• Journal of Veterinary Clinics
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• v.9 no.2
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• pp.391-399
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• 1992

This study was carried out to evaluate the effects of doxapram after medetomidine treatment. Twenty dogs were sedated with medetomidine(0.04mg/kg IM) Ten dogs were injected doxapram(2mg/kg IV) as a experimental group and ten dogs were injected with saline(5$m\ell$ IV) as a control group in twenty minutes after the injection of medetomidine. Recovery time, heart rate, respiratory rate, body temperature. blood chemistry, electrocardiogram findings (ECG) were recorded. The results obtained were as follows ; 1. Medetomidine revealed fast and excellent sedative effect. 2. Recovery time was shorted by doxapram(p<0.01) 3. Respiratory rates were decreased significantly by medetommidine, but increased remarkably after the injection of doxapram and them decreased gradually and revealed normal levels(p<0.01). 4. Herts rates were decreased significantly by medetomidine but increased remarkably after the injection of doxapram and then decreased gradually and revealed normal levels(p<0.01). 5. Body temperature were increased slightly and then decreased by medetomldine and in experimental group revealed with higher levels than those of control group(p<0.01) 6. Arrhythmias were observed after the injection of medetomidine, but relieved after the injection of doxapram . There was no another change on electrocardiograms.

• Journal of Veterinary Clinics
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• v.32 no.1
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• pp.120-122
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• 2015

Hepatoid gland tumors in dogs usually occur in the perianal region, but arise occasionally from other areas such as the tail, back, and thigh. This report describes two cases of ectopic hepatoid gland adenomas in dogs. The tumors have been observed in the lumbar area of the back and in the axillary region, respectively. The cytological and histopathological features were consistent with hepatoid gland adenoma. Although ectopic hepatoid gland tumors have been described previously in literatures, this is the first report of ectopic hepatoid gland adenoma cases in dogs in South Korea.

• Journal of Veterinary Clinics
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• v.34 no.4
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• pp.245-248
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• 2017

Modified rush ASIT protocol has been performed to identify the ideal schedule that allows the dose considered effective to be reached in the shortest possible time with the fewest adverse effects. Ten atopic dogs of this study includes fulfillment of Favrot's criteria. Offending allergens were identified by the use of IDST. During the induction period, the dogs were received a total of 15 injections. Ten injections were administrated every 30 minutes in a day with gradually increasing amounts and concentrations of allergens, and the last 5 injections were administered every 3 days. Disease severity was quantified by using the canine atopic dermatitis extent and severity index (CADESI). During induction period, reduction rate from baseline scores varied between 1% and 67% and the improvement of ${\geq}50%$ was recorded after induction period of therapy for CADESI-03 score in 6 of the 10 dogs. This study of ten dogs with atopic dermatitis provide evidence for the efficacy and safety of modified rush ASIT for clinical improvement.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.364-369
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• 1998

The purposes of the present study were to compare the effects of viscoelastic materials available in phacoemulsification in dogs and to evaluate $ARTZ^{\circledR}$ as their substitute. Six eyes from the healthy adult dogs were used in each group with different viscoelastic materials, $Healon$^{\circledR}, Viscoat^{\circledR}$ and $Occucoat^{\circledR} and ARTZ^{\circledR}$. The phacoemulsification was carried out with surgical micmscope(Leica M65l, Germany) and pbacoemulsiscation gystemGfidek 6000, Japan). $ARTZ^{\circledR}$ had lower pseudoplasocity than other viscoelastics. There was not significant difference in phacotime, rate of posterior capsule rupture, incidence of the intraocular inflammation among the viscoelastic materials. The corneal thickness in all groups was significantly increased in a day after operation and decreased gradually. However $ARTZ$^{\circledR}$ had more time to recover the preoperative thickness than the others. CoBiunctival congestion in the group with $ARTZ^{\circledR}$ was more severe but. there were no postoperative posterior capsule opacity and visual loss. The present study indirated that $ARTZ^{\circledR}$ could be used as viscoelastic material in dogs with respect to the vision after surgery.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.358-362
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• 2001

Brain dead (BD) patients remain the largest source of solid organs for transplantation. BD has shown to decrease graft function and survival in rodent models. The aim of this study was to evaluate how brain death affects graft viability in the donor and kidney tolerance to cold preservation as assessed by survival in a canine transplantation. 13 Beagle dogs were used for the study. Brain death was induced by the sudden inflation of a subdural balloon catheter with continuous monitoring of arterial blood pressure and eletroencephalographic activity (n=3). Sixteen hours after conformation of brain death, kidney graft were retrieved (n=6). Non-BD donors served as controls (n=4). All kidneys were flushed with University of Wisconsin (UW) solution and preserved for 24 hours at 4$^{\circ}C$ before transplantation. Recipient survival rates, serum creatinine level were analyzed. Brain death induced the well-known Cushing reaction with a severe increase in blood pressure and tachycardia. Thereafter, cardiac function returned progressively to baseline within 8 hours and remained stable until the end of the experiment. All of dogs in both group transplanted were survived until 7 days (100%), and the kidneys showed functional early rejection at 8.3$\pm$0.5 days and 8.5$\pm$0.5 days after transplantation, in BD and allograft group, respectively. BD kidneys were functionally similar to control kidneys for 7 days after transplantated. Brain death has no deleterious effect on preservation injury and survival of dog kidney transplantation, although it induces changes in hemodynamic parameters. This study reveals that kidneys from BD donors do not exhibit more ischemia reperfusion injury, and support good early function and survival.

• Journal of Veterinary Clinics
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• v.30 no.4
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• pp.278-282
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• 2013

This study was performed in 41 dogs with unilateral or bilateral medial patella luxation (MPL) and/or cranial cruciate ligament rupture (CCLR). These dogs were classified into 4 groups according to MPL grading system. Radiographic evaluation was performed for pelvis and stifle joint in the dogs. Norberg, inclination, quadriceps and femoral varus angle were measured and analyzed with MPL grading and the existence of cranial cruciate ligament rupture. The Norberg and inclination angle showed no differences between 4 grading groups and between CCLR and no CCLR groups. However, quadriceps and femoral varus angle were statistically different between grade 1, 2 and grade 3, 4 groups. They also have shown the statistical difference between CCLR and no CCLR group. Further studies for how these parameters affect the prognosis and the results of surgical treatment of MPL should be needed.

• Toxicological Research
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• v.17 no.4
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• pp.297-301
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• 2001

The acute toxicity of CJ-50005, an inactivated whole virus vaccine derived from hepatitis A virus (HM175) grown in human MRC-5 diploid fibroblast culture, was tested in Sprague Dawley (SD) rats and beagle dogs. CJ-50005 was orally and intramuscularly administered up to the maximum dose of 81$\mu\textrm{g}$/kg. as much as 3,000 times of the expected clinical dose, in SD rats and was intramuscularly administered up to 27 $\mu\textrm{g}$/kg, as much as 1,000 times of the expected clinical dose, in beagle dogs. In these experiments, there were no death and clinical changes which were related to CJ-50005 administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of CJ-50005 over 81$\mu\textrm{g}$/kg in SD rats and over 27$\mu\textrm{g}$/kg in beagle dogs was proved to be safe, and it is thought that CJ-50005 may not show any toxicity in its clinical use.

• Journal of Veterinary Clinics
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• v.27 no.4
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• pp.392-396
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• 2010

Blood glucose curves in the management for diabetic patients have several limitations including intermittent assessment of blood glucose concentration, hospitalization, patient restraint, and repeated phlebotomy. The aim of this study was to apply and evaluate a wireless continuous glucose monitoring system (CGMS) in healthy dogs. Subcutaneous interstitial glucose concentrations in 7 dogs were continuously monitored and recorded by wireless CGMS. During induced hyperglycemia, the interstitial glucose concentrations were compared with whole blood glucose concentrations measured by glucometer and serum glucose concentrations measured by automated chemistry analyzer, respectively. There were no significant differences among interstitial, whole blood and serum glucose concentrations. The interstitial glucose concentrations had a good correlation to serum glucose concentrations. The real-time wireless CGMS is a valuable tool for monitoring system of glucose concentrations in dogs. Use of the CGMS for diabetic patients will provide accurate information over traditional blood glucose curves.

• Journal of Veterinary Clinics
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• v.34 no.3
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• pp.200-203
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• 2017

The objective of this study was to evaluate the effectiveness of the minimally invasive plate osteosynthesis (MIPO) method for treatment of tibial shaft fractures in dogs by comparing MIPO radiographic and fracture healing time results with those from the popular open reduction and internal fixation (ORIF) technique. In this clinical study at the Royal Animal Medical Center, five consecutive dogs with diagnoses of comminuted tibial shaft fractures were treated with the MIPO surgical approach. For comparison, an additional five breed-, age-, and weight-matched dogs with comminuted tibial shaft fractures were treated with the ORIF technique. Mean healing time was $75.6{\pm}12.5$ days in the MIPO group and $131.8{\pm}18.6$ days in the ORIF group (p < 0.01). The mean surgery time in the MIPO group ($36.4{\pm}3.5$ minutes) was significantly shorter (p < 0.01) than that for the ORIF group ($47.0{\pm}2.2$ minutes). Based on the short surgical and healing times, the MIPO approach is clinically superior to the ORIF approach and should be the preferred approach in tibial fracture cases.

• Journal of Veterinary Clinics
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• v.22 no.2
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• pp.136-140
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• 2005

This experiment is designed to determine the relationship between groomers' activities and stress. The experimenter worked with 2 female dogs and 3 male dogs owned by clients. They were 22 months old on an average and weighed 5.5kg on an average. The concentration of cortisol in blood was measured with radioimmunoassy(RIA). The concentration of cortisol in blood was high in the morning and evening and was low in the afternoon. In a normal condition, the concentration of cortisol in blood was $1.4{\mu}g/dL$, which increased to $4.98{\mu}g/dL$ after 1 hr of grooming, and then returned to normal at the termination of grooming. The survey shows that grooming acted as a stressor, which seems to have an influence on the health of dogs. So it is absolutely necessary that systematic and constant research should be conducted to reduce stress at the time of grooming.