• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.33-39
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• 1994

We have studied the effect of loading amount and particle size on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) matrix. Release rate increased as the loading amount and particle size increase. We also studied the effect of additives (lactose and algin) on the rate of release of 5-FU. Both algin and lactose promoted the rate of release. The ability to increase the rate is in the order of algin>lactose>5-FU. Scanning electron microscope study clearly shows that large cavities and cracks are created. The results imply that, by the proper combinations of the amount of the additive, $EVA_c$ and drug, the rate of drug release can be modulated over a wide range of values.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05c
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• pp.193-198
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• 1996

The effect of dynamic strain aging (DSA) on the leak-before-break (LBB) analysis was estimated through the evaluation of leakage-size-crack and flaw stability in SA106 Gr.C piping steel. Also. the results were represented as a form of "LBB allowable load window". In the DSA temperature region. the leakage-size-crack length was smaller than that at other temperatures and it increased with increasing tensile strain rate. In the results of flaw stability analysis. the lowest instability load appeared at the temperature corresponding to minimum J- R curve which was caused by DSA. The instability load near the plant operating temperature depended on the loading rate of J-R data. and decreased with increasing tensile strain rate. These are due to the strain hardening characteristic and strain rate sensitivity of DSA. In the "LBB allowable load window". LBB allowable region was the narrowest at the temperature and loading conditions where DSA occurs.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.7
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• pp.116-125
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• 1997

An investigation was performed to study the impact damage in CFRP laminated composites subjected to impact loading. A finite element model has been developed for predicting the impact damage in laminated composite plates resulting from the ballistic impact. The finite element model was based on the higher-order shear deformation theory and was used to predict the initial intraply matrix cracking and the shape and size of interface delamination in laminated composites. Numerical simulation was performed and then the initiation of the matrix cracking and the shape and size of impacted induced delamination were predicted, and te results were compared with those of impact experiments with the same dimension and stacking sequences. A linear relationship holds between impact velocity and length and width of delamination. As impact velocity is increased, the increase of delamination length is highger than the increase of delamination width.

• Computers and Concrete
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• v.16 no.5
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• pp.683-701
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• 2015

When approached using nonlinear finite element (FE) techniques, structural analyses generate, for real RC structures, large complex numerical problems. Damage is a major part of concrete behavior, and the discretization technique is critical to limiting the size of the problem. Based on previous work, the ${\mu}$ damage model has been designed to activate the various damage effects correlated with monotonic and cyclic loading, including unilateral effects. Assumptions are formulated to simplify constitutive relationships while still allowing for a correct description of the main nonlinear effects. After presenting classical 2D finite element applications on structural elements, an enhanced simplified FE description including a damage description and based on the use of multi-fiber beam elements is provided. Improvements to this description are introduced both to prevent dependency on mesh size as damage evolves and to take into account specific phenomena (permanent strains and damping, steel-concrete debonding). Applications on RC structures subjected to cyclic loads are discussed, and results lead to justifying the various concepts and assumptions explained.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2002.10a
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• pp.147-152
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• 2002

The mechanism of the aerosol(mist) generation generally consists of spin-off, splash, and evaporation/condensation. Host researchers showed some theoretical model for predicting the particulate size and generation rate without real cutting in turning operation. These models were based on the spin-off mechanism, and verified good for modeling the process. However, in real machining, the cutting tool destroys the flow direction of the cutting fluid and generate the heat by the relative motion of between tool and workpicee, and so the mass loading of the mist is greatly increased as compared with non-cutting. In this paper, we show some experimental data that the mist formation characteristics of cutting is different from that of non-cutting.

• Wind and Structures
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• v.20 no.4
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• pp.489-508
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• 2015

In this paper, a novel methodology is proposed to obtain optimum location of outriggers. The method utilizes genetic algorithm (GA) for shape and size optimization of outrigger-braced tall structures. In spite of previous studies (simplified methods), current study is based on exact modeling of the structure in a computer program developed on Matlab in conjunction with OpenSees. In addition to that, exact wind loading distribution is calculated in accordance with ASCE 7-10. This is novel since in previous studies wind loading distributions were assumed to be uniform or triangular. Also, a new penalty coefficient is proposed which is suitable for optimization of tall buildings. Newly proposed penalty coefficient improves the performance of GA and results in a faster convergence. Optimum location and number of outriggers is investigated. Also, contribution of factors like central core and outrigger rigidity is assessed by analyzing several design examples. According to the results of analysis, exact wind load distribution and modeling of all structural elements, yields optimum designs which are in contrast of simplified methods results. For taller frames significant increase of wind pressure changes the optimum location of outriggers obtained by simplified methods. Ratio of optimum location to the height of the structure for minimizing weight and satisfying serviceability constraints is not a fixed value. Ratio highly depends on height of the structure, core and outriggers stiffness and lateral wind loading distribution.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.11a
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• pp.109-112
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• 2008

A performance of micro thruster was measured with catalyst bed that was prepared by different catalyst loading condition for the optimization of catalyst bed size. Among the catalyst loading conditions, pH level of precursor solution was changed by several solutions like Nitric acid or Sodium hydroxide. For the each case, it was heated at different drying temperatures that can affect the phase of catalyst loaded on support. From these results, it was studied that the effect of catalyst loading condition on the performance. 90wt% hydrogen peroxide was used as a monopropellant, and platinum was chosen as a catalyst. Characteristic velocity efficiency and temperature efficiency were used for the performance evaluation.

• Structural Engineering and Mechanics
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• v.84 no.3
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• pp.361-373
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• 2022

This paper examines the flexural performance of concrete beams reinforced with glass fibre-reinforced polymer (GFRP) bars under fatigue loading. Experiments were carried out on concrete beams of size 1500×200×100 mm reinforced with 10 mm and 13 mm diameter GFRP bars under fatigue loading. Experimental investigations revealed that fatigue loading affects both strength and serviceability properties of GFRP reinforced concrete. Experimental results indicated that (i) the concrete beams experienced increase in deflection with increase in number of cycles and failed suddenly due to snapping of rebars and (ii) the fatigue life of concrete beams drastically decreased with increase in stress level. Analytical model presented a procedure for predicting the deflection of concrete beams reinforced with GFRP bars under cyclic loading. Deflection of concrete beams was computed by considering the aspects such as stiffness degradation, force equilibrium equations and effective moment of inertia. Nonlinear finite element (FE) analysis was performed on concrete beams reinforced with GFRP bars. Appropriate constitutive relationships for concrete and GFRP bars were considered in the numerical modelling. Concrete non linearity has been accounted through concrete damage plasticity model available in ABAQUS. Deflection versus number of cycles obtained experimentally for various beams was compared with the analytical and numerical predictions. It was observed that the predicted values are comparable (less than 20% difference) with the corresponding experimental observations.

• Geomechanics and Engineering
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• v.35 no.6
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• pp.627-636
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• 2023

The essence of subgrade mud pumping under train load is the migration of fine particles in subgrade soil. The migration of fine particles will change the pore structure of overlying ballast, thus affecting the mechanical properties and hydraulic properties of ballast layer. It is of great theoretical significance and engineering value to study the effect of fine particle migration on the pore structure of ballast layer under cyclic loading. In this paper, a tailor-made subgrade mud pumping test model and an X-ray computed tomography (CT) scanning equipment were used to study the influence of migration of fine particles in subgrade soil on the pore parameters (plane porosity, volume porosity, pore distribution and pore connectivity) of overlying ballast under cyclic loading. The results show that the compression of ballast pores and the blockage of migrated fine particles make the porosity of ballast layer decreases gradually. And the percentage of small pores in ballast layer increases, while the percentage of large pores decreases; the connectivity of pores also gradually decreases. Based on the test results, an empirical model of ballast porosity evolution under cyclic loading is established and verified.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.4102-4102
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• 2001

In multivariate analysis, absorbance spectrum is measured over a band of wavelengths. One does not often pay attention to the size of this wavelength band. However, it is desirable that spectrum is measured at only necessary wavelengths as long as the acceptable accuracy of prediction can be met. In this paper, the method of selecting an optimal band of wavelengths based on the loading vector analysis was proposed and applied for determining total protein in human serum using near-infrared transmission spectroscopy and PLSR. Loading vectors in the full spectrum PLSR were used as reference in selecting wavelengths, but only the first loading vector was used since it explains the spectrum best. Absorbance spectra of sera from 97 outpatients were measured at 1530∼1850 nm with an interval of 2 nm. Total protein concentrations of sera were ranged from 5.1 to 7.7 g/㎗. Spectra were measured by Cary 5E spectrophotometer (Varian, Australia). Serum in the 5 mm-pathlength cuvette was put in the sample beam and air in the reference beam. Full spectrum PLSR was applied to determine total protein from sera. Next, the wavelength region of 1672∼1754 nm was selected based on the first loading vector analysis. Standard Error of Cross Validation (SECV) of full spectrum (1530∼l850 nm) PLSR and selected wavelength PLSR (1672∼1754 nm) was respectively 0.28 and 0.27 g/㎗. The prediction accuracy between the two bands was equal. Wavelength selection based on loading vector in PLSR seemed to be simple and robust in comparison to other methods based on correlation plot, regression vector and genetic algorithm. As a reference of wavelength selection for PLSR, the loading vector has the advantage over the correlation plot since the former is based on multivariate model whereas the latter, on univariate model. Wavelength selection by the first loading vector analysis requires shorter computation time than that by genetic algorithm and needs not smoothing.