• 제목/요약/키워드: Korean-Chinese herbal medicines

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중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(X) (Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (X))

  • 최소진;김영숙;김주환;김진숙
    • 생약학회지
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    • 제45권4호
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    • pp.359-365
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    • 2014
  • Aldose reductase (AR) is the key enzyme of the polyol pathway in the development of the diabetic complications. Sixty seven Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Buddleja crispa (twigs and leaves), Taiwania flousiana (twigs and leaves), Sloanea hemsleyana (fruits), Euphorbia nemetocypha (whole plants), Photinia glomerata (twigs and leaves), Vitex yunnanensis (twigs and leaves) exhibited a significant inhibitory activity against AR. Particularly, S. hemsleyana and V. yunnanensis showed 1.2-4.5 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VII) (Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (VII))

  • 이윤미;김영숙;김주환;김진숙
    • 생약학회지
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    • 제44권2호
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    • pp.161-167
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    • 2013
  • Aldose reductase (AR) has been shown to play an important role in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 59 Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 10 herbal medicines, Catalpa fargesii (stem and leaf), Saussurea Laniceps(whole plant), Alnus nepalensis(stem and leaf), Swertia macrosperma (whole plant), Woodfordia fruticosa (stem and leaf), Elsholtzia bodinieri (whole plant), Elsholtzia fruticosa (whole plant), Rosa multiflora (fruit), Nardostachys chinensis (whole plant), Eurya groffii (stem and leaf) exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG) as positive control. Particularly, 4 herbal medicines, C. fargesii (stem and leaf), S. Laniceps (whole plant), A. nepalensis (stem and leaf), S. macrosperma (whole plant) showed two times more potent inhibitory activity than TMG ($5.37{\mu}g/ml$).

한약재 포제 가공의 현대적 연구 현황 (A Literature Survey of the Modern Techniques Used for the Processing of Herbal Medicines)

  • 오주희;신재석;안은석;이성준;이종철;임준홍;홍시갑;홍준기;이영주
    • Journal of Pharmaceutical Investigation
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    • 제39권4호
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    • pp.275-297
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    • 2009
  • Herbal medicines have been used worldwide, particularly in the Far East countries, for thousands of years. Herbal medicines comprise complex mixtures of different phytochemical substances, and their nature may vary substantially depending on many factors related to the cultivation condition, area and harvest time. The processing of the herbal medicines significantly affects their pharmacological and toxicological properties. In this paper, we discuss current research that deals with the techniques for processing Chinese herbal medicines. These results will provide a scientific basis for developing new techniques for the processing of herbal medicines.

중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (V) (Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (V))

  • 이윤미;김영숙;김주환;김진숙
    • 생약학회지
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    • 제42권2호
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    • pp.187-194
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    • 2011
  • Aldose reductase (AR), the key enzyme in the polyol pathway, plays an important role in the development of the diabetic complications. None of Aldose reductase Inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Fifty two Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, twelve herbal medicines, Artemisia anomala (aerial part), Centella asiatica (aerial part), Scutellaria baicalensis (root), Senecio chrysanthermoides (whole plant), Gleditsia japonica (twig), Zizyphus jujube (twig, leaf), Citrus aurantium (fruit), Hydnocarpus anthelmintica (fruit), Potaninia mongolica (aerial part), Tribulus terrestris (fruit), Artemisia apiacea (aerial part) and Eclipta prostrate (aerial part) exhibited a significant inhibitory activity against AR. Particularly, Artemisia anomala, Centella asiatica and Scutellaria baicalensis showed four times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

16종 다용한약재의 산지별 As, Cd, Pb, Co, Cr 농도 및 특성고찰 -한국과 중국산의 평균농도, 최소-최대농도와 법적 허용농도초과비율을 중심으로- (As, Cd, Pb, Co, Cr Concentration and Property Evaluation in Frequently Using 16 Oriental Herbal Medicines -Mainly Average, Lowest, Highest Concentration and Percent Exceeding Value of Legal Allowance in Korean and Chinese Origines-)

  • 김기동;박해모;서용찬;이선동
    • 대한예방한의학회지
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    • 제16권3호
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    • pp.167-183
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    • 2012
  • Objective : Average, lowest, highest concentration and exceeding value of legal allowance of As, Cd, Pb, Co, Cr in frequently using 16 oriental herbal medicines in korea(Astragali Radix, Ginseng, Citri Unshii Pericarpium, Aurantii Fructus Immaturus, Angelicae Gigantis Radix, Cnidii Rhizoma, Paeoniae Radix, Rehmanniae Radix Preparata, Zingiberis Rhizoma Crudus, Zizyphi Fructus, Atractylodis Rhizoma Alba, Hoelen, Dioscoreae Rhizoma, Corni Fructus, Schisandrae Fructus, Lycii Fructus) was evaluated according to their origines (korea, china) and property was also discussed according to the medicinally active part and individuals regardless origines. Method : Korean and Chinese herbal medicines were evenly sampled from corresponding country nationwide. Pre-treatment was executed according to the KFDA(Korea Food and Drug Administration) regulation and analysis was performed according to the Korean Environmental Analysis QA/QC. Result : Not much difference was observed according to their origines. However, lowest, highest and percent exceeding value of legal allowance was showed some consistent differences according to the medicinally active part and individuals. Co and Cr was can not be evaluated since their legal regulation was not established yet. Conclusion : The average concentration of As, Cd, Pb, Co, Cr in frequently using 16 oriental herbal medicines in korea showed no noticeable difference according to their origines. Regardless the origin, some consistent differences were observed according to the individuals and medicinally active parts.

중국 약용식물의 최종당화산물 생성저해활성 검색 (X) (Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (X))

  • 김영숙;이윤미;김주환;김진숙
    • 생약학회지
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    • 제44권3호
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    • pp.305-311
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    • 2013
  • Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 54 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 6 herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Punica granatum (peels), Terminalia chebula (fruits), Rheum palmatum (roots), Oxyria digyna (stems and leaves), Anisodus luridus (roots) and Quercus schottkyana(stems and leaves) showed more potent inhibitory activity (approximately 9-43 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).

A review of atopic dermatitis in traditional Chinese medicine

  • Lee, Sang-Chang;Lee, Young-Seob;Seong, Man-Jun;Choi, Mi-Sun;Kang, Suk-Hoon;Lee, Sheng-Ho;Kim, Jong-Hak;Kim, Min-San;Kwon, Dong-Yeul
    • Journal of Evidence-Based Herbal Medicine
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    • 제1권2호
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    • pp.35-43
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    • 2008
  • Herbal medicines have an accurate effect on atopic dermatitis, and at the same time, they hardly have adverse reactions. However, herbal medicines are difficult to be quantitatively analyzed due to low-quality preparation and types. In addition, herbal medicines have raised many problems as they have not been standardized and their active components have not been analyzed. Patients with atopic dermatitis began to recognize the effectivity and safety of herbal medicines. Accordingly, standardization, biological analyses, animal experiments and clinical trials should be generally performed in order that herbal medicines may be recognized all over the world. A standard, which is to objectively judge the curative effect of atopic dermatitis, should be established as soon as possible. Case studies and RCTs (Randomized Controlled Trials) should be actively performed on the basis of rigid clinical trial design to the end that the curative effect of herbal medicines is recognized all the world over.

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Thin Layer Chromatography: Bioactive Metabolites of Components of Traditional Chinese Medicines by Intestinal Bacteria

  • Kim, Dong-Hyun
    • Natural Product Sciences
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    • 제10권4호
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    • pp.152-167
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    • 2004
  • Traditional Chinese Medicines (TCM) have attracted great interest in recent researchers as alternative medicines for incurable diseases. This review focuses on qualitative and quantitative analytical approaches for bioactive metabolites of components flavonoids and saponins of traditional Chinese medicines by TLC system, although various methods have been introduced. Emphasis will be put on the processes of metabolite extraction from intestinal bacterial cultures or urines, separation (mobile phase) and detection. The identified metabolites by selection of extraction solvent and detection methods are also discussed. In addition, metabolite determinations of flavonoids (baicalin, apiin, rutin, quercetin, quercitrin, kaempferol, diosmin, hesperidin, poncirin, naringin, puerarin, daidzin, daidzein, tectoridin) and saponins (ginsenosides, kalopanaxsaponins, glycyrrhizin, chiisanoside, saikosaponins, soyasaponins) in culture fluid, in urine and in some herbal formula extracts are summarized. These bioactive metabolites of these components by intestinal microflora should be connected to pharmacological actions.

한약 복용 후 발생한 메트헤모글로빈혈증 1예 (Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report)

  • 현세은;황필주;남경필;유은경;한만용
    • Clinical and Experimental Pediatrics
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    • 제52권3호
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    • pp.385-388
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    • 2009
  • 8세 여아가 증상 발현 3일전부터 한약을 복용 후, 내원 20시간 전에 발생한 청색증과 호흡곤란을 주소로 응급실에 내원하였다. 내원 당시 메트헤모글로빈 수치가 23.7%로, 메트헤모글로빈혈증 진단 하에 methylene blue로 치료하였다. 한약 성분은 암모니아가 239.41 mg/L로 높게 측정되었다. 이에 한약 복용 후 발생한 메트헤모글로빈혈증 1예를 보고하고자 한다.

방제 연구를 위한 새로운 접근: 네트워크 약리학 (New Approach for Herbal Formula Research: Network Pharmacology)

  • 한상용;김윤경
    • 동의생리병리학회지
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    • 제30권6호
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    • pp.385-396
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    • 2016
  • It is a fact that the existing pharmacological research method is difficult to explain the effect and mechanism of action of herbal formula of Korean medicine. We are now very pleased with the development of modern science and the development of a methodology for studying herbal formula characterized by network targets and multi-component therapeutics over the human body. In this review, systems pharmacology or network pharmacology is demonstrated how these are applied to explain the effectiveness of herbal medicine. The post-genomic era provides a unique opportunity for the two fields to understand and benefit from each other. In particular, recent research trends, research methodology, useful databases and results of research on herbal formula are introduced. China already has a policy of scientific development of traditional chinese medicine (TCM) and the development of Chinese medicine industry with a focus on herbal formula research at national level, and in Korea, it is urgent to support and nurture the methodology appropriate to the characteristics of the herbal formula in order to study the safety and efficacy of Korean medicine.