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http://dx.doi.org/10.7742/jksr.2016.10.5.307

Usefulness of 18F-Florbetaben in Alzheimer's Disease Diagnosis  

Lee, Hyo-Yeong (Department of Radiological Science, Dong Eui University)
Im, In-Chul (Department of Radiological Science, Dong Eui University)
Song, Min-jae (Department of Nuclear Medicine, Inje University Busan Paik Hospital)
Shin, Seong-gyu (Department of Radiology, Dong-A University Hospital)
Publication Information
Journal of the Korean Society of Radiology / v.10, no.5, 2016 , pp. 307-312 More about this Journal
Abstract
Alzheimer's disease is the most common degenerative brain diseases that causes dementia. ${\beta}$-amyloid neuritic plaque density that accumulates in the brain is difficult to perform daily living, such as memory loss, language ability deterioration. It is used to estimate ${\beta}$-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive impairment. Using the $^{18}F$-Florbetaben with high sensitivity and specificity for the ${\beta}$-amyloid neuritic plaque density to evaluate the usefulness for the early diagnosis of Alzheimer's disease. In $^{18}F$-FDG Brain imaging shows no specific findings. And it appeared on the MR-Brain imaging without atrophy of the hippocampus. However, the intake of ${\beta}$-amyloid neuritic plaque density in $^{18}F$-Florbetaben informs that it is the progress of Alzheimer's disease. Therefore, $^{18}F$-Florobetaben is very useful for early diagnosis of Alzheimer's disease.
Keywords
Alzheimer's disease; ${\beta}$-amyloid neuritic plaque density; $^{18}F$-Florbetaben;
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