• Journal of Korean Medicine for Obesity Research
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• v.15 no.1
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• pp.9-23
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• 2015

Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba-containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangjihwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model. Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined. Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes. Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.

• Journal of Acupuncture Research
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• v.20 no.5
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• pp.82-92
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• 2003

Objective: To appreciate the effect of San-Yin-Jiao(SP-6) pressure on duratof delivery time and quantity of blood loss in order to verify the possibility of application to clinic of San-Yin-Jiao pressure. Methods: The design of this study is nonequivalent control group non- synchronized design. The subjects are 39 persons who are made up of SP-6 pressure applied(experimental) group 20 persons and to control group 19 persons. Collected data were analyzed as frequency, percentage, t-test, $x^2-test$ using SPSS 10.0 WIN Program. Conclusions: San-Yin-Jiao(SP-6) pressure not only make short duration of delivery time, but also decline quantity of blood loss in effect. 1. It could be necessary that the study of the effects of San-Yin-Jio(SP-6) pressure on duration of delivery time and quantity of blood loss for primipara be done repeatedly. 2. It could be necessary to increase this sort of study through free random experimental design in order to generalize this experimental result.

• Journal of Microbiology and Biotechnology
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• v.21 no.4
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• pp.400-404
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• 2011

Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions. In this study, we investigated the effect of selenium on gastric mucosal lesions in rats. To confirm the curative effect of selenium against indomethacin-induced gastric ulcers, gastric ulcers were induced by oral administration of 25 mg/kg indomethacin, and then different doses (10, 50, and 100 ${\mu}g$/kg of body weight) of selenium or vehicle were treated by oral gavage for 3 days. Oral administration of indomethacin clearly increased the gastric ulcer area in the stomach, whereas selenium applied for 3 days significantly decreased the gastric ulcer area in a dose-dependent manner. In addition, selenium markedly reduced the increase of lipid peroxidation induced by indomethacin in the gastric mucosa and increased activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner. These results reveal that selenium can heal indomethacin-induced gastric ulcers through elimination of the lipid peroxides and activation of radical scavenging enzymes.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.409-412
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• 2019

국내의 미세먼지 문제가 심각해짐에 따라 대기 오염에 관한 분야의 관심이 높아지고 있다. 현재 정부는 최근 IT 융합 기술의 발전에 따라 빅데이터, 클라우드, 등 사물인터넷 기반 장치의 확산 및 고도화를 위한 기술 접목에 많은 지원과 관심을 보이며 기상청을 통해서는 국내 대기 오염으로 인한 사회적 비용을 낮추기 위해 공공 데이터(Application Program Interface, API)를 활용 다양한 정보 서비스를 지원하고 있다. 하지만 기상청에서 제공하는 정보 서비스에는 한계가 있다. 특히 기상청에서 운영되고 있는 장비들은 고가의 장비로써 비용 및 공간적 설치 제약이 따르며, 약 15km 범위를 한 개소로 담당하여 기상 데이터에 대한 신뢰도에 문제가 발생하고 있다. 본 논문에서는 오픈 하드웨어 기반 소형 기상관측 장비를 활용한 기상지수 및 미세먼지 측정 데이터 제공 시스템을 제안한다. 본 논문에서 제안한 시스템은 기상 계측이 필요한 지역의 작은 공간을 활용, 기상관측 장비를 통해 관측된 데이터와 기상청에서 제공하는 생활 기상지수 알고리즘을 토대로 해당 지역에 맞는 맞춤형 정보를 제공하여 사회적 비용을 낮출 수 있을 것으로 기대한다.

• The Journal of Internal Korean Medicine
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• v.25 no.4
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• pp.65-74
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• 2004

Object : This is a study of acute stage stroke patients designed for comparison of combined Eastern and Western medical treatments and Oriental treatments alone. Methods : 51 patients were diagnosed by Brain-CT and Brain-MRI scan as having suffered stroke. They had entered Dong-eui hospital within seven days of attack, and remained over seven days, all between November 2002 and August 2003. Patients were divided into two groups: a group treated with both Eastern and Western medical treatments, and a group treated only with Oriental medical treatments (but examinations were done and medications were given in hypertension, Diabetes Mellitus and so on). Results : The Eastern-Western medical treatment group showed significant changes in NIHSS. A rate of improvement figure of 24.94% was obtained for the Eastern-Western medical treatment group, and for the Oriental medical group a figure of 7.84% was obtained. Conclusion : The East-West medical treatment group had significant rate of development that measure for NIHSS by treated comparatively dependent patients. And oriental medical treatment group had significant rate of development that measure for NIHSS by treated comparatively independent patients. The NIHSS measure for the Eastern-Western medical treatment group shows a significant rate of improvement for relatively dependent patients, and the NIHSS measure for the Oriental medical treatment group shows a significant rate of development for relatively independent patients.

• The Journal of Internal Korean Medicine
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• v.30 no.1
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• pp.119-128
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• 2009

Purpose : This study was conducted to find the possibility of DSOM (Diagnosis System of Oriental Medicine) as a diagnostic method according to alcohol intake. Method : 49 men who drink alcohol over 40g per day and whose AUDIT scores were over 12 were allocated to the drinker group. 30 men who do not drink alcohol at all were allocated to the control (non-drinker) group. The study period was from June 15, 2006 to September 30, 2008. All of both groups were analyzed using DSOM. Result : There were some differences between the drinker group and the non-drinker group in stagnation of Ki(氣滯), deficiency of Yin(陰虛), insufficiency of Yang(陽虛), heat syndrome(熱), dryness (燥), and lung(肺). A group whose gamma-GTP is over twice the normal condition shows meaningful difference in stagnation of Ki(氣滯), heat syndrome(熱), dryness(燥), and insufficiency of Yang(陽虛). Conclusion : We found out that DSOM can be a diagnostic method on alcoholic liver disease patients. However, other studies to supplement it should be continued.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.85-92
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• 2011

Objectives : This study was designed to compare the effect between method of regulating ascending kidney water and descending heart fire and sweet bee venom pharmacopuncture on peripheral facial paralysis. Methods : We investigated 30 cases of patient with peripheral facial paralysis who visited at Dept. of Acupuncture & Moxibustion, of Oriental Medicine Dong-eui University from November 29, 2010 to May 15, 2011. Subjects were divided randomly into two groups, group A and group B. We applied method of regulating ascending kidney water and descending heart fire twice or three times a week for group A and sweet bee venom pharmacopuncture with same cycle for group B. We measured the effect of treatment to each group five times by using Yanagihara's unweighed grading system. at first examination, after 1 week, 2 weeks, 3 weeks, and 4 weeks. Results : Both groups showed significant improvement in Yanagihara's scores. And group A was improved better than group B for two weeks from the first examination significantly. But after one week from then, the Yanagihara's scores of group B were higher than those of group A significantly. There were no significant differences during other period. Conclusions : Method of regulating ascending kidney water and descending heart fire is more effective than sweet bee venom pharmacopuncture on peripheral facial paralysis during acute period. And after acute period, sweet bee venom pharmacopuncture is more effective than method of regulating ascending kidney water and descending heart fire.

• Journal of Microbiology and Biotechnology
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• v.19 no.11
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• pp.1355-1363
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• 2009

In the present study, the neuroprotective effects of astaxanthin on $H_2O_2$-mediated apoptotic cell death, using cultured mouse neural progenitor cells (mNPCs), were investigated. To cause apoptotic cell death, mNPCs were pretreated with astaxanthin for 8 h and followed by treatment of 0.3 mM $H_2O_2$. Pretreatment of mNPCs with astaxanthin significantly inhibited $H_2O_2$-mediated apoptosis and induced cell growth in a dose-dependent manner. In Western blot analysis, astaxanthin-pretreated cells showed the activation of p-Akt, p-MEK, p-ERK, and Bcl-2, and the reduction of p-P38, p-SAPK/JNK, Bax, p-GSK3b, cytochrome c, caspase-3, and PARP. Because $H_2O_2$ triggers caspases activation, this study examined whether astaxanthin can inhibit caspases activation in $H_2O_2$-treated mNPCs. After $H_2O_2$ treatment, caspases activities were prominently increased, but astaxanthin pretreatment significantly inhibited $H_2O_2$-mediated caspases activation. Astaxanthin pretreatment also significantly recovered the ATP production ability of $H_2O_2$-treated cells. These findings indicate that astaxanthin inhibits $H_2O_2$-mediated apoptotic features in mNPCs. Inhibition assays with SB203580 ($10\;{\mu}M$, a specific inhibitor of p38) and PD98059 ($10\;{\mu}M$, a specific inhibitor of MEK) clearly showed that astaxanthin can inhibit $H_2O_2$-mediated apoptotic death via modulation of p38 and MEK signaling pathways.

• Proceedings of the Korea Information Processing Society Conference
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• 2003.11a
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• pp.357-360
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• 2003

본 논문에서는 Linux 운영체제에서의 kernel hardening을 설계 및 구현한다. 커널 내에서 panic 이 발생할 경우 복구가 가늠한 경우에는 정상적인 동작이 될 수 있도록 한다. 이렇게 함으로써 Linux Kernel Hardening 기능은 안정적인 커널의 동작을 보장한다. 본 논문에서 Lmux Kernel Hardening을 보장하기 위하여 커널 내 ASSERT() 함수를 중심으로 설계 및 구현을 한다.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.6
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• pp.427-433
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• 2007

Generally, H.V.A.C load capacity in early planning phase can presume with maximum thermal load. Basic data can prove by air conditioning equipment system data analysis at existing building. There are poor and not reliable alternative presentation. In this paper, measured data after use H.V.A.C load calculation K-load program reply choosing standard building and variables simulation. And I founded peak load correlation graph and mode for several kinds of variable and contents of size. I wish that equipment designer is beaconed to produce optimum capacity at building as quantitative through this result.