• Earthquakes and Structures
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• 제20권1호
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• pp.97-107
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• 2021

A comprehensive study on seismic performance of wood frame building in hilly regions is presented. Specifically, seismic fragility assessment of a typical wood frame building at various locations of the northeast region of India are demonstrated. A three-dimensional simplified model of the wood frame building is developed with due consideration to nonlinear behaviour of shear walls under lateral loads. In doing so, a trilinear model having improved capability to capture the force-deformation behaviour of shear walls including the strength degradation at higher deformations is proposed. The improved capability of the proposed model to capture the force-deformation behaviour of shear wall is validated by comparing with the existing experimental results. The structural demand values are obtained from nonlinear time history analysis (NLTHA) of the three-dimensional wood frame model considering the effect of uncertainty due to record to record variation of ground motions and structural parameters as well. The ground motion bins necessary for NLTHA are prepared based on the identified hazard level from probabilistic seismic hazard analysis of the considered locations. The maximum likelihood estimates of the lognormal fragility parameters are obtained from the observed failure cases and the seismic fragilities corresponding to different locations are estimated accordingly. The results of the numerical study show that the wood frame constructions commonly found in the region are likely to suffer minor cracking or damage in the shear walls under the earthquake occurrence corresponding to the estimated seismic hazard level; however, poses negligible risk against complete collapse of such structures.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5517-5523
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• 2012

Purpose: To evaluate the diagnostic accuracy of ultrasonograph and fine-needle aspiration cytologic examination (USG-FNAC) in the staging of axillary lymph node metastasis in breast cancer patients.Methods: We conducted an electronic search of the literature addressing the performance of USG-FNAC in diagnosis of axillary lymph node metastasis in databases such as Pubmed, Medline, Embase, Ovid and Cochrane library. We introduced a series of diagnostic test indices to evaluate the performance of USG-FNAC by the random effect model (REM), including sensitivity, specificity, likelihood ratios, and diagnostic odds ratios and area under the curve (AUC). Results: A total of 20 studies including 1371 cases and 1289 controls were identified. The pooled sensitivity was determined to be 0.66 (95% CI 0.64-0.69), specificity 0.98 (95% CI 0.98-0.99), positive likelihood ratio 22.7 (95% CI 15.0-34.49), negative likelihood ratio 0.32 (95% CI 0.25-0.41), diagnostic OR 84.2 (95% CI 53.3-133.0). Due to the marginal threshold effect found in some indices of diagnostic validity, we used a summary SROC curve to aggregate data, and obtained a symmetrical curve with an AUC of 0.942. Conclusion: The results of this meta-analysis indicated that the USG-FNAC techniques have acceptable diagnostic validity indices and can be used for early staging of axillary lymph node in breast cancer patients.

• Journal of Electrical Engineering and Technology
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• 제11권2호
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• pp.529-536
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• 2016

In this paper we proposed an unsupervised algorithm to estimate the reverberation time (RT) directly from the reverberant speech signal. For estimation process we use maximum likelihood estimation (MLE) which is a very well-known and state of the art method for estimation in the field of signal processing. All existing RT estimation methods are based on the decay rate distribution. The decay rate can be obtained either from the energy envelop decay curve analysis of noise source when it is switch off or from decay curve of impulse response of an enclosure. The analysis of a pre-existing method of reverberation time estimation is the foundation of the proposed method. In one of the state of the art method, the reverberation decay is modeled as a Laplacian distribution. In this paper, the proposed method models the reverberation decay as a Gamma distribution along with the unification of an effective technique for spotting free decay in reverberant speech. Maximum likelihood estimation technique is then used to estimate the RT from the free decays. The method was motivated by our observation that the RT of a reverberant signal when falls in specific range, then the decay rate of the signal follows Gamma distribution. Experiments are carried out on different reverberant speech signal to measure the accuracy of the suggested method. The experimental results reveal that the proposed method performs better and the accuracy is high in comparison to the state of the art method.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2753-2758
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• 2013

Various studies examining the relationship between Ezrin overexpression and response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results. We accordingly conducted a meta-analysis of 7 studies (n = 318 patients) that evaluated the correlation between Ezrin and histologic response to chemotherapy and clinical prognosis (death). Data were synthesized in receiver operating characteristic curves and with fixed-effects and random-effects likelihood ratios and risk ratios. Quantitative synthesis showed that Ezrin is not a prognostic factor for the response to chemotherapy. The positive likelihood ratio was 0.538 (95% confidence interval [95% CI], 0.296- 0.979; random-effects calculation), and the negative likelihood ratio was 2.151 (95% CI, 0.905- 5.114; random-effects calculations). There was some between-study heterogeneity, but no study showed strong discriminating ability. Conversely, Ezrin positive status tended to be associated with a lower 2-year survival (risk ratio, 2.45; 95% CI, 1.26-4.76; random-effects calculation) with some between-study heterogeneity that disappeared when only studies that employed immunohistochemistry were considered (risk ratio, 2.97; 95% CI, 2.01- 4.40; fixed-effects calculation). To conclude, Ezrin is not associated with the histologic response to chemotherapy in patients with osteosarcoma, whereas Ezrin positivity was associated with a lower 2-year survival rate regarding risk of death at 2 years. Expression change of Ezrin is an independent prognostic factor in patients with osteosarcoma.

• Asian-Australasian Journal of Animal Sciences
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• 제28권6호
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• pp.876-887
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• 2015

Dicer, an ribonuclease type III type endonuclease, is the key enzyme involved in biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs), and thus plays a critical role in RNA interference through post transcriptional regulation of gene expression. This enzyme has not been well studied in the Indian water buffalo, an important species known for disease resistance and high milk production. In this study, the primary coding sequence (5,778 bp) of bubaline dicer (GenBank: AB969677.1) was determined and the bubaline Dicer1 biocomputationally characterized to determine the phylogenetic signature among higher eukaryotes. The evolutionary tree revealed that all the transcript variants of Dicer1 belonging to a specific species were within the same node and the sequences belonging to primates, rodents and lagomorphs, avians and reptiles formed independent clusters. The bubaline dicer1 is closely related to that of cattle and other ruminants and significantly divergent from dicer of lower species such as tapeworm, sea urchin and fruit fly. Evolutionary divergence analysis conducted using MEGA6 software indicated that dicer has undergone purifying selection over the time. Seventeen divergent sequences, representing each of the families/taxa were selected to study the specific regions of positive vis-$\grave{a}$-vis negative selection using different models like single likelihood ancestor counting, fixed effects likelihood, and random effects likelihood of Datamonkey server. Comparative analysis of the domain structure revealed that Dicer1 is conserved across mammalian species while variation both in terms of length of Dicer enzyme and presence or absence of domain is evident in the lower organisms.

• 한국산학기술학회논문지
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• 제17권5호
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• pp.645-652
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• 2016

입력 랜덤 변수(input random variable)의 통계 모델링은 기계시스템의 신뢰성 해석(reliability analysis), 신뢰성 기반 설계(reliability-based design optimization), 해석모델의 통계적 검정(validation) 및 보정(calibration)을 위해 반드시 필요하다. 대표적인 통계모델링 기법에는 Akaike Information Criterion (AIC), AIC correction (AICc), Bayesian Information Criterion, Maximum Likelihood Estimation (MLE), Bayesian 방법 등이 있다. 이러한 방법들은 기본적으로 주어진 데이터로부터 후보 모델의 우도함수값을 이용하여 후보 모델 중 가장 적합한 모델을 선택하는 방법이며, 방법에 따라 데이터 수 혹은 파라미터의 수를 고려하여 모델을 선정한다. 하지만 실제 현장에서 데이터의 통계모델링을 하는 엔지니어는 각 방법의 장단점에 대한 이해가 부족하여 어떤 방법이 정확한 방법인지 몰라 통계모델링 수행 시 어려움이 있다. 본 논문에서는 다양한 통계모델링 방법들을 비교하고 각 방법의 장단점 분석을 통해 가장 적합한 모델링 기법을 제안하고자 한다. 각 방법의 검증을 위해 다양한 모분포를 가정하고 다양한 사이즈의 샘플을 임의로 생성하여 시뮬레이션을 수행하였으며, 실제 공학 데이터를 사용하여 통계모델링 방법의 유효성을 검증하였다.

• 제어로봇시스템학회논문지
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• 제13권11호
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• pp.1092-1098
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• 2007

A mobile robot localization problem can be classified into following three sub-problems as an observation likelihood model, a motion model and a filtering technique. So far, we have developed the range sensor based, integrated localization scheme, which can be used in human-coexisting real environment such as a science museum and office buildings. From those experiences, we found out that there are several significant issues to be solved. In this paper, we focus on three key issues, and then illustrate our solutions to the presented problems. Three issues are listed as follows: (1) Investigation of design requirements of a desirable observation likelihood model, and performance analysis of our design (2) Performance evaluation of the localization result by computing the matching error (3) The semi-global localization scheme to deal with localization failure due to abrupt wheel slippage In this paper, we show the significance of each concept, developed solutions and the experimental results. Experiments were carried out in a typical modern building environment, and the results clearly show that the proposed solutions are useful to develop practical and integrated localization schemes.

• 대한전자공학회논문지TC
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• 제47권8호
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• pp.32-41
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• 2010

골드 코드를 이용한 다중 프리앰블의 사용을 제안하고 성능을 분석한다. 다중 프리앰블은 한 시스템에서 모드 또는 응용의 종류에 따라 각자 다른 프리앰블을 사용하는 것이다. 골드 코드를 사용하는 다중 프리앰블의 수신은 최대 우도 (ML, maximum likelihood) 알고리듬을 사용하여 간단한 구조로 구현할 수 있으며, 골드 코드 특성은 상호 상관 특성이 우수하여 잡음에 강하다. 길이가 128 비트인 다중 프리앰블에 대한 최대 우도 검출 시 검출 실패 확률을 구하고, 컴퓨터 모의실험을 통해 성능 분석 및 타당성을 입증한다. 결과적으로 이론과 실험이 오차 범위 내에서 일치함을 확인하였다.

• 응용통계연구
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• 제23권6호
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• pp.1115-1124
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• 2010

두 비율비교 비열등성 임상시험(non-inferiority trial)에서의 검정은 두 비율간에 차이가 없다는 영가설에 근거한 정규근사 산출식이 흔히 사용 된다. 본 연구에서는 두 비율차이가 영이 아니라는 가설에서 유도된 Miettinen과 Nurminen이 제안한 우도 스코어검정(likelihood score test)과 Farrington과 Manning의 검정 그리고 비대칭도(skewness)을 보정한 Gart와 Nam이 제안한 검정방법을 소개하고 모의실험을 통하여 제 1종 오류와 검정력을 비교하여 비열등성 임상시험에서 검정방법의 결정에 가이드라인을 제시하고자 한다.

• Journal of Electrical Engineering and Technology
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• 제6권4호
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• pp.563-572
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• 2011

Reliability is an essential factor in a navigation system. Therefore, an integrity monitoring system is considered one of the most important parts in an avionic navigation system. A fault due to systematic malfunctioning definitely requires integrity reinforcement through systematic analysis. In this paper, we propose a method to detect faults of the GPS signal by using a distributed nonlinear filter based probability test. In order to detect faults, consistency is examined through a likelihood ratio between the main and auxiliary particle filters (PFs). Specifically, the main PF which includes all the measurements and the auxiliary PFs which only do partial measurements are used in the process of consistency testing. Through GPS measurement and the application of the autonomous integrity monitoring system, the current study illustrates the performance of the proposed fault detection algorithm.