• Journal of Oriental Neuropsychiatry
• /
• v.33 no.4
• /
• pp.401-424
• /
• 2022

Objectives: As effective treatments for dementia are lacking in Western medicine, complementary and alternative medicine (CAM) is considered a useful option. While the quality of life (QoL) is a vital outcome for patients with dementia, the QoL of patients receiving CAM for dementia remains ambiguous. This study aimed to determine the effect of CAM on QoL outcomes in dementia patients. Methods: A search was performed using the keywords "dementia," "Alzheimer's," "cognitive impairment," "Chinese," "Korean," "oriental," "herbal," "acupuncture," and "quality of life". All quantitative data were synthesized using R version 4.1.1. Results: Twenty-five randomized controlled trials (RCTs), 16 pre-post trials, and two cohort studies were selected for the systematic review. QoL in Alzheimer's disease (QOL-AD) (n=11, 25.6%) and geriatric QoL in dementia (GQOL-D, n=9, 20.9%) were the most utilized QoL instruments. Significant benefits in QoL were observed after receiving mind, body, combined mind and body, nursing, oriental medicine, and acupuncture therapies. In the meta-analysis, the combined effect was shown to significantly increase QOL-AD compared to before CAM interventions (standardized mean difference, SMD: 0.507; 95% confidence interval (CI), 0.191~0.824; p<0.01). The overall synthesized estimates in the GQOL-D showed a significantly improved QoL (SMD: 0.537, 95% CI: 0.238~0.837 p<0.01; one group; SMD: 1.465, 95% CI: 0.934~1.996, p<0.01). The seven studies assessing the cost-effectiveness of CAM reported uncertain outcomes. Conclusions: This study showed that CAM interventions benefited patients with dementia by improving their QoL. While additional standardized research is required, CAMs are suggested as effective clinical management for patients with dementia. They are also suggested as complementing therapies for these patients.

• Communications of the Korean Mathematical Society
• /
• v.19 no.1
• /
• pp.93-111
• /
• 2004

In this paper, we use a generalized Brownian motion process to define a generalized Feynman integral and a generalized Fourier-Feynman transform. We also define the concepts of the multiple Lp analytic generalized Fourier-Feynman transform and the generalized convolution product of functional on function space $C_{a,\;b}[0,\;T]$. We then verify the existence of the multiple $L_{p}$ analytic generalized Fourier-Feynman transform for functional on function space that belong to a Banach algebra $S({L_{a,\;b}}^{2}[0, T])$. Finally we establish some relationships between the multiple $L_{p}$ analytic generalized Fourier-Feynman transform and the generalized convolution product for functionals in $S({L_{a,\;b}}^{2}[0, T])$.

• Journal of the Korean Society of Radiology
• /
• v.14 no.5
• /
• pp.685-693
• /
• 2020

This study was performed to compare the differences between total fat area, subcutaneous fat area and visceral fat area according to L1-S1 inter vertebral disc level in asymptomatic Korean patients with non-contrast abdominal CT scan. The location of the maximum fat ratio of the total fat area is the total fat area measured in male L2-3, L3-4, L4-5, female L4-5, and L5-S1. The location showing the maximum fat ratio of the subcutaneous fat area is the subcutaneous fat area measured in male L4-5, and the woman is the subcutaneous fat area measured in L4-5 and L5-S1. The location of the maximum fat ratio of visceral fat area was the visceral fat area measured in L1-2 and L2-3 males, and there was no difference in visceral fat area according to the measured position in females. Although abdominal fat measurement is common at the L4-5 inter vertebral disc level, fat distribution varies widely depending on nationality, race, and gender. Therefore, it is necessary to analyze through the research data which location to choose according to the research purpose, and to mention why the location is appropriate.

• Clinical and Experimental Pediatrics
• /
• v.49 no.2
• /
• pp.198-202
• /
• 2006

Purpose : Fas is a cell surface receptor that transduces apoptotic death signals. Interaction of extracelluar domain of Fas with Fas ligand(FasL) triggers the apoptotic process in many diseases. We investigated the expression of Fas and FasL in the hippocampus of 7-day-old newborn rat brains following hypoxia-ischemia injury. Methods : The 7-days-old newborn rats were exposed to 8 percent oxygen for two hours after the ligation of right common carotid arteries. The newborn rats were killed and their brains were removed at 12, 14 and 48 hours after hypoxic-ischemic injury. The expressions of Fas and FasL of the right hippocampus were observed by western blotting and immunofluorescent staining. Results : Fas and FasL were strongly expressed in the right hippocampus ipsilateral to the ligation of the common carotid artery by western blotting at 12 hours following hypoxic-ischemic injury, and then slowly decreased. The immunofluorescent expressions of Fas and FasL strongly increased in the CA1 area of the right hippocampus at 12 and 24 hours following hypoxic-ischemic injury. The immunofluorescent expression of Fas decreased at 48 hours, but the expression of FasL persisted strongly at 48 hours following hypoxic-ischemic injury. Conclusion : The interaction of Fas with FasL on the cell surface may be involved in neuronal injury following hypoxic-ischemic injury in the developing brain.

• Asian-Australasian Journal of Animal Sciences
• /
• v.28 no.8
• /
• pp.1202-1208
• /
• 2015

The effects of daily dietary Bacillus subtilis (Bs), and adding L-tryptophan, fructan, or casein to fecal fermentation broths were investigated as means to reduce the production of noxious gas during manure fermentation caused by ammonia, hydrogen sulfide ($H_2S$), and 3-methylindole (skatole). Eighty swine ($50.0{\pm}0.5kg$) were equally apportioned to an experimental group given Bs in daily feed, or a control group without Bs. After 6 weeks, fresh manure was collected from both groups for fermentation studies using a $3{\times}3$ orthogonal array, in which tryptophan, casein, and fructan were added at various concentrations. After fermentation, the ammonia, $H_2S$, L-tryptophan, skatole, and microflora were measured. In both groups, L-tryptophan was the principle additive increasing skatole production, with significant correlation (r = 0.9992). L-tryptophan had no effect on the production of ammonia, $H_2S$, or skatole in animals fed Bs. In both groups, fructan was the principle additive that reduced $H_2S$ production (r = 0.9981). Fructan and Bs significantly interacted in $H_2S$ production (p = 0.014). Casein was the principle additive affecting the concentration of ammonia, only in the control group. Casein and Bs significantly interacted in ammonia production (p = 0.039). The predominant bacteria were Bacillus spp. CWBI B1434 (26%) in the control group, and Streptococcus alactolyticus AF201899 (36%) in the experimental group. In summary, daily dietary Bs reduced ammonia production during fecal fermentation. Lessening L-tryptophan and increasing fructan in the fermentation broth reduced skatole and $H_2S$.

• Publications of The Korean Astronomical Society
• /
• v.20 no.1 s.24
• /
• pp.1-5
• /
• 2005

We report molecular line observations of CO(1-0), $^{13}CO(1-0)$, CS(2-1), and HCN(1-0) with SRAO 6m telescope toward L1014-IRS which is thought to be a very faint infrared source embedded in previously known 'starless' core L1014. The CO(1-0) observations find several components with different velocities along the line of sight of L1014, $4km\;s^{-1}$ and between $40{\sim}50km\;s^{-1}$. We find a parsec scale CO molecular outflow at the $4km\;s^{-1}$ component for the first time the direction of which is coincident with that of the small scale (${\sim}500pc$) outflow previously found. Although the observation is not covered for whole area of the outflow, the size of the molecular outflow seems not very inconsistent with the expected age of L1014-IRS. More accurate size and shape of the molecular outflow from L1014-IRS will be determined from the full coverage mapping in CO over the outflow region in very near future.

• Journal of Electrochemical Science and Technology
• /
• v.12 no.2
• /
• pp.279-284
• /
• 2021

The high theoretical specific capacity of lithium-sulfur (Li-S) batteries makes them a more promising energy storage system than conventional lithium-ion batteries (LIBs). However, the slow kinetics of the electrochemical conversion reaction seriously hinders the utilization of Li-S as an active battery material and has prevented the successful application of Li-S cells. Therefore, exploration of alternatives that can overcome the sluggish electrochemical reaction is necessary to increase the performance of Li-S batteries. In this work, an ionic liquid (IL) is proposed as a functional additive to promote the electrochemical reactivity of the Li-S cell. The sluggish electrochemical reaction is mainly caused by precipitation of low-order polysulfide (l-PS) onto the positive electrode, so the IL is adopted as a solubilizer to remove the precipitated l-PS from the positive electrode to promote additional electron transfer reactions. The ILs effectively dissolve l-PS and greatly improve the electrochemical performance by allowing greater utilization of l-PS, which results in a higher initial specific capacity, together with a moderate retention rate. The results presented here confirmed that the use of an IL as an additive is quite effective at enhancing the overall performance of the Li-S cell and this understanding will enable the construction of highly efficient Li-S batteries.

• Journal of the Korean Mathematical Society
• /
• v.49 no.3
• /
• pp.641-658
• /
• 2012

The goal of this paper is to develop a nonlinear observer-based control strategy for a multi-variables continuous stirred tank reactor (CSTR). A new robust nonlinear observer is constructed to estimate the whole process state variables. The observer is coupled with a nonlinear controller, designed based on the input-output linearization for controlling the concentration and reactor temperature. The closed loop system is shown to be globally asymptotically stable based on Lyapunov arguments. Finally, computer simulations are developed for showing the performance of the proposed controller.

• Food Science and Preservation
• /
• v.11 no.1
• /
• pp.117-121
• /
• 2004

We investigated antimicrobial effects of commercial vinegar on the harmful food-born organisms. As a result, antimicrobial effects of brown rice vinegar showed stronger than persimmon and artificial vinegar. In 10${\mu}$L/mL concentration of brown rice vinegar was completely inhibited about 5 strains except for V. parahaemolyticus, it was inhibited 15${\mu}$L/mL concentration. Therefore vinegars were effective for inhibition acitivity against food borne organisms. S. aureus and E. coli treated with 25${\mu}$L/mL concentratioin brown rice vinegar was observed by scanning electron micrographs(SEM). The cells were expanede and a part of cell wall was completely destructed by brown rice vinegar.

• Microbiology and Biotechnology Letters
• /
• v.43 no.3
• /
• pp.187-194
• /
• 2015

In this study, L. plantarum, when reacting with the culture media of potential pathogenic bacteria, exhibited an increase in growth rate and antimicrobial activity. In order to examine the characteristics and the nature of the reaction with the bacteria, this study carried out experiments involving culturing the test bacteria in M9 minimal media. Subsequently, the supernatant was incrassated by the decompression-drying method. Through colony forming unit assay, it was confirmed that L. plantarum had the function of growth inhibition to various bacteria. After culturing L. plantarum with bacterial media, the growth rate of L. plantarum was measured by absorbance (OD₆₀₀), the results showed that the growth rate (E. coli treatment group: OD₆₀₀ = 0.848, S. typhimurium treatment group: OD₆₀₀ = 0.848) increased, as compared with the non-treated control group (OD₆₀₀ = 0.48). In contrast, the concentrate itself did not induce the growth of L. plantarum. These results were observed as a universal phenomenon of the Lactobacillus species. Moreover, the increase in antimicrobial activity was observed in L. plantarum, which reacted with the culture media of E. coli and S. typhimurium, through a disc diffusion assay, and the result of growth inhibition against various bacteria was induced. Finally, based on the analysis results of the characteristics of bacteria culture media, which increased the growth rate of L. plantarum and antibacterial activity, the bacterial media had a tolerance for catabolic enzymes, pH 2−8 and heat. Therefore, this substance can be said to be a small molecule which is highly stable under various conditions.