• Biomedical Science Letters
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• v.29 no.4
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• pp.330-335
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• 2023

The corazonin (Crz) gene showed two subtypes of different length at laval and pupal stage. The long subtype fade out in adult central nerve system (CNS) but the short one survive through all the life cycle from larva to adult. The short subtype has the same base sequences with mature Crz mRNA and detected in both brain and ventral nerve cord (VNC). The long one, on the contrary, was detected only in the brain tissue. As observed in above results, Crz neurons develop in different pattern in the CNS of scuttle fly and the Crz gene expresses two different subtypes. These results suggest that this neurotransmitter may perform differential neurophysiological functions in the scuttle fly. Variation in the amino acid composition of the final active undecapeptide supports in strong those possibilities. We expect further studies on the relationship between neurophysiological functions of Crz and behavioral characteristics of the scuttle fly.

• Journal of the Korean Society of Costume
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• v.50 no.7
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• pp.113-127
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• 2000

The purpose of this study was to examine the symbolic meaning of oriental numbers based on Yin-Yang(陰陽) theory. Based on the thought of Yin-Yang Wu-Hsing(陰陽五行), the number was divided the number of the heaven (positive number) 1, 3. 5, 7, 9 from the number cf the earth(negative number) 2. 4, 6, 8, 10. It was descrived very well in the dress and its ornaments and the folk customs. In the costume of the Court, there were 9, 7, 5, 3 patterns costume for the king and queen. Even though an even number, 12 patterns costume for the emperor symbolized 12 months and made it of the principal of the universe. Korean traditional costume Han-bock(韓服) was formed with the three dimentional principal of circle (圓.$\bigcirc$), square(方.$\square$) and triangularity(角.$\Delta$). In the middle of odd numbers, number 3 was regarded as a holy number of the heaven (天), the earth(地) and a man(人). Taken for a highest number. number 3 had the symbolism of wishes for good fortune. Number 10 and number 100, which meant the fullness and the long life, were used regularly. With Ten longevity patterns(十長生紋), the feast of a hundred-day-old baby, our race prayed for the healthy long life. As mentioned above. the symbolism of the number though the costume prefered the positive number to the negative one. Accommodating to the universal principal and the cycle. The deep meaning and the symbolism of the number has been implied the mental wishes.

• Clean Technology
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• v.27 no.3
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• pp.223-231
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• 2021

In order to address many issues associated with large volume changes of silicon, which has very low electrical conductivity but offers about 10 times higher theoretical capacity than graphite (Gr), a silicon nanoparticles/hollow carbon (SiNP/HC) composite having bimodal-mesopores was prepared using silica nanoparticles as a template. A control SiNP/C composite without a hollow structure was also prepared for comparison. The physico-chemical and electrochemical properties of SiNP/HC were analyzed by X-ray diffractometry, X-ray photoelectron spectroscopy, nitrogen adsorption/desorption measurements for surface area and pore size distribution, scanning electron microscopy, transmission electron microscopy, galvanostatic cycling, and cyclic voltammetry tests to compare them with those of the SiNP/C composite. The SiNP/HC composite showed significantly better cycle life and efficiency than the SiNP/C, with minimal increase in electrode thickness after long cycles. A hybrid composite, SiNP/HC@Gr, prepared by physical mixing of the SiNP/HC and Gr at a 50:50 weight ratio, exhibited even better cycle life and efficiency than the SiNP/HC at low capacity. Thus, silicon/carbon composites designed to have hollow spaces capable of accommodating volume expansion were found to be highly effective for long cycle life of silicon-based composites. However, further study is required to improve the low initial coulombic efficiency of SiNP/HC and SiNP/HC@Gr, which is possibly because of their high surface area causing excessive electrolyte decomposition for the formation of solid-electrolyte-interface layers.

• 한국사회정책
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• v.23 no.1
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• pp.203-225
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• 2016

The permanent disability benefit(PDB) system whose purpose lies in helping affected workers with their self-realization through compensating them for their work-related injury or disease and facilitating their timely return to work is very important in terms of social welfare. Actually, the portions of PDB's in all WCI expenditures have been on the sharp increase. In spite of its positive aspects like this, however, an excessive amount of PDB's may have negative impacts on the affected workers' will to work or return to work, and increasing trends in the amount of PDB's payable in annuity will remain in an aging or aged society a potentially risky factor posing a threat to the soundness of WCI budgets. In this respect, the author attempted herein to identify the long-term reality of trends in the number of claimants entitled to PDB's and the amount of PDB's payable to them through making the long-term budget projections of PDB's; address problems with PDB's payable in annuity, which are or will potentially be one of the gravest burdens in securing the soundness of WCI budgets; and discuss how to optimize the amount of PDB's through studying & analyzing overseas cases and income replacement rates and what kinds of improvements are thinkable. It's recommended to reduce the absolute amount of benefits payable in annuity in a phased way considering claimants' life-cycle instead of sticking to the current system, which takes the form of lifelong pension plan.

• Journal of the Korean housing association
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• v.23 no.6
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• pp.49-59
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• 2012

This study suggested a new model in consideration of long life and constructability of apartment house suggested in the former part. New model suggested the possibility of cost saving based on the idea that people trend to reject because of the recognition that the new model would cost a lot of expense which work as the barrier for the expansion and distribution at the local market so as to prepare the ground for its activation. The Study was aimed at verifying the possibility of cost saving through comparing it with the existing standard apartment house system centered on the skeleton and cladding system among the new structural design models suggested in the former part. Assuming that these existing standard both models should be changed structural design into new model system, the quantity volume, cost and construction period along with the alteration of finished materials between two models were compared altogether. Simultaneously BIM library was built for easy taking-off bill of quantity and consideration of working methodology for construction working cycle, which was translated into construction cost so as to derive the cost of the two subject systems to be counted. Through the analysis, it was concluded that new model would secure variability in the future and constructability along with shortening the construction period (29%) and achieve cost saving (13%) of construction against the those of existing model.

• Structural Engineering and Mechanics
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• v.52 no.5
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• pp.889-901
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• 2014

Very long life fatigue tests were carried out on 16Mn steel base metal and its welded joint by using the ultrasonic fatigue testing technique. Specimen shapes (round and plate) were considered for both the base metal and welded joint. The results show that the specimens present different S-N curve characteristics in the region of $10^5-10^9$ cycles. The round specimens showed continuously decreasing tendency while plate specimens showed a steep decreasing step and an asymptotic horizontal one. The fatigue strength of round specimen was found higher than plate specimen. The fatigue strength of as-welded joint was 45.0% of the base material for butt joint and 40% for cruciform as-welded joint. It was found that fracture can still occur in butt joint beyond $5{\times}10^6$ cycles. The cruciform joint has a fatigue limit in the very long life fatigue regime ($10^7-10^9$ cycles). Fatigue strength of butt as-welded joint was much higher as compared to cruciform as-welded joint. Improvement in fatigue strength of welded joint was found due to UPT. The observation of fracture surface showed crack mainly initiated from welded toe at fusion areas or geometric discontinuity sites at the surface in butt joint and from welded toe in cruciform joint.

• Biomolecules & Therapeutics
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• v.21 no.2
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• pp.114-120
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• 2013

Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma cells to B-Raf inhibitor, we used chronic selection to establish B-Raf (V600E) melanoma clones with acquired resistance to the new oncogenic B-Raf inhibitor UI-152. Whereas the parental A375P cells were highly sensitive to UI-152 ($IC_{50}$ < $0.5{\mu}M$), the resistant sub-line (A375P/Mdr) displayed strong resistance to UI-152 ($IC_{50}$ < $20{\mu}M$). Immunofluorescence analysis indicated the absence of an increase in the levels of P-glycoprotein multidrug resistance (MDR) transporter in A375P/Mdr cells, suggesting that resistance was not attributable to P-glycoprotein overexpression. In UI-152-sensitive A375P cells, the anti-proliferative activity of UI-152 appeared to be due to cell-cycle arrest at $G_0/G_1$ with the induction of apoptosis. However, we found that A375P/Mdr cells were resistant to the apoptosis induced by UI-152. Interestingly, UI-152 preferentially induced autophagy in A375P/Mdr cells but not in A375P cells, as determined by GFP-LC3 puncta/cell counts. Further, autophagy inhibition with 3-methyladenine (3-MA) partially augmented growth inhibition of A375P/Mdr cells by UI-152, which implies that a high level of autophagy may protect UI-152-treated cells from undergoing growth inhibition. Together, our data implicate high rates of autophagy as a key mechanism of acquired resistance to the oncogenic B-Raf inhibitor, in support of clinical studies in which combination therapy with autophagy targeted drugs is being designed to overcome resistance.

• Journal of the Korean housing association
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• v.16 no.5
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• pp.67-74
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• 2005

The performance of building should be deteriorated with time while the building would maintain and manage the function and performance to get a living condition. For the efficient maintenance of the building, the repair cycle would be provided and applied during the service-life time. The service-life time of the building components would be needed to determine the repair time and the repair scope. The service-life time of the building components would be calculated with the 1st repair time and the recovery rate of the performance, considering the recovery rate after repaired. In this paper, the 1st repair time would be estimated with the normal probability distribution, choice probability and 3rd quadratic function. The recovery rate of the building components assumes various level according to the research target and utility area. The results of this study are as follows ; first, most of the components of the building work would range about 30 years in the service-life time and the components of the mechanical works range from 28 years to 37 years, those of the electrical works would be about 31 years.

• Management & Information Systems Review
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• v.7
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• pp.227-245
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• 2001

The object that we have researched the design for a long life of product is to search for the method to cope with the various environment problems where our mankind is confronting in the field of Production Design. The environment problem on earth is affecting seriously the enterprise which produces the product, the user who consumes it and even the field of product design. Now we live our daily life with a lot of artifacts while the citification and modernization have been progressing around us. Especially, 20 century was the times of the highly advanced scientific civilization and industrialization. Therefore it affected decisively our life environment base nowadays. The result was that our human life became rich because of the advanced development of industry, productivity and distribution structure. On the other side, the industrial system in the period of these massive production and massive consuming is bearing various problems proportionally. Those are the depletion of resources and energy, earth environmental pollution and various kinds of waste. In addition, the material which cannot recycle is appearing at the large quantity. This is the actuality of now. Our subject is how product design will cope with it as counter measures and the subject is very important to our mankind and earth environment.

• Clean Technology
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• v.21 no.2
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• pp.85-89
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• 2015

Utilized in a variety of electronic components, electronic components industry with metallic ink technology was established itself as a major technology research and development was gradually increasing, silver ink that is excellent in conductivity and stability, have long been used in the industry of electronic components in recent years and silver ink has been the size of nanoscale particles dispersed by developing display, an electronic tag, a flexible circuit board or the like used in the semiconductor and electronics as has been highlighted in, however industry modernization of equipment by increasing the production and consumption of products generated during the production process and environmental pollutants by use of waste products is expected to bring a serious environmental problem. In this study, prepared by a wet reduction method, the manufacturing process of the silver nano-ink to the entire process of the environmental impact assessment (LCA) was evaluated using the techniques. Life cycle assessment software GaBi 6 was used as received from the relevant agencies of the silver nano-ink data with reference to the manufacturing process, building inventory was international organization for standardization (ISO) 14040, 14044 compliant LCA conducted over four stages.