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http://dx.doi.org/10.17703/JCCT.2019.5.3.317

The Effects of Heated Radish Extract on the Prevention of Ulcerative Colitis Inflammation  

Kim, Hyun Kyoung (Dept. of Food Science and Enginerring, Seowon Univ)
Publication Information
The Journal of the Convergence on Culture Technology / v.5, no.3, 2019 , pp. 317-326 More about this Journal
Abstract
The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both MAPK) and nuclear factor-kappa B (NF-${\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazin.
Keywords
Heated radish extract; Dextran sulfate sodium; Ulcerative colitis; Apoptosist; Sulfasalazine;
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Times Cited By KSCI : 6  (Citation Analysis)
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