Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (X)

중국 약용식물의 최종당화산물 생성저해활성 검색 (X)

  • Kim, Young Sook (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Yun Mi (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Joo Hwan (Department of Life Science, Gachon University) ;
  • Kim, Jin Sook (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 김영숙 (한국한의학연구원 한약연구본부 한의신약개발그룹) ;
  • 이윤미 (한국한의학연구원 한약연구본부 한의신약개발그룹) ;
  • 김주환 (가천대학교 생명과학과) ;
  • 김진숙 (한국한의학연구원 한약연구본부 한의신약개발그룹)
  • Received : 2013.08.01
  • Accepted : 2013.08.14
  • Published : 2013.09.30
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Abstract

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 54 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 6 herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Punica granatum (peels), Terminalia chebula (fruits), Rheum palmatum (roots), Oxyria digyna (stems and leaves), Anisodus luridus (roots) and Quercus schottkyana(stems and leaves) showed more potent inhibitory activity (approximately 9-43 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).

Keywords

References

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