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Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (X)  

Kim, Young Sook (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Lee, Yun Mi (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Joo Hwan (Department of Life Science, Gachon University)
Kim, Jin Sook (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.3, 2013 , pp. 305-311 More about this Journal
Abstract
Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 54 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 6 herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Punica granatum (peels), Terminalia chebula (fruits), Rheum palmatum (roots), Oxyria digyna (stems and leaves), Anisodus luridus (roots) and Quercus schottkyana(stems and leaves) showed more potent inhibitory activity (approximately 9-43 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).
Keywords
Advanced glycation end products (AGEs); diabetic complications; Chinese herbal medicines;
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Times Cited By KSCI : 5  (Citation Analysis)
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1 Kaur, S., Arora, S., Kaur, K. and Kumar, S. (2002) The in vitro antimutagenic activity of Triphala-an Indian herbal drug. Food Chem. Toxicol. 40: 527-534.   DOI
2 Jagtap, A. G. and Karkera, S. G. (1999) Potential aqueous extract of Terminalia Chebula as an anticaries agent. J. Ethnopharmocol. 68: 299-306.   DOI
3 Anwesa Bag, Subir Kumar Bhattacharyya, and Rabi Ranjan Chattopadhyay (2013) The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Pac. J. Trop. Biomed. 3: 244-252.   DOI
4 Wang, Z. W., Wang, J. S., Luo, J., Wei, D. D. and Kong, L. Y. (2012) Three new phenolic glucosides from the roots of Rheum palmatum. Chem. Pharm. Bull. 60: 241-245.   DOI
5 Zhang, C., Li, L., Xiao, Y. Q., Tian, G. F., Chen, D. D., Wang, Y., Li, Y. T. and Huang, W. Q. (2010) Two new anthraquinone glycosides from the roots of Rheum palmatum. J. Asian Nat. Prod. Res. 12: 1026-1032.   DOI
6 Wang, C. C., Huang, Y. J., Chen, L. G., Lee, L. T. and Yang, L. L. (2002) Inducible nitric oxide synthase inhibitors of Chinese herbs III. Rheum palmatum. Planta Med. 68: 869-874.   DOI
7 Vysotskaia, N. B. (1956) Pharmacological study of an alkaloid extracted from the roots of Anisodus luridus (Himalayan Scopolia)]. Farmakol Toksikol. 19: 52-53.
8 Brownlee, M. (2005) The Pathobiology of diabetic complications: A unifying mechanism. Diabetes 54: 1615-1625.   DOI
9 Larkins, R. G. and Dunlop, M. E. (1992) The link between hyperglycaemia and diabetic nephropathy. Diabetologia 35: 499-504.   DOI
10 Ahmed, N. (2005) Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pract. 67: 3-21.   DOI
11 Huebschmann, A.G., Vlassara, H., Regensteiner, J. G. and Reusch, J. (2006) Diabetes and advanced glycoxidation end products. Diabetes care 29: 1420-1432.   DOI
12 Yokozawa, T., Nakagawa, T. and Terasawa, K. (2001) Effects of oriental medicines on the production of advanced glycation endproducts. J. trad. Med. 18: 107-112.
13 Jang, D. S., Lee, Y. M., Kim, Y. S. and Kim, J. S. (2006) Screening of Korean traditional herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation. Kor. J. Pharmacogn. 37: 48-52.
14 Lee, Y. M., Kim, Y. S., Kim, J. M., Jang, D. S., Kim, J. H., Yoo, J. L. and Kim, J. S. (2008) Screening of Korean herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation (II). Kor. J. Pharmacogn. 39: 223-227.
15 Jang, D. S., Kim, J. M., Lee, Y. M., Kim, Y. S., Kim. J.-H. and Kim, J. S. (2006) Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata. Chem. Pharm. Bull. 54: 1315-1317.   DOI
16 Yang, S., Litchfield, J. E. and Baynes, J. W. (2003) AGE breakers cleave model compounds, but do not break maillard crosslinks in skin and tail collagen from diabetic rats. Arch. Biochem. Biophys. 412: 42-46.   DOI
17 Jeong, I. H., Kim, J. M., Jang, D. S., Kim, J. H., Cho, J. H. and Kim, J. S. (2009) Screening of Korean herbal medicines with iInhibitory activity on advanced glycation end products (AGEs) formation (III). Kor. J. Pharmacogn. 40: 382-387.
18 Kim, J. M., Kim, Y. S., Kim, J. H., Yoo, J. L. and Kim, J. S. (2009) Screening of herbal medicines from China and Vietnam with inhibitory activity on advanced glycation end products (AGEs) formation (IV). Kor. J. Pharmacogn. 40: 388-393.
19 Kim, Y. S., Choi, S. H., Kim, J. H. and Kim, J. S. (2011) Screening of herbal medicines from China with inhibitory activity on advanced glycation end products (AGEs) formation (V) Kor. J. Pharmacogn. 42: 46-53.
20 Vinson, J. A. and Howard, III T. B. (1996) Inhibition of protein glycation and advanced glycation endproducts by ascorbic acid and other vitamins and nutrients. J. Nutr. Biochem. 7: 659-663.   DOI
21 Lee, Y. M., Kim, Y. S., Kim, J. H. and Kim, J. S. (2011) Screening of herbal medicines from China with inhibitory activity on advanced glycation end products (AGEs) formation (VI) Kor. J. Pharmacogn. 42: 161-168.
22 Sudheesh, S., Vijayalakshmi, N. R. (2005) Flavonoides from Punica granatum-potential antiperoxidative agents. Fitoterapia 76: 181-186.   DOI
23 Choi, S. J., Kim, Y. S., Song, Y. J., Lee, Y. M., Kim, J. H. and Ki., J. S. (2012) Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (VII). Kor. J. Pharmacogn. 43: 345-351.
24 Choi, S. J., Song, Y. J., Kim, Y. S., Kim, J. H., Sun Hang, Tran The Bach and Kim., J. S. (2012) Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (VIII). Kor. J. Pharmacogn. 43: 338-344.
25 National Pharmacopoeia Committee, (2010) Pharmacopoeia of People's Republic of China, Part 1, 87. Chemical Industry Press, Beijing
26 Caceres, L., Giron, M.,. Alverado, S. R. and Torres, M.F. (1987) Screening of antimicrobial activity of plants popularly used in Guatemala for treatment of dermatomucosal diseases. J. Ethnopharmacol. 20: 223-237.   DOI
27 Usta, C., Ozdemir, S., Schiariti, M. and Puddu, P. E. (2013) The pharmacological use of ellagic acid-rich pomegranate fruit. Int. J. Food Sci .Nutr. 2013 May 24. [Epub ahead of print]
28 Kirtikar, K. R., Basu, B. D. and Terminalia, chebula. (1935) In: Indian Medicinal Plants. Kirtikar KR, Basu BD (eds). 2nd ed. Vol. 1, 1020- 1023. Lalit Mohan Basu Publications, Allahabad, India.
29 Malekzadeh, F., Ehsanifar, H., Shahamat, M., Levin, M. and Colwell, R. R. (2001) Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. Int. J. Antimicrob. Ag. 18: 85-88.   DOI
30 Saleem, A., Husheem, M., Harkonen, P. and Pihlaja, K. (2002) Inhbition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. fruit. J. Ethnopharmacol. 81: 327-336.   DOI
31 Senthilkumar, G. P. and Subramanian, S. P. (2008) Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats. J. Appl. Biomed. 6: 105-115.