Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Efficacy of Modified Rush Allergen-Specific Immunotherapy on Canine Atopic Dermatitis

  • Lee, Wang-Hui (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Park, Seong-Jun (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungnam National University)
  • Received : 2017.05.28
  • Accepted : 2017.06.11
  • Published : 2017.08.31
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Abstract

Modified rush ASIT protocol has been performed to identify the ideal schedule that allows the dose considered effective to be reached in the shortest possible time with the fewest adverse effects. Ten atopic dogs of this study includes fulfillment of Favrot's criteria. Offending allergens were identified by the use of IDST. During the induction period, the dogs were received a total of 15 injections. Ten injections were administrated every 30 minutes in a day with gradually increasing amounts and concentrations of allergens, and the last 5 injections were administered every 3 days. Disease severity was quantified by using the canine atopic dermatitis extent and severity index (CADESI). During induction period, reduction rate from baseline scores varied between 1% and 67% and the improvement of ${\geq}50%$ was recorded after induction period of therapy for CADESI-03 score in 6 of the 10 dogs. This study of ten dogs with atopic dermatitis provide evidence for the efficacy and safety of modified rush ASIT for clinical improvement.

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References

  1. Favrot C, Steffan J, Seewald W, Picco F. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 2010; 21: 23-31. https://doi.org/10.1111/j.1365-3164.2009.00758.x
  2. Fontaine J, Olivry T. Treatment of canine atopic dermatitis with cyclosporine: a pilot clinical study. Vet Rec 2001; 148: 662-663. https://doi.org/10.1136/vr.148.21.662
  3. Griffin CE, Hillier A. The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy. Vet Immunol Immunopathol 2001; 81: 363-383. https://doi.org/10.1016/S0165-2427(01)00348-8
  4. Halliwell R. Revised nomenclature for veterinary allergy. Vet Immunol Immunopathol 2006; 114: 207-208. https://doi.org/10.1016/j.vetimm.2006.08.013
  5. Hillier A, DeBoer DJ. The ACVD task forece on canine atopic dermatitis (XVII): intradermal testing. Vet Immunol Immunopathol 2001; 81: 289-304. https://doi.org/10.1016/S0165-2427(01)00313-0
  6. Mueller RS, Bettenay SV. Evaluation of the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. Am J Vet Res 2001; 62: 307-310. https://doi.org/10.2460/ajvr.2001.62.307
  7. Mueller RS, Fieseler KV, Zabel S, Rosychuk RAW. Conventional and rush allergen-specific immunotherapy in the treatment of canine atopic dermatitis. In: Advances in Veterinary Dermatology. Iowa: Wiley-Blackwell 2004: 60-69.
  8. Nuttall TJ, Halliwell REW. Serum antibodies to Malassezia yeasts in canine atopic dermatitis. Vet Dermatol 2001; 12: 327-332. https://doi.org/10.1046/j.0959-4493.2001.00261.x
  9. Olivry T, DeBoer DJ, Griffin CE, Halliwell RE, Hill PB, Hillier A, Marsella R, Sousa CA. The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol 2001; 81: 143-146. https://doi.org/10.1016/S0165-2427(01)00343-9
  10. Olivry T, Marsella R, Iwasaki T, Mueller R. Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Vet Dermatol 2007; 18: 78-86. https://doi.org/10.1111/j.1365-3164.2007.00569.x
  11. Olivry T, Mueller RS. Evidence-based veterinary dermatology: a systematic review on the pharmacotherapy of canine atopic dermatitis. Vet Dermatol 2003; 14: 121-146. https://doi.org/10.1046/j.1365-3164.2003.00335.x
  12. Patterson R, Harris KE. Rush immunotherapy in a dog with severe ragweed and grass pollen allergy. Ann Allergy Asthma Immunol 1999; 83: 213-216. https://doi.org/10.1016/S1081-1206(10)62642-7
  13. Reedy LM, Miller WH, Willemse T. Immunotherapy. In: Allergic skin disease of dog and cat, 2nd ed. Philadelphia: WB Saunders. 1997: 116-149.
  14. Schnabl B, Bettenay SV, Dow K, Meueller RS. Results of allergen-specific immunotherapy in 117 dogs with atopic dermatitis. Vet Rec 2006; 158: 81-85. https://doi.org/10.1136/vr.158.3.81
  15. Scott DW, Miller WH, Griffin CE. Skin immune system and allergic skin disease. In: Muller and Kirk's Small animal dermatology, 6th ed. Philadelphia: WB Saunders. 2001: 597-601.
  16. Song KH, Lee JY, Liu J, Lee SE, Park SJ, Kim DH. Prevalence of causative allergen on canine atopic dermatitis in Daejeon area. J Vet Clin 2005; 22: 26-30.
  17. Willemse A, Van den Brom WE, Rijnberk A. Effect of hyposensitisation on atopic dermatitis in dogs. J Am Vet Med Assoc 1984; 184: 1277-1280.
  18. Youn HY, Kang HS, Bhang DH, Kim MK, Hwang CY, Han HR. Allergens causing atopic diseases in canine. J Vet Sci 2002; 3: 335-41.
  19. Zur G, White SD, Ihrke PJ, Kass PH, Toebe N. Canine atopic dermatitis: a retrospective study of 169 cases examined at the University of California, Davis, 1992-1998. Part II. Response to hyposensitization. Vet Dermatol 2002; 13: 103-111. https://doi.org/10.1046/j.1365-3164.2002.00286.x

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