Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Pharmacological Management of Germinal Matrix-Intraventricular Hemorrhage

  • Jaewoo Chung (Department of Neurosurgery, Dankook University College of Medicine) ;
  • Sang Koo Lee (Department of Neurosurgery, Dankook University College of Medicine) ;
  • Chun-Sung Cho (Department of Neurosurgery, Dankook University College of Medicine) ;
  • Young Jin Kim (Department of Neurosurgery, Dankook University College of Medicine) ;
  • Jung Ho Ko (Department of Neurosurgery, Dankook University College of Medicine) ;
  • Jung-Ho Yun (Department of Neurosurgery, Dankook University College of Medicine) ;
  • Jin-Shup So (Department of Neurosurgery, Dankook University Hospital) ;
  • In-Ho Jung (Department of Neurosurgery, Dankook University Hospital)
  • Received : 2022.12.05
  • Accepted : 2023.02.14
  • Published : 2023.05.01
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Abstract

Germinal matrix-intraventricular hemorrhage (GM-IVH) is among the devastating neurological complications with mortality and neurodevelopmental disability rates ranging from 14.7% to 44.7% in preterm infants. The medical techniques have improved throughout the years, as the morbidity-free survival rate of very-low-birth-weight infants has increased; however, the neonatal and long-term morbidity rates have not significantly improved. To this date, there is no strong evidence on pharmacological management on GM-IVH, due to the limitation of well-designed randomized controlled studies. However, recombinant human erythropoietin administration in preterm infants seems to be the only effective pharmacological management in limited situations. Hence, further high-quality collaborative research studies are warranted in the future to ensure better outcomes among preterm infants with GM-IVH.

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References

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