• 건축역사연구
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• 제16권6호
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• pp.101-120
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• 2007

This paper aims at studying on the medium of cultural interchange regarding who did and how to introduced the new trend of architecture during the period of Koryo Dynasty. Before the era of Koryo Dynasty, Kyungjang(Sutra Pitaka, 經藏) was mainly centered in Kyeongnu with a substantial function of storage. In the early Koryo Dynasty, however, Daejangjeon(大藏殿), which was spatialized for worship, began to appear. Normally, fixed walls were installed and the Sutras were enshrined inside Daejangjeon, while Jeonryunjang (revolving wheel sutras), a type of rational bookshelf, was introduced, and a new trend became developed in Kyungjang construction. Jeonryunjang(revolving wheel sutras, 轉輪藏) is a dharma instrument with a rotational function so that one revolution gives an effect of reading the enshrined Sutra one time, and began to be created actively in the period of the Northern Song. It is considered that the introduction of Jeonryunjang(revolving wheel sutras) to Daejangjeon was resulted from Haejokuksa(慧照國師) Damjin(曇眞) who visited the Kangnam areas in the Northern Song at that time. The Kangjeol areas in the Northern Song, where Damjin concentratively itinerated three times, were the place in which Jeonryunjang was created in many temples. Since Damjin, historical materials and excavated data regarding constructing Jeonryunjang have been discovered in the Buddhist temples, which are related to his pupils and dharma lineage. The only existing Jeonryunjang of Yongmusa Temple in Korea is the one that Joeung Daesunsa, who succeeded to the dharma lineage of Haesokuksa, promoted, and supports strongly such introduction of Jeonryunjang by Haesokuksa.

• 대한지리학회지
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• 제40권3호
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• pp.353-368
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• 2005

한국의 사회지리학은 영미 계통의 도시사회지리학을 중심으로 연구되어 왔으며 촌락사회지리학에 대해서는 개념적, 이론적 논의가 매우 빈곤한 편이다. 이 글에서는 20세기 전반 동안 촌락 경관에 대한 사회지리학적 연구로 시작된 독일 사회지리학의 개념적 기초를 파악한 후, 1980년대 이후 크게 발달한 영어권 촌락사회지리학의 등장 배경과 연구 동향을 조망하였다. 국내외 선행 연구들을 검토하면서 촌락 경관이 촌락성의 표상이며 지방과 국가 정체성의 핵심 요소가 된다는 점, 그리고 물리적 실체일 뿐만 아니라 사회적, 정신적, 문화적 실체라는 점을 정리할 수 있었고, 이러한 인식 위에서 한국 촌락의 경관적, 장소적 보편성과 특수성에 상응하는 주요 개념들을 모색해 보았다. 연구자는 이것을 세 가지 차원으로 나누어 제안하였는데, 지리적 사회집단으로서의 종족집단, 사회집단의 지역화과정, 사회적 공간으로서의 촌락권이 그것이다. 특히 전통 문화의 산실로서 촌락경관은 일상적 삶, 농업, 관광 사업의 중심에 있고 각 지역의 정체성은 물론 국가 정체성을 구성하는 매우 중요한 요소로 간주되고 있다. 이에 편승하여 최근에는 학제적 수준에서 마을 연구가 크게 부흥하고 있다. 연구자는 이러한 지성 세계의 동향에 촌락지리학이 동참하기 위해서는 사회지리학적 개념들과 역사지리적 시각에서 복안을 찾아야 할 것이라 제안하였다.

• 대한지리학회지
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• 제47권1호
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• pp.1-12
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• 2012

종족(宗族)과 월남민(越南民)의 아이덴티티로부터 확인되는 한국인의 특정한 집단적 정체성은 오랜 시간에 걸쳐 자연스럽게 형성된 것이 아니고 인위적으로 구성된 사회적 산물이다. 한국학을 지향하는 한국 인문지리학이 설정해야 할 목적 중 하나는 현대 한국인이 개인적으로나 집단적으로 공유하는 아이덴티티의 복합적이고도 경합적인 구성을 장소와의 관계 속에서 분석함으로써 보편적 한국인의 미래상, 즉 아이덴티티를 구체적으로 모색하는 것이다. 그러기 위해 한국 인문지리학은 아이덴티티, 장소, 이데올로기 또는 권력으로 구성되는 삼자 관계의 역동성, 지속성, 은밀성을 노출시키기 위하여 특정 장소를 연구의 출발점으로 삼을 필요가 있다. 그리고 이 때 한국 인문지리학이 지향해야 할 궁극적 목표는 전지구화의 시대에 적합한 장소 개념, 즉 외향적이고 진취적인 장소 의식을 한국인들에게 널리 전파시키는 것이다.

• Molecules and Cells
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• 제22권3호
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• pp.314-322
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• 2006

The whole mitochondrial genome (14,915 nt) of Pollicipes mitella (Crustacea, Maxillopoda, Cirripedia, Thoracica) was sequenced and characterized. It is the shortest of the 31 completely sequenced crustacean mitochondrial genomes, with the exception of a copepod Tigriopus japonicus (14,628 nt). It consists of the usual 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and 1 relatively short non-coding region (294 nt). The thoracican cirripeds apart from Megabalanus volcano have the same arrangement of protein-coding genes as Limulus polypemus, but there are frequent tRNA gene translocations (at least 8). Some interesting translocation features that may be specific to the thoracican cirriped lineage are as follows: 1) trnK-trnQ lies between the control region and trnI, 2) trnA-trnE lies between trnN and trnS1, 3) trnP lies between ND4L and trnT, and 4) trnY-trnC lies between trnS2 and ND1. In P. mitella there are two trnL genes (L1 and L2) in the typical crustacean positions (ND1-L1-LrRNA and CO1-L2-CO2). The present result is compared and discussed with the other three cirriped mitochondrial genomes from one pedunculate (Pollicipes polymerus) and two sessiles (Tetraclita japonica and M. volcano) published so far. Mitochondrial protein phylogenies reconstructed by the BI and ML algorithms show that the thoracican Cirripedia is monophyletic (BPP 100/BP 100) and associated with Remipedia (BPP 98/BP 35). In addition, Oligostraca, including Ostracoda, Branchiura, and Pentastomida, is a monophyletic group (BPP 99/BP 68), and is basal to all the other examined arthropods. Remipedia + Cirripedia appears as an independent lineage within Arthropoda, apart from Thoracopoda (Malacostraca, Branchiopda, and Cephalocarida). The Thoracopoda is paraphyletic to Hexapoda. The present result suggests that the monophylies of Crustacea and Maxillopoda should be reconsidered.

• Biomolecules & Therapeutics
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• 제28권1호
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• pp.34-44
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• 2020

Mesenchymal stem cells (MSCs) have been proposed as an alternative therapy to be applied into several pathologies of the nervous system. These cells can be obtained from adipose tissue, umbilical cord blood and bone marrow, among other tissues, and have remarkable therapeutic properties. MSCs can be isolated with high yield, which adds to their ability to differentiate into non-mesodermal cell types including neuronal lineage both in vivo and in vitro. They are able to restore damaged neural tissue, thus being suitable for the treatment of neural injuries, and possess immunosuppressive activity, which may be useful for the treatment of neurological disorders of inflammatory etiology. Although the long-term safety of MSC-based therapies remains unclear, a large amount of both pre-clinical and clinical trials have shown functional improvements in animal models of nervous system diseases following transplantation of MSCs. In fact, there are several ongoing clinical trials evaluating the possible benefits this cell-based therapy could provide to patients with neurological damage, as well as their clinical limitations. In this review we focus on the potential of MSCs as a therapeutic tool to treat neurological disorders, summarizing the state of the art of this topic and the most recent clinical studies.

• International Journal of Stem Cells
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• 제7권2호
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• pp.108-117
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• 2014

Background and Objectives: Genomic imprinting is an inheritance phenomenon by which a subset of genes are expressed from one allele of two homologous chromosomes in a parent of origin-specific manner. Even though fine-tuned regulation of genomic imprinting process is essential for normal development, no other means are available to study genomic imprinting in human during embryonic development. In relation with this bottleneck, differentiation of human embryonic stem cells (hESCs) into specialized lineages may be considered as an alternative to mimic human development. Methods and Results: In this study, hESCs were differentiated into three lineage cell types to analyze temporal and spatial expression of imprinted genes. Of 19 imprinted genes examined, 15 imprinted genes showed similar transcriptional level among two hESC lines and two human induced pluripotent stem cell (hiPSC) lines. Expressional patterns of most imprinted genes were varied in progenitors and fully differentiated cells which were derived from hESCs. Also, no consistence was observed in the expression pattern of imprinted genes within an imprinting domain during in vitro differentiation of hESCs into three lineage cell types. Conclusions: Transcriptional expression of imprinted genes is regulated in a cell type- specific manner in hESCs during in vitro differentiation.

• 헤리티지:역사와 과학
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• 제49권4호
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• pp.156-179
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• 2016

일본 이세만(伊勢灣) 바다의 가미시마(神島)에 있는 야츠시로(八代) 신사에는 거울을 중심으로 한 많은 중요문화재가 소장되어 있다. 그 중에 표비(??)가 포함되어 있는데, 통일신라시대 및 고려시대의 마구 계보와 연결되고 있음을 확신할 수 있다. 그와 유사한 사례를 포함하여 형식분류와 야츠시로 신사 소장 재갈의 위치 정립을 시행하였다. A형 재갈은 3형식으로 분류할 수 있었다. 이를 통해 야츠시로 신사 소장 재갈의 연대는 상대적으로 가장 늦은 단계의 형식에 속한다. 또한 이들 재갈을 제작하던 공방은 철기제작, 청동기제작, 단조 및 주조 기술을 보유하고 있던 공방이지만, 그 가운데 철기제작 기술과 형태를 우선하는 공방군으로 볼 수 있었다. 이들 재갈을 말에 장착했을 때, 외부에서 보이는 부분을 동합금으로 제작하고 함(銜) 및 입문(立聞)의 각부는 철 소재로 하는 등 청동기제작기술과 철기제작기술을 복합시켜 장식성과 실용성을 높이는 제작과정을 보이고 있다.

• Parasites, Hosts and Diseases
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• 제59권1호
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• pp.103-108
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• 2021

To date, there is no report on the genetic diversity of ticks in these regions. A total of 370 representative ticks from the south and east regions of Kazakhstan (SERK) and Xinjiang Uygur Autonomous Region (XUAR) were selected for molecular comparison. A fragment of the mitochondrial cytochrome c oxidase subunit I (cox1) gene, ranging from 631 bp to 889 bp, was used to analyze genetic diversity among these ticks. Phylogenetic analyses indicated 7 tick species including Hyalomma asiaticum, Hyalomma detritum, Hyalomma anatolicum, Dermacentor marginatus, Rhipicephalus sanguineus, Rhipicephalus turanicus and Haemaphysalis erinacei from the SERK clustered together with conspecific ticks from the XUAR. The network diagram of haplotypes showed that i) Hy. asiaticum from Almaty and Kyzylorda Oblasts together with that from Yuli County of XUAR constituted haplogroup H-2, and the lineage from Chimkent City of South Kazakhstan was newly evolved; and ii) the R. turanicus ticks sampled in Israel, Almaty, South Kazakhstan, Usu City, Ulugqat and Baicheng Counties of XUAR were derivated from an old lineage in Alataw City of XUAR. These findings indicate that: i) Hy. asiaticum, R. turanicus and Ha. erinacei shared genetic similarities between the SERK and XUAR; and ii) Hy. marginatum and D. reticulatus show differences in their evolution.

• Journal of Ginseng Research
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• 제46권1호
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• pp.104-114
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• 2022

Background: Abnormalities of myelin, which increases the efficiency of action potential conduction, are found in neurological disorders. Korean Red Ginseng (KRG) demonstrates therapeutic efficacy against some of these conditions, however effects on oligodendrocyte (OL)s are not well known. Here, we examined the effects of KRG-derived components on development and protection of OL-lineage cells. Methods: Primary OL precursor cell (OPC) cultures were prepared from neonatal mouse cortex. The protective efficacies of the KRG components were examined against inhibitors of mitochondrial respiratory chain activity. For in vivo function of Rb1 on myelination, after 10 days of oral gavage into adult male mice, forebrains were collected. OPC proliferation were assessed by BrdU incorporation, and differentiation and myelination were examined by qPCR, western blot and immunocytochemistry. Results: The non-saponin promoted OPC proliferation, while the saponin promoted differentiation. Both processes were mediated by AKT and extracellular regulated kinase (ERK) signaling. KRG extract, the saponin and non-saponin protected OPCs against oxidative stress, and both KRG extract and the saponin significantly increased the expression of the antioxidant enzyme. Among 11 major ginsenosides tested, Rb1 significantly increased OL membrane size in vitro. Moreover, Rb1 significantly increased myelin formation in adult mouse brain. Conclusion: All KRG components prevented OPC deaths under oxidative stress. While non-saponin promoted proliferation, saponin fraction increased differentiation and OL membrane size. Furthermore, among all the tested ginsenosides, Rb1 showed the biggest increase in the membrane size and significantly enhanced myelination in vivo. These results imply therapeutic potentials of KRG and Rb1 for myelin-related disorders.

• 한국노년학
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• 제34권2호
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• pp.277-297
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• 2014

본 연구는 청년기 손자녀의 인식을 기초로 조손간의 유대관계를 이해하는 것에 목적을 두었으며 손자녀 성(손자, 손녀)과 조부모 혈족(친조부모, 외조부모)에 따라 구분하여 조손관계를 분석하였다. 연구대상은 조부모님이 적어도 한 분 이상 생존해 계시는 만 19~25세의 청년세대 501명을 대상으로 자기보고식 설문지를 통해 평가하였다. 손자녀와 조부모간의 직접적 관계에 기초한 주요 특성변인들이 손자녀 성에 따라 차이가 있는지 t검증을 실시하고, 조손유대에 대한 부모특성변인들과 개인특성변인들의 설명력을 확인하기 위해 위계적 회귀분석을 실시하였으며, 그 결과는 다음과 같다. 첫째, 손자녀 성에 따라 친조부모와의 가치유사성, 친조부모와의 유대, 외조부모와의 접촉에서 유의미한 차이가 나타났다. 둘째, 지각된 아버지-조부모 관계 질, 어머니-조부모 관계 질, 접촉, 가치유사성은 모든 조손관계에서 조손유대를 유의미하게 예측하였으나, 각 특성변인의 상대적인 설명력은 각 조손관계에 따라 다양한 양상으로 나타나 조손유대를 설명하는 메커니즘이 손자, 손녀와 부계, 모계에 따라 다름을 보여주었다. 이러한 결과에 기초한 한국문화적 맥락에 따른 함의와 후속연구를 위한 제언을 논의에 제시하였다.