• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2004.11a
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• pp.216-219
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• 2004

Construction clients are the key player in that they initiate construction projects and are in a position to influence the efficiency and productivity of the projects. Construction projects by nature require team-working so clients's leadership is the crux of project success. The objective of this paper is to suggest characteristics of construction clients' leadership in terms of best practice based on the analysis of project success cases. Four key elements of construction clients' leadership are identified and best practice from the case studies were related to the elements.

• Korea Journal of Cosmetic Science
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• v.1 no.1
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• pp.31-43
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• 2019

Melanosomes are specific melanin-containing intracellular organelles of epidermal melanocytes. In epidermal melanocytes, there are three kinds of key player proteins. Rab27a, melanophilin or Slac2-a and Myosin 5a form a tripartite complex connects the melanosome. Mature melanosomes make movements through the tripartite protein complex along actin filaments.In this study, we found that the haplamine (6-Methoxyflindersine) induced melanosome aggregation around the nucleus in epidermal melanocyte. In an attempt to elucidate the inhibitory effect of haplamine on melanosome transport, effect of haplamineon the expression level of Rab27a, melanophilin and Myosin 5a was measured. The results indicated that haplamine up to 5��M effectively suppressed mRNA and protein expression level of melanophilin.To determine the upstream regulator of melanophilin regulated by haplamine, we checked the level of MITF, c-JUN and USF1. Those are possible transcription factor of melanophilin. Among them,treatment of USF1 siRNA decreased mRNA and protein expression level of USF1 as well as melanophilin. Also, treatment of haplamine decreased mRNA and protein expression level of melanophilin as well as USF1 in a dose-dependent manner. Consequently, we found the inhibitory effect of haplamine on melanosome transport in melan-a melanocyte. Treatment of haplamine reduced melanophilin expression level which is a key protein of melanosome transport. We identified that USF1 could be a major transcription factor of melanophilin regulated by haplamine.

• IMMUNE NETWORK
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• v.23 no.4
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• pp.30.1-30.18
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• 2023

About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes.

• BMB Reports
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• v.46 no.6
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• pp.316-321
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• 2013

Gastric cancer remains the main cause of cancer death all around the world, and upregulated activation of the nonreceptor tyrosine kinase c-SRC (SRC) is a key player in the development. In this study, we found that expression of Src is also increased in clinical gastric cancer samples, with the protein level increased more significantly than that at the RNA level. Further study revealed that miR34a and miR203, two tumor suppressive miRNAs, inversely correlate with the expression of Src. Restoration of miR34a and miR203 decreased Src expression in gastric cancer cell lines, which in turn inhibited cell growth and cell migration. In summary, our study here revealed that posttranscriptional regulation of Src contributes to the deregulated cell growth and metastasis in gastric cancer, and targeting Src by miR34a or miR203 mimics would be a promising strategy in therapy.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.46 no.2
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• pp.10-18
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• 2009

In this paper, we propose a novel method for authenticating a user's personal-usage using a secure portable storage, so that the user carrying the secure portable storage is able to consume his/her own broadcast programs freely, regardless of the location of the devices. The proposed authentication process is performed by a portable personal-usage authentication device, an access-control module for the portable personal-usage authentication device, and a player integrating the access control module. The portable personal-usage authentication device plays a role of secure storage in which domain authentication information is securely stored, while the access-control module is in charge of accessing the authentication information and, consequently, acquiring a decryption key. The player decrypts the broadcast programs in real time and processes the decrypted media streams. In this Paper, we describe the structure and procedure of the proposed model, and verify its feasibility by implementation.

• Journal of Digital Contents Society
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• v.18 no.8
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• pp.1481-1487
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• 2017

In this article we describe our preliminary work to create VR interactive storytelling particularly for building empathic relationships between the reader (or the player) and story characters. As a practical guideline for developing empathy-based VR interactive story, we propose four key factors: first, narrativity considering narrative theories and concepts including the notion of focalization by Gerald Genette; second, interactivity for balancing between narrative and player control in interactive storytelling domain; third, consideration of virtual reality in human computer interaction domain; fourth, empathy in narrative from the viewpoint of psychology and cognitive science. We also introduce an example interactive storytelling scenario based on Little Red Riding Hood story. Finally we conclude with our VR implementation using Unreal game engine and HTC Vive.

• Journal of Korea Game Society
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• v.13 no.2
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• pp.39-48
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• 2013

In MMORPGs(Massively Multi-player Online Role-Playing Games) a large number of players actively interact with one another in a virtual world. Therefore MMORGs must be able to quickly process real-time access requests and process requests from numerous gaming users. A key challenge is that the workload of the game server increases as the number of gaming users increases. To address this workload problem, many developers apply with distributed server architectures which use dynamic map partitioning and load balancing according to the server function. Therefore most MMORPG servers partition a virtual world into zones and each zone runs on multiple game servers. These methods cause of players frequently move between game servers, which imposes high overhead for data updates. In this paper, we propose a new architecture that apply with an arithmetic server dedicated to data operation. This architecture enables the existing game servers to process more access and job requests by reducing the load. Through mathematical modeling and experimental results, we show that our scheme yields higher efficiency than the existing ones.

• Journal of Korea Water Resources Association
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• v.55 no.3
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• pp.217-227
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• 2022

Since China adopted Public-Private Partnerships (PPPs) in the water sector in the early 1990s, PPPs have played a key role in improving infrastructure development in China. As the Chinese water market became one of the most enormous and potential existing in the world, once a water player settles down in the market, the company tends to be the world-leading water player on the basis of the number of people served from water infrastructure. Unlike the early PPP period overwhelmed by several water transnational corporations, local water players began to dominate the domestic market and have recently expanded their influence overseas. The Chinese government has continuously intervened to promote private sector participation of local water players in the PPP development process in legal and institutional aspects. Thus this article examined the development of water PPPs in China and analyzed the successful elements of local water players' growth related to the government policy.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2002.11a
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• pp.225-229
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• 2002

The electronic voting becomes new challenging area in cryptographic application. A variety of schemes are designed and implemented based on cryptographic protocols. Initiated by ICU, one of best practices was votopia[1] which was successfully served into the Internet voting based on modified Ohkubo et al.'s scheme[2] under Public Key Infrastructure (PKI) and Java technology. Votopia was used to select the Most Valuable Player and Best Goal Keepers of 2002 FIFA World Cup Korea/Japan$\^$TM/ through the Internet where most voters can access and cast their ballots from any place and at any time. However, votopia assumed that the resources of the Internet voters only connected via wired environment. In this paper, we suggest how to extend votopia to mobile voting which has limited computing resources.

• Journal of the Korea Safety Management & Science
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• v.15 no.3
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• pp.163-170
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• 2013

There are many pros and cons for whether smart glasses and watch would be further going technology or not beyond smart phone. What have to do domestically is to find acting ways to catch up with technological gap in short term basis through analyses and investigations in technological issues, patents profile, market forecast. In this paper, firstly we investigate and review technological issues and form factors of smart glasses and HMD, and secondly analyze technological tendency and identify their core technology and intension from global key player's patents analyses connected with smart glasses, and conclusively suggest technological prospects and it's countermeasures.