1 |
Shintani, T., Yamazaki, F., Katoh, T., Umekawa, M., Matahira, Y., Hori, S., Kakizuka, A., Totani, K., Yamamoto, K. and Ashida, H. (2010) Glucosamine induces autophagy via an mTOR-independent pathway. Biochem. Biophys. Res. Commun. 391, 1775-1779.
DOI
ScienceOn
|
2 |
Su, F., Bradley, W. D., Wang, Q., Yang, H., Xu, L., Higgins, B., Kolinsky, K., Packman, K., Kim, M. J., Trunzer, K., Lee, R. J., Schostack, K., Carter, J., Albert, T., Germer, S., Rosinski, J., Martin, M., Simcox, M. E., Lestini, B., Heimbrook, D. and Bollag, G. (2012) Resistance to selective braf inhibition can be mediated by modest upstream pathway activation. Cancer Res. 72, 969-978.
DOI
|
3 |
Tsai, J., Lee, J. T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N. K., Sproesser, K., Li, L., Smalley, K. S., Fong, D., Zhu, Y. L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S. H., Schlessinger, J., Zhang, K. Y., West, B. L., Powell, B., Habets, G., Zhang, C., Ibrahim, P. N., Hirth, P., Artis, D. R., Herlyn, M. and Bollag, G. (2008) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc. Natl. Acad. Sci. U.S.A. 105, 3041-3046.
DOI
ScienceOn
|
4 |
Ullman, E., Fan, Y., Stawowczyk, M., Chen, H. M., Yue, Z. and Zong, W. X. (2008) Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ. 15, 422-425.
DOI
ScienceOn
|
5 |
Williams, A., Sarkar, S., Cuddon, P., Ttofi, E. K., Saiki, S., Siddiqi, F. H., Jahreiss, L., Fleming, A., Pask, D., Goldsmith, P., O'Kane, C. J., Floto, R. A. and Rubinsztein, D. C. (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 4, 295-305.
DOI
ScienceOn
|
6 |
Wu, C. P., Calcagno, A. M. and Ambudkar, S. V. (2008) Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. Curr. Mol. Pharmacol. 1, 93-105.
DOI
|
7 |
Wu, Y. T., Tan, H. L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., Ong, C. N., Codogno, P. and Shen, H. M. (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J. Biol. Chem. 285, 10850-10861.
DOI
|
8 |
McCubrey J, A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Wong, E. W., Chang, F., Lehmann, B., Terrian, D. M., Milella, M., Tafuri, A., Stivala, F., Libra, M., Basecke, J., Evangelisti, C., Martielli, A. M. and Franklin, R. A. (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biocheim. Biophys. Acta 1773, 1263-1284.
DOI
ScienceOn
|
9 |
Nazarian, R., Shi, H., Wang, Q., Kong, X., Koya, R. C., Lee, H., Chen, Z., Lee, M. K., Attar, N., Sazegar, H., Chodon, T., Nelson, S. F., McArthur, G., Sosman, J. A., Ribas, A. and Lo, R. S. (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468, 973-977.
DOI
ScienceOn
|
10 |
Ng, G. and Huang, J. (2005) The significance of autophagy in cancer. Mol. Carcinog. 43, 183-187.
DOI
ScienceOn
|
11 |
Nobili, S., Landini, I., Giglioni, B. and Mini, E. (2006) Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 7, 861-879.
DOI
ScienceOn
|
12 |
Pao, W., Miller, V. A., Politi, K. A., Riely, G. J., Somwar, R., Zakowski, M. F., Kris, M. G. and Varmus, H. (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, e73.
DOI
ScienceOn
|
13 |
Engelman, J. A. and Janne, P. A. (2008) Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin. Cancer Res. 14, 2895-2899.
DOI
ScienceOn
|
14 |
Pattingre, S., Bauvy, C. and Codogno, P. (2003) Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J. Biol. Chem. 278, 16667-16674.
DOI
ScienceOn
|
15 |
Petiot, A., Ogier-Denis, E., Blommaart, E. F., Meijer, A. J. and Codogno, P. (2000) Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275, 992-998.
DOI
ScienceOn
|
16 |
Seglen, P. O. and Gordon, P. B. (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 79, 1889-1992.
DOI
ScienceOn
|
17 |
Flaherty, K. T., Puzanov, I., Kim, K. B., Ribas, A., McArthur, G. A., Sosman, J. A., O'Dwyer, P. J., Lee, R. J., Grippo, J. F., Nolop, K. and Chapman, P. B. (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 908-819.
|
18 |
Gottesman, M. M. (2002) Mechanisms of cancer drug resistanace. Annu. Rev. Med. 53, 615-627.
DOI
ScienceOn
|
19 |
Jiang, C. C., Lai, F., Thorne, R. F., Yang, F., Liu, H., Hersey, P. and Zhang, X. D. (2011) MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720. Clin. Cancer Res. 17, 721-730.
DOI
|
20 |
Johannessen, C. M., Boehm, J. S., Kim, S. Y., Thomas, S. R., Wardwell, L., Johnson, L. A., Emery, C. M., Stransky, N., Cogdill, A. P., Barretina, J., Caponigro, G., Hieronymus, H., Murray, R. R., Salehi-Ashtiani, K., Hill, D. E., Vidal, M., Zhao, J. J., Yang, X., Alkan, O., Kim, S., Harris, J. L., Wilson, C. J., Myer, V. E., Finan, P. M., Root, D. E., Roberts, T. M., Golub, T., Flaherty, K. T., Dummer, R., Weber, B. L., Sellers, W. R., Schlegel, R., Wargo, J. A., Hahn, W. C. and Garraway, L. A. (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468, 968-972.
DOI
ScienceOn
|
21 |
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y. and Yoshimori, T. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19, 5720-5728.
DOI
ScienceOn
|
22 |
Karbowniczek, M., Cash, T., Cheung, M., Robertson, G. P., Astrinidis, A. and Henske, E. P. (2004) Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J. Biol. Chem. 279, 29930-29937.
DOI
ScienceOn
|
23 |
Kim, Y.-K., Ahn, S. K. and Lee, M. (2012) Differential sensitivity of melanoma cell lines with differing B-Raf mutational status to the new oncogenic B-Raf kinase inhibitor UI-152. Cancer Lett. 320, 215-224.
DOI
ScienceOn
|
24 |
Ma, X., Piao, S., Wang, D. W., McAfee, Q. W., Nathanson, K. L., Lum, J. J., Li, L. Z. and Amaravadi, R. K. (2011) Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clin. Cancer Res. 17, 3478-3489.
DOI
|
25 |
Maddodi, N., Huang, W., Havighurst, T., Kim, K., Longley, B. J. and Setaluri, V. (2010) Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF. J. Invest. Dermatol. 130, 1657-1667.
DOI
ScienceOn
|
26 |
Marcus, A. I., Peters, U., Thomas, S. L., Garrett, S., Zelnak, A., Kapoor, T. M. and Giannakakou, P. (2005) Mitotic kinesin inhibitors induce mitotic arrest and cell death in taxol-resistant and -sensitive cancer cells. J. Biol. Chem. 280, 11569-11577.
DOI
ScienceOn
|
27 |
Blagosklonny, M. V. (2007) Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events. Cell Cycle 6, 70-74.
DOI
|
28 |
Ahn, J.-H. and Lee, M. (2011) Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2. Cancer Lett. 310, 188-197.
DOI
ScienceOn
|
29 |
Ahn, J.-H., Ahn, S. K. and Lee, M. (2012) The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts. Biochem. Biophys. Res. Commun. 417, 857-863.
DOI
ScienceOn
|
30 |
Ahn, J.-H., Eum, K.-H. and Lee, M. (2010) Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts. BMB Rep. 43, 205-211.
DOI
ScienceOn
|
31 |
Cagnol, S. and Chambard, J. C. (2010) ERK and cell death: mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence. FEBS J. 277, 2-21.
DOI
ScienceOn
|
32 |
Corcelle, E., Nebout, M., Bekri, S., Gauthier, N., Hofman, P., Poujeol, P., Fenichel, P. and Mograbi, B. (2006) Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Cancer Res. 66, 6861-6870.
DOI
ScienceOn
|
33 |
Dhomen, N. and Marais, R. (2009) BRAF signaling and targeted therapies in melanoma. Hematol. Oncol. Clin. North Am. 23, 529-545.
DOI
ScienceOn
|
34 |
Eisen, T., Ahmad, T., Flaherty, K. T., Gore, M., Kaye, S., Marais, R., Gibbens, I., Hackett, S., James, M., Schuchter, L. M., Nathanson, K. L., Xia, C., Simantov, R., Schwartz, B., Poulin-Costello, M., O'Dwyer, P. J. and Ratain, M. J. (2006) Sorafenib in advanced melanoma: A Phase II randomised discontinuation trial analysis. Br. J. Cancer 95, 581-586.
DOI
ScienceOn
|