• Experimental and Molecular Medicine
• /
• 제50권12호
• /
• pp.5.1-5.15
• /
• 2018

Targeting hair follicle regeneration has been investigated for the treatment of hair loss, and fundamental studies investigating stem cells and their niche have been described. However, knowledge of stem cell metabolism and the specific regulation of bioenergetics during the hair regeneration process is currently insufficient. Here, we report the hair regrowth-promoting effect of a newly synthesized novel small molecule, IM176OUT05 (IM), which activates stem cell metabolism. IM facilitated stemness induction and maintenance during an induced pluripotent stem cell generation process. IM treatment mildly inhibited mitochondrial oxidative phosphorylation and concurrently increased glycolysis, which accelerated stemness induction during the early phase of reprogramming. More importantly, the topical application of IM accelerated hair follicle regeneration by stimulating the progression of the hair follicle cycle to the anagen phase and increased the hair follicle number in mice. Furthermore, the stem cell population with a glycolytic metabotype appeared slightly earlier in the IM-treated mice. Stem cell and niche signaling involved in the hair regeneration process was also activated by the IM treatment during the early phase of hair follicle regeneration. Overall, these results show that the novel small molecule IM promotes tissue regeneration, specifically in hair regrowth, by restructuring the metabolic configuration of stem cells.

• Journal of Menopausal Medicine
• /
• 제24권3호
• /
• pp.183-187
• /
• 2018

Objectives: The present mini review aimed to summarize the existing knowledge regarding the beneficial and adverse effects of raloxifene in menopausal women. Methods: This study is a review of relevant publications about the effects of raloxifene on sleep disorder, depression, venous thromboembolism, the plasma concentration of lipoprotein, breast cancer, and cognitive function among menopausal women. Results: Raloxifene showed no significant effect on depression and sleep disorder. Verbal memory improved with administration of 60 mg/day of raloxifene while a mild cognitive impairment risk reduction by 33% was observed with administration of 120 mg/day of raloxifene. Raloxifene was associated with a 50% decrease in the need for prolapse surgery. The result of a meta-analysis showed a significant decline in the plasma concentration of lipoprotein in the raloxifene group compared to placebo (standardized mean difference, -0.43; 10 trials). A network meta-analysis showed that raloxifene significantly decreased the risk of breast cancer (relative risk, 0.572; 95% confidence interval, 0.327-0.881; P = 0.01). In terms of adverse effects of raloxifene, the odds ratio (OR) was observed to be 1.54 (P = 0.006), indicating 54% increase in the risk of deep vein thrombosis (DVT) while the OR for pulmonary embolism (PE) was 1.05, suggesting a 91% increase in the risk of PE alone (P = 0.03). Conclusions: Raloxifene had no significant effect on depression and sleep disorder but decreased the concentration of lipoprotein. Raloxifene administration was associated with an increased risk of DVT and PE and a decreased risk of breast cancer and pelvic organ prolapse in postmenopausal women.

• 한국콘텐츠학회논문지
• /
• 제19권10호
• /
• pp.45-58
• /
• 2019

현재 우리나라에서는 현대인들의 일상이 갈수록 각박해져가고 있어 성인들이 어릴 적 감성으로 돌아가 온라인에서 여러 가지 문화들을 접하게 되면서 몇 년 전부터 일명 키덜트 세대가 등장해 현재 장난감 수집 취미를 가지고 있는 사람들이 많이 존재하고 있다. 하지만 현재 온라인상에서 개인 간의 장난감 거래를 위한 정형화된 시스템이 존재하지 않아 메이저 포털 사이트의 카페를 이용하고 있어 전문적인 지식 습득과 상호 간의 정보 공유가 어렵고 장난감 거래를 하면서 보안이나 사기 피해에 노출되고 있어 이를 개선하는 연구가 필요하다. 따라서 본 논문에서는 웹 기반 장난감 거래 시스템을 설계하고 구현한다. 본 논문에서는 현재 상용화되고 있는 다양한 거래 및 중개 시스템들의 장단점을 분석하여 장난감 수집을 취미를 가지고 있는 많은 이용자들에게 전문적인 장난감 지식과 정보 교류의 기회를 제공할 수 있는 중개 시스템을 설계하고 구현했다. 제안하는 시스템은 보안, 인터페이스, 회원의 신뢰성 등의 부분에서 시스템적으로 기존 시스템을 개선했다. 제안하는 시스템을 통해 안전하고 편리한 거래 환경을 통하여 장난감 시장 활성화에 큰 도움이 될 것이다.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2008년 영문 학술대회
• /
• pp.680-685
• /
• 2008

The ejector is a simple device which can transport a low-pressure secondary flow by using a high-pressure primary flow. In general, it consists of a primary driving nozzle, a mixing section, and a diffuser. The ejector system entrains the secondary flow through a shear action generated by the primary jet. Until now, a large number of researches have been made to design and evaluate the ejector systems, where it is assumed that the ejector system has an infinite secondary chamber which can supply mass infinitely. However, in almost all of the practical applications, the ejector system has a finite secondary chamber implying steady flow can be possible only after the flow inside ejector has reached an equilibrium state after the starting process. To the authors' best knowledge, there are no reports on the starting characteristics of the ejector systems and none of the works to date discloses the detailed flow process until the secondary chamber flow reaches an equilibrium state. The objective of the present study is to investigate the starting process of an ejector-diffuser system. The present study is also planned to identify the operating range of ejector-diffuser systems where the steady flow assumption can be applied without uncertainty. The results obtained show that the one and only condition in which an infinite mass entrainment is possible is the generation of a recirculation zone near the primary nozzle exit. The flow in the secondary chamber attains a state of dynamic equilibrium at this point.

• 의학교육논단
• /
• 제23권3호
• /
• pp.160-167
• /
• 2021

Rapid developments in technology as part of the Fourth Industrial Revolution have created a demand for educational technology (EdTech) and a gradual transition from traditional teaching and learning to EdTech-assisted learning in medical education. EdTech is a portmanteau (blended word) combining the concepts of education and technology, and it refers to various attempts to solve education-related problems through information and communication technology. The aim of this study was to explore the use of key EdTech applications in medical education programs. A scoping review was conducted by searching three databases (PubMed, CINAHL, and Educational Sources) for articles published from 2000 to June 2021. Twenty-one studies were found that presented relevant descriptions of the effectiveness of EdTech in medical education programs. Studies on the application and effectiveness of EdTech were categorized as follows: (1) artificial intelligence with learner-adaptive evaluation and feedback, (2) augmented/virtual reality for improving learning participation and academic achievement through immersive learning, and (3) social media/social networking services with learner-directed knowledge generation, sharing, and dissemination in medical communities. Although this review reports the effectiveness of EdTech in various medical education programs, the number of studies and the validity of the identified research designs are insufficient to confirm the educational effects of EdTech. Future studies should utilize suitable research designs and examine the instructional objectives achievable by EdTech-based applications to strengthen the evidence base supporting the application of EdTech by medical educators and institutions.

• 한국수산과학회지
• /
• 제54권6호
• /
• pp.1045-1051
• /
• 2021

Eighty-nine different types of commercially salt-fermented fishery products comprising various raw materials were analyzed for total aerobic bacteria, number of coliform bacteria, fecal coliform, and Escherichia coli. The food-poisoning bacterial content of the samples was investigated using next-generation sequencing. The mean mass of total aerobic bacteria in Jeotgal was 6-1.8×10⁹ CFU/g, and that in Aekjeot and Sikhae was 4-2.2×10⁵ CFU/mL and 1.9×10⁵-8.4×10⁸ CFU/g, respectively. Coliform bacteria were detected in 9 (28.1%) of 32 Jeotgal samples; 15 (46.8%) of 32 seasonal Jeotgal samples; and in 5 (55.5%) of 9 Sikhae samples. Fecal coliform and E. coli were not detected in 86 of the 89 samples. Yersinia enterocolitica was detected only in Galchi jeot (salt-fermented hairtail) (1 type) and not in other Jeotgal samples. These results contribute to our knowledge regarding the bacterial stability of salt-fermented fishery products.

• 기록학연구
• /
• 제21호
• /
• pp.355-383
• /
• 2009

기록관리 공동체의 사명은 한국사회의 어제와 오늘을 담은 기록을 수집하고, 안전하게 관리하여 다음 세대로 전승하는 데 있다. 지난 10년간 우리 기록관리 공동체는 이 사명을 책임 있게 완수하기 위해 다각적인 활동을 벌였고 어느 정도 그 성과를 이루었다. 그러나 지난 한 해 동안 벌어진 일련의 사건은 앞으로 이루어야 할 과업에 비해 지금까지 이룬 성과라고 하는 것이 너무나 빈약하다는 것을 절감할 수밖에 없게 했다. 이 논문의 목적은 전자기록관리와 관련하여 그 동안 이룬 성과와 앞으로의 과제를 점검하는 데 있다. 우선 전자기록이 '기록'으로서 갖는 속성과 '전자' 형태를 취함으로서 갖게 되는 속성을 검토하는 데에서 시작하여, 전자기록의 장기 보존 대책의 전반적 현황을 살펴 볼 것이다. 그리고 앞으로 남은 과제를 전자기록관리원칙에 기반 한 정책, 통합적 전자기록관리 체제, 장기보존 기능 개발과 구현, 그리고 지식확산과 협력의 네 가지 측면에서 제안하고자 한다.

• Journal of Microbiology and Biotechnology
• /
• 제28권12호
• /
• pp.2113-2120
• /
• 2018

Cross-reactive material 197 ($CRM_{197}$) is a non-toxic mutant of diphtheria toxin containing a single amino acid substitution of glycine 52 with glutamic acid. $CRM_{197}$ has been used as a carrier protein for poorly immunogenic polysaccharide antigens to improve immune responses. In this study, to develop a sandwich ELISA that can detect $CRM_{197}$ and $CRM_{197}$ conjugate vaccines, we generated a human anti-$CRM_{197}$ monoclonal antibody (mAb) 3F9 using a phage-displayed human synthetic Fab library and produced mouse anti-$CRM_{197}$ polyclonal antibody. The affinity ($K_D$) of 3F9 for $CRM_{197}$ was 3.55 nM, based on Bio-Layer interferometry, and it bound specifically to the B fragment of $CRM_{197}$. The sandwich ELISA was carried out using 3F9 as a capture antibody and the mouse polyclonal antibody as a detection antibody. The detection limit of the sandwich ELISA was <1 ng/ml $CRM_{197}$. In addition, the 3F9 antibody bound to the $CRM_{197}$-polysaccharide conjugates tested in a dose-dependent manner. This ELISA system will be useful for the quantification and characterization of $CRM_{197}$ and $CRM_{197}$ conjugate vaccines. To our knowledge, this study is the first to generate a human monoclonal antibody against $CRM_{197}$ and to develop a sandwich ELISA for $CRM_{197}$ conjugate vaccines.

• 한국건설관리학회논문집
• /
• 제22권2호
• /
• pp.80-87
• /
• 2021

SOC 예산 부족과 불충분한 건설자금 문제 등으로 건설사의 체감경기가 악화되고 있다. 이러한 상황에서 건설 VE는 건설 수익향상을 통해 이러한 상황에 대처하는 수단이 될 수 있다. 본 연구는 Importance Performance Analysis를 실행하여 효과적인 시공VE의 전략을 수립하기 위한 건설사의 강점 항목과 약점 항목을 도출하였다. 건설사들은 건설VE에 대한 지원·협력·지식 등 12개 항목에서 강점을 지닌다. 반면, 'VE리더의 VE 경험', '상세비용 추정', '아이디어 생성·평가' 등은 약점이 있는 것으로 나타났다. 본 연구는 제도적 관점에서 VE 활성화에 중점을 두었던 기존 연구와 달리 건설기업 관점에서 효과적인 시공VE 수행을 위한 전략을 도출하였다는 점에서 의의가 있다.

• 문화기술의 융합
• /
• 제7권3호
• /
• pp.571-576
• /
• 2021

본 연구는 기존 휘트니스 사업의 문제점을 극복하고, 코로나 시국에 대한 늘어난 수요를 충족시킬 수 있는 휘트니스 시스템을 구축하고자 수행되었다. 비대면 휘트니스 에듀테인먼트 서비스를 위한 플랫폼 기술로써 다양한 신체 부위 운동 및 네트워크형 정보 동기화가 가능한 차세대 휘트니스 운동 기구이다. 휘트니스 장비의 운동 정보를 동기화하여, MR 기반 아바타를 통한 학습형 콘텐츠로 구성하였다. 이용하는 사용자의 누적 운동 효과에 따른, LSTM 기반 알고리즘을 적용한 A.I 분석으로 운동량 분석을 통한 맞춤형 평가 시스템의 적용성을 검토하여 정량화된 결과를 도출하였다. 학계 전문가를 통한, 체계적 운동 기법 적용을 위한 모션 캡처 및 3D 가시화 휘트니스 프로그램으로 이용자의 휘트니스 지식 및 운동능력 향상에 기여할 것이라 판단된다.