• The Journal of the Convergence on Culture Technology
• /
• v.5 no.3
• /
• pp.317-326
• /
• 2019

The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both MAPK) and nuclear factor-kappa B (NF-${\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazin.

• The Journal of the Korea Contents Association
• /
• v.20 no.12
• /
• pp.417-425
• /
• 2020

In the present study, practical measures were to be presented for prevention of smartphone game addiction and school violence by analysis of the effects aspect of the smartphone game addition by elementary school students on school violence awareness. For this purpose, a questionnaire survey was conducted for the subject of 6th graders attending an elementary school located in K city of Jeollanam-do, and a total of 258 copies were utilized as the final analysis data. Considering the analysis results, significant differences in the smartphone game addition were observed first as a function of the elementary school students' sex and game use time. The level of smartphone game addiction was observed to become higher for male students than female students, and the higher the longer the game use time during a day. Secondly, a positive (+) correlation was observed to exist between the smartphone game addiction and the school violence awareness. Thirdly, the variable affecting the school violence awareness among individual sub-variables for the smartphone game addiction was shown to be a problem with loss of control and power of reality test. The higher the addiction level of each variable, the negative tendency for school violence awareness was shown to be increased. Based on such analysis results, policy-wise, practical suggestions as well as directions for the follow-up studies have been presented for the improvement of smartphone game addiction and school violence awareness.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.47 no.6
• /
• pp.445-453
• /
• 2021

Objectives: Periodontitis is the most common chronic disease that causes tooth loss and is related to systemic diseases such as cardiovascular disease and diabetes. An objective indicator of the current activity of periodontitis is necessary. Soluble forms of the receptor for advanced glycation end products (sRAGE) are markers that reflect the status of inflammatory diseases. In this study, the relationship between sRAGE and periodontitis was analyzed to determine whether it can be used to diagnose the current state of periodontitis. Patients and Methods: Eighty-four patients without any systemic diseases were diagnosed with periodontitis using three classifications of periodontitis. Demographics and oral examination data such as plaque index (PI), bleeding on probing (BOP) index, and probing pocket depth (PPD) were analyzed according to each classification. In addition, correlation and partial correlation between sRAGE and the values indicating periodontitis were analyzed. Results: In each classification, the level of sRAGE tended to decrease if periodontitis was present or severe, but this change was not statistically significant. sRAGE and periodontitis-related variables exhibited a weak correlation, among which the BOP index showed a relatively strong negative correlation (ρ=-0.20). Based on this, on analyzing the correlation between the BOP index and sRAGE in the group with more severe periodontitis (PPD≥5 mm group, severe group of AAP/CDC [American Academy of Periodontology/Centers for Disease Control and Prevention], periodontitis group of López), the correlation further increased (ρ=-0.23, -0.40, -0.50). Partial correlation analysis of the sRAGE and BOP index showed a stronger negative correlation (ρ=-0.36, -0.55, -0.45). Conclusion: sRAGE demonstrated a tendency to decrease upon increased severity of periodontitis according to the classifications used. Above all, the correlation with the BOP index, which reflects the current state of periodontitis, was higher in the group with severe periodontitis. This indicates that the current status of periodontitis can be diagnosed through sRAGE.

• Journal of Internet Computing and Services
• /
• v.23 no.3
• /
• pp.47-56
• /
• 2022

The safe driving reward system aims to reduce the loss of life and property by reducing the occurrence of accidents by motivating safe driving and encouraging active participation by providing direct reward to vehicle drivers who have performed safe driving. In the case of the existing digital tachograph, the goal is to limit dangerous driving by recording the driving status of the vehicle whereas the safe driving reward system is a support measure to increase the effect of accident prevention and induces safe driving with financial reward when safe driving is performed. In other words, in an area where accidents due to speeding are high, direct reward is provided to motivate safe driving to prevent traffic accidents when safe driving instructions such as speed compliance, maintaining distance between vehicles, and driving in designated lanes are performed. Since these safe operation data and reward histories must be managed transparently and safely, the reward evidences and histories were constructed using the closed blockchain Hyperledger Fabric. However, while transparency and safety are guaranteed in the blockchain system, low data processing speed is a problem. In this study, the sequential block generation speed was as low as 10 TPS(transaction per second), and as a result of applying the acceleration function a high-performance network of 1,000 TPS or more was implemented.

• Journal of Korean Society of Disaster and Security
• /
• v.14 no.4
• /
• pp.17-27
• /
• 2021

Streamflow prediction is a very vital disaster mitigation approach for effective flood management and water resources planning. Lately, torrential rainfall caused by climate change has been reported to have increased globally, thereby causing enormous infrastructural loss, properties and lives. This study evaluates the contribution of rainfall to streamflow prediction in normal and peak rainfall scenarios, typical of the recent flood at Piney Resort in Vernon, Hickman County, Tennessee, United States. Daily streamflow, water level, and rainfall data for 20 years (2000-2019) from two USGS gage stations (03602500 upstream and 03599500 downstream) of the Piney River watershed were obtained, preprocesssed and fitted with Long short term memory (LSTM) model. Tensorflow and Keras machine learning frameworks were used with Python to predict streamflow values with a sequence size of 14 days, to determine whether the model could have predicted the flooding event in August 21, 2021. Model skill analysis showed that LSTM model with full data (water level, streamflow and rainfall) performed better than the Naive Model except some rainfall models, indicating that only rainfall is insufficient for streamflow prediction. The final LSTM model recorded optimal NSE and RMSE values of 0.68 and 13.84 m³/s and predicted peak flow with the lowest prediction error of 11.6%, indicating that the final model could have predicted the flood on August 24, 2021 given a peak rainfall scenario. Adequate knowledge of rainfall patterns will guide hydrologists and disaster prevention managers in designing efficient early warning systems and policies aimed at mitigating flood risks.

• The Korea Journal of Herbology
• /
• v.33 no.3
• /
• pp.63-70
• /
• 2018

Objective : Previous studies showed that water extract of Plantago asiatica (Plantaginis asiaticae Folium, PAF) significantly controlled in body weights, adipose tissue weights and blood lipid profiles in obese C57BL/6 mice. To investigate the mechanism of anti-obesity action of PAF, expressions of obesity-related proteins were identified such as p-AMPK and p-ACC in hypothalamus, UCP-1 in brown adipose tissue, p-AMPK, p-ACC, SREBP-1c, $PPAR{\gamma}$, HMGCR and CPT-1 in liver. Method : Five-weeks old male C57BL/6 mice were divided into 5 groups; ND (normal diet + 0.9% saline), HFD (high-fat diet + 0.9% saline), PC (high-fat diet+Garcinia cambogia 500 mg/kg), PAF 100 and 300 (high-fat diet + PAF 100 or 300 mg/kg). PAF was treated orally for 6 weeks. The protein expression of AMPK, p-AMPK, ACC, p-ACC, $PPAR{\gamma}$, SREBP-1c, HMGCR, CPT-1 and UCP-1 were identified by expression levels of proteins through western blot analysis. Result : The results showed that protein expressions on hypothalamic p-AMPK and p-ACC did not differ between the HFD and PAF groups. In addition, PAF did not affect the increase of UCP-1 in brown adipose tissue. The protein expression levels of hepatic p-AMPK, p-ACC and CPT-1 increased in PAF groups compared to HFD group. And those of $PPAR{\gamma}$, SREBP-1c and HMG-CoA decreased in PAF groups compared to HFD group. Conclusion : These results suggest that the PAF administration induce weight loss via inhibition of lipid metabolism-related protein expressions in hepatic tissues. Therefore, PAF could be used as a potent material of anti-obesity products for prevention and treatment of obesity.

• Journal of Applied Biological Chemistry
• /
• v.65 no.4
• /
• pp.269-275
• /
• 2022

Betula platyphylla extract includes various materials which showed biological activity such as terpenoids. For this reason, Betula platyphylla extract has been used to alleviate inflammation. In this study, extract of Betula platyphylla was obtained and purified using several solvents and evaluated whether they showed effect on prevention of hair loss. Cell cytotoxicity assay was performed to investigate the effect of extracts on cell proliferation. Western blotting was performed to observe the changes in expression of several related growth factors such as β-catenin, VEGF, IGF1, and cyclin D. Also, 5-α-reductase activity was measured. The ethyl acetate extract was divided into four partial extracts and named as H3-1, H3-2, H3-3, and H3-4. The H3-2 extract showed proliferation activity of human derma papilla cell and increased the protein expression of several related growth factors such as β-catenin, VEGF, IGF1, and cyclin D, comparable to the effect of Ethyl 3,4,5-Trimethoxy Benzoate (ETB)and Lupeol (LPO). Moreover, we found that the fraction H3 was shown to decrease 5-α-reductase activity while ETB and LPO had no significant effect on 5-α-reductase activity.

• 한국체육학회지인문사회과학편
• /
• v.51 no.4
• /
• pp.407-417
• /
• 2012

The purpose of the study was to determine the effects of pilates mat exercise on cardiovascular disease risk factors and inflammation markers in sarcopenic obesity elderly. All subjects were sarcopenic obesity(height for each of the arms, legs, appendicular muscle mass ratio of 1.16kg/m², 4.31kg/m², 5.21kg/m² under and % body fat is more than 30%) elderly performed the pilates mat exercise during 12-week for 60 minutes 3 times a weeks. All subjects of this study were examined the changes in cardiovascular disease risk factors(TC, TG, HDL-C, LDL-C, Glucose, Insulin) and inflammation markers(fibrinogen, adiponectin, leptin, CRP). The results of the study in the exercise group were as follows; The weight, % body fat, TC, TG, LDL-C, fibrinogen, CRP had significantly decreased and muscle mass, HDL-C, adiponectin had significantly increased. And also, pilates mat exercise can effective to improve sarcopenic obesity, and pilates mat exercises performed coy shrink obesity to cardiovascular disease and inflammatory response indicators of older women as old man's physical features of the deterioration of the prevention of obesity and muscle strength loss, causing the effective exercise method is meant to be.

• Journal of Service Research and Studies
• /
• v.13 no.1
• /
• pp.176-185
• /
• 2023

This study is a study to develop a model to measure the economic performance when introducing industrial safety design, which is emerging as a necessity for industrial accident prevention measures due to the increase in the industrial site nursing accident rate and the enforcement of the Serious Accident Punishment Act. To this end, studies on the concept of industrial safety management and industrial safety design and economic performance measurement in the field of industrial safety were conducted in terms of theoretical background. Based on the theoretical background, opinions on drafts of related indicators were collected through user opinion surveys, and focus group interviews and Delphi techniques were conducted with experts, and research was conducted to advance the model. In order to secure objectivity, the causal relationship between the introduction of industrial safety design, cost reduction effect, and sales increase effect was tested through regression analysis. After going through these steps, two models of economic performance measurement of industrial safety design were finally developed: a model based on the first-stage disaster loss cost reduction effect and a second-stage sales increase effect. In order to be applied to actual industrial sites, it should be able to be presented as a standard for the degree of service level agreement of industrial safety design beyond a simple checklist.

• Asia Marketing Journal
• /
• v.10 no.4
• /
• pp.1-33
• /
• 2009

This research investigates the effect of brand-self identification on brand attachment and brand commitment focusing on luxury brand. Another purpose of this study is to examine how the relationships among brand identification, brand attachment and brand committment are moderated by consumers' regulatory focus. Structural Equation Modeling using 214 questionnaires was conducted to test hypothesized model. The results reveal that perceived luxury brand personality including excitement, competence, and sophistication influences brand-self identification positively, which in turn has a signifiant positive effect on the brand attachment. It is also found that consumers' emotional attachment to luxury brands has a positive influence on the luxury brand commitment while the effect of the brand-self identification on the brand commitment is not signifiant. This finding strongly supports that brand attachment and brand commitment are distinct construct, which confirms the results of the previous studies. In addition, the results show that consumers-luxury brands relationships are moderated by consumers' regulatory focus. This finding explains that prevention-focused individuals who have interdependent self-view respond to the loss caused by relationship break more sensitively compared to the promotion-focused consumers. Finally, based on the findings of this study, theoretical contribution and managerial implications are discussed.