±2.1 in the hCG group (p=0.014). The live birth rates were 21.4%, 30.5%, and 28.2% in those groups, respectively (p=0.126). Conclusion: In normal responders, a dual-trigger approach appears superior to an hCG trigger alone with regard to the number of top-quality embryos produced. However, no clinical benefit was apparent in terms of live birth rates.

• Asian-Australasian Journal of Animal Sciences
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• 제24권10호
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• pp.1386-1392
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• 2011

The aim of the present work was to study the effects of a polyherbal supplement on cross bred does, starting from the last month of pregnancy to weaning, on milk yield, kid birth weight and growth rate. Thirty does were divided into three treatments of ten each in individual pens: low level supplementation (LS), high level supplementation (HS) and non-supplemented treatment (NS) as control. Low supplemented goats were given 125 mg/kg BW/d of polyherbal combination; high supplemented goats were given 250 mg/kg BW/d. The study was carried out in 2008. Fifty-nine kids were born from all the experimental animals. There was no difference on milk yield between supplemented groups and control (p>0.05), although polyherbal supplementation had positive effect on litter birth weight and growth rate compared to control. Weaning weights were higher (p<0.001) in LS and HS compared to NS does. In both supplemented treatments compared to control, mortalities and morbidities were also lower in kids born. It is concluded that pre-partum to weaning supplementation increases kids growth rates and weaning weights, as well as reduces kid mortalities, but it doesn't have significant effect on milk production.

• Clinical and Experimental Pediatrics
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• 제54권9호
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• pp.363-367
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• 2011

Central venous catheters (CVCs) are regularly used in intensive care units, and catheter-related bloodstream infection (CRBSI) remains a leading cause of healthcare-associated infections, particularly in preterm infants. Increased survival rate of extremely-low-birth-weight infants can be partly attributed to routine practice of CVC placement. The most common types of CVCs used in neonatal intensive care units (NICUs) include umbilical venous catheters, peripherally inserted central catheters, and tunneled catheters. CRBSI is defined as a laboratory-confirmed bloodstream infection (BSI) with either a positive catheter tip culture or a positive blood culture drawn from the CVC. BSIs most frequently result from pathogens such as gram-positive cocci, coagulase-negative staphylococci, and sometimes gram-negative organisms. CRBSIs are usually associated with several risk factors, including prolonged catheter placement, femoral access, low birth weight, and young gestational age. Most NICUs have a strategy for catheter insertion and maintenance designed to decrease CRBSIs. Specific interventions slightly differ between NICUs, particularly with regard to the types of disinfectants used for hand hygiene and appropriate skin care for the infant. In conclusion, infection rates can be reduced by the application of strict protocols for the placement and maintenance of CVCs and the education of NICU physicians and nurses.

• Journal of Preventive Medicine and Public Health
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• 제21권1호
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• pp.10-20
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• 1988

각 의료기관에서 분만하는 산모와 신생아의 특성을 비교분석하고 의료기관별 산모와 신생아의 위험수준을 조사하여 특정 의료기관에서 관찰한 연구결과를 해석하는데 참고 자료를 제공하기 위하여 대구시내 3개 대학병원, 2개 종합병원,2개 개인의원, 1개 조산소, 그리고 1개 모자보건센터에서 1987년 4월 1일 부터 4월 30일 까지 1개월간(1개 대학병원은 2개월간) 분만한 산모 1,410명을 대상으로 산모의 연령, 교육수준, 의료비 지불방법, 산과력 및 특정의료기관을 선택한 이유를 면담 조사하고 병원기록지에서 신생아의 출생시 체중의 조사하였다. 대학병원과 종합병원을 이용한 산모의 평균 연령은 각각 27.5세, 26.7세로 조산소(25.4세)와 모자보건센터(26.1세)를 이용한 산모보다 많았고, 교육수준은 대학병원(평균 12.7년)과 종합병원(평균 12.2년) 산모가 조산소(평균 9.2년) 및 모자보건센터(평균 9.3년) 산모보다 월등히 높았다. 그리고 의료보험 대상자도 대학병원(78.1%)과 종합병원(82.9%) 산모가 개인의원(44.3%), 조산소(29.1%)나 모자보건센터(5.4%) 보다 많았다. 모자보건센터는 2번째 출산이 47.3%로 가장 많았으나 다른 의료기관은 모두 초산부가 $56.0{\sim}61.7%$로 제일 많았다. 산모의 산과력 비교에서는 대학병원 산모가 자연유산 경험율이 상대적으로 다른 의료기관 산모보다 높았고 사산 경험자도 소수였으나 조산소와 모자보건센터에서 분만한 산모는 사산 경험자가 1명도 없었다. 대학병원 산모의 경우 37주 이하의 조산아 출생율(11.4%)과 2,499gm이하의 저체중아 출생율($5.8{\sim}13.0%$)은 타 의료기관 보다 현저히 높았다. 이에 따라 제왕절개술에 의한 분만율은 의료기관간에 차이가 많았다. 결국 대구시내 대학병원과 종합병원에서 분만하는 산모들은 사회경제적으로 중, 상류층과 소득고하를 막론하고 고위험산모들이 많고 조산소와 모자보건센터는 저소득충의 산모 가운데 산과적으로 저위험군들이 많이 이용하고 있다. 따라서 특정 의료기관을 대상으로 조사한 자료를 해석하는데 많은 제한성이 있으며 전체 산모의 특성으로 일반화하는 것은 불가능한 것으로 생각된다.

• Journal of Korean Neurosurgical Society
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• 제66권3호
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• pp.258-262
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• 2023

Germinal matrix-intraventricular hemorrhage (GM-IVH) is among the devastating neurological complications with mortality and neurodevelopmental disability rates ranging from 14.7% to 44.7% in preterm infants. The medical techniques have improved throughout the years, as the morbidity-free survival rate of very-low-birth-weight infants has increased; however, the neonatal and long-term morbidity rates have not significantly improved. To this date, there is no strong evidence on pharmacological management on GM-IVH, due to the limitation of well-designed randomized controlled studies. However, recombinant human erythropoietin administration in preterm infants seems to be the only effective pharmacological management in limited situations. Hence, further high-quality collaborative research studies are warranted in the future to ensure better outcomes among preterm infants with GM-IVH.

• Journal of Nutrition and Health
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• 제55권5호
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• pp.572-586
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• 2022

본 연구는 미숙아의 체중을 추적 조사하여 성장곡선 체중 z-score 값으로 성장 상태를 확인하고 관련 요인을 탐색하기 위한 종단적 연구이다. 출생 체중, 재태연령, 출생 시 NICU에서의 의료적 처치 (CPR, 산소치료, 위장관 삽관), NICU 입원 기간 및 퇴원연령, 수유 문제, 일일 추정 수유량이 체중 성장에 유의하게 영향을 가지는 것이 확인되었다. 출생 체중과 연령이 적은 그룹이 유의하게 초기 성장 정도가 더 낮았으나 교정연령 3개월 이후부터 12개월까지의 체중에 차이가 없었다. 하지만 재태연령 40주 이후의 연령-체중 z-score가 평균 이하인 그룹이 출생 체중이 유의하게 낮은 것으로 보아 장기적인 성장에 출생체중이 영향을 미치는 것으로 보인다. 또한 NICU에서 의료적 처치를 받고 NICU 입원 기간이 긴 경우 성장곡선의 50 백분율 이하로 성장에 유의한 차이가 있었고, 퇴원 후 2개월간 수유과정 중 문제가 없으며 더 많은 양을 섭취한 그룹이 성장곡선에서 더 상위에 있었으며 더 잘 자랐다. 또한 NICU 퇴원 후 가정에서 자녀가 초기보다 하향 성장을 하고 있을 때, 외부의 도움 및 커뮤니티 케어를 필요로 하므로 미숙아 성장 지원을 위하여 커뮤니티 케어 도입의 필요성을 시사하였다. 본 연구 결과를 통하여 미숙아의 출생 체중 및 연령, NICU에서의 처치는 초기의 체중 성장에 영향을 끼치며, 재태연령 40주 이후의 성장 증진과 성장지연 위험을 감소시키기 위해서 올바른 섭취를 통한 원활한 영양공급이 중요함을 알 수 있다. 미숙아 성장 추적은 NICU 퇴원 후에도 지속되어야 하며 성장 증진 관련 변수, 특히 영양 지원에 적극적인 개입과 지지가 필요하다.

• 여성건강간호학회지
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• 제8권3호
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• pp.424-434
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• 2002

Background & purpose Since the 1970's the rate of breast-feeding has decreased significantly. The Korean National Institute of Health reported that the rate of breastfeeding was 68.9% in 1982 and 14.1% in 1997. There are many influencing factors including: the lack of education and information on breast feeding, lack of faith in breast feeding, increment of the rate of working, lack of encouragement by supporters in difficult situations, and nurses' low level of knowledge about breast feeding. Such a lack of knowledge and support of breast-feeding at home by family members create another dilemma to the problem of breast-feeding. If problems arise and family members are unable to provide assistance due to the deficiency of knowledge, mothers show a tendency to abandon breast-feeding. The purpose of this research is to find out the rate of breast-feeding practice by time sequence of 1 week, 6 weeks and 12 weeks after birth and influencing factors on breast-feeding practice centered on the postpartal women who were 3discharged from one hospital, which is located in Seoul and provides simple breast-feeding education and continuous postnatal telephone consultation. Methodology The subjects of this research were 54 women who gave birth in a hospital located in Seoul from 1 March 2000 to 31 April 2000. After birth the subjects were educated individually about breast-feeding and telephone consultations were conducted. On the 1st week, 6th week, and 12th week, the subjects were surveyed about their breast-feeding practice rates and methods by telephone. Results 1) Complete breast-feeding rate: Within one week after birth, the subjects showed 64.2% complete breast-feeding rate. Within 6 weeks, 39.6%, and 12 weeks, 34.1%. 2) Partial breast-feeding rate: Within one week after birth, the subjects showed 32.1% partial breast-feeding rate. Within 6 weeks, 39.6%, and 12 weeks 15.1%. 3) Complete bottle-feeding rate Within one week after birth, the subjects showed 1.9% complete bottle-feeding rate. Within 6 weeks of giving birth 15.1%, and 12 weeks 17.0%. These results show that individual education about breast-feeding and continuous postnatal telephone consultation influenced on the practice of breast-feeding. On considering the reality of the hospital situation in which nurses could not operate education program due to the work-load, it is necessary to find out selectively those mothers who are unable to breast feed and provide education individually and continuous support by telephone follow up. Futhermore, the active role of lactation nurse specialist and their efficient management of breast-feeding for the successful practice is required.