• Molecules and Cells
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• v.37 no.7
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• pp.540-546
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• 2014

Several types of genetic and epigenetic regulation have been implicated in the development of drug resistance, one significant challenge for cancer therapy. Although changes in the expression of non-coding RNA are also responsible for drug resistance, the specific identities and roles of them remain to be elucidated. Long non-coding RNAs (lncRNAs) are a type of ncRNA (> 200 nt) that influence the regulation of gene expression in various ways. In this study, we aimed to identify differentially expressed lncRNAs in 5-fluorouracil-resistant colon cancer cells. Using two pairs of 5-FU-resistant cells derived from the human colon cancer cell lines SNU-C4 and SNU-C5, we analyzed the expression of 90 lncRNAs by qPCR-based profiling and found that 19 and 23 lncRNAs were differentially expressed in SNU-C4R and SNU-C5R cells, respectively. We confirmed that snaR and BACE1AS were down-regulated in resistant cells. To further investigate the effects of snaR on cell growth, cell viability and cell cycle were analyzed after transfection of siRNAs targeting snaR. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. Our results provide an important insight into the involvement of lncRNAs in 5-FU resistance in colon cancer cells.

• Journal of the Korean Society of Radiology
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• v.10 no.5
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• pp.307-312
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• 2016

Alzheimer's disease is the most common degenerative brain diseases that causes dementia. ${\beta}$-amyloid neuritic plaque density that accumulates in the brain is difficult to perform daily living, such as memory loss, language ability deterioration. It is used to estimate ${\beta}$-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive impairment. Using the $^{18}F$-Florbetaben with high sensitivity and specificity for the ${\beta}$-amyloid neuritic plaque density to evaluate the usefulness for the early diagnosis of Alzheimer's disease. In $^{18}F$-FDG Brain imaging shows no specific findings. And it appeared on the MR-Brain imaging without atrophy of the hippocampus. However, the intake of ${\beta}$-amyloid neuritic plaque density in $^{18}F$-Florbetaben informs that it is the progress of Alzheimer's disease. Therefore, $^{18}F$-Florobetaben is very useful for early diagnosis of Alzheimer's disease.

• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.2
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• pp.211-216
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• 2008

In this study, we have developed a program which can calculate phase and group velocities, attenuation and wave structures of each mode in multi-layered plates. The wave structures of each mode are obtained, varying material properties and number of layers. The key in the success of guided wave NDE is how to optimize the mode selection scheme by minimizing energy loss when a structure is in contact with liquid. In this study, the normalized out-of-plane displacements at the surface of a free plate are used to predict the variation of modal attenuation and verily the correlation between attenuation and wave structure. It turns out that the guided wave attenuation can be efficiently obtain from the out-of-plane displacement variation of a free wave guide alleviating such mathematical difficulties in extracting complex roots for the eigenvalue problem of a liquid loaded wave guide. Through this study, the concert to optimize guided wave mode selection is accomplished to enhance sensitivity and efficiency in nondestructive evaluation for multi-layered structures.

• Journal of dental hygiene science
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• v.17 no.3
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• pp.202-208
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• 2017

Korea has been running the community oral health program for the elderly, including topical fluoride application and scaling. The aim of this study was to compare the subjective and objective oral health status of 345 participants according to the number of participants in the program and of 37 participants before and after the 5-year program. The survey consisted of an interview questionnaire and oral examinations. Analysis of variance was used to compare the variables of the 345 participants according to the numbers of participants. Paired t-test was used to compare the oral health statuses before and after the 5-year program in 37 subjects. There was no difference in subjective oral health status according to the number of participants in the oral health program in the elderly, including subjective health status, subjective oral health status, satisfaction with oral health, concern about oral health, need of dental treatment, oral pain, tooth sensitivity, subjective periodontal health, and subjective symptoms of periodontitis. The community periodontal index (CPI) of the 1 time participants was significantly higher than that of 3 times, 4 times or 5 times participants in the upper center, lower left, lower center, and lower right areas. There was a significant improvement in CPI from $2.59{\pm}1.14$ to $1.41{\pm}1.54$ (p<0.001) and positive oral behavioral change (daily tooth brushing frequency from $2.27{\pm}0.73$ to $2.54{\pm}0.90$) before and 5 years after the program. However, the program did not prevent tooth loss as the numbers of the remaining teeth significantly reduced from $23.77{\pm}1.84$ to $21.95{\pm}2.03$ over 5 years. We showed that running the community oral health program for the elderly for more than three years might have positive effects on the periodontal health of participants.

• Nuclear Engineering and Technology
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• v.38 no.2
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• pp.185-194
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• 2006

Transient operations for an integral type reactor, SMART-P, have been experimentally investigated using a thermal-hydraulic integral test facility, VISTA (Experimental Verification by Integral Simulation of Transients and Accidents), in order to verify the system design and performance of the SMART-P, a pilot plant of SMART. The VISTA facility was subjected to various accident conditions such as feedwater increase and decrease, loss of coolant flow, and control rod withdrawal accidents in order to elucidate the thermal-hydraulic responses following such accidents and finally to verify the system design of the SMARTP. Full functional control logics have been implemented in the VISTA facility in order to control the required control action for an accident simulation. As one of the sensitivity tests to verify the PRHRS performance, the effects of the initial water level in the compensation tank are experimentally investigated. When the initial water level is 16%, the water is quickly drained and nitrogen gas is then introduced into the PRHR system, resulting in deterioration of the PRHRS performance. It is thus found that nitrogen ingression should be prevented to ensure stable PRHRS operation.

• Journal of Energy Engineering
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• v.14 no.1
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• pp.54-61
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• 2005

The APR1400 is an Advanced Pressurized Water Reactor with 3983 MWt power, 2×4 loops, and direct vessel injection system. The Fluidic Device (FD) is adopted to regulate the safety injection flow rate in a Safety Injection Tank (SIT) of APR1400. The performance of a newly designed fluidic Device is evaluated by analyzing a Large Break Loss-of-Coolant Accident (LBLOCA) using TRAC-M/F90, version 3.782. The analysis results show that the TRAC-M code reasonably predicts the important phenomena of blowdown, refill and reflood phases of LBLOCA. The sensitivity studies about gas/water volume changes in a SIT and K factor changes in a SI system were also done to understand the important phenomena with a Fluidic Device in APR1400.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.10
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• pp.1151-1156
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• 2012

In this paper, the baseband filter is proposed in order to maintain a constant sensitivity regardless of distances for 77 GHz automotive radar system. Using existing DCOC loop circuit can remove DC offset and also cancel differences of received power depending on the distance. Measured results show that the maximum gain is 51 dB and high pass cutoff frequency can be tuned from 5 kHz to 15 kHz. The slope of high pass filter can be tuned from -10 to -40 dB/decade for the distance compensation. The measured NF and IIP3 are 26 dB and +4.5 dBm with 4.3 mA at 1.0 V supply voltage, respectively. The fabricated die size $500{\mu}m{\times}1,050{\mu}m$ excluding the in/out pads.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.75-76
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• 2008

본 논문에서는 한국형 에너지 관리 시스템의 계통 해석용 프로그램을 위한 공통 데이터 모델의 구축에 대해 다루었다. 공통 데이터 모델이란 다양한 어플리케이션이 공유하여 사용할 수 있는 계통 모델의 데이터베이스를 가리키며 본 논문에서는 토폴로지 프로세서(topology processor, TP), 상태추정(state estimator, SE), 급전원 조류계산(dispatcher power flow, DPF), 휴전계획(outage scheduler, OS), 부하 분포계수(bus load distribution factor, BLDF), 송전 손실 민감도 계수(transmission loss sensitivity factor, TLSF) 등을 위한 공통 모델에 대해 다루었다. 공통 모델의 구축을 위해 각 어플리케이션에서 필요한 정보를 수집하여 전력계통의 토폴로지 구조과 계통 설비를 모델링 하였다. 최종적으로 계층적(hierarchy) 구조와 비계층적(non-hierarchy) 구조로 나뉘어진 직접(direct) 및 간접(indirect) 인덱스 코드를 사용하여 데이터로의 빠른 접근이 가능한 실시간 데이터베이스 형태를 제시하였다.

• BMB Reports
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• v.41 no.6
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• pp.448-454
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• 2008

Two full-length cDNAs, PutPMP3-1 and PutPMP3-2, encoding PMP3 family proteins were isolated from Puccinellia tenuiflora, a monocotyledonous halophyte. Expression of both genes was induced by low temperature, salt stress, dehydration, ABA, and $NaHCO_3$. Transcripts of PutPMP3-2 were more strongly induced by these stresses relative to those of PutPMP3-1, particularly under low temperature and dehydration conditions. Expression of PutPMP3-1 and PutPMP3-2 in yeast mutants lacking the PMP3 gene can functionally complement the membrane hyper-polarization and salt sensitivity phenotypes resulting from PMP3 deletion. To compare the functions of PutPMP3-1 and PutPMP3-2, the orthologous genes in rice (OsLti6a and OsLti6b) were isolated. Both OsLti6a and OsLti6b could functionally complement the loss of PMP3 in yeast. PutPMP3-2 and OsLti6a were more effective in reversing membrane hyperpolarization than PutPMP3-1 and OsLti6b. However, the four yeast transformants each showed similar levels of salt tolerance. These results imply that these PMP3 family members don't function identically under different stress tolerance conditions.

• Journal of Advanced Marine Engineering and Technology
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• v.34 no.6
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• pp.846-851
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• 2010

A liquid-air interface sensing system using the flat end surfaces of a fused-silica fiber coupler has been demonstrated. The principle is based on the additional optical loss caused by changing the refractive index of the external material at the boundary of the end face made of a fiber. The immersion characteristics of this system with respect to the different splitting ratios of the couplers were investigated to determine the sensitivity when it responses to water and air. These experimental data are very useful for selecting the coupling ratio of a coupler in order to develop a multiple sensing probe system. In the proposed sensor structure, it can be emphasize that the sensing probe can be appropriately arrayed on the basis of splitting ratio of the coupler. As a result, it is expected that the proposed liquid-air interface sensors can also be applied to monitor flooding that occurs in multiple areas at the same time.