• Biomolecules & Therapeutics
• /
• v.28 no.2
• /
• pp.152-162
• /
• 2020

Cerebral ischemia exhibits a multiplicity of pathophysiological mechanisms. During ischemic stroke, the reactive oxygen species (ROS) concentration rises to a peak during reperfusion, possibly underlying neuronal death. Recombinant human erythropoietin (EPO) supplementation is one method of treating neurodegenerative disease by reducing the generation of ROS. We investigated the therapeutic effect of PEGylated EPO (P-EPO) on ischemic stroke. Mice were administered P-EPO (5,000 U/kg) via intravenous injection, and middle cerebral artery occlusion (MCAO) followed by reperfusion was performed to induce in vivo ischemic stroke. P-EPO ameliorated MCAO-induced neurological deficit and reduced behavioral disorder and the infarct area. Moreover, lipid peroxidation, expression of inflammatory proteins (cyclooxygenase-2 and inducible nitric oxide synthase), and cytokine levels in blood were reduced by the P-EPO treatment. In addition, higher activation of nuclear factor kappa B (NF-κB) was found in the brain after MCAO, but NF-κB activation was reduced in the P-EPO-injected group. Treatment with the NF-κB inhibitor PS-1145 (5 mg/kg) abolished the P-EPO-induced reduction of infarct volume, neuronal death, neuroinflammation, and oxidative stress. Moreover, P-EPO was more effective than EPO (5,000 U/kg) and similar to a tissue plasminogen activator (10 mg/kg). An in vitro study revealed that P-EPO (25, 50, and 100 U/mL) treatment protected against rotenone (100 nM)-induced neuronal loss, neuroinflammation, oxidative stress, and NF-κB activity. These results indicate that the administration of P-EPO exerted neuroprotective effects on cerebral ischemia damage through anti-oxidant and anti-inflammatory properties by inhibiting NF-κB activation.

• Journal of Navigation and Port Research
• /
• v.40 no.6
• /
• pp.469-476
• /
• 2016

This study investigates cargo management issues in the shipbuilding and marine equipment industry. Problems are analyzed concerning the absence of information about exact cargo location and condition, damage, loss, replacement, and transportation delays during the import and export process. Then, improvements are proposed to solve these problems. To illustrate, real time information about the status and location of cargo should be communicated between import/export and logistics companies to facilitate material logistics for shipbuilding & marine equipment. In addition, a standard cargo classification and recognition system should be established to reduce delivery delays and mistakes, so then enhancing logistical efficiency. Moreover, it is also necessary to nurture professional shipbuilding & marine equipment forwarders to strengthen their expertise with professional education and training.

• Archives of Plastic Surgery
• /
• v.47 no.2
• /
• pp.187-193
• /
• 2020

Upper limb nerve damage is a common condition, and evidence suggests that functional recovery may be limited following peripheral nerve repair in cases of delayed reconstruction or reconstruction of long nerve defects. A 26-year-old man presented with traumatic injury from a wide, blunt wound of the right forearm caused by broken glass, with soft tissue loss, complete transection of the radial and ulnar arteries, and a large median nerve gap. The patient underwent debridement and subsequent surgery with a microsurgical free radial fasciocutaneous flap to provide a direct blood supply to the hand; the cephalic vein within the flap was employed as a venous vascularized chamber to wrap the sural nerve graft and to repair the wide gap (14 cm) in the median nerve. During the postoperative period, the patient followed an intensive rehabilitation program and was monitored for functional performance over 5 years of follow-up. Our assessment demonstrated skin tropism and sufficient muscle power to act against strong resistance (M5) in the muscles previously affected by paralysis, as well as a good localization of stimuli in the median nerve region and an imperfect recovery of two-point discrimination (S3+). We propose a novel and efficient procedure to repair >10-cm peripheral nerve gap injuries related to upper limb trauma.

• Korean Journal of Agricultural Science
• /
• v.39 no.4
• /
• pp.467-471
• /
• 2012

In this study, we investigated the antioxidative and antiaging activity of Perilla frutescens using LLC-$PK_1$ porcine renal epithelial cell and WI-38 human diploid fibroblast cell. The extract from Perilla frutescens showed strong protective effect against nitric oxide (NO) and superoxide ($O_2{^-}$)-induced oxidative stress generated by sodium nitroprusside (SNP) and pyrogallol, respectively. The result showed that P. frutescens increased the cell viability and showed scavenging activity of NO and $O_2{^-}$. In addition, the extract of P. frutescens exerted the protective effect against peroxynitrite ($ONOO^-$) induced by 3-morpholinosydnonimine. It suggests that P. frutescens would have the protective role against $ONOO^-$ itself and its precursors, NO and $O_2{^-}$. Furthermore, the aging model of hydrogen peroxide ($H_2O_2$)-treated WI-38 human diploid fibroblast was employed to investigate the anti-aging effect of P. frutescens. $H_2O_2$-treated WI-38 cells showed the loss of cell viability, however before-treatment with P. frutescens to WI-38 cells under premature senescence could delay the cellular aging process. The present study suggests the antioxidative and antiaging potential against free radical-induced oxidative damage of P. frutescens.

• Journal of the Korean Society of Safety
• /
• v.27 no.6
• /
• pp.172-177
• /
• 2012

In areas around Deoksan Li and Deokjeon Li, Inje Eup, Inje Gun, located between $38^{\circ}2^{\prime}55^{{\prime}{\prime}}N$ and $38^{\circ}5^{\prime}50^{{\prime}{\prime}}N$ in latitude and $128^{\circ}11^{\prime}20^{{\prime}{\prime}}E$ and $128^{\circ}18^{\prime}20^{{\prime}{\prime}}E$ in longitude, large-sized avalanche disasters occurred due to Typhoon Ewiniar in 2006. As a result, 29 people were dead or missing, along with a total of 37.25 billion won of financial loss(Gangwon Province, 2006). To evaluate such landslide and debris flow risk areas and their vulnerability, this study applied a technique called 'Weight of Evidence' based on GIS. Especially based on the overlay analysis of aerial images before the occurrence of landslides and debris flows in 2005 and after 2006, this study extracted 475 damage-occurrence areas in a shape of point, and established a DB by using such factors as topography, hydrologic, soil and forest physiognomy through GIS. For the prediction diagram of debris flow and landslide risk areas, this study calculated W+ and W-, the weighted values of each factor of Weight Evidence, while overlaying the weighted values of factors. Besides, the diagram showed about 76% in prediction accuracy, and it was also found to have a relatively high correlationship with the areas where such natural disasters actually occurred.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.25 no.4
• /
• pp.476-481
• /
• 2019

Early detection of fire is an important measure for minimizing the loss of life and property damage. However, fire and smoke need to be simultaneously detected. In this context, numerous studies have been conducted on image-based fire detection. Conventional fire detection methods are compute-intensive and comprise several algorithms for extracting the flame and smoke characteristics. Hence, deep learning algorithms and convolution neural networks can be alternatively employed for fire detection. In this study, recorded image data of fire in a ship engine room were analyzed. The flame and smoke characteristics were extracted from the outer box, and the YOLO (You Only Look Once) convolutional neural network algorithm was subsequently employed for learning and testing. Experimental results were evaluated with respect to three attributes, namely detection rate, error rate, and accuracy. The respective values of detection rate, error rate, and accuracy are found to be 0.994, 0.011, and 0.998 for the flame, 0.978, 0.021, and 0.978 for the smoke, and the calculation time is found to be 0.009 s.

• Journal of Internet Computing and Services
• /
• v.20 no.3
• /
• pp.1-11
• /
• 2019

Today's software systems are becoming larger and more complicated, and the risk of accidents and failures have also grown larger. Software failures and accidents in industrial fields such as automobiles, nuclear power plants, railroad industries, etc. may lead to severe damage of property and human life. The safety-related international standards, such as IEC 61508 have been established and applied to industries for decades. The safety life cycle specified in the standards emphasize the activities to develop safety requirements through hazard and risk analysis in the early stage of software development. In this paper, we propose 'Hazard Analysis Process based on STPA using SysML' in order to ensure the safety of software at the early stage of software development. The proposed hazard analysis can be effectively performed minimizing the loss of hazard by using the BDD and the IBD of SysML to define the control structure of a system. The proposed method also improves the specification of the safety constraints(requirement) by using SD. As a result, it is possible to identify the hazard without missing and identify the hazard scenarios in detail, and safety can be sufficiently ensured in the early stage of software development.

• The Journal of Engineering Geology
• /
• v.33 no.3
• /
• pp.489-502
• /
• 2023

Urban floods pose significant challenges to cities worldwide, driven by the interplay between urbanization and climate change. This review examines recent studies of urban floods to understand their causes, impacts, and potential mitigation strategies. Urbanization, with its increase in impermeable surfaces and altered drainage patterns, disrupts natural water flow, exacerbating surface runoff during intense rainfall events. The impacts of urban floods are far-reaching, affecting lives, infrastructure, the economy, and the environment. Loss of life, property damage, disruptions to critical services, and environmental consequences underscore the urgency of effective urban flood management. To mitigate urban floods, integrated flood management strategies are crucial. Sustainable urban planning, green infrastructure, and improved drainage systems play pivotal roles in reducing flood vulnerabilities. Early warning systems, emergency response planning, and community engagement are essential components of flood preparedness and resilience. Looking to the future, climate change projections indicate increased flood risks, necessitating resilience and adaptation measures. Advances in research, data collection, and modeling techniques will enable more accurate flood predictions, thus guiding decision-making. In conclusion, urban flooding demands urgent attention and comprehensive strategies to protect lives, infrastructure, and the economy.

• The Journal of Korean Medicine
• /
• v.25 no.4
• /
• pp.61-78
• /
• 2004

Objective : This study was undertaken to determine whether Gamibaegi-eum (BGU) in vitro and in vivo exerts a beneficial effect against cell injury induced by reactive oxygen species (ROS) in the human intestine. Methods : Effects of BGU in vitro on cell injury were examined using Caco-2 cells, cultured human intestinal cell line. Exposure of cells to H₂O₂ induced increases in the loss of cell viability in a time and dose-dependent fashion. Results : BGU prevented H₂O₂-induced cell death and its effect was dose-dependent over a concentration range of 0.05­1%. H₂O₂-induced cell death was prevented by catalase, the hydrogen peroxide scavenger enzyme, and deferoxamine, the iron chelator. However, the potent antioxidant DPPD did not affect H₂O₂-induced cell death. H₂O₂ increased lipid peroxidation, which was inhibited by BGU and DPPD. H₂O₂ caused DNA damage in a dose-dependent manner, which was prevented by BGU, catalase, and deferoxamine, but not DPPD. BGU restored ATP depletion induced by H₂O₂. BGU inhibited generation of superoxide and H₂O₂ and scavenged directly H₂O₂. Oral administration of mepirizole in vivo at a dose of 200mg/kg resulted in ulcer lesions in the stomach and the proximal duodenum. Pretreatment of BGU(0.1%/kg, orally) and catalase (800Units/kg, i.v.) significantly decreased the size of ulcers. Mepirizole increased lipid peroxidation in the mucosa of the duodenum, suggesting an involvement of ROS. Pretreatment of BGU and catalase significantly inhibited lipid peroxidation induced by mepirizole. Morphological studies showed that mepirizole treatment causes duodenal injury and its effect is prevented by BGU. Conclusion : These results indicate that BGU exerts a protective effect against cell injury in vitro and in vivo through antioxidant action. The present study suggests that BGU may playa therapeutic role in the treatment of human gastrointestinal diseases mediated by ROS.

• Journal of Periodontal and Implant Science
• /
• v.42 no.3
• /
• pp.67-72
• /
• 2012

Purpose: Rheumatoid arthritis (RA) is a chronic multi-systemic disease that causes damage to the bone and connective tissues. This study was conducted in order to accurately measure the correlation between RA and periodontitis, and to obtain an unbiased estimate of the effect of RA on periodontal indices. Methods: In this historical cohort study, which was conducted from February to May 2011 in Hamadan city, Iran, 53 exposed people (with RA) were compared with 53 unexposed people (without RA) in terms of clinical periodontal indices (the outcomes of interest) including 1) plaque index (PI), 2) bleeding on probing (BOP), and 3) clinical attachment loss (CAL). Results: A sample of 106 volunteers were evaluated, 53 rheumatoid versus 53 non-rheumatoid subjects. There was a statistically significant correlation between RA and BOP (P<0.001) and between RA and CAL (P<0.001). However, there was no statistically significant correlation between RA and any of the periodontal indices. No correlation was seen between gender and any of the indices either. There was a strong positive correlation between age and all three periodontal indices (P<0.001). Conclusions: The present study indicated a potential effect of RA on periodontal indices. However, much more evidence based on a prospective cohort study is needed to support the cause and effect relationship between RA and periodontal indices.