Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지

Factors Affecting the Rate of Release of 5-Fluorouracil from Ethylene-Vinyl Acetate Matrices

  • Oh, Seaung-Youl (Biomaterial Laboratory, Korea Research Institute of Chemical Technology) ;
  • Chung, Hee-Won (Biomaterial Laboratory, Korea Research Institute of Chemical Technology) ;
  • Cho, Sun-Hang (Biomaterial Laboratory, Korea Research Institute of Chemical Technology) ;
  • Lee, Hai-Bang (Biomaterial Laboratory, Korea Research Institute of Chemical Technology)
  • Published : 1994.09.20
Download PDF
⟨ Previous Next ⟩

Abstract

We have studied the effect of loading amount and particle size on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) matrix. Release rate increased as the loading amount and particle size increase. We also studied the effect of additives (lactose and algin) on the rate of release of 5-FU. Both algin and lactose promoted the rate of release. The ability to increase the rate is in the order of algin>lactose>5-FU. Scanning electron microscope study clearly shows that large cavities and cracks are created. The results imply that, by the proper combinations of the amount of the additive, $EVA_c$ and drug, the rate of drug release can be modulated over a wide range of values.

Keywords