• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.8 no.6
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• pp.460-469
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• 2015

This study's aim is for reducing big data transfer time of IoT healthcare devices by modulating digital bits into Manchester code including zero-voltage idle as information for secondary compressed binary cluster's compartment after two step compression of compressing binary data into primary and secondary binary compressed clusters for each binary clusters having compression benefit of 1 bit or 2 bits. Also this study proposed that as department information of compressed binary clusters, inserting idle signal into Manchester code will have benefit of reducing transfer time in case of compressing binary cluster into secondary compressed binary cluster by 2 bits, because in spite of cost of 1 clock idle, another 1 bit benefit can play a role of reducing 1 clock transfer time. Idle signal is also never consecutive because the signal is for compartment information between two adjacent secondary compressed binary cluster. Voltage transition on basic rule of Manchester code is remaining while inserting idle signal, so DC balance can be guaranteed. This study's simulation result said that even compressed binary data by another compression algorithms could be transferred faster by as much as about 12.6 percents if using this method.

• Tuberculosis and Respiratory Diseases
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• v.45 no.4
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• pp.714-722
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• 1998

Background: Rifampicin (RFP) is a key component of the antituberculous short-course chemotherapy and the RFP resistance is a marker of multi-drug resistant (MDR) tuberculosis. RPoB gene encodes the $\beta$-subunit of RNA polymerase of M. tuberculosis which is the target of RFP. And the mutations of rpoB gene have been found in about 96% of rifampicin resistant clinical isolates of M. tuberculosis. So in order to find a rapid and clinically useful diagnostic method in identifying the RFP resistance, we compared the PCR -line probe method with PCR-SSCP for the detection of the rpoB gene mutation in cultured M. tuberculosis. Methods: 45 clinical isolates were collected from patients who visited Sung Kyun Kwan University Hospital. The RFP susceptibility test was referred to the referral laboratory of the Korean Tuberculosis Institute. 33 were rifampicin resistant and 12 were rifampicin susceptible. The susceptibility results were compared with the results of the PCR-BSCP and PCR-line probe method. Results: We could find rpoB mutations in 27/33(81.8%) RFP-resistant strains by PCR-line probe method, and in 23/33 (69.7%) by PCR-SSCP and there was no significant difference between two methods. There was no mutation in rifampicinn susceptible strains by both methods. Conclusion: PCR-line probe method would be a rapid, sensitive and specific method for the detection of rifampicin resistant Mycobacterium tuberculosis.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.255-260
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• 2012

Patients with non-small cell lung cancer (NSCLC) who have activating epidermal growth factor receptor (EGFR) mutations derive clinical benefit from treatment with EGFR-tyrosine kinase inhibitors ((EGFR-TKIs)-namely gefitinib and erlotinib. However, these patients eventually develop resistance to EGFR-TKIs. Despite the fact that this acquired resistance may be the result of a secondary mutation in the EGFR gene, such as T790M or amplification of the MET proto-oncogene, there are other mechanisms which need to be explored. MicroRNAs (miRs) are a class of small non-coding RNAs that play pivotal roles in tumorigenesis, tumor progression and chemo-resistance. In this study, we firstly successfully established a gefitinib resistant cell line-HCC827/GR, by exposing normal HCC827 cells (an NSCLC cell line with a 746E-750A in-frame deletion of EGFR gene) to increasing concentrations of gefitinib. Then, we found that miR-214 was significantly up-regulated in HCC827/GR. We also showed that miR-214 and PTEN were inversely expressed in HCC827/GR. Knockdown of miR-214 altered the expression of PTEN and p-AKT and re-sensitized HCC827/GR to gefitinib. Taken together, miR-214 may regulate the acquired resistance to gefitinib in HCC827 via PTEN/AKT signaling pathway. Suppression of miR-214 may thus reverse the acquired resistance to EGFR-TKIs therapy.

• Journal of IKEEE
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• v.2 no.1 s.2
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• pp.150-159
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• 1998

This paper described the recognition of the Off-line handwritten Hangul based on neural network using a feature extraction method. Features of Hangul can be extracted by a $5{\times}5$ window method which is the modified $3{\times}3$ mask method. These features are coded to binary patterns in order to use neural network's inputs efficiently. Hangul character is recognized by the consonant, the vertical vowel, and the horizontal vowel, separately. In order to verify the recognition rate, three different coding methods were used for neural networks. Three methods were the fixed-code method, the learned-code I method, and the learned-code II method. The result was shown that the learned-code II method was the best among three methods. The result of the learned-code II method was shown 100% recognition rate for the vertical vowel, 100% for the horizontal vowel, and 98.33% for the learned consonants and 93.75% for the new consonants.

• Molecules and Cells
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• v.37 no.2
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• pp.149-160
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• 2014

Plant breeders have focused on improving plant architecture as an effective means to increase crop yield. Here, we identify the main-effect quantitative trait loci (QTLs) for plant shape-related traits in rice (Oryza sativa) and find candidate genes by applying whole genome re-sequencing of two parental cultivars using next-generation sequencing. To identify QTLs influencing plant shape, we analyzed six traits: plant height, tiller number, panicle diameter, panicle length, flag leaf length, and flag leaf width. We performed QTL analysis with 178 $F_7$ recombinant inbred lines (RILs) from a cross of japonica rice line 'SNU-SG1' and indica rice line 'Milyang23'. Using 131 molecular markers, including 28 insertion/deletion markers, we identified 11 main- and 16 minor-effect QTLs for the six traits with a threshold LOD value > 2.8. Our sequence analysis identified fifty-four candidate genes for the main-effect QTLs. By further comparison of coding sequences and meta-expression profiles between japonica and indica rice varieties, we finally chose 15 strong candidate genes for the 11 main-effect QTLs. Our study shows that the whole-genome sequence data substantially enhanced the efficiency of polymorphic marker development for QTL fine-mapping and the identification of possible candidate genes. This yields useful genetic resources for breeding high-yielding rice cultivars with improved plant architecture.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.1
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• pp.13-18
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• 2018

Objective: Meat quality including muscle color in chickens is an important trait and continuous selective pressures for fast growth and high yield have negatively impacted this trait. This study was conducted to investigate genetic variations responsible for regulating muscle color. Methods: Whole genome re-sequencing analysis using Illumina HiSeq paired end read method was performed with pooled DNA samples isolated from two broiler chicken lines divergently selected for muscle color (high muscle color [HMC] and low muscle color [LMC]) along with their random bred control line (RAN). Sequencing read data was aligned to the chicken reference genome sequence for Red Jungle Fowl (Galgal4) using reference based genome alignment with NGen program of the Lasergene software package. The potential causal single nucleotide polymorphisms (SNPs) showing non-synonymous changes in coding DNA sequence regions were chosen in each line. Bioinformatic analyses to interpret functions of genes retaining SNPs were performed using the ingenuity pathways analysis (IPA). Results: Millions of SNPs were identified and totally 2,884 SNPs (1,307 for HMC and 1,577 for LMC) showing >75% SNP rates could induce non-synonymous mutations in amino acid sequences. Of those, SNPs showing over 10 read depths yielded 15 more reliable SNPs including 1 for HMC and 14 for LMC. The IPA analyses suggested that meat color in chickens appeared to be associated with chromosomal DNA stability, the functions of ubiquitylation (UBC) and quality and quantity of various subtypes of collagens. Conclusion: In this study, various potential genetic markers showing amino acid changes were identified in differential meat color lines, that can be used for further animal selection strategy.

• Journal of the Korean Society of Clothing and Textiles
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• v.35 no.2
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• pp.146-155
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• 2011

This study examines the design characteristics of figure skating costumes by a content analysis of their design elements. The content analysis method for the study was used based on 185 photos of female figure skaters. A total of 218 coding units in 15 categories were used. In the category of color, unicolor costumes were the mainstay and represented 48.11% of the total costumes. Black costumes showed the highest rate (13.51%), followed by red (7.57%) and blue (7.03%). In the dual-color costumes, combinations of red and black and white and black, represented 4.32% of all costumes. A camisole was the most popular type of neckline (20.54%). Stand collars with neck decorations were found in 5.95% of the costumes. In addition, 98.2% of all figure skating costumes had decorations (crystal beads 21.86% were the most frequently used decoration type), 65.41% exposed all the shoulders and arms, 70.81% of the costumes did not have sleeves, 5.41% of the costumes had arm decorations, and 3.78% had wrist decorations. In the analysis of the hem of skirts, 32.40% had a curved line, 30.73% had a straight line, and 15.08% had an unrecognizable form. In general, the figure skating costumes have stand collars with neck decorations, arm and wrist decorations, and irregular skirt hems that are not found in everyday dresses. To emphasize and intensify a theatrical effect, the costumes were fabulously decorated with spangles, crystal beads, feathers, and lace; black, red, and blue were frequently used. The skirts had frills, fringe, flared lines, and beads on them to reflect the stage lights and emphasize movements.

• Journal of Broadcast Engineering
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• v.9 no.4 s.25
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• pp.446-454
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• 2004

With the growth of multimedia systems, compressing image data has become more important in the area of multimedia services. Since a compressed image bitstream can often be seriously distorted by various types of channel noise, an error concealment algorithm becomes a very important issue. In order to solve this problem, Hsia proposed the error concealment algorithm where he recovered lost block data using 1D boundary matching vectors. His algorithm, however, requires high computational complexity since each matching vector needs MAD (Mean Absolute Difference) values of all pixels, which is either a boundary line top or a boundary line bottom of a damaged block. We propose a hierarchical search-based fast error concealment scheme as well as its approximated version to reduce computational time. In the proposed scheme, a hierarchical search is applied to reduce the number of checking points for searching a vector. The error concealment schemes proposed in this paper can be about 3 times faster than Hsia's with keeping visual quality and PSNR.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.7 no.2
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• pp.55-72
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• 1997

This paper presents a digital signature scheme for facsimile document which directly embeds a signature onto the document. We use multiple reference lines which have been scanned just before and modify each distance of changing pels both on the reference line specified by key and on the coding line with a single bit of the signature data. The time to take in signature is reduced by spreading of signature. Non-repudiation in origin, the 3rd condition of digital signature is realized by proposed digital signature scheme. The transmitter embeds the signature secretly and transfers it, and the receiver makes a check of any forgery on the signature and the document. This scheme is compatible with the ITU-T.4(CCITT G3 or G4 facsimile standards). The total amount of data transmitted and the image quality are about the same to that of the original document, and thus a third party notices that no signature is embedded on the document.

• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.10
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• pp.1754-1766
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• 2010

Excessive consumption, pollution, and am expanding global population are seen as very important issues that must be solved through reusable materials and the reduction of energy consumption. This study examines the values and design elements such as line, color, and textures in eco-friendly fashion that could contribute to the product development of an eco-friendly brand. The following methods of analysis were used in this study. An in-depth interview (where the interviewer records the response of interviewers to questions) was used to grasp the diverse design properties of products that customers need or want and the recorded interviews were documented by computer using open coding. The results show that the personal, economic, and social value of eco-friendly fashion has increased, in addition to the environmental value. The needs and preference of customers for eco-friendly fashion design were diversified and the consumer consciousness was more advanced than the consciousness of experts. This shows that it is not enough to consider the effect on the environment. In conclusion, understanding the personal, environmental, economic, and social value from the viewpoint of customers, finding the optimal design factors, and reflecting them in the development of products are necessary for advanced eco-friendly fashion.