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http://dx.doi.org/10.15429/jkomor.2015.15.1.9

Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice  

Yoo, Jae Sang (Bonghwang Korean Medicine Clinic)
Ku, Ja Ryong (Soricheong Luck Korean Medicine Clinic)
Yoon, Ki Hyeon (Department of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University,)
Jo, Ju Heum (Woosim Korean Medicine Clinic)
Jang, Du Hyon (Chungnam Korean Medicine Clinic)
Jung, Yang Sam (Jungyangsam Korean Medicine Clinic)
Kim, Jong Hoon (Neungin Korean Medicine Clinic)
Kim, Byeong Chul (Goryo Korean Medicine Clinic)
Seok, Hoa Jun (Soojung Korean Medicine Clinic)
Yoon, Michung (Department of Medical Engineering and Health Management, College of Science & Technology, MokWon University)
Roh, Jong Seong (Department of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University,)
Shin, Soon Shik (Department of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University,)
Publication Information
Journal of Korean Medicine for Obesity Research / v.15, no.1, 2015 , pp. 9-23 More about this Journal
Abstract
Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba-containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangjihwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model. Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined. Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes. Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.
Keywords
Gangji-hwan; Gamisoche-hwan; Pakistani Ephedra Herba; Chinese Ephedra Herba; Obesity; Leptin;
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Times Cited By KSCI : 6  (Citation Analysis)
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